Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00422:Cep162'

6145

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cep162

Ensembl Gene

ENSMUSG00000056919

Gene Name

centrosomal protein 162

Synonyms

4922501C03Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL00422

Quality Score

Status

Chromosome

Chromosomal Location

87189577-87255536 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 87227167 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 461 (D461G)

Ref Sequence

ENSEMBL: ENSMUSP00000091319 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093802]

Predicted Effect

probably benign
Transcript: ENSMUST00000093802
AA Change: D461G

PolyPhen 2 Score 0.244 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: D461G

Domain	Start	End	E-Value	Type
low complexity region	198	208	N/A	INTRINSIC
low complexity region	528	539	N/A	INTRINSIC
coiled coil region	630	674	N/A	INTRINSIC
coiled coil region	695	899	N/A	INTRINSIC
coiled coil region	953	1124	N/A	INTRINSIC
coiled coil region	1235	1386	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144137

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188289

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	T	19: 57,068,186	A359T	probably damaging	Het
Ajuba	A	T	14: 54,571,769	Y400*	probably null	Het
Cckar	T	A	5: 53,699,829	D342V	possibly damaging	Het
Cdc123	A	G	2: 5,798,449	V253A	probably benign	Het
Chd7	G	A	4: 8,859,106	E2399K	probably damaging	Het
Cln8	G	A	8: 14,896,637	C217Y	probably benign	Het
Dchs1	A	G	7: 105,758,029	V2119A	possibly damaging	Het
Dhx33	T	C	11: 71,001,620	S108G	probably benign	Het
Dip2a	T	A	10: 76,313,236	M194L	probably benign	Het
Dnah11	T	C	12: 118,068,096	K1779R	probably damaging	Het
Fads3	T	G	19: 10,055,681	F328V	possibly damaging	Het
Flad1	A	G	3: 89,405,853		probably null	Het
Gm5346	A	G	8: 43,626,351	F279L	probably damaging	Het
Gm7535	G	T	17: 17,911,888		probably benign	Het
Gnpat	A	G	8: 124,885,013	E513G	probably damaging	Het
H2-M5	A	G	17: 36,987,840	I238T	probably damaging	Het
Hoxd12	G	A	2: 74,675,427	R114Q	probably damaging	Het
Ide	T	C	19: 37,276,532	I903V	unknown	Het
Ifi209	T	G	1: 173,638,963	D120E	possibly damaging	Het
Map3k10	T	C	7: 27,668,469	D248G	probably damaging	Het
Mat2b	C	A	11: 40,687,738	G41C	probably damaging	Het
Mfsd4a	T	C	1: 132,040,594	I369V	probably benign	Het
Myom1	T	A	17: 71,126,098	V1480E	probably damaging	Het
Myom2	A	T	8: 15,069,490	D127V	probably damaging	Het
Olfml2b	T	A	1: 170,669,066	V422E	probably damaging	Het
Pkn3	G	A	2: 30,081,104	A228T	probably damaging	Het
Rad17	A	T	13: 100,629,525	I365K	probably benign	Het
Rad17	A	T	13: 100,629,523	S366T	probably damaging	Het
Rpp14	G	A	14: 8,083,934	G30E	possibly damaging	Het
Slco1a6	A	C	6: 142,161,017	C15G	probably benign	Het
Spag9	T	A	11: 94,097,866	F571I	probably benign	Het
Ttc27	T	A	17: 74,780,816	C459S	probably damaging	Het
Washc2	A	G	6: 116,256,676	T888A	probably benign	Het
Zcchc7	A	T	4: 44,931,318	H490L	possibly damaging	Het

Other mutations in Cep162

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00584:Cep162	APN	9	87221090	splice site	probably benign
IGL01387:Cep162	APN	9	87211811	missense	probably benign	0.08
IGL01862:Cep162	APN	9	87253933	missense	possibly damaging	0.90
IGL02304:Cep162	APN	9	87227147	splice site	probably benign
IGL02558:Cep162	APN	9	87225733	missense	probably benign	0.04
IGL02558:Cep162	APN	9	87225726	missense	probably benign
IGL02602:Cep162	APN	9	87246153	missense	probably benign	0.19
IGL02636:Cep162	APN	9	87248379	missense	possibly damaging	0.90
IGL02680:Cep162	APN	9	87246744	missense	possibly damaging	0.64
IGL03195:Cep162	APN	9	87225786	missense	probably benign	0.00
PIT4378001:Cep162	UTSW	9	87217145	missense	probably benign	0.01
PIT4431001:Cep162	UTSW	9	87244345	missense	probably benign	0.00
PIT4434001:Cep162	UTSW	9	87193648	missense	probably damaging	1.00
R0060:Cep162	UTSW	9	87237825	splice site	probably benign
R0218:Cep162	UTSW	9	87211809	missense	possibly damaging	0.73
R0366:Cep162	UTSW	9	87220484	missense	probably damaging	0.96
R0468:Cep162	UTSW	9	87193697	missense	probably damaging	1.00
R0764:Cep162	UTSW	9	87201745	missense	probably damaging	1.00
R1386:Cep162	UTSW	9	87221202	missense	probably benign
R1614:Cep162	UTSW	9	87212932	missense	probably damaging	1.00
R1633:Cep162	UTSW	9	87203683	missense	probably benign	0.23
R1831:Cep162	UTSW	9	87206932	missense	probably damaging	1.00
R1847:Cep162	UTSW	9	87204080	missense	probably benign	0.06
R1941:Cep162	UTSW	9	87199995	missense	probably benign	0.14
R2228:Cep162	UTSW	9	87244331	missense	probably benign	0.05
R2256:Cep162	UTSW	9	87206914	missense	probably damaging	1.00
R2257:Cep162	UTSW	9	87206914	missense	probably damaging	1.00
R2936:Cep162	UTSW	9	87227414	missense	probably benign
R3005:Cep162	UTSW	9	87232060	missense	probably benign	0.00
R3508:Cep162	UTSW	9	87231977	critical splice donor site	probably null
R3689:Cep162	UTSW	9	87225694	nonsense	probably null
R3743:Cep162	UTSW	9	87217177	splice site	probably benign
R4118:Cep162	UTSW	9	87204176	missense	probably benign	0.30
R4380:Cep162	UTSW	9	87200003	missense	probably damaging	0.99
R4450:Cep162	UTSW	9	87225808	missense	probably damaging	1.00
R4540:Cep162	UTSW	9	87212939	missense	probably damaging	1.00
R4598:Cep162	UTSW	9	87203795	missense	possibly damaging	0.95
R4700:Cep162	UTSW	9	87206862	missense	probably damaging	1.00
R4941:Cep162	UTSW	9	87225969	intron	probably benign
R5356:Cep162	UTSW	9	87206895	missense	probably damaging	1.00
R5468:Cep162	UTSW	9	87227237	missense	probably benign	0.00
R5579:Cep162	UTSW	9	87203671	missense	probably benign	0.26
R5859:Cep162	UTSW	9	87204092	missense	probably damaging	1.00
R6114:Cep162	UTSW	9	87203710	missense	probably benign
R6143:Cep162	UTSW	9	87212851	critical splice donor site	probably null
R6422:Cep162	UTSW	9	87232016	missense	possibly damaging	0.92
R6517:Cep162	UTSW	9	87222174	missense	probably damaging	0.99
R6576:Cep162	UTSW	9	87217145	missense	probably benign	0.01
R6782:Cep162	UTSW	9	87211684	missense	probably benign	0.07
R6867:Cep162	UTSW	9	87217081	nonsense	probably null
R7293:Cep162	UTSW	9	87203783	missense	probably benign	0.01
R7355:Cep162	UTSW	9	87253955	nonsense	probably null
R7391:Cep162	UTSW	9	87248494	nonsense	probably null
R7426:Cep162	UTSW	9	87192766	missense	probably damaging	1.00
R7593:Cep162	UTSW	9	87204197	missense	probably benign	0.40
R7710:Cep162	UTSW	9	87232119	missense	probably damaging	1.00
R7841:Cep162	UTSW	9	87244316	missense	probably benign	0.00
R7949:Cep162	UTSW	9	87206848	missense	probably benign	0.04
R8351:Cep162	UTSW	9	87192850	nonsense	probably null
R8451:Cep162	UTSW	9	87192850	nonsense	probably null
R8552:Cep162	UTSW	9	87244308	missense	probably benign	0.34
X0063:Cep162	UTSW	9	87222042	critical splice donor site	probably null
Z1177:Cep162	UTSW	9	87199980	critical splice donor site	probably null

Posted On

2012-04-20