Mutagenetix > Incidental Mutation

Incidental Mutation 'R8211:Zfp938'

636174

Institutional Source

Beutler Lab

Gene Symbol

Zfp938

Ensembl Gene

ENSMUSG00000062931

Gene Name

zinc finger protein 938

Synonyms

B230315N10Rik

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R8211 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

82224850-82241280 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82226585 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 67 (N67S)

Ref Sequence

ENSEMBL: ENSMUSP00000047110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041264] [ENSMUST00000156218]

AlphaFold

E9Q9G3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000041264
AA Change: N67S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: N67S

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART
ZnF_C2H2	161	188	2.82e1	SMART
ZnF_C2H2	267	289	1.23e0	SMART
ZnF_C2H2	295	317	2.91e-2	SMART
ZnF_C2H2	323	345	2.4e-3	SMART
ZnF_C2H2	351	373	7.26e-3	SMART
ZnF_C2H2	379	401	4.65e-1	SMART
ZnF_C2H2	407	429	1.47e-3	SMART
ZnF_C2H2	435	457	5.59e-4	SMART
ZnF_C2H2	463	485	1.82e-3	SMART
ZnF_C2H2	491	513	3.63e-3	SMART
ZnF_C2H2	519	541	7.67e-2	SMART
ZnF_C2H2	547	569	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000156218

SMART Domains

Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700007G11Rik	A	G	5: 98,329,435	I28V	possibly damaging	Het
A330017A19Rik	A	G	17: 46,890,383		probably benign	Het
Adamtsl3	T	C	7: 82,523,163	S445P	probably damaging	Het
Afp	T	C	5: 90,501,486	I304T	possibly damaging	Het
Alk	G	A	17: 71,869,707	A1534V	probably benign	Het
Ank3	C	T	10: 69,867,398	P287L	unknown	Het
Appl1	T	C	14: 26,945,598	I367V	probably benign	Het
Arpin	T	A	7: 79,935,244	M1L	probably damaging	Het
Aven	C	T	2: 112,559,775	R8W	probably benign	Het
B430203G13Rik	A	T	12: 17,924,539	H82L	noncoding transcript	Het
Bcl11a	T	A	11: 24,078,394	S2T	probably damaging	Het
Cfap46	T	A	7: 139,633,304	M1605L	unknown	Het
Chga	C	A	12: 102,561,419	Q111K	possibly damaging	Het
Drc7	A	G	8: 95,056,079	E24G	unknown	Het
Dst	T	C	1: 34,212,451	L2195P	probably damaging	Het
Enpp5	G	A	17: 44,081,511		probably null	Het
Fat2	A	G	11: 55,312,209	L13P	possibly damaging	Het
Grhl1	T	C	12: 24,586,152		probably null	Het
Ikbke	A	G	1: 131,271,778	I326T	probably damaging	Het
Krt26	C	T	11: 99,335,284	D195N	probably damaging	Het
Lamc2	A	T	1: 153,166,278	C37S	probably damaging	Het
Lrriq1	A	G	10: 103,170,547	L1239P	probably damaging	Het
Mrps5	T	A	2: 127,603,724	H390Q	probably benign	Het
Nphp3	T	A	9: 104,031,897	C769S	possibly damaging	Het
Obscn	A	G	11: 59,115,794	S1181P	probably damaging	Het
Olfr921	G	A	9: 38,775,281	V9M	noncoding transcript	Het
Pabpc6	G	T	17: 9,669,457	A55E	probably damaging	Het
Pcdha9	A	T	18: 36,998,859	E327V	possibly damaging	Het
Pds5b	A	G	5: 150,728,942	T225A	possibly damaging	Het
Pi4ka	A	C	16: 17,282,905	I1807S		Het
Pick1	T	A	15: 79,248,730	I330N	probably damaging	Het
Rbm46	C	T	3: 82,865,468	R119Q	probably benign	Het
Rubcn	A	C	16: 32,836,543	C502W	possibly damaging	Het
Slc26a10	G	A	10: 127,173,965	R571C	probably benign	Het
Slc44a2	A	T	9: 21,348,138	N587Y	probably damaging	Het
Slfn2	T	G	11: 83,069,759	V188G	possibly damaging	Het
Smok2b	T	C	17: 13,235,793	V280A	probably benign	Het
Snx19	A	G	9: 30,437,465	E798G	probably benign	Het
Sspo	T	C	6: 48,492,609		probably null	Het
Ugt2b37	T	C	5: 87,242,376	I404V	probably benign	Het
Vmn1r160	T	C	7: 22,871,326	F35L	possibly damaging	Het
Vmn1r193	A	T	13: 22,219,116	Y235*	probably null	Het
Vmn2r53	T	C	7: 12,581,916	I659V	probably benign	Het
Vmn2r91	A	G	17: 18,106,500	D349G	probably damaging	Het
Zfp292	A	T	4: 34,806,163	S2299T	probably benign	Het

