Incidental Mutation 'R8283:Vmn2r101'
ID |
638342 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r101
|
Ensembl Gene |
ENSMUSG00000094892 |
Gene Name |
vomeronasal 2, receptor 101 |
Synonyms |
EG627576 |
MMRRC Submission |
067706-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.124)
|
Stock # |
R8283 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
19797493-19832579 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 19832253 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Asparagine
at position 750
(Y750N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131583
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171914]
|
AlphaFold |
E9PZS9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000171914
AA Change: Y750N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000131583 Gene: ENSMUSG00000094892 AA Change: Y750N
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
466 |
1.6e-36 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
6.4e-22 |
PFAM |
Pfam:7tm_3
|
595 |
830 |
1.4e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 65 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb1b |
C |
T |
5: 8,856,086 (GRCm39) |
P65S |
probably damaging |
Het |
Adcy3 |
A |
T |
12: 4,250,935 (GRCm39) |
R565W |
probably damaging |
Het |
Arl14 |
A |
T |
3: 69,129,868 (GRCm39) |
N5I |
probably benign |
Het |
Arl6ip6 |
A |
G |
2: 53,082,250 (GRCm39) |
E39G |
possibly damaging |
Het |
Aven |
C |
T |
2: 112,390,120 (GRCm39) |
R8W |
probably benign |
Het |
Axl |
C |
T |
7: 25,463,379 (GRCm39) |
D633N |
probably benign |
Het |
Boc |
A |
T |
16: 44,340,800 (GRCm39) |
L50Q |
noncoding transcript |
Het |
Calml3 |
A |
G |
13: 3,854,097 (GRCm39) |
V36A |
probably damaging |
Het |
Ccdc183 |
G |
A |
2: 25,502,160 (GRCm39) |
A238V |
probably damaging |
Het |
Ccndbp1 |
A |
G |
2: 120,839,065 (GRCm39) |
|
probably benign |
Het |
Ccr9 |
A |
G |
9: 123,608,696 (GRCm39) |
Y126C |
probably damaging |
Het |
Cdhr1 |
T |
C |
14: 36,804,737 (GRCm39) |
N491S |
probably benign |
Het |
Celsr2 |
C |
T |
3: 108,303,771 (GRCm39) |
G2429D |
probably damaging |
Het |
Cts6 |
T |
C |
13: 61,349,457 (GRCm39) |
T84A |
probably damaging |
Het |
Dcpp2 |
T |
C |
17: 24,118,384 (GRCm39) |
|
probably null |
Het |
Drosha |
A |
G |
15: 12,890,587 (GRCm39) |
I945V |
possibly damaging |
Het |
Dsg1b |
A |
G |
18: 20,524,963 (GRCm39) |
Q133R |
probably benign |
Het |
Enpp1 |
T |
A |
10: 24,550,554 (GRCm39) |
E174D |
probably benign |
Het |
Esrrb |
A |
G |
12: 86,468,732 (GRCm39) |
H15R |
probably benign |
Het |
Fbxl12 |
T |
C |
9: 20,550,017 (GRCm39) |
T213A |
probably benign |
Het |
Fnbp4 |
C |
A |
2: 90,577,115 (GRCm39) |
T149K |
probably damaging |
Het |
Foxj1 |
A |
T |
11: 116,224,893 (GRCm39) |
F158Y |
probably benign |
Het |
Frrs1 |
A |
G |
3: 116,671,952 (GRCm39) |
T17A |
probably benign |
Het |
Gm10110 |
C |
T |
14: 90,135,677 (GRCm39) |
V76M |
noncoding transcript |
Het |
Gm45844 |
T |
C |
7: 7,244,901 (GRCm39) |
Y11C |
possibly damaging |
Het |
Hnrnpl |
T |
C |
7: 28,513,697 (GRCm39) |
V220A |
|
Het |
Iars2 |
T |
A |
1: 185,020,288 (GRCm39) |
R949* |
probably null |
Het |
Ice1 |
T |
C |
13: 70,752,549 (GRCm39) |
E1179G |
probably damaging |
Het |
Mast4 |
A |
G |
13: 102,895,177 (GRCm39) |
L782P |
probably damaging |
Het |
Mcmdc2 |
A |
C |
1: 10,004,263 (GRCm39) |
K581T |
possibly damaging |
Het |
Men1 |
A |
T |
19: 6,386,848 (GRCm39) |
D186V |
probably damaging |
Het |
Morc2b |
T |
G |
17: 33,355,675 (GRCm39) |
N699T |
probably benign |
Het |
Mrgpra2b |
A |
G |
7: 47,114,465 (GRCm39) |
L89P |
probably damaging |
Het |
Naip1 |
C |
T |
13: 100,563,695 (GRCm39) |
G490E |
probably damaging |
Het |
Ntm |
T |
C |
9: 28,923,508 (GRCm39) |
Y224C |
probably damaging |
Het |
Nup88 |
A |
T |
11: 70,849,166 (GRCm39) |
D262E |
probably benign |
Het |
Or10ag52 |
T |
C |
2: 87,043,683 (GRCm39) |
V149A |
probably benign |
Het |
Or51l4 |
T |
A |
7: 103,404,019 (GRCm39) |
I258L |
possibly damaging |
Het |
Or8b54 |
G |
A |
9: 38,686,577 (GRCm39) |
V9M |
noncoding transcript |
Het |
Oscp1 |
A |
G |
4: 125,980,393 (GRCm39) |
M293V |
probably benign |
Het |
Pcdhgc3 |
C |
A |
18: 37,940,694 (GRCm39) |
A365D |
probably damaging |
Het |
Pcyt2 |
A |
T |
11: 120,501,548 (GRCm39) |
F388I |
probably benign |
Het |
Pgm2l1 |
C |
G |
7: 99,902,460 (GRCm39) |
A136G |
probably benign |
Het |
Phf14 |
T |
G |
6: 11,987,636 (GRCm39) |
D638E |
probably benign |
Het |
Pnpla7 |
A |
G |
2: 24,940,935 (GRCm39) |
K1096E |
probably damaging |
Het |
Prkcb |
T |
A |
7: 122,199,948 (GRCm39) |
C586* |
probably null |
Het |
Rnf187 |
T |
A |
11: 58,829,241 (GRCm39) |
R124W |
probably damaging |
Het |
Sema3a |
T |
C |
5: 13,450,030 (GRCm39) |
Y36H |
probably damaging |
Het |
Setd7 |
T |
G |
3: 51,428,796 (GRCm39) |
S345R |
probably benign |
Het |
Sgms1 |
T |
C |
19: 32,137,035 (GRCm39) |
D177G |
probably damaging |
Het |
Snx19 |
T |
C |
9: 30,374,522 (GRCm39) |
L927S |
possibly damaging |
Het |
Sorbs1 |
G |
C |
19: 40,365,244 (GRCm39) |
R180G |
probably benign |
Het |
Sorl1 |
T |
C |
9: 41,942,294 (GRCm39) |
D977G |
probably damaging |
Het |
Sptan1 |
C |
T |
2: 29,870,212 (GRCm39) |
R121W |
probably damaging |
Het |
Srgap2 |
T |
C |
1: 131,291,771 (GRCm39) |
D152G |
probably damaging |
Het |
Suclg2 |
T |
A |
6: 95,474,700 (GRCm39) |
|
probably null |
Het |
Tacc2 |
T |
C |
7: 130,227,034 (GRCm39) |
S1240P |
probably benign |
Het |
Tbc1d12 |
C |
T |
19: 38,825,353 (GRCm39) |
A68V |
probably benign |
Het |
Tex14 |
G |
A |
11: 87,365,241 (GRCm39) |
D62N |
probably damaging |
Het |
Thyn1 |
C |
T |
9: 26,918,155 (GRCm39) |
T181I |
probably benign |
Het |
Trio |
T |
A |
15: 27,756,628 (GRCm39) |
H2056L |
possibly damaging |
Het |
Ubn2 |
T |
A |
6: 38,475,663 (GRCm39) |
L1207Q |
probably damaging |
Het |
Usp17lb |
T |
C |
7: 104,490,013 (GRCm39) |
S305G |
probably damaging |
Het |
Wif1 |
G |
A |
10: 120,931,952 (GRCm39) |
S292N |
probably benign |
Het |
Xpo6 |
T |
G |
7: 125,727,421 (GRCm39) |
Q528H |
possibly damaging |
Het |
|
Other mutations in Vmn2r101 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01121:Vmn2r101
|
APN |
17 |
19,809,936 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02125:Vmn2r101
|
APN |
17 |
19,809,963 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02300:Vmn2r101
|
APN |
17 |
19,832,199 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02682:Vmn2r101
|
APN |
17 |
19,832,507 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL02825:Vmn2r101
|
APN |
17 |
19,810,132 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02862:Vmn2r101
|
APN |
17 |
19,831,867 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02943:Vmn2r101
|
APN |
17 |
19,831,666 (GRCm39) |
missense |
probably damaging |
0.99 |
R0371:Vmn2r101
|
UTSW |
17 |
19,810,394 (GRCm39) |
missense |
probably benign |
0.07 |
R0462:Vmn2r101
|
UTSW |
17 |
19,810,431 (GRCm39) |
missense |
probably benign |
0.04 |
R0492:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R0654:Vmn2r101
|
UTSW |
17 |
19,810,373 (GRCm39) |
missense |
probably benign |
0.01 |
R1120:Vmn2r101
|
UTSW |
17 |
19,797,723 (GRCm39) |
splice site |
probably benign |
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R1676:Vmn2r101
|
UTSW |
17 |
19,832,184 (GRCm39) |
missense |
probably benign |
0.00 |
R2023:Vmn2r101
|
UTSW |
17 |
19,810,368 (GRCm39) |
nonsense |
probably null |
|
R2149:Vmn2r101
|
UTSW |
17 |
19,809,225 (GRCm39) |
missense |
probably benign |
0.00 |
R2350:Vmn2r101
|
UTSW |
17 |
19,810,045 (GRCm39) |
missense |
probably benign |
0.01 |
R2760:Vmn2r101
|
UTSW |
17 |
19,809,901 (GRCm39) |
missense |
probably benign |
0.14 |
R3085:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
R3086:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
R3719:Vmn2r101
|
UTSW |
17 |
19,809,811 (GRCm39) |
missense |
possibly damaging |
0.50 |
R3771:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
R3773:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
R4225:Vmn2r101
|
UTSW |
17 |
19,831,951 (GRCm39) |
missense |
probably damaging |
1.00 |
R4248:Vmn2r101
|
UTSW |
17 |
19,809,376 (GRCm39) |
missense |
probably damaging |
1.00 |
R4290:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4291:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4293:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4307:Vmn2r101
|
UTSW |
17 |
19,810,423 (GRCm39) |
missense |
probably damaging |
1.00 |
R4721:Vmn2r101
|
UTSW |
17 |
19,832,287 (GRCm39) |
missense |
probably damaging |
0.99 |
R4829:Vmn2r101
|
UTSW |
17 |
19,832,229 (GRCm39) |
missense |
probably benign |
0.03 |
R5022:Vmn2r101
|
UTSW |
17 |
19,831,649 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5110:Vmn2r101
|
UTSW |
17 |
19,831,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5244:Vmn2r101
|
UTSW |
17 |
19,831,788 (GRCm39) |
missense |
probably damaging |
1.00 |
R5397:Vmn2r101
|
UTSW |
17 |
19,809,104 (GRCm39) |
missense |
probably damaging |
1.00 |
R5875:Vmn2r101
|
UTSW |
17 |
19,809,092 (GRCm39) |
missense |
probably damaging |
0.99 |
R5944:Vmn2r101
|
UTSW |
17 |
19,809,769 (GRCm39) |
missense |
probably benign |
0.00 |
R6216:Vmn2r101
|
UTSW |
17 |
19,811,267 (GRCm39) |
missense |
probably benign |
0.00 |
R6334:Vmn2r101
|
UTSW |
17 |
19,810,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6512:Vmn2r101
|
UTSW |
17 |
19,809,146 (GRCm39) |
missense |
probably damaging |
1.00 |
R6607:Vmn2r101
|
UTSW |
17 |
19,832,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R6965:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
R7101:Vmn2r101
|
UTSW |
17 |
19,809,350 (GRCm39) |
missense |
probably null |
0.14 |
R7183:Vmn2r101
|
UTSW |
17 |
19,832,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R7344:Vmn2r101
|
UTSW |
17 |
19,832,059 (GRCm39) |
missense |
probably benign |
0.38 |
R7375:Vmn2r101
|
UTSW |
17 |
19,831,652 (GRCm39) |
missense |
probably damaging |
1.00 |
R7574:Vmn2r101
|
UTSW |
17 |
19,831,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7575:Vmn2r101
|
UTSW |
17 |
19,831,654 (GRCm39) |
missense |
probably benign |
0.01 |
R7592:Vmn2r101
|
UTSW |
17 |
19,811,443 (GRCm39) |
splice site |
probably null |
|
R7626:Vmn2r101
|
UTSW |
17 |
19,832,192 (GRCm39) |
nonsense |
probably null |
|
R7715:Vmn2r101
|
UTSW |
17 |
19,832,177 (GRCm39) |
missense |
probably damaging |
1.00 |
R7730:Vmn2r101
|
UTSW |
17 |
19,831,950 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8078:Vmn2r101
|
UTSW |
17 |
19,810,507 (GRCm39) |
missense |
probably benign |
0.07 |
R8228:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
R8712:Vmn2r101
|
UTSW |
17 |
19,811,397 (GRCm39) |
missense |
probably benign |
0.24 |
R8765:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R9091:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
R9092:Vmn2r101
|
UTSW |
17 |
19,809,807 (GRCm39) |
missense |
probably benign |
0.07 |
R9113:Vmn2r101
|
UTSW |
17 |
19,811,288 (GRCm39) |
missense |
possibly damaging |
0.56 |
R9158:Vmn2r101
|
UTSW |
17 |
19,809,161 (GRCm39) |
missense |
probably benign |
0.00 |
R9168:Vmn2r101
|
UTSW |
17 |
19,809,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R9235:Vmn2r101
|
UTSW |
17 |
19,810,238 (GRCm39) |
missense |
probably damaging |
0.99 |
R9270:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
R9290:Vmn2r101
|
UTSW |
17 |
19,811,395 (GRCm39) |
missense |
probably benign |
0.05 |
R9296:Vmn2r101
|
UTSW |
17 |
19,810,047 (GRCm39) |
missense |
probably damaging |
0.98 |
R9602:Vmn2r101
|
UTSW |
17 |
19,831,780 (GRCm39) |
nonsense |
probably null |
|
R9706:Vmn2r101
|
UTSW |
17 |
19,809,925 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r101
|
UTSW |
17 |
19,809,237 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGTCCTTGCCTTTAAGGTCAG -3'
(R):5'- AGCAACCATGATCTTCCCTTTAG -3'
Sequencing Primer
(F):5'- TGGCTAATGTTATCAAGAGGTCC -3'
(R):5'- CCCTTTAGTGCTGTGGAAGAC -3'
|
Posted On |
2020-07-28 |