Incidental Mutation 'PIT4431001:Cep162'
ID 555252
Institutional Source Beutler Lab
Gene Symbol Cep162
Ensembl Gene ENSMUSG00000056919
Gene Name centrosomal protein 162
Synonyms 4922501C03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # PIT4431001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 87071630-87137589 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87126398 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 171 (R171S)
Ref Sequence ENSEMBL: ENSMUSP00000091319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093802]
AlphaFold Q6ZQ06
Predicted Effect probably benign
Transcript: ENSMUST00000093802
AA Change: R171S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: R171S

DomainStartEndE-ValueType
low complexity region 198 208 N/A INTRINSIC
low complexity region 528 539 N/A INTRINSIC
coiled coil region 630 674 N/A INTRINSIC
coiled coil region 695 899 N/A INTRINSIC
coiled coil region 953 1124 N/A INTRINSIC
coiled coil region 1235 1386 N/A INTRINSIC
Coding Region Coverage
  • 1x: 93.2%
  • 3x: 90.7%
  • 10x: 84.7%
  • 20x: 71.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449I24Rik A G 5: 146,439,322 (GRCm39) I29V probably benign Het
5730455P16Rik C A 11: 80,254,750 (GRCm39) C357F probably damaging Het
Actr1a A T 19: 46,370,731 (GRCm39) probably null Het
Adcy1 C G 11: 7,014,089 (GRCm39) Q164E possibly damaging Het
Arhgap35 A T 7: 16,295,536 (GRCm39) S1176R possibly damaging Het
Atad2b A G 12: 5,081,795 (GRCm39) T1235A possibly damaging Het
Atosb C A 4: 43,036,024 (GRCm39) G236C probably damaging Het
Atp8a2 T C 14: 59,892,075 (GRCm39) D1091G probably benign Het
Bmp6 T C 13: 38,669,906 (GRCm39) S397P probably benign Het
C3 A T 17: 57,513,242 (GRCm39) N1468K probably benign Het
Ccnjl CGCG CGCGGCG 11: 43,470,534 (GRCm39) probably benign Het
Ccr1 T C 9: 123,764,231 (GRCm39) I100V probably benign Het
Chd8 T C 14: 52,455,706 (GRCm39) H994R probably damaging Het
Cntn3 T A 6: 102,441,527 (GRCm39) K6N probably benign Het
Cope A G 8: 70,765,417 (GRCm39) E289G probably damaging Het
Cpne8 T G 15: 90,436,178 (GRCm39) E279A probably damaging Het
Cyp11a1 A T 9: 57,923,555 (GRCm39) probably null Het
Dcp2 A G 18: 44,545,638 (GRCm39) K333R probably benign Het
Dpp6 G T 5: 27,836,496 (GRCm39) V329F probably benign Het
Drc1 T A 5: 30,504,417 (GRCm39) D186E probably damaging Het
Dsc2 G A 18: 20,179,334 (GRCm39) Q245* probably null Het
Eef1e1 T C 13: 38,842,938 (GRCm39) E11G probably damaging Het
Emilin2 G A 17: 71,562,990 (GRCm39) P915S probably benign Het
Fpgt A G 3: 154,792,422 (GRCm39) M535T possibly damaging Het
Fxyd3 G A 7: 30,770,780 (GRCm39) L37F probably damaging Het
Gal3st2c T A 1: 93,935,834 (GRCm39) I62N probably damaging Het
Gdpd3 T C 7: 126,365,647 (GRCm39) I2T probably benign Het
Gm9611 T C 14: 42,115,888 (GRCm39) M169V Het
Ints3 G A 3: 90,303,767 (GRCm39) T720I probably damaging Het
Itpr2 T G 6: 146,256,218 (GRCm39) M992L probably benign Het
L3mbtl2 T A 15: 81,560,508 (GRCm39) H256Q probably benign Het
Lama2 T C 10: 26,977,426 (GRCm39) T1918A probably damaging Het
Lpcat2b G A 5: 107,581,997 (GRCm39) G442D probably damaging Het
Lrp1b C T 2: 40,894,767 (GRCm39) V2268M Het
Macc1 T C 12: 119,410,246 (GRCm39) L338P probably benign Het
Mtmr2 T C 9: 13,704,475 (GRCm39) F201L probably benign Het
Mtr C T 13: 12,227,329 (GRCm39) V772M probably damaging Het
Mtus2 A G 5: 148,013,515 (GRCm39) T103A probably benign Het
Myo5c A G 9: 75,159,853 (GRCm39) I294V possibly damaging Het
Ncam1 A T 9: 49,709,993 (GRCm39) F13I probably benign Het
Or4a75 T C 2: 89,448,201 (GRCm39) I112V probably benign Het
Paqr6 A T 3: 88,273,084 (GRCm39) I52F possibly damaging Het
Pde2a T G 7: 101,151,104 (GRCm39) V271G probably damaging Het
Pde7b T C 10: 20,276,291 (GRCm39) H405R possibly damaging Het
Plxnb1 A G 9: 108,929,786 (GRCm39) Y214C probably damaging Het
Pmp22 T C 11: 63,042,067 (GRCm39) F101L probably benign Het
Pold1 A G 7: 44,188,318 (GRCm39) L520P probably damaging Het
Pramel1 A G 4: 143,124,960 (GRCm39) T295A possibly damaging Het
Psg20 A T 7: 18,408,475 (GRCm39) I415N probably damaging Het
Ptcd2 T A 13: 99,476,527 (GRCm39) R71* probably null Het
Ptgs1 A T 2: 36,130,692 (GRCm39) N197I probably damaging Het
Rbfox3 T C 11: 118,386,047 (GRCm39) D333G probably damaging Het
Rfx7 T A 9: 72,525,253 (GRCm39) H814Q probably benign Het
Rptn TGGGTCAGAAAGGCAGGCATGACCAGAGTCCTCACCAGGGTCAGAAAGGCAGGCATGACCAGAGTCCTCACCAGGGTCAGAAAGGCAGACAAGACCTGAGTTCTCACCAGGGTCAGAAAGGCAGACAAGACCAGAGTCCTCACCTGGGTCAGAAAGGCAGGCATGACCAGAGTCCTCACCGGGGTCAGAAAGGCAGGCAAGACCAGAGTCCTCACCAGGGTCAGAAAGGCAG TGGGTCAGAAAGGCAGGCATGACCAGAGTCCTCACCAGGGTCAGAAAGGCAGACAAGACCTGAGTTCTCACCAGGGTCAGAAAGGCAGACAAGACCAGAGTCCTCACCTGGGTCAGAAAGGCAGGCATGACCAGAGTCCTCACCGGGGTCAGAAAGGCAGGCAAGACCAGAGTCCTCACCAGGGTCAGAAAGGCAG 3: 93,304,704 (GRCm39) probably benign Het
Serpina3i A T 12: 104,231,432 (GRCm39) H23L probably benign Het
Sipa1l1 T A 12: 82,443,290 (GRCm39) V860E probably benign Het
Slc12a1 T A 2: 125,032,124 (GRCm39) Y592N possibly damaging Het
Slco2a1 T C 9: 102,927,467 (GRCm39) F120S probably damaging Het
Smyd4 T C 11: 75,294,339 (GRCm39) F740S probably damaging Het
Sppl2a T C 2: 126,765,396 (GRCm39) Y242C probably damaging Het
Sqle A G 15: 59,195,509 (GRCm39) K288R probably benign Het
Tbc1d17 A G 7: 44,494,498 (GRCm39) S246P probably benign Het
Tenm3 G A 8: 48,688,642 (GRCm39) T2315M probably damaging Het
Tgfb1i1 C T 7: 127,848,353 (GRCm39) R191C probably damaging Het
Thumpd3 T A 6: 113,036,939 (GRCm39) N279K probably benign Het
Tmed5 T A 5: 108,277,887 (GRCm39) H95L possibly damaging Het
Tmem161a T C 8: 70,634,674 (GRCm39) L443P probably damaging Het
Ttc38 C A 15: 85,720,328 (GRCm39) Q97K probably benign Het
Unc13c C A 9: 73,656,829 (GRCm39) C1124F probably damaging Het
Vmn2r102 A G 17: 19,896,958 (GRCm39) T102A possibly damaging Het
Vwce G A 19: 10,641,946 (GRCm39) E891K possibly damaging Het
Xkr5 A T 8: 18,984,361 (GRCm39) S394T possibly damaging Het
Zan C T 5: 137,390,326 (GRCm39) C4747Y unknown Het
Zfp804a T C 2: 82,089,536 (GRCm39) F1122L probably benign Het
Other mutations in Cep162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Cep162 APN 9 87,109,220 (GRCm39) missense probably benign 0.24
IGL00584:Cep162 APN 9 87,103,143 (GRCm39) splice site probably benign
IGL01387:Cep162 APN 9 87,093,864 (GRCm39) missense probably benign 0.08
IGL01862:Cep162 APN 9 87,135,986 (GRCm39) missense possibly damaging 0.90
IGL02304:Cep162 APN 9 87,109,200 (GRCm39) splice site probably benign
IGL02558:Cep162 APN 9 87,107,779 (GRCm39) missense probably benign
IGL02558:Cep162 APN 9 87,107,786 (GRCm39) missense probably benign 0.04
IGL02602:Cep162 APN 9 87,128,206 (GRCm39) missense probably benign 0.19
IGL02636:Cep162 APN 9 87,130,432 (GRCm39) missense possibly damaging 0.90
IGL02680:Cep162 APN 9 87,128,797 (GRCm39) missense possibly damaging 0.64
IGL03195:Cep162 APN 9 87,107,839 (GRCm39) missense probably benign 0.00
circus UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
moscow UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
smiley UTSW 9 87,099,134 (GRCm39) nonsense probably null
PIT4378001:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
PIT4434001:Cep162 UTSW 9 87,075,701 (GRCm39) missense probably damaging 1.00
R0060:Cep162 UTSW 9 87,119,878 (GRCm39) splice site probably benign
R0218:Cep162 UTSW 9 87,093,862 (GRCm39) missense possibly damaging 0.73
R0366:Cep162 UTSW 9 87,102,537 (GRCm39) missense probably damaging 0.96
R0468:Cep162 UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
R0764:Cep162 UTSW 9 87,083,798 (GRCm39) missense probably damaging 1.00
R1386:Cep162 UTSW 9 87,103,255 (GRCm39) missense probably benign
R1614:Cep162 UTSW 9 87,094,985 (GRCm39) missense probably damaging 1.00
R1633:Cep162 UTSW 9 87,085,736 (GRCm39) missense probably benign 0.23
R1831:Cep162 UTSW 9 87,088,985 (GRCm39) missense probably damaging 1.00
R1847:Cep162 UTSW 9 87,086,133 (GRCm39) missense probably benign 0.06
R1941:Cep162 UTSW 9 87,082,048 (GRCm39) missense probably benign 0.14
R2228:Cep162 UTSW 9 87,126,384 (GRCm39) missense probably benign 0.05
R2256:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2257:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2936:Cep162 UTSW 9 87,109,467 (GRCm39) missense probably benign
R3005:Cep162 UTSW 9 87,114,113 (GRCm39) missense probably benign 0.00
R3508:Cep162 UTSW 9 87,114,030 (GRCm39) critical splice donor site probably null
R3689:Cep162 UTSW 9 87,107,747 (GRCm39) nonsense probably null
R3743:Cep162 UTSW 9 87,099,230 (GRCm39) splice site probably benign
R4118:Cep162 UTSW 9 87,086,229 (GRCm39) missense probably benign 0.30
R4380:Cep162 UTSW 9 87,082,056 (GRCm39) missense probably damaging 0.99
R4450:Cep162 UTSW 9 87,107,861 (GRCm39) missense probably damaging 1.00
R4540:Cep162 UTSW 9 87,094,992 (GRCm39) missense probably damaging 1.00
R4598:Cep162 UTSW 9 87,085,848 (GRCm39) missense possibly damaging 0.95
R4700:Cep162 UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
R4941:Cep162 UTSW 9 87,108,022 (GRCm39) intron probably benign
R5356:Cep162 UTSW 9 87,088,948 (GRCm39) missense probably damaging 1.00
R5468:Cep162 UTSW 9 87,109,290 (GRCm39) missense probably benign 0.00
R5579:Cep162 UTSW 9 87,085,724 (GRCm39) missense probably benign 0.26
R5859:Cep162 UTSW 9 87,086,145 (GRCm39) missense probably damaging 1.00
R6114:Cep162 UTSW 9 87,085,763 (GRCm39) missense probably benign
R6143:Cep162 UTSW 9 87,094,904 (GRCm39) critical splice donor site probably null
R6422:Cep162 UTSW 9 87,114,069 (GRCm39) missense possibly damaging 0.92
R6517:Cep162 UTSW 9 87,104,227 (GRCm39) missense probably damaging 0.99
R6576:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
R6782:Cep162 UTSW 9 87,093,737 (GRCm39) missense probably benign 0.07
R6867:Cep162 UTSW 9 87,099,134 (GRCm39) nonsense probably null
R7293:Cep162 UTSW 9 87,085,836 (GRCm39) missense probably benign 0.01
R7355:Cep162 UTSW 9 87,136,008 (GRCm39) nonsense probably null
R7391:Cep162 UTSW 9 87,130,547 (GRCm39) nonsense probably null
R7426:Cep162 UTSW 9 87,074,819 (GRCm39) missense probably damaging 1.00
R7593:Cep162 UTSW 9 87,086,250 (GRCm39) missense probably benign 0.40
R7710:Cep162 UTSW 9 87,114,172 (GRCm39) missense probably damaging 1.00
R7841:Cep162 UTSW 9 87,126,369 (GRCm39) missense probably benign 0.00
R7949:Cep162 UTSW 9 87,088,901 (GRCm39) missense probably benign 0.04
R8351:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8451:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8552:Cep162 UTSW 9 87,126,361 (GRCm39) missense probably benign 0.34
R8755:Cep162 UTSW 9 87,114,064 (GRCm39) missense probably benign 0.02
R8762:Cep162 UTSW 9 87,109,314 (GRCm39) missense probably benign 0.00
R9640:Cep162 UTSW 9 87,126,352 (GRCm39) missense probably benign 0.06
X0063:Cep162 UTSW 9 87,104,095 (GRCm39) critical splice donor site probably null
Z1177:Cep162 UTSW 9 87,082,033 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CTGCTTCTCGGAGAATCTCC -3'
(R):5'- GAGTTACCTGAGTCATGGGATGATAC -3'

Sequencing Primer
(F):5'- GAGAATCTCCCTGGACAACGTG -3'
(R):5'- CCTGAGTCATGGGATGATACATATAC -3'
Posted On 2019-06-07