Incidental Mutation 'R7846:Vps8'
| ID |
606647 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
045900-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7846 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 21351070 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 916
(Q916K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093905
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
[ENSMUST00000156580]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096191
AA Change: Q916K
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: Q916K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
AA Change: Q918K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: Q918K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115397
AA Change: Q918K
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: Q918K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117598
AA Change: Q916K
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: Q916K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118923
AA Change: Q918K
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: Q918K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
AA Change: Q486K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156580
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232357
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abraxas1 |
A |
G |
5: 100,954,698 (GRCm39) |
V247A |
probably damaging |
Het |
| Acot13 |
G |
T |
13: 25,002,133 (GRCm39) |
T103K |
probably damaging |
Het |
| Acsl6 |
A |
T |
11: 54,251,901 (GRCm39) |
I683F |
probably damaging |
Het |
| Acss2 |
A |
T |
2: 155,402,953 (GRCm39) |
H577L |
probably damaging |
Het |
| Ahctf1 |
A |
T |
1: 179,614,638 (GRCm39) |
V382D |
probably damaging |
Het |
| Aldob |
T |
C |
4: 49,538,858 (GRCm39) |
H220R |
probably damaging |
Het |
| Ankrd1 |
C |
T |
19: 36,094,218 (GRCm39) |
V169M |
probably damaging |
Het |
| Atp5f1a |
G |
A |
18: 77,869,015 (GRCm39) |
R413H |
possibly damaging |
Het |
| Cep76 |
A |
G |
18: 67,762,975 (GRCm39) |
F283L |
probably damaging |
Het |
| Chrna5 |
A |
T |
9: 54,912,391 (GRCm39) |
D397V |
probably benign |
Het |
| Coro7 |
T |
C |
16: 4,488,400 (GRCm39) |
D90G |
probably damaging |
Het |
| Csnk1g3 |
A |
G |
18: 54,081,177 (GRCm39) |
N383D |
probably benign |
Het |
| Cwf19l2 |
C |
A |
9: 3,477,889 (GRCm39) |
Q865K |
probably damaging |
Het |
| Cyth2 |
C |
A |
7: 45,460,378 (GRCm39) |
W149C |
probably damaging |
Het |
| Dgkh |
C |
A |
14: 78,856,026 (GRCm39) |
R349L |
probably damaging |
Het |
| Dnajc1 |
G |
T |
2: 18,224,704 (GRCm39) |
T383N |
possibly damaging |
Het |
| Efcab3 |
T |
A |
11: 104,605,571 (GRCm39) |
|
probably null |
Het |
| Extl3 |
A |
T |
14: 65,313,181 (GRCm39) |
M667K |
probably damaging |
Het |
| Fam149a |
G |
T |
8: 45,811,678 (GRCm39) |
A75E |
|
Het |
| Fgd4 |
T |
G |
16: 16,240,590 (GRCm39) |
Q713P |
probably damaging |
Het |
| Frat2 |
T |
A |
19: 41,836,215 (GRCm39) |
I46F |
probably damaging |
Het |
| Gzmc |
A |
G |
14: 56,469,017 (GRCm39) |
V234A |
probably damaging |
Het |
| H2-Q4 |
A |
G |
17: 35,599,134 (GRCm39) |
N135D |
probably damaging |
Het |
| Ighv1-85 |
A |
T |
12: 115,963,937 (GRCm39) |
V21D |
possibly damaging |
Het |
| Itprid1 |
A |
G |
6: 55,955,320 (GRCm39) |
Q976R |
possibly damaging |
Het |
| Kcna6 |
A |
T |
6: 126,715,983 (GRCm39) |
V302E |
probably damaging |
Het |
| Kdm3b |
G |
T |
18: 34,942,293 (GRCm39) |
V795L |
possibly damaging |
Het |
| Kdm5b |
G |
A |
1: 134,545,578 (GRCm39) |
R913H |
probably damaging |
Het |
| Lpp |
T |
A |
16: 24,426,876 (GRCm39) |
M1K |
probably null |
Het |
| Med12l |
T |
C |
3: 59,172,355 (GRCm39) |
S1704P |
probably damaging |
Het |
| Mfsd10 |
G |
T |
5: 34,793,456 (GRCm39) |
S95* |
probably null |
Het |
| Napepld |
C |
T |
5: 21,880,721 (GRCm39) |
E225K |
probably benign |
Het |
| Ndfip2 |
T |
C |
14: 105,535,448 (GRCm39) |
F245L |
probably damaging |
Het |
| Oaf |
G |
A |
9: 43,134,077 (GRCm39) |
R215C |
probably damaging |
Het |
| Or10k2 |
A |
G |
8: 84,268,526 (GRCm39) |
H251R |
probably damaging |
Het |
| Or13a20 |
C |
T |
7: 140,232,374 (GRCm39) |
H161Y |
probably damaging |
Het |
| Or51i1 |
A |
G |
7: 103,670,736 (GRCm39) |
I263T |
possibly damaging |
Het |
| Or52z15 |
A |
G |
7: 103,332,407 (GRCm39) |
I161V |
probably benign |
Het |
| Or5p6 |
A |
G |
7: 107,631,199 (GRCm39) |
I117T |
probably benign |
Het |
| Or8b47 |
A |
G |
9: 38,435,675 (GRCm39) |
T216A |
probably benign |
Het |
| Pcdhgb2 |
A |
T |
18: 37,825,273 (GRCm39) |
I755F |
possibly damaging |
Het |
| Pde4dip |
A |
G |
3: 97,622,490 (GRCm39) |
L1573P |
probably damaging |
Het |
| Peg3 |
A |
T |
7: 6,713,650 (GRCm39) |
V524E |
probably damaging |
Het |
| Phc1 |
G |
T |
6: 122,310,329 (GRCm39) |
T126N |
probably damaging |
Het |
| Phf1 |
C |
A |
17: 27,154,291 (GRCm39) |
Y169* |
probably null |
Het |
| Pramel25 |
A |
T |
4: 143,520,563 (GRCm39) |
D269V |
probably benign |
Het |
| Prl3a1 |
G |
A |
13: 27,456,442 (GRCm39) |
E99K |
probably damaging |
Het |
| Prss57 |
G |
A |
10: 79,623,213 (GRCm39) |
A78V |
probably damaging |
Het |
| Ptprb |
A |
T |
10: 116,119,453 (GRCm39) |
T196S |
probably benign |
Het |
| Rgsl1 |
A |
T |
1: 153,701,783 (GRCm39) |
C224S |
possibly damaging |
Het |
| Rtn4 |
T |
C |
11: 29,643,274 (GRCm39) |
V29A |
unknown |
Het |
| Selplg |
G |
A |
5: 113,957,481 (GRCm39) |
T275M |
probably damaging |
Het |
| Skint11 |
C |
T |
4: 114,102,076 (GRCm39) |
T363I |
possibly damaging |
Het |
| Slc22a29 |
T |
A |
19: 8,170,851 (GRCm39) |
I289F |
probably benign |
Het |
| Slc26a2 |
A |
G |
18: 61,331,776 (GRCm39) |
S552P |
probably benign |
Het |
| Sptb |
T |
A |
12: 76,655,300 (GRCm39) |
K1480* |
probably null |
Het |
| Sptbn1 |
C |
A |
11: 30,092,153 (GRCm39) |
M537I |
probably damaging |
Het |
| Sqor |
A |
T |
2: 122,627,008 (GRCm39) |
H43L |
probably benign |
Het |
| Srcin1 |
C |
A |
11: 97,416,926 (GRCm39) |
E913* |
probably null |
Het |
| Srgap1 |
A |
G |
10: 121,621,397 (GRCm39) |
L1032P |
probably damaging |
Het |
| Stc2 |
T |
C |
11: 31,315,413 (GRCm39) |
K142R |
probably benign |
Het |
| Stox1 |
A |
C |
10: 62,495,305 (GRCm39) |
N989K |
probably damaging |
Het |
| Tert |
T |
A |
13: 73,776,314 (GRCm39) |
L355H |
probably damaging |
Het |
| Tfb2m |
A |
G |
1: 179,358,926 (GRCm39) |
F319S |
probably damaging |
Het |
| Trps1 |
A |
G |
15: 50,695,273 (GRCm39) |
F341L |
probably damaging |
Het |
| Ttk |
T |
C |
9: 83,725,732 (GRCm39) |
V218A |
probably benign |
Het |
| Vmn1r159 |
A |
G |
7: 22,542,696 (GRCm39) |
I112T |
probably benign |
Het |
| Wdr12 |
A |
T |
1: 60,121,225 (GRCm39) |
D364E |
probably damaging |
Het |
| Ylpm1 |
A |
G |
12: 85,104,042 (GRCm39) |
E2019G |
probably damaging |
Het |
| Zfp267 |
C |
A |
3: 36,219,738 (GRCm39) |
T587N |
probably benign |
Het |
| Zfp507 |
A |
G |
7: 35,493,963 (GRCm39) |
L360P |
probably damaging |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGATTCCAAGTCTGAGGCG -3'
(R):5'- TGTCTATCACTGGGTTACACACTC -3'
Sequencing Primer
(F):5'- GCGCCCTTGGATTAGAATTCTTAGAC -3'
(R):5'- TGGGTTACACACTCAAACTACAGG -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation