Incidental Mutation 'R8676:Tmem89'
ID 661394
Institutional Source Beutler Lab
Gene Symbol Tmem89
Ensembl Gene ENSMUSG00000025652
Gene Name transmembrane protein 89
Synonyms 1700024B07Rik
MMRRC Submission 068531-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R8676 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 108914619-108915563 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 108915027 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 132 (L132F)
Ref Sequence ENSEMBL: ENSMUSP00000142016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026744] [ENSMUST00000098376] [ENSMUST00000192852]
AlphaFold Q9DA04
Predicted Effect probably benign
Transcript: ENSMUST00000026744
SMART Domains Protein: ENSMUSP00000026744
Gene: ENSMUSG00000025652

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM89 23 47 6.3e-16 PFAM
Pfam:TMEM89 46 166 1.1e-62 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098376
SMART Domains Protein: ENSMUSP00000095979
Gene: ENSMUSG00000023259

DomainStartEndE-ValueType
Pfam:Sulfate_transp 69 458 4.4e-113 PFAM
low complexity region 471 484 N/A INTRINSIC
PDB:3LLO|A 489 546 2e-16 PDB
low complexity region 554 593 N/A INTRINSIC
low complexity region 638 650 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191404
Predicted Effect unknown
Transcript: ENSMUST00000192852
AA Change: L132F
SMART Domains Protein: ENSMUSP00000142016
Gene: ENSMUSG00000025652
AA Change: L132F

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM89 23 47 1.8e-15 PFAM
Pfam:TMEM89 45 118 1.3e-37 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 93% (54/58)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610037L13Rik A G 4: 107,895,599 (GRCm38) N152D unknown Het
1700021F05Rik A G 10: 43,532,937 (GRCm38) L70S probably benign Het
Acsm3 T A 7: 119,775,169 (GRCm38) S281R probably damaging Het
Adipor2 G T 6: 119,363,486 (GRCm38) probably benign Het
Alk T C 17: 71,897,941 (GRCm38) S1079G probably damaging Het
Ankrd27 T C 7: 35,602,584 (GRCm38) probably null Het
Anxa6 C A 11: 55,001,282 (GRCm38) E283* probably null Het
Bnc2 T C 4: 84,276,313 (GRCm38) H858R possibly damaging Het
Btnl6 T C 17: 34,508,069 (GRCm38) S496G probably benign Het
Ccdc88a T C 11: 29,460,860 (GRCm38) S449P probably benign Het
Cdh23 A T 10: 60,410,910 (GRCm38) D916E probably damaging Het
Cfap43 A T 19: 47,748,017 (GRCm38) L1345H possibly damaging Het
Cyld A T 8: 88,729,510 (GRCm38) H396L probably benign Het
Cyp20a1 A G 1: 60,379,420 (GRCm38) T340A possibly damaging Het
Dera A T 6: 137,830,204 (GRCm38) I217F probably damaging Het
Dnah11 A G 12: 118,190,804 (GRCm38) L247P probably damaging Het
Eftud2 G A 11: 102,868,621 (GRCm38) T152M probably damaging Het
Epb41l2 C T 10: 25,443,776 (GRCm38) T169M probably benign Het
Fam186a T C 15: 99,947,142 (GRCm38) D407G unknown Het
Fam189a2 T C 19: 23,988,494 (GRCm38) K214E probably damaging Het
Gli3 T A 13: 15,715,034 (GRCm38) C578S probably damaging Het
Gm436 G A 4: 144,670,113 (GRCm38) R350C possibly damaging Het
Gm6408 A G 5: 146,482,427 (GRCm38) N84S probably benign Het
Heatr5a AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA 12: 51,887,919 (GRCm38) probably benign Het
Herc2 C A 7: 56,188,613 (GRCm38) T3296K probably damaging Het
Hnf4g A T 3: 3,643,073 (GRCm38) probably benign Het
Hyal4 C A 6: 24,755,827 (GRCm38) Q15K probably damaging Het
Itpr3 G A 17: 27,118,677 (GRCm38) probably benign Het
Kcna3 A G 3: 107,036,592 (GRCm38) E57G probably damaging Het
Kcnc3 C A 7: 44,591,596 (GRCm38) D237E probably benign Het
Map3k8 A G 18: 4,343,137 (GRCm38) V130A probably benign Het
Mpp7 A G 18: 7,440,430 (GRCm38) probably null Het
Myh13 T A 11: 67,342,485 (GRCm38) L610Q probably damaging Het
Olfr1020 T A 2: 85,849,902 (GRCm38) M150K probably benign Het
Olfr1339 C A 4: 118,735,038 (GRCm38) P170T probably damaging Het
Olfr917 T C 9: 38,665,768 (GRCm38) I25M probably benign Het
Pcdhb5 A T 18: 37,321,076 (GRCm38) T170S probably benign Het
Polr3b T A 10: 84,680,387 (GRCm38) H626Q probably benign Het
Prkg1 A T 19: 31,764,746 (GRCm38) L26Q probably damaging Het
Prob1 T C 18: 35,653,986 (GRCm38) N405S possibly damaging Het
Proz T G 8: 13,073,630 (GRCm38) S300R probably damaging Het
Psg19 A G 7: 18,794,065 (GRCm38) I251T probably benign Het
Rcbtb1 T C 14: 59,229,952 (GRCm38) I413T possibly damaging Het
Rnf144b T A 13: 47,228,976 (GRCm38) Y103N probably damaging Het
Rspry1 G C 8: 94,632,119 (GRCm38) G194R probably benign Het
Scn2b A G 9: 45,125,619 (GRCm38) I142V probably damaging Het
Spata20 A T 11: 94,481,781 (GRCm38) L588H probably damaging Het
Stk32b T A 5: 37,457,159 (GRCm38) H335L probably benign Het
Taar4 A C 10: 23,960,903 (GRCm38) D137A possibly damaging Het
Tchh CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC 3: 93,446,708 (GRCm38) probably benign Het
Tek A T 4: 94,849,837 (GRCm38) H708L probably benign Het
Ugt2b38 T C 5: 87,411,822 (GRCm38) I404V probably benign Het
Vmn1r16 C T 6: 57,322,829 (GRCm38) M269I probably benign Het
Vmn1r201 A G 13: 22,475,252 (GRCm38) K212R probably damaging Het
Vmn2r11 A C 5: 109,053,760 (GRCm38) F293V probably damaging Het
Zdhhc17 A T 10: 110,962,379 (GRCm38) probably benign Het
Zfp423 C A 8: 87,782,710 (GRCm38) M335I probably benign Het
Zfp74 T C 7: 29,934,654 (GRCm38) Y543C probably damaging Het
Zfp975 A T 7: 42,662,840 (GRCm38) S116R probably benign Het
Other mutations in Tmem89
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0060:Tmem89 UTSW 9 108,915,417 (GRCm38) missense probably damaging 1.00
R0060:Tmem89 UTSW 9 108,915,417 (GRCm38) missense probably damaging 1.00
R0063:Tmem89 UTSW 9 108,914,812 (GRCm38) missense probably benign 0.00
R0063:Tmem89 UTSW 9 108,914,812 (GRCm38) missense probably benign 0.00
R2447:Tmem89 UTSW 9 108,914,800 (GRCm38) missense probably damaging 0.98
R4778:Tmem89 UTSW 9 108,915,375 (GRCm38) missense probably damaging 0.98
R4906:Tmem89 UTSW 9 108,914,761 (GRCm38) unclassified probably benign
R5529:Tmem89 UTSW 9 108,915,477 (GRCm38) missense probably damaging 0.98
R9095:Tmem89 UTSW 9 108,914,661 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- AGGAAATCGCATCTACCCCG -3'
(R):5'- CTTTCCAGTGTTTGCCGGAG -3'

Sequencing Primer
(F):5'- GTGGCTGGGGTCACAATCAC -3'
(R):5'- GGAATAGGTCACTGGGTCTCC -3'
Posted On 2021-03-08