Incidental Mutation 'R8170:Vmn2r25'
| ID |
634036 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r25
|
| Ensembl Gene |
ENSMUSG00000094672 |
| Gene Name |
vomeronasal 2, receptor 25 |
| Synonyms |
EG545874 |
| MMRRC Submission |
067596-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R8170 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 123829976 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 58
(R58S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
| AlphaFold |
W4VSP2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162046
AA Change: R58S
PolyPhen 2
Score 0.087 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: R58S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
100% (76/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,411,713 (GRCm39) |
V595A |
probably benign |
Het |
| A430033K04Rik |
A |
G |
5: 138,645,315 (GRCm39) |
E400G |
possibly damaging |
Het |
| Abca16 |
C |
T |
7: 120,065,005 (GRCm39) |
T554I |
probably damaging |
Het |
| Acadm |
T |
A |
3: 153,650,035 (GRCm39) |
R10W |
possibly damaging |
Het |
| Arhgap45 |
G |
A |
10: 79,863,706 (GRCm39) |
A819T |
probably damaging |
Het |
| Arhgef25 |
A |
G |
10: 127,023,048 (GRCm39) |
W120R |
probably damaging |
Het |
| Atg7 |
A |
T |
6: 114,678,151 (GRCm39) |
Q347L |
probably benign |
Het |
| Atl2 |
T |
C |
17: 80,163,690 (GRCm39) |
I316V |
possibly damaging |
Het |
| B4galnt3 |
A |
T |
6: 120,183,577 (GRCm39) |
|
probably null |
Het |
| Baiap2l1 |
A |
T |
5: 144,214,502 (GRCm39) |
Y397* |
probably null |
Het |
| Cacna1b |
A |
G |
2: 24,568,886 (GRCm39) |
|
probably null |
Het |
| Capn10 |
T |
C |
1: 92,862,686 (GRCm39) |
S31P |
probably damaging |
Het |
| Casp8ap2 |
C |
T |
4: 32,615,490 (GRCm39) |
|
probably benign |
Het |
| Ccdc122 |
A |
T |
14: 77,329,318 (GRCm39) |
I124L |
probably benign |
Het |
| Ccdc90b |
A |
G |
7: 92,210,750 (GRCm39) |
S3G |
probably benign |
Het |
| Cdc14b |
A |
T |
13: 64,363,549 (GRCm39) |
|
probably null |
Het |
| Chd5 |
T |
A |
4: 152,461,040 (GRCm39) |
M1210K |
probably benign |
Het |
| Clec18a |
T |
G |
8: 111,807,551 (GRCm39) |
K133T |
probably damaging |
Het |
| Cog4 |
T |
A |
8: 111,592,663 (GRCm39) |
M413K |
probably damaging |
Het |
| Cpa5 |
A |
T |
6: 30,624,594 (GRCm39) |
I145L |
probably benign |
Het |
| Ctdspl2 |
T |
G |
2: 121,837,423 (GRCm39) |
S397A |
probably benign |
Het |
| Dnah8 |
T |
A |
17: 30,892,797 (GRCm39) |
I794N |
probably damaging |
Het |
| Ednrb |
T |
A |
14: 104,060,640 (GRCm39) |
T218S |
possibly damaging |
Het |
| Eif3b |
T |
A |
5: 140,412,530 (GRCm39) |
|
probably null |
Het |
| Fanci |
A |
C |
7: 79,083,305 (GRCm39) |
|
probably null |
Het |
| Fat2 |
C |
T |
11: 55,161,281 (GRCm39) |
V3150M |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 15,858,792 (GRCm39) |
Y3808C |
probably damaging |
Het |
| Gabrr1 |
T |
A |
4: 33,162,718 (GRCm39) |
L428Q |
probably damaging |
Het |
| Garnl3 |
G |
C |
2: 32,905,235 (GRCm39) |
P488R |
possibly damaging |
Het |
| Gli3 |
T |
C |
13: 15,894,793 (GRCm39) |
S656P |
probably benign |
Het |
| Gpr153 |
T |
C |
4: 152,364,634 (GRCm39) |
I230T |
probably damaging |
Het |
| Hoxc6 |
A |
G |
15: 102,918,293 (GRCm39) |
N86D |
probably benign |
Het |
| Iqch |
T |
G |
9: 63,336,312 (GRCm39) |
R985S |
probably damaging |
Het |
| Jun |
T |
A |
4: 94,938,559 (GRCm39) |
N317I |
probably damaging |
Het |
| Kif26a |
T |
G |
12: 112,141,752 (GRCm39) |
|
probably null |
Het |
| Map4k3 |
T |
C |
17: 80,913,289 (GRCm39) |
H627R |
possibly damaging |
Het |
| Misp |
T |
A |
10: 79,662,300 (GRCm39) |
I239N |
probably benign |
Het |
| Mpzl2 |
