Incidental Mutation 'R7782:Vps8'
| ID |
599339 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
045838-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7782 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 21330308 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 727
(I727N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093905
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000096191
AA Change: I727N
PolyPhen 2
Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: I727N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096192
AA Change: I729N
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: I729N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115397
AA Change: I729N
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: I729N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117598
AA Change: I727N
PolyPhen 2
Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: I727N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118923
AA Change: I729N
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: I729N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
AA Change: I297N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
100% (80/80) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933415A04Rik |
GTGTGTGTATGTGTGT |
GTGTGTGT |
11: 43,478,239 (GRCm39) |
|
probably null |
Het |
| Adamts16 |
A |
G |
13: 70,984,265 (GRCm39) |
S133P |
probably damaging |
Het |
| Adamts17 |
T |
C |
7: 66,774,802 (GRCm39) |
W1001R |
probably damaging |
Het |
| Aox4 |
T |
A |
1: 58,270,251 (GRCm39) |
|
probably null |
Het |
| B4galnt4 |
C |
T |
7: 140,644,988 (GRCm39) |
P221S |
probably damaging |
Het |
| BC005537 |
C |
T |
13: 24,987,382 (GRCm39) |
R7W |
possibly damaging |
Het |
| BC034090 |
T |
C |
1: 155,108,410 (GRCm39) |
|
probably benign |
Het |
| Best2 |
T |
A |
8: 85,736,143 (GRCm39) |
D312V |
probably damaging |
Het |
| Bod1l |
A |
T |
5: 41,975,286 (GRCm39) |
D2009E |
probably benign |
Het |
| Ccdc158 |
A |
C |
5: 92,793,373 (GRCm39) |
S672A |
probably benign |
Het |
| Ccdc43 |
A |
T |
11: 102,588,443 (GRCm39) |
L31Q |
probably damaging |
Het |
| Cdcp3 |
G |
A |
7: 130,904,466 (GRCm39) |
|
probably null |
Het |
| Chaf1a |
T |
G |
17: 56,369,291 (GRCm39) |
H507Q |
probably benign |
Het |
| Clptm1l |
A |
G |
13: 73,752,439 (GRCm39) |
Y28C |
probably damaging |
Het |
| Cp |
G |
A |
3: 20,029,223 (GRCm39) |
|
probably null |
Het |
| Crocc |
C |
T |
4: 140,752,597 (GRCm39) |
A1432T |
probably benign |
Het |
| Crybg2 |
A |
G |
4: 133,801,137 (GRCm39) |
T457A |
probably benign |
Het |
| Csnk2a1-ps3 |
C |
T |
1: 156,352,552 (GRCm39) |
T251I |
probably damaging |
Het |
| Dennd4a |
A |
G |
9: 64,814,202 (GRCm39) |
D1473G |
probably damaging |
Het |
| Diaph3 |
A |
G |
14: 87,274,940 (GRCm39) |
F172S |
probably benign |
Het |
| Dnajc5b |
A |
G |
3: 19,629,006 (GRCm39) |
N100S |
probably benign |
Het |
| Dusp13b |
G |
A |
14: 21,791,404 (GRCm39) |
T16I |
possibly damaging |
Het |
| Epb42 |
T |
G |
2: 120,864,916 (GRCm39) |
K58N |
probably benign |
Het |
| Fat1 |
A |
G |
8: 45,403,948 (GRCm39) |
Y233C |
probably damaging |
Het |
| Fcgbp |
T |
A |
7: 27,784,460 (GRCm39) |
Y173* |
probably null |
Het |
| Fign |
T |
A |
2: 63,809,506 (GRCm39) |
D588V |
probably damaging |
Het |
| Fignl2 |
C |
T |
15: 100,951,188 (GRCm39) |
V365M |
unknown |
Het |
| Fnip2 |
A |
C |
3: 79,415,430 (GRCm39) |
Y203D |
probably benign |
Het |
| Ftsj3 |
CCTTCTTCTTCTTCTTCT |
CCTTCTTCTTCTTCT |
11: 106,143,377 (GRCm39) |
|
probably benign |
Het |
| Gfral |
C |
A |
9: 76,100,572 (GRCm39) |
V289L |
probably benign |
Het |
| H2bc21 |
T |
A |
3: 96,128,487 (GRCm39) |
|
probably null |
Het |
| Heatr5b |
G |
T |
17: 79,103,370 (GRCm39) |
T1161K |
probably damaging |
Het |
| Hectd4 |
A |
T |
5: 121,443,784 (GRCm39) |
I1335F |
possibly damaging |
Het |
| Htt |
T |
A |
5: 35,040,336 (GRCm39) |
