Incidental Mutation 'R7831:Cyp2a5'
ID 605619
Institutional Source Beutler Lab
Gene Symbol Cyp2a5
Ensembl Gene ENSMUSG00000005547
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms Coh
MMRRC Submission 045885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R7831 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 26534764-26542689 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 26534940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 51 (T51I)
Ref Sequence ENSEMBL: ENSMUSP00000005685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005685] [ENSMUST00000168869] [ENSMUST00000169007]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000005685
AA Change: T51I

PolyPhen 2 Score 0.714 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000005685
Gene: ENSMUSG00000005547
AA Change: T51I

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
Pfam:p450 34 491 4e-151 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000168869
AA Change: T51I
SMART Domains Protein: ENSMUSP00000130640
Gene: ENSMUSG00000005547
AA Change: T51I

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
PDB:2PG7|D 25 60 9e-14 PDB
SCOP:d1jpza_ 30 60 6e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169007
SMART Domains Protein: ENSMUSP00000128865
Gene: ENSMUSG00000005547

DomainStartEndE-ValueType
Pfam:p450 1 116 1.1e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (87/87)
MGI Phenotype PHENOTYPE: Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,247,404 (GRCm39) V2384I possibly damaging Het
Acsl1 A G 8: 46,972,043 (GRCm39) D297G probably benign Het
Ap2a1 C A 7: 44,550,436 (GRCm39) R944L probably damaging Het
Apbb1ip A G 2: 22,756,933 (GRCm39) Y398C probably damaging Het
Atp8a2 A T 14: 60,011,202 (GRCm39) V968D probably damaging Het
Becn1 T C 11: 101,181,279 (GRCm39) T341A probably benign Het
Card11 G T 5: 140,859,167 (GRCm39) S1126R possibly damaging Het
Ccdc51 T C 9: 108,921,058 (GRCm39) L315S probably damaging Het
Cdk12 T C 11: 98,140,653 (GRCm39) L1298P unknown Het
Cep170b A T 12: 112,711,234 (GRCm39) D1538V probably benign Het
Cfap52 A T 11: 67,826,782 (GRCm39) F348I possibly damaging Het
Clip1 A T 5: 123,751,342 (GRCm39) M813K Het
Col19a1 G A 1: 24,565,563 (GRCm39) T256I unknown Het
Col6a3 A T 1: 90,724,268 (GRCm39) C2027* probably null Het
Crisp4 A T 1: 18,199,013 (GRCm39) N140K probably benign Het
Crocc2 G T 1: 93,143,195 (GRCm39) A1266S probably benign Het
Cyfip2 G A 11: 46,087,273 (GRCm39) R1206C probably damaging Het
Cyp24a1 T A 2: 170,327,860 (GRCm39) M461L probably damaging Het
Cyp2b19 C T 7: 26,466,565 (GRCm39) H398Y possibly damaging Het
Cyp4a29 G A 4: 115,107,367 (GRCm39) V234I probably benign Het
Dicer1 T G 12: 104,675,059 (GRCm39) K734N probably damaging Het
Dnai1 T C 4: 41,614,695 (GRCm39) probably null Het
Entpd3 G A 9: 120,373,025 (GRCm39) G14D probably damaging Het
Entrep3 G A 3: 89,091,520 (GRCm39) probably null Het
Ermp1 T C 19: 29,595,367 (GRCm39) T634A probably benign Het
Evc C T 5: 37,476,427 (GRCm39) G374D probably damaging Het
Fcgbp C A 7: 27,806,404 (GRCm39) T2124K probably damaging Het
Fgf8 G A 19: 45,730,876 (GRCm39) P50S probably benign Het
Fmnl1 C T 11: 103,088,999 (GRCm39) R1074W unknown Het
Galnt18 C T 7: 111,155,665 (GRCm39) V223M possibly damaging Het
Galnt2 A G 8: 125,058,817 (GRCm39) N295S probably benign Het
Grip1 T G 10: 119,854,011 (GRCm39) V600G probably damaging Het
Insm2 T A 12: 55,647,323 (GRCm39) C356S probably damaging Het
Itpr2 T A 6: 146,193,082 (GRCm39) I1672F probably benign Het
Kdm1b T G 13: 47,204,098 (GRCm39) N76K probably benign Het
Khnyn T A 14: 56,125,303 (GRCm39) probably null Het
Kidins220 C T 12: 25,111,230 (GRCm39) A1167V possibly damaging Het
Krt40 T C 11: 99,432,087 (GRCm39) D208G probably benign Het
Lars1 T A 18: 42,350,627 (GRCm39) D894V probably benign Het
Lmx1a A T 1: 167,668,521 (GRCm39) N266I probably benign Het
Mrgprb5 T A 7: 47,817,997 (GRCm39) K246M probably benign Het
Mrpl2 G A 17: 46,959,598 (GRCm39) G176R possibly damaging Het
Muc21 T A 17: 35,929,651 (GRCm39) T1512S unknown Het
Nell1 T A 7: 49,632,548 (GRCm39) F60L possibly damaging Het
Nnt G A 13: 119,506,630 (GRCm39) A453V possibly damaging Het
Opa1 A G 16: 29,467,755 (GRCm39) K940R probably benign Het
Opn5 A C 17: 42,891,510 (GRCm39) I309S probably null Het
Or1af1 C T 2: 37,109,723 (GRCm39) T74I probably damaging Het
Or1r1 A C 11: 73,875,257 (GRCm39) M59R probably damaging Het
Or2ag15 T A 7: 106,340,620 (GRCm39) I174F probably damaging Het
P3h3 T G 6: 124,832,118 (GRCm39) E256A possibly damaging Het
Pald1 G T 10: 61,191,593 (GRCm39) T65K probably damaging Het
Pcnx3 T C 19: 5,735,989 (GRCm39) Y279C probably damaging Het
Pik3c2b G A 1: 132,998,980 (GRCm39) S367N possibly damaging Het
Pik3cb T C 9: 98,970,666 (GRCm39) T342A probably benign Het
Pkd1l3 A T 8: 110,357,990 (GRCm39) E837D possibly damaging Het
Ppp2r2b T A 18: 42,834,597 (GRCm39) Y191F probably benign Het
Ppp4r4 G A 12: 103,557,080 (GRCm39) E439K possibly damaging Het
Ptprk A G 10: 28,444,404 (GRCm39) I946V possibly damaging Het
Ror1 A G 4: 100,298,295 (GRCm39) N556S probably benign Het
Ryr3 C T 2: 112,757,183 (GRCm39) A391T possibly damaging Het
Selp G A 1: 163,972,584 (GRCm39) probably null Het
Setx T C 2: 29,047,120 (GRCm39) L1866S probably damaging Het
Setx T A 2: 29,069,866 (GRCm39) V2557E possibly damaging Het
Slc66a3 T A 12: 17,047,632 (GRCm39) probably null Het
Slit2 A G 5: 48,402,025 (GRCm39) T805A probably benign Het
Sorbs3 T G 14: 70,440,481 (GRCm39) N89T possibly damaging Het
Sorl1 C A 9: 42,001,257 (GRCm39) V248L probably benign Het
Srebf2 T A 15: 82,066,288 (GRCm39) V612E probably damaging Het
Sv2c T A 13: 96,113,200 (GRCm39) Y583F probably damaging Het
Tada1 G T 1: 166,217,442 (GRCm39) R193I probably damaging Het
Tnrc6b C G 15: 80,764,580 (GRCm39) A694G possibly damaging Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Ttn C T 2: 76,711,425 (GRCm39) G8372D unknown Het
Ube2g2 A G 10: 77,470,576 (GRCm39) T68A Het
Ubl7 T G 9: 57,821,918 (GRCm39) V89G possibly damaging Het
Ush2a T A 1: 188,492,038 (GRCm39) I3109N probably damaging Het
Utp20 T A 10: 88,598,632 (GRCm39) K115* probably null Het
Vmn2r26 T A 6: 124,016,758 (GRCm39) Y407* probably null Het
Yod1 G T 1: 130,646,986 (GRCm39) V288F probably damaging Het
Zbed5 A C 5: 129,930,798 (GRCm39) N249T possibly damaging Het
