Incidental Mutation 'R8228:Vmn2r101'
ID 637080
Institutional Source Beutler Lab
Gene Symbol Vmn2r101
Ensembl Gene ENSMUSG00000094892
Gene Name vomeronasal 2, receptor 101
Synonyms EG627576
MMRRC Submission 067661-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R8228 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 19797493-19832579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19811284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 456 (T456I)
Ref Sequence ENSEMBL: ENSMUSP00000131583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171914]
AlphaFold E9PZS9
Predicted Effect probably benign
Transcript: ENSMUST00000171914
AA Change: T456I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: T456I

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 466 1.6e-36 PFAM
Pfam:NCD3G 509 562 6.4e-22 PFAM
Pfam:7tm_3 595 830 1.4e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610030E20Rik T C 6: 72,324,500 (GRCm39) probably null Het
1700008O03Rik A G 7: 44,009,729 (GRCm39) Y158H probably benign Het
4930438A08Rik T A 11: 58,182,381 (GRCm39) I252N Het
A930011G23Rik G A 5: 99,524,980 (GRCm39) P60S probably damaging Het
Abcf1 A G 17: 36,271,933 (GRCm39) probably null Het
AI987944 T C 7: 41,026,260 (GRCm39) T14A probably damaging Het
Alox12b T C 11: 69,054,755 (GRCm39) Y253H probably damaging Het
Anapc1 T A 2: 128,461,837 (GRCm39) K1756* probably null Het
Arid5b T A 10: 68,114,536 (GRCm39) E2V possibly damaging Het
Atp13a1 G A 8: 70,251,569 (GRCm39) V545M probably damaging Het
Atp2b4 TTCTTC TTCTTCCTCTTC 1: 133,629,459 (GRCm39) probably benign Het
Cert1 A G 13: 96,679,723 (GRCm39) T18A probably benign Het
Cfap119 G A 7: 127,184,179 (GRCm39) T239M probably benign Het
Col1a1 T G 11: 94,836,426 (GRCm39) probably null Het
Csdc2 C T 15: 81,833,411 (GRCm39) T136I possibly damaging Het
Dpp9 A T 17: 56,498,129 (GRCm39) I609N probably damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG,TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Gjb6 T C 14: 57,361,926 (GRCm39) R112G probably benign Het
Gm19410 A G 8: 36,252,992 (GRCm39) K646E possibly damaging Het
Grik5 T C 7: 24,709,933 (GRCm39) E934G probably damaging Het
Grik5 A T 7: 24,745,735 (GRCm39) F446Y possibly damaging Het
Iffo2 C G 4: 139,302,483 (GRCm39) N75K probably damaging Het
Kif15 A G 9: 122,821,041 (GRCm39) N649D possibly damaging Het
Lrit2 G A 14: 36,791,148 (GRCm39) A276T probably damaging Het
Mcm8 T C 2: 132,684,714 (GRCm39) probably null Het
Mmut A G 17: 41,248,219 (GRCm39) E82G possibly damaging Het
Or4n4 A G 14: 50,518,997 (GRCm39) S238P probably damaging Het
Or5w8 T A 2: 87,688,284 (GRCm39) M255K probably benign Het
Pcdhga8 A G 18: 37,861,236 (GRCm39) Q764R probably benign Het
Pcgf2 T C 11: 97,582,865 (GRCm39) Y138C probably benign Het
Phf20l1 G T 15: 66,511,789 (GRCm39) V922F possibly damaging Het
Pkd1l2 A T 8: 117,792,514 (GRCm39) I426N probably damaging Het
Psmd6 T C 14: 14,116,843 (GRCm38) N160S possibly damaging Het
Robo1 A G 16: 72,809,768 (GRCm39) D1172G probably benign Het
Sdr9c7 T C 10: 127,734,544 (GRCm39) Y11H possibly damaging Het
Sec24c G T 14: 20,739,975 (GRCm39) A635S probably benign Het
Tex2 T C 11: 106,457,997 (GRCm39) I478V probably benign Het
Traip T C 9: 107,838,265 (GRCm39) M166T probably benign Het
Trdn T C 10: 33,033,014 (GRCm39) S80P probably damaging Het
Trim46 G T 3: 89,142,255 (GRCm39) T744N probably benign Het
Tsc1 C A 2: 28,566,141 (GRCm39) A520D probably benign Het
Usp36 T C 11: 118,155,716 (GRCm39) E852G possibly damaging Het
Zc3h7a A G 16: 10,956,954 (GRCm39) F885S probably damaging Het
Zfp335 G A 2: 164,746,818 (GRCm39) R354W probably damaging Het
Zfp456 C A 13: 67,514,533 (GRCm39) C391F probably damaging Het
Other mutations in Vmn2r101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Vmn2r101 APN 17 19,809,936 (GRCm39) missense probably damaging 0.99
IGL02125:Vmn2r101 APN 17 19,809,963 (GRCm39) missense possibly damaging 0.95
IGL02300:Vmn2r101 APN 17 19,832,199 (GRCm39) missense probably damaging 1.00
IGL02682:Vmn2r101 APN 17 19,832,507 (GRCm39) missense possibly damaging 0.82
IGL02825:Vmn2r101 APN 17 19,810,132 (GRCm39) missense probably benign 0.00
IGL02862:Vmn2r101 APN 17 19,831,867 (GRCm39) missense probably damaging 1.00
IGL02943:Vmn2r101 APN 17 19,831,666 (GRCm39) missense probably damaging 0.99
R0371:Vmn2r101 UTSW 17 19,810,394 (GRCm39) missense probably benign 0.07