V2166D |
probably benign |
Het |
| Ipo5 |
G |
C |
14: 121,170,537 (GRCm39) |
K436N |
possibly damaging |
Het |
| Iqca1l |
A |
G |
5: 24,749,224 (GRCm39) |
L758P |
probably damaging |
Het |
| Itga6 |
A |
G |
2: 71,671,879 (GRCm39) |
E794G |
probably damaging |
Het |
| Itga9 |
G |
A |
9: 118,672,712 (GRCm39) |
C148Y |
|
Het |
| Kcnip2 |
A |
C |
19: 45,785,524 (GRCm39) |
|
probably null |
Het |
| Kcnk6 |
T |
C |
7: 28,925,269 (GRCm39) |
T116A |
possibly damaging |
Het |
| Kctd21 |
A |
G |
7: 96,997,297 (GRCm39) |
I257V |
probably benign |
Het |
| Kif19a |
G |
A |
11: 114,672,748 (GRCm39) |
R299Q |
probably damaging |
Het |
| Kifc2 |
G |
A |
15: 76,548,328 (GRCm39) |
G391R |
probably benign |
Het |
| Klrg2 |
A |
G |
6: 38,604,562 (GRCm39) |
V381A |
possibly damaging |
Het |
| Mob1b |
A |
G |
5: 88,897,542 (GRCm39) |
|
probably null |
Het |
| Or13p8 |
T |
C |
4: 118,584,106 (GRCm39) |
Y221H |
probably damaging |
Het |
| Or6c69 |
T |
G |
10: 129,747,392 (GRCm39) |
S252R |
probably damaging |
Het |
| Or6c75 |
T |
C |
10: 129,337,020 (GRCm39) |
V81A |
probably benign |
Het |
| Or7c70 |
T |
C |
10: 78,683,447 (GRCm39) |
I101V |
probably benign |
Het |
| Oxsm |
C |
A |
14: 16,240,925 (GRCm38) |
A375S |
possibly damaging |
Het |
| Pcdha3 |
T |
C |
18: 37,081,193 (GRCm39) |
V645A |
probably damaging |
Het |
| Pcdhb15 |
T |
A |
18: 37,607,788 (GRCm39) |
V340E |
possibly damaging |
Het |
| Pced1a |
G |
A |
2: 130,264,435 (GRCm39) |
P132S |
probably damaging |
Het |
| Pla2r1 |
C |
T |
2: 60,334,531 (GRCm39) |
V414M |
probably benign |
Het |
| Plekhg4 |
A |
C |
8: 106,104,399 (GRCm39) |
I493L |
probably benign |
Het |
| Plekhj1 |
T |
A |
10: 80,634,179 (GRCm39) |
|
probably benign |
Het |
| Pmfbp1 |
G |
T |
8: 110,254,412 (GRCm39) |
K482N |
probably damaging |
Het |
| Ppil3 |
T |
C |
1: 58,473,574 (GRCm39) |
N92S |
probably benign |
Het |
| Ppt2 |
A |
G |
17: 34,844,686 (GRCm39) |
S156P |
probably benign |
Het |
| Prss41 |
A |
T |
17: 24,056,087 (GRCm39) |
D255E |
probably benign |
Het |
| Psg25 |
T |
A |
7: 18,255,227 (GRCm39) |
M430L |
probably benign |
Het |
| Rffl |
A |
T |
11: 82,703,595 (GRCm39) |
C109* |
probably null |
Het |
| Rock2 |
A |
G |
12: 17,021,111 (GRCm39) |
E991G |
probably benign |
Het |
| Rpap2 |
A |
G |
5: 107,768,058 (GRCm39) |
I299V |
probably benign |
Het |
| Rras |
T |
C |
7: 44,670,529 (GRCm39) |
S158P |
probably benign |
Het |
| Serpinb10 |
G |
A |
1: 107,463,196 (GRCm39) |
|
probably benign |
Het |
| Smyd3 |
A |
T |
1: 178,799,859 (GRCm39) |
I360N |
possibly damaging |
Het |
| Synm |
A |
G |
7: 67,384,714 (GRCm39) |
S541P |
probably damaging |
Het |
| Tasor |
A |
G |
14: 27,193,901 (GRCm39) |
T1034A |
probably benign |
Het |
| Tbc1d31 |
C |
A |
15: 57,821,764 (GRCm39) |
T813K |
possibly damaging |
Het |
| Trav7n-4 |
A |
G |
14: 53,329,103 (GRCm39) |
M38V |
probably benign |
Het |
| Tulp3 |
A |
C |
6: 128,301,943 (GRCm39) |
N359K |
possibly damaging |
Het |
| Twf1 |
T |
C |
15: 94,480,654 (GRCm39) |
K196E |
probably benign |
Het |
| Usp24 |
A |
T |
4: 106,173,771 (GRCm39) |
N35Y |
probably damaging |
Het |
| Usp46 |
T |
A |
5: 74,162,772 (GRCm39) |
E342D |
probably benign |
Het |
| Vps50 |
T |
A |
6: 3,532,202 (GRCm39) |
|
probably null |
Het |
| Wdr90 |
C |
T |
17: 26,065,300 (GRCm39) |
R1652Q |
probably damaging |
Het |
| Zfp11 |
A |
T |
5: 129,734,027 (GRCm39) |
V478E |
possibly damaging |
Het |
| Zfp493 |
A |
G |
13: 67,935,123 (GRCm39) |
K359E |
probably benign |
Het |
| Zfp536 |
T |
C |
7: 37,268,126 (GRCm39) |
Y430C |
probably damaging |
Het |
| Zfpm1 |
A |
G |
8: 123,063,689 (GRCm39) |
D916G |
unknown |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTTCACGTGGGTCTACAC -3'
(R):5'- ACATCAGAACCTCTCAGTGATG -3'
Sequencing Primer
(F):5'- GGGTCTACACAGGTCTTCAAGTAC -3'
(R):5'- TGTACACACGGAGGGGACAC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation