Mutagenetix > Incidental Mutation

Incidental Mutation 'R8211:Zfp938'

636174

Institutional Source

Beutler Lab

Gene Symbol

Zfp938

Ensembl Gene

ENSMUSG00000062931

Gene Name

zinc finger protein 938

Synonyms

B230315N10Rik

MMRRC Submission

067634-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

R8211 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

82060684-82077114 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82062419 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 67 (N67S)

Ref Sequence

ENSEMBL: ENSMUSP00000047110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041264] [ENSMUST00000156218]

AlphaFold

E9Q9G3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000041264
AA Change: N67S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: N67S

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART
ZnF_C2H2	161	188	2.82e1	SMART
ZnF_C2H2	267	289	1.23e0	SMART
ZnF_C2H2	295	317	2.91e-2	SMART
ZnF_C2H2	323	345	2.4e-3	SMART
ZnF_C2H2	351	373	7.26e-3	SMART
ZnF_C2H2	379	401	4.65e-1	SMART
ZnF_C2H2	407	429	1.47e-3	SMART
ZnF_C2H2	435	457	5.59e-4	SMART
ZnF_C2H2	463	485	1.82e-3	SMART
ZnF_C2H2	491	513	3.63e-3	SMART
ZnF_C2H2	519	541	7.67e-2	SMART
ZnF_C2H2	547	569	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000156218

SMART Domains

Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330017A19Rik	A	G	17: 47,201,309 (GRCm39)		probably benign	Het
Adamtsl3	T	C	7: 82,172,371 (GRCm39)	S445P	probably damaging	Het
Afp	T	C	5: 90,649,345 (GRCm39)	I304T	possibly damaging	Het
Alk	G	A	17: 72,176,702 (GRCm39)	A1534V	probably benign	Het
Ank3	C	T	10: 69,703,228 (GRCm39)	P287L	unknown	Het
Appl1	T	C	14: 26,667,555 (GRCm39)	I367V	probably benign	Het
Arpin	T	A	7: 79,584,992 (GRCm39)	M1L	probably damaging	Het
Aven	C	T	2: 112,390,120 (GRCm39)	R8W	probably benign	Het
B430203G13Rik	A	T	12: 17,974,540 (GRCm39)	H82L	noncoding transcript	Het
Bcl11a	T	A	11: 24,028,394 (GRCm39)	S2T	probably damaging	Het
Cfap299	A	G	5: 98,477,294 (GRCm39)	I28V	possibly damaging	Het
Cfap46	T	A	7: 139,213,220 (GRCm39)	M1605L	unknown	Het
Chga	C	A	12: 102,527,678 (GRCm39)	Q111K	possibly damaging	Het
Drc7	A	G	8: 95,782,707 (GRCm39)	E24G	unknown	Het
Dst	T	C	1: 34,251,532 (GRCm39)	L2195P	probably damaging	Het
Enpp5	G	A	17: 44,392,402 (GRCm39)		probably null	Het
Fat2	A	G	11: 55,203,035 (GRCm39)	L13P	possibly damaging	Het
Grhl1	T	C	12: 24,636,151 (GRCm39)		probably null	Het
Ikbke	A	G	1: 131,199,515 (GRCm39)	I326T	probably damaging	Het
Krt26	C	T	11: 99,226,110 (GRCm39)	D195N	probably damaging	Het
Lamc2	A	T	1: 153,042,024 (GRCm39)	C37S	probably damaging	Het
Lrriq1	A	G	10: 103,006,408 (GRCm39)	L1239P	probably damaging	Het
Mrps5	T	A	2: 127,445,644 (GRCm39)	H390Q	probably benign	Het
Nphp3	T	A	9: 103,909,096 (GRCm39)	C769S	possibly damaging	Het
Obscn	A	G	11: 59,006,620 (GRCm39)	S1181P	probably damaging	Het
Or8b54	G	A	9: 38,686,577 (GRCm39)	V9M	noncoding transcript	Het
Pabpc6	G	T	17: 9,888,386 (GRCm39)	A55E	probably damaging	Het
Pcdha9	A	T	18: 37,131,912 (GRCm39)	E327V	possibly damaging	Het
Pds5b	A	G	5: 150,652,407 (GRCm39)	T225A	possibly damaging	Het
Pi4ka	A	C	16: 17,100,769 (GRCm39)	I1807S		Het
Pick1	T	A	15: 79,132,930 (GRCm39)	I330N	probably damaging	Het
Rbm46	C	T	3: 82,772,775 (GRCm39)	R119Q	probably benign	Het
Rubcn	A	C	16: 32,656,913 (GRCm39)	C502W	possibly damaging	Het
Slc26a10	G	A	10: 127,009,834 (GRCm39)	R571C	probably benign	Het
Slc44a2	A	T	9: 21,259,434 (GRCm39)	N587Y	probably damaging	Het
Slfn2	T	G	11: 82,960,585 (GRCm39)	V188G	possibly damaging	Het
Smok2b	T	C	17: 13,454,680 (GRCm39)	V280A	probably benign	Het
Snx19	A	G	9: 30,348,761 (GRCm39)	E798G	probably benign	Het
Sspo	T	C	6: 48,469,543 (GRCm39)		probably null	Het
Ugt2b37	T	C	5: 87,390,235 (GRCm39)	I404V	probably benign	Het
Vmn1r160	T	C	7: 22,570,751 (GRCm39)	F35L	possibly damaging	Het
Vmn1r193	A	T	13: 22,403,286 (GRCm39)	Y235*	probably null	Het
Vmn2r53	T	C	7: 12,315,843 (GRCm39)	I659V	probably benign	Het
Vmn2r91	A	G	17: 18,326,762 (GRCm39)	D349G	probably damaging	Het
Zfp292	A	T	4: 34,806,163 (GRCm39)	S2299T	probably benign	Het

Other mutations in Zfp938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Zfp938	APN	10	82,063,355 (GRCm39)	utr 3 prime	probably benign
IGL00743:Zfp938	APN	10	82,062,317 (GRCm39)	missense	probably benign
IGL01764:Zfp938	APN	10	82,063,624 (GRCm39)	splice site	probably benign
IGL01814:Zfp938	APN	10	82,062,052 (GRCm39)	missense	probably benign
IGL02244:Zfp938	APN	10	82,061,906 (GRCm39)	missense	possibly damaging	0.86
IGL02865:Zfp938	APN	10	82,062,026 (GRCm39)	missense	probably benign	0.33
R0372:Zfp938	UTSW	10	82,063,662 (GRCm39)	missense	probably damaging	1.00
R0666:Zfp938	UTSW	10	82,061,606 (GRCm39)	missense	probably damaging	1.00
R0964:Zfp938	UTSW	10	82,061,253 (GRCm39)	missense	probably benign	0.00
R1453:Zfp938	UTSW	10	82,063,632 (GRCm39)	critical splice donor site	probably null
R1672:Zfp938	UTSW	10	82,060,982 (GRCm39)	missense	probably benign
R1929:Zfp938	UTSW	10	82,061,381 (GRCm39)	missense	probably damaging	1.00
R1959:Zfp938	UTSW	10	82,061,465 (GRCm39)	missense	probably damaging	1.00
R2127:Zfp938	UTSW	10	82,061,876 (GRCm39)	missense	probably benign
R2271:Zfp938	UTSW	10	82,061,381 (GRCm39)	missense	probably damaging	1.00
R2900:Zfp938	UTSW	10	82,061,340 (GRCm39)	missense	possibly damaging	0.92
R4502:Zfp938	UTSW	10	82,062,105 (GRCm39)	missense	possibly damaging	0.73
R4503:Zfp938	UTSW	10	82,062,105 (GRCm39)	missense	possibly damaging	0.73
R4886:Zfp938	UTSW	10	82,061,957 (GRCm39)	missense	probably benign	0.33
R4934:Zfp938	UTSW	10	82,062,012 (GRCm39)	missense	possibly damaging	0.86
R5174:Zfp938	UTSW	10	82,061,838 (GRCm39)	missense	possibly damaging	0.53
R5410:Zfp938	UTSW	10	82,061,092 (GRCm39)	missense	possibly damaging	0.89
R6284:Zfp938	UTSW	10	82,063,400 (GRCm39)	missense	possibly damaging	0.73
R6491:Zfp938	UTSW	10	82,063,363 (GRCm39)	makesense	probably null
R6575:Zfp938	UTSW	10	82,061,160 (GRCm39)	nonsense	probably null
R6649:Zfp938	UTSW	10	82,061,232 (GRCm39)	missense	probably damaging	0.99
R7992:Zfp938	UTSW	10	82,061,777 (GRCm39)	missense	possibly damaging	0.53
R8313:Zfp938	UTSW	10	82,061,422 (GRCm39)	missense	possibly damaging	0.75
R8963:Zfp938	UTSW	10	82,061,287 (GRCm39)	missense	possibly damaging	0.61
X0066:Zfp938	UTSW	10	82,061,931 (GRCm39)	missense	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- TACTGCTTGGCTCACATCC -3'
(R):5'- CAAATGAATCACAGGAAAGCTAGT -3'

Sequencing Primer
(F):5'- CATAAGGCTTTTCTCCAATGGG -3'
(R):5'- TCACAGGAAAGCTAGTGTTACTC -3'

Posted On

2020-07-13