R0462:Vmn2r101 UTSW 17 19,810,431 (GRCm39) missense probably benign 0.04
R0492:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R0654:Vmn2r101 UTSW 17 19,810,373 (GRCm39) missense probably benign 0.01
R1120:Vmn2r101 UTSW 17 19,797,723 (GRCm39) splice site probably benign
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1676:Vmn2r101 UTSW 17 19,832,184 (GRCm39) missense probably benign 0.00
R2023:Vmn2r101 UTSW 17 19,810,368 (GRCm39) nonsense probably null
R2149:Vmn2r101 UTSW 17 19,809,225 (GRCm39) missense probably benign 0.00
R2350:Vmn2r101 UTSW 17 19,810,045 (GRCm39) missense probably benign 0.01
R2760:Vmn2r101 UTSW 17 19,809,901 (GRCm39) missense probably benign 0.14
R3085:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3086:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3719:Vmn2r101 UTSW 17 19,809,811 (GRCm39) missense possibly damaging 0.50
R3771:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R3773:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R4225:Vmn2r101 UTSW 17 19,831,951 (GRCm39) missense probably damaging 1.00
R4248:Vmn2r101 UTSW 17 19,809,376 (GRCm39) missense probably damaging 1.00
R4290:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4291:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4293:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r101 UTSW 17 19,810,423 (GRCm39) missense probably damaging 1.00
R4721:Vmn2r101 UTSW 17 19,832,287 (GRCm39) missense probably damaging 0.99
R4829:Vmn2r101 UTSW 17 19,832,229 (GRCm39) missense probably benign 0.03
R5022:Vmn2r101 UTSW 17 19,831,649 (GRCm39) critical splice acceptor site probably null
R5110:Vmn2r101 UTSW 17 19,831,897 (GRCm39) missense possibly damaging 0.92
R5244:Vmn2r101 UTSW 17 19,831,788 (GRCm39) missense probably damaging 1.00
R5397:Vmn2r101 UTSW 17 19,809,104 (GRCm39) missense probably damaging 1.00
R5875:Vmn2r101 UTSW 17 19,809,092 (GRCm39) missense probably damaging 0.99
R5944:Vmn2r101 UTSW 17 19,809,769 (GRCm39) missense probably benign 0.00
R6216:Vmn2r101 UTSW 17 19,811,267 (GRCm39) missense probably benign 0.00
R6334:Vmn2r101 UTSW 17 19,810,112 (GRCm39) missense possibly damaging 0.83
R6512:Vmn2r101 UTSW 17 19,809,146 (GRCm39) missense probably damaging 1.00
R6607:Vmn2r101 UTSW 17 19,832,296 (GRCm39) missense probably damaging 1.00
R6965:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R7101:Vmn2r101 UTSW 17 19,809,350 (GRCm39) missense probably null 0.14
R7183:Vmn2r101 UTSW 17 19,832,440 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r101 UTSW 17 19,832,059 (GRCm39) missense probably benign 0.38
R7375:Vmn2r101 UTSW 17 19,831,652 (GRCm39) missense probably damaging 1.00
R7574:Vmn2r101 UTSW 17 19,831,899 (GRCm39) missense possibly damaging 0.91
R7575:Vmn2r101 UTSW 17 19,831,654 (GRCm39) missense probably benign 0.01
R7592:Vmn2r101 UTSW 17 19,811,443 (GRCm39) splice site probably null
R7626:Vmn2r101 UTSW 17 19,832,192 (GRCm39) nonsense probably null
R7715:Vmn2r101 UTSW 17 19,832,177 (GRCm39) missense probably damaging 1.00
R7730:Vmn2r101 UTSW 17 19,831,950 (GRCm39) missense possibly damaging 0.81
R8078:Vmn2r101 UTSW 17 19,810,507 (GRCm39) missense probably benign 0.07
R8283:Vmn2r101 UTSW 17 19,832,253 (GRCm39) missense probably damaging 1.00
R8712:Vmn2r101 UTSW 17 19,811,397 (GRCm39) missense probably benign 0.24
R8765:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R9091:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9092:Vmn2r101 UTSW 17 19,809,807 (GRCm39) missense probably benign 0.07
R9113:Vmn2r101 UTSW 17 19,811,288 (GRCm39) missense possibly damaging 0.56
R9158:Vmn2r101 UTSW 17 19,809,161 (GRCm39) missense probably benign 0.00
R9168:Vmn2r101 UTSW 17 19,809,138 (GRCm39) missense probably damaging 1.00
R9235:Vmn2r101 UTSW 17 19,810,238 (GRCm39) missense probably damaging 0.99
R9270:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9290:Vmn2r101 UTSW 17 19,811,395 (GRCm39) missense probably benign 0.05
R9296:Vmn2r101 UTSW 17 19,810,047 (GRCm39) missense probably damaging 0.98
R9602:Vmn2r101 UTSW 17 19,831,780 (GRCm39) nonsense probably null
R9706:Vmn2r101 UTSW 17 19,809,925 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r101 UTSW 17 19,809,237 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- AAGCTTGGCTCTCAGTTTTCACTG -3'
(R):5'- GTGTTACTAATACAGGCACTAAGC -3'

Sequencing Primer
(F):5'- TCGAACACTTAGGTTTTTACTTAGTC -3'
(R):5'- TGTTTACCCTGAGGAGCA -3'
Posted On 2020-07-13