Other mutations in Zfp938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Zfp938	APN	10	82227521	utr 3 prime	probably benign
IGL00743:Zfp938	APN	10	82226483	missense	probably benign
IGL01764:Zfp938	APN	10	82227790	splice site	probably benign
IGL01814:Zfp938	APN	10	82226218	missense	probably benign
IGL02244:Zfp938	APN	10	82226072	missense	possibly damaging	0.86
IGL02865:Zfp938	APN	10	82226192	missense	probably benign	0.33
R0372:Zfp938	UTSW	10	82227828	missense	probably damaging	1.00
R0666:Zfp938	UTSW	10	82225772	missense	probably damaging	1.00
R0964:Zfp938	UTSW	10	82225419	missense	probably benign	0.00
R1453:Zfp938	UTSW	10	82227798	critical splice donor site	probably null
R1672:Zfp938	UTSW	10	82225148	missense	probably benign
R1929:Zfp938	UTSW	10	82225547	missense	probably damaging	1.00
R1959:Zfp938	UTSW	10	82225631	missense	probably damaging	1.00
R2127:Zfp938	UTSW	10	82226042	missense	probably benign
R2271:Zfp938	UTSW	10	82225547	missense	probably damaging	1.00
R2900:Zfp938	UTSW	10	82225506	missense	possibly damaging	0.92
R4502:Zfp938	UTSW	10	82226271	missense	possibly damaging	0.73
R4503:Zfp938	UTSW	10	82226271	missense	possibly damaging	0.73
R4886:Zfp938	UTSW	10	82226123	missense	probably benign	0.33
R4934:Zfp938	UTSW	10	82226178	missense	possibly damaging	0.86
R5174:Zfp938	UTSW	10	82226004	missense	possibly damaging	0.53
R5410:Zfp938	UTSW	10	82225258	missense	possibly damaging	0.89
R6284:Zfp938	UTSW	10	82227566	missense	possibly damaging	0.73
R6491:Zfp938	UTSW	10	82227529	makesense	probably null
R6575:Zfp938	UTSW	10	82225326	nonsense	probably null
R6649:Zfp938	UTSW	10	82225398	missense	probably damaging	0.99
R7992:Zfp938	UTSW	10	82225943	missense	possibly damaging	0.53
R8313:Zfp938	UTSW	10	82225588	missense	possibly damaging	0.75
R8963:Zfp938	UTSW	10	82225453	missense	possibly damaging	0.61
X0066:Zfp938	UTSW	10	82226097	missense	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- TACTGCTTGGCTCACATCC -3'
(R):5'- CAAATGAATCACAGGAAAGCTAGT -3'

Sequencing Primer
(F):5'- CATAAGGCTTTTCTCCAATGGG -3'
(R):5'- TCACAGGAAAGCTAGTGTTACTC -3'

Posted On

2020-07-13