Incidental Mutation 'IGL02198:Igsf10'
ID 284123
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igsf10
Ensembl Gene ENSMUSG00000036334
Gene Name immunoglobulin superfamily, member 10
Synonyms 6530405F15Rik, CMF608, Adlican2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # IGL02198
Quality Score
Status
Chromosome 3
Chromosomal Location 59224156-59251815 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59233399 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 1778 (I1778N)
Ref Sequence ENSEMBL: ENSMUSP00000141391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039419] [ENSMUST00000193455] [ENSMUST00000194546]
AlphaFold Q3V1M1
Predicted Effect possibly damaging
Transcript: ENSMUST00000039419
AA Change: I1778N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000037246
Gene: ENSMUSG00000036334