|Institutional Source||Beutler Lab|
|Gene Name||cytochrome P450, family 4, subfamily f, polypeptide 39|
|Essential gene?||Possibly non essential (E-score: 0.362)|
|Stock #||R9402 (G1)|
|Chromosomal Location||32468462-32492479 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 32491209 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000003413 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000003413]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cyp4f39||
(F):5'- TACGACTGCAGGAAGAGCTG -3'
(R):5'- GGGGCCATTTGTTCCAATCTATC -3'
(F):5'- CTGCAGGAAGAGCTGAGGTG -3'
(R):5'- CTTTAAGGTCCATGAGGGCATAC -3'