T |
A |
9: 44,955,019 (GRCm39) |
V27E |
probably damaging |
Het |
| Mta3 |
T |
C |
17: 84,099,090 (GRCm39) |
S385P |
probably damaging |
Het |
| Muc5b |
G |
A |
7: 141,414,737 (GRCm39) |
S2561N |
unknown |
Het |
| Myh8 |
A |
G |
11: 67,179,092 (GRCm39) |
H495R |
probably benign |
Het |
| Nbeal1 |
G |
C |
1: 60,276,310 (GRCm39) |
V684L |
probably benign |
Het |
| Nlrp5 |
A |
T |
7: 23,133,135 (GRCm39) |
T927S |
probably benign |
Het |
| Nr5a2 |
T |
A |
1: 136,868,385 (GRCm39) |
D310V |
probably benign |
Het |
| Nrbp1 |
A |
G |
5: 31,403,147 (GRCm39) |
T207A |
probably damaging |
Het |
| Nxf1 |
G |
T |
19: 8,748,414 (GRCm39) |
L14F |
probably benign |
Het |
| Or2a25 |
G |
A |
6: 42,889,125 (GRCm39) |
A223T |
possibly damaging |
Het |
| Or6c207 |
T |
A |
10: 129,104,917 (GRCm39) |
N92Y |
possibly damaging |
Het |
| Pcdhb15 |
A |
G |
18: 37,608,637 (GRCm39) |
E623G |
probably damaging |
Het |
| Pid1 |
T |
C |
1: 84,262,721 (GRCm39) |
|
probably null |
Het |
| Plcb2 |
C |
A |
2: 118,541,934 (GRCm39) |
R892L |
possibly damaging |
Het |
| Polr1a |
C |
G |
6: 71,897,733 (GRCm39) |
P243A |
probably benign |
Het |
| Pot1a |
A |
G |
6: 25,758,802 (GRCm39) |
*326Q |
probably null |
Het |
| Ppp5c |
G |
T |
7: 16,741,071 (GRCm39) |
F335L |
probably damaging |
Het |
| Prl8a2 |
T |
C |
13: 27,536,794 (GRCm39) |
Y139H |
probably benign |
Het |
| Rogdi |
G |
T |
16: 4,829,601 (GRCm39) |
R93S |
probably benign |
Het |
| Rsph6a |
C |
A |
7: 18,791,505 (GRCm39) |
R225S |
probably damaging |
Het |
| Septin8 |
T |
C |
11: 53,428,684 (GRCm39) |
S408P |
possibly damaging |
Het |
| Sf3a2 |
T |
A |
10: 80,639,131 (GRCm39) |
|
probably null |
Het |
| Shank3 |
T |
C |
15: 89,433,043 (GRCm39) |
S1263P |
possibly damaging |
Het |
| Speer4f2 |
A |
C |
5: 17,579,459 (GRCm39) |
D86A |
|
Het |
| Spmip8 |
A |
T |
8: 96,046,686 (GRCm39) |
I120F |
probably damaging |
Het |
| Stard9 |
T |
C |
2: 120,530,529 (GRCm39) |
F2262S |
possibly damaging |
Het |
| Svep1 |
T |
A |
4: 58,069,378 (GRCm39) |
I2803F |
probably benign |
Het |
| Taf1c |
C |
T |
8: 120,329,565 (GRCm39) |
|
probably null |
Het |
| Tasor2 |
G |
A |
13: 3,624,881 (GRCm39) |
Q1690* |
probably null |
Het |
| Tfap2a |
C |
T |
13: 40,872,744 (GRCm39) |
V317I |
probably benign |
Het |
| Thnsl2 |
T |
C |
6: 71,106,317 (GRCm39) |
T370A |
probably benign |
Het |
| Tmem201 |
C |
T |
4: 149,803,177 (GRCm39) |
G564S |
probably benign |
Het |
| Ttc41 |
A |
C |
10: 86,612,030 (GRCm39) |
E1101A |
probably damaging |
Het |
| Ugcg |
T |
A |
4: 59,211,974 (GRCm39) |
F113L |
possibly damaging |
Het |
| Unc80 |
G |
T |
1: 66,690,692 (GRCm39) |
V2456L |
probably benign |
Het |
| Vav3 |
A |
T |
3: 109,331,323 (GRCm39) |
N74I |
probably damaging |
Het |
| Wdr97 |
C |
A |
15: 76,247,819 (GRCm39) |
F1614L |
|
Het |
| Ylpm1 |
T |
A |
12: 85,080,801 (GRCm39) |
M1499K |
probably benign |
Het |
| Zfp647 |
A |
G |
15: 76,795,571 (GRCm39) |
V363A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
|
R0366:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
|
R1780:Vmn2r25
|
UTSW |
6 |
123,805,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1833:Vmn2r25
|
UTSW |
6 |
123,816,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2154:Vmn2r25
|
UTSW |
6 |
123,816,805 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Vmn2r25
|
UTSW |
6 |
123,817,057 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAAGTCTTTTCAACAATGTCTTAC -3'
(R):5'- CCAAGATCCTCAACTGAACAGATAT -3'
Sequencing Primer
(F):5'- GTAGCTTGCCTACACTCTAGAAGG -3'
(R):5'- GTTGTTCTCATTTTATTCCAGG -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation