Incidental Mutation 'R2154:Vmn2r25'
ID |
234615 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r25
|
Ensembl Gene |
ENSMUSG00000094672 |
Gene Name |
vomeronasal 2, receptor 25 |
Synonyms |
EG545874 |
MMRRC Submission |
040157-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.119)
|
Stock # |
R2154 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 123816805 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 259
(T259S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
AlphaFold |
W4VSP2 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000162046
AA Change: T259S
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
SMART Domains |
Protein: ENSMUSP00000124342 Gene: ENSMUSG00000094672 AA Change: T259S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700030K09Rik |
A |
G |
8: 73,208,959 (GRCm39) |
E363G |
probably benign |
Het |
Abca3 |
A |
G |
17: 24,596,693 (GRCm39) |
Y382C |
probably damaging |
Het |
Abca5 |
A |
G |
11: 110,183,000 (GRCm39) |
I1019T |
probably benign |
Het |
Acox3 |
A |
T |
5: 35,762,568 (GRCm39) |
S481C |
probably damaging |
Het |
Ankrd7 |
T |
A |
6: 18,870,030 (GRCm39) |
M261K |
probably benign |
Het |
Aqr |
A |
C |
2: 113,967,485 (GRCm39) |
M510R |
probably damaging |
Het |
Arpc1a |
A |
T |
5: 145,029,369 (GRCm39) |
T56S |
probably benign |
Het |
Asap2 |
A |
T |
12: 21,162,084 (GRCm39) |
T14S |
probably damaging |
Het |
Aspg |
A |
G |
12: 112,087,408 (GRCm39) |
E288G |
probably benign |
Het |
Atp2c2 |
A |
G |
8: 120,482,841 (GRCm39) |
N901S |
probably benign |
Het |
Cabcoco1 |
A |
G |
10: 68,267,092 (GRCm39) |
L205P |
probably damaging |
Het |
Cant1 |
A |
G |
11: 118,302,263 (GRCm39) |
L18P |
probably damaging |
Het |
Cdca2 |
G |
A |
14: 67,914,425 (GRCm39) |
P945S |
probably damaging |
Het |
Cfap74 |
A |
G |
4: 155,513,753 (GRCm39) |
K522E |
possibly damaging |
Het |
Chek1 |
C |
A |
9: 36,635,279 (GRCm39) |
V35F |
probably damaging |
Het |
Cpa6 |
A |
T |
1: 10,407,547 (GRCm39) |
M330K |
probably damaging |
Het |
Creb3l4 |
G |
T |
3: 90,145,792 (GRCm39) |
N246K |
probably damaging |
Het |
Cyp2c55 |
T |
A |
19: 39,022,819 (GRCm39) |
V319D |
probably damaging |
Het |
Dapk1 |
T |
A |
13: 60,877,317 (GRCm39) |
S519T |
probably benign |
Het |
Dhx38 |
T |
C |
8: 110,287,306 (GRCm39) |
S221G |
probably benign |
Het |
Dis3l |
T |
A |
9: 64,214,545 (GRCm39) |
N981I |
probably benign |
Het |
Dock4 |
T |
A |
12: 40,870,661 (GRCm39) |
V1467E |
probably damaging |
Het |
Dock4 |
ACCTGCTCTGCC |
ACCTGCTCTGCCTGCTCTGCC |
12: 40,894,547 (GRCm39) |
|
probably benign |
Het |
Dok5 |
G |
A |
2: 170,642,816 (GRCm39) |
G38D |
probably damaging |
Het |
Ercc6l2 |
T |
C |
13: 64,013,821 (GRCm39) |
S631P |
probably damaging |
Het |
Fat4 |
A |
T |
3: 38,941,688 (GRCm39) |
S194C |
probably damaging |
Het |
Fcsk |
T |
A |
8: 111,615,704 (GRCm39) |
T542S |
probably benign |
Het |
Garem2 |
T |
C |
5: 30,313,297 (GRCm39) |
S54P |
probably damaging |
Het |
Gdf10 |
T |
C |
14: 33,656,346 (GRCm39) |
I436T |
probably damaging |
Het |
Gfod1 |
T |
C |
13: 43,456,946 (GRCm39) |
T10A |
possibly damaging |
Het |
Gucy1a1 |
A |
G |
3: 82,018,458 (GRCm39) |
|
probably null |
Het |
Heatr5b |
G |
T |
17: 79,138,873 (GRCm39) |
Q90K |
probably benign |
Het |
Ikzf3 |
T |
A |
11: 98,376,475 (GRCm39) |
K211* |
probably null |
Het |
Itgam |
A |
C |
7: 127,684,749 (GRCm39) |
D373A |
probably damaging |
Het |
Itpripl2 |
A |
G |
7: 118,089,107 (GRCm39) |
F484S |
probably damaging |
Het |
Kat6b |
A |
T |
14: 21,718,735 (GRCm39) |
H1138L |
probably benign |
Het |
Kif16b |
T |
C |
2: 142,532,500 (GRCm39) |
K1213R |
probably damaging |
Het |
Klra3 |
G |
C |
6: 130,310,107 (GRCm39) |
R138G |
probably benign |
Het |
Mmp25 |
T |
A |
17: 23,850,048 (GRCm39) |
Y504F |
probably damaging |
Het |
Mtf2 |
A |
G |
5: 108,228,797 (GRCm39) |
K38E |
possibly damaging |
Het |
Myh14 |
A |
C |
7: 44,301,853 (GRCm39) |
|
probably null |
Het |
Nedd4l |
T |
A |
18: 65,343,401 (GRCm39) |
H820Q |
probably damaging |
Het |
Nfkb1 |
T |
C |
3: 135,307,240 (GRCm39) |
T562A |
probably benign |
Het |
Or8b49 |
G |
T |
9: 38,505,707 (GRCm39) |
L63F |
probably damaging |
Het |
Pds5a |
A |
T |
5: 65,807,841 (GRCm39) |
V464E |
probably damaging |
Het |
Peak1 |
C |
T |
9: 56,114,496 (GRCm39) |
V452M |
probably damaging |
Het |
Phf2 |
T |
C |
13: 48,973,549 (GRCm39) |
Y372C |
unknown |
Het |
Poc1a |
T |
A |
9: 106,162,773 (GRCm39) |
|
probably null |
Het |
Prss33 |
C |
T |
17: 24,053,817 (GRCm39) |
V87M |
probably damaging |
Het |
Psmc2 |
C |
G |
5: 22,008,127 (GRCm39) |
L344V |
possibly damaging |
Het |
Ptpn12 |
C |
A |
5: 21,207,466 (GRCm39) |
Q297H |
probably damaging |
Het |
Rabgap1 |
T |
C |
2: 37,365,453 (GRCm39) |
V242A |
probably damaging |
Het |
Rad1 |
C |
A |
15: 10,486,721 (GRCm39) |
H39Q |
possibly damaging |
Het |
Rad51ap2 |
A |
G |
12: 11,507,986 (GRCm39) |
H636R |
probably benign |
Het |
Samd9l |
C |
T |
6: 3,372,945 (GRCm39) |
D1439N |
possibly damaging |
Het |
Sbno1 |
A |
T |
5: 124,516,574 (GRCm39) |
D1266E |
probably benign |
Het |
Sidt2 |
T |
C |
9: 45,856,638 (GRCm39) |
D477G |
probably damaging |
Het |
Slc22a13 |
T |
C |
9: 119,037,753 (GRCm39) |
K125R |
probably benign |
Het |
Slc6a1 |
G |
T |
6: 114,284,731 (GRCm39) |
G263V |
probably damaging |
Het |
Slmap |
A |
G |
14: 26,139,402 (GRCm39) |
Y771H |
probably damaging |
Het |
Smg1 |
A |
T |
7: 117,757,299 (GRCm39) |
|
probably benign |
Het |
Spinkl |
A |
T |
18: 44,302,194 (GRCm39) |
N32K |
probably benign |
Het |
Stxbp1 |
T |
A |
2: 32,692,868 (GRCm39) |
I383F |
probably damaging |
Het |
Taf3 |
C |
T |
2: 9,956,377 (GRCm39) |
E597K |
possibly damaging |
Het |
Tln2 |
T |
C |
9: 67,209,842 (GRCm39) |
T432A |
probably damaging |
Het |
Tmco6 |
T |
C |
18: 36,874,740 (GRCm39) |
V409A |
probably benign |
Het |
Tstd2 |
T |
C |
4: 46,129,235 (GRCm39) |
T198A |
probably damaging |
Het |
Vmn1r230 |
T |
A |
17: 21,067,063 (GRCm39) |
M84K |
probably damaging |
Het |
Vmn1r45 |
T |
A |
6: 89,910,965 (GRCm39) |
S2C |
possibly damaging |
Het |
Vmn2r70 |
A |
G |
7: 85,212,923 (GRCm39) |
S495P |
possibly damaging |
Het |
Vmn2r97 |
A |
T |
17: 19,167,584 (GRCm39) |
R613* |
probably null |
Het |
Yme1l1 |
T |
C |
2: 23,052,520 (GRCm39) |
L58P |
probably damaging |
Het |
Zan |
G |
A |
5: 137,412,511 (GRCm39) |
|
probably benign |
Het |
Zfhx4 |
A |
G |
3: 5,466,801 (GRCm39) |
T2320A |
possibly damaging |
Het |
Zfp407 |
T |
C |
18: 84,227,774 (GRCm39) |
D1945G |
possibly damaging |
Het |
|
Other mutations in Vmn2r25 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
R0366:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
R1780:Vmn2r25
|
UTSW |
6 |
123,805,424 (GRCm39) |
missense |
probably damaging |
1.00 |
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
R1833:Vmn2r25
|
UTSW |
6 |
123,816,643 (GRCm39) |
missense |
probably benign |
0.01 |
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3946:Vmn2r25
|
UTSW |
6 |
123,817,057 (GRCm39) |
missense |
probably damaging |
0.97 |
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
R8170:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGATAATCCTCCACCAAAGTGTG -3'
(R):5'- CTTATCAGTTTTCAATGCACACCG -3'
Sequencing Primer
(F):5'- GTTGTGATCCAGACATTACC -3'
(R):5'- CGCAGCTCTGTATCAGGGAATTG -3'
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Posted On |
2014-10-01 |