Zbtb5 T C 4: 44,995,244 (GRCm39) T47A probably damaging Het
Zcchc14 T C 8: 122,331,984 (GRCm39) T460A not run Het
Zfp712 A C 13: 67,200,483 (GRCm39) probably null Het
Zfyve16 A T 13: 92,658,836 (GRCm39) H358Q probably benign Het
Other mutations in Cyp2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01354:Cyp2a5 APN 7 26,536,528 (GRCm39) missense possibly damaging 0.82
IGL01744:Cyp2a5 APN 7 26,540,434 (GRCm39) missense probably damaging 1.00
IGL02155:Cyp2a5 APN 7 26,542,471 (GRCm39) missense probably benign 0.06
IGL03076:Cyp2a5 APN 7 26,535,299 (GRCm39) missense probably damaging 0.99
PIT4696001:Cyp2a5 UTSW 7 26,540,404 (GRCm39) missense probably benign 0.18
R0762:Cyp2a5 UTSW 7 26,538,298 (GRCm39) nonsense probably null
R0980:Cyp2a5 UTSW 7 26,538,431 (GRCm39) splice site probably null
R1078:Cyp2a5 UTSW 7 26,534,966 (GRCm39) missense probably benign 0.33
R1511:Cyp2a5 UTSW 7 26,535,361 (GRCm39) missense probably damaging 1.00
R1780:Cyp2a5 UTSW 7 26,541,301 (GRCm39) intron probably benign
R1803:Cyp2a5 UTSW 7 26,534,971 (GRCm39) splice site probably null
R1899:Cyp2a5 UTSW 7 26,538,458 (GRCm39) nonsense probably null
R1977:Cyp2a5 UTSW 7 26,535,347 (GRCm39) missense probably benign 0.15
R2215:Cyp2a5 UTSW 7 26,539,900 (GRCm39) missense probably damaging 1.00
R2258:Cyp2a5 UTSW 7 26,536,528 (GRCm39) missense possibly damaging 0.82
R3051:Cyp2a5 UTSW 7 26,542,410 (GRCm39) missense possibly damaging 0.77
R3052:Cyp2a5 UTSW 7 26,542,410 (GRCm39) missense possibly damaging 0.77
R3053:Cyp2a5 UTSW 7 26,542,410 (GRCm39) missense possibly damaging 0.77
R4387:Cyp2a5 UTSW 7 26,540,479 (GRCm39) missense probably damaging 0.97
R4832:Cyp2a5 UTSW 7 26,534,970 (GRCm39) critical splice donor site probably null
R5054:Cyp2a5 UTSW 7 26,540,529 (GRCm39) missense probably damaging 1.00
R5622:Cyp2a5 UTSW 7 26,535,299 (GRCm39) missense probably damaging 1.00
R5867:Cyp2a5 UTSW 7 26,542,383 (GRCm39) missense probably benign 0.09
R5998:Cyp2a5 UTSW 7 26,536,578 (GRCm39) missense probably benign 0.00
R6186:Cyp2a5 UTSW 7 26,542,813 (GRCm39) unclassified probably benign
R7338:Cyp2a5 UTSW 7 26,542,372 (GRCm39) missense probably damaging 1.00
R7350:Cyp2a5 UTSW 7 26,536,208 (GRCm39) missense probably benign 0.37
R7536:Cyp2a5 UTSW 7 26,539,903 (GRCm39) missense probably damaging 1.00
R7722:Cyp2a5 UTSW 7 26,536,543 (GRCm39) missense probably benign 0.31
R7983:Cyp2a5 UTSW 7 26,539,866 (GRCm39) missense probably benign 0.40
R8805:Cyp2a5 UTSW 7 26,540,530 (GRCm39) missense probably damaging 0.99
R9378:Cyp2a5 UTSW 7 26,539,879 (GRCm39) missense probably damaging 1.00
R9481:Cyp2a5 UTSW 7 26,540,511 (GRCm39) missense possibly damaging 0.95
R9620:Cyp2a5 UTSW 7 26,536,636 (GRCm39) missense possibly damaging 0.75
Z1088:Cyp2a5 UTSW 7 26,540,532 (GRCm39) missense probably damaging 1.00
Z1176:Cyp2a5 UTSW 7 26,536,199 (GRCm39) missense probably damaging 1.00
Z1176:Cyp2a5 UTSW 7 26,534,922 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGACCAAAGTCCGTCCTTCTG -3'
(R):5'- TAGGAAGTGGCGCTGATGTC -3'

Sequencing Primer
(F):5'- CTGTCTCTGGATGTATAAAAGCAAGC -3'
(R):5'- GCGCTGATGTCTTCACAAG -3'
Posted On 2019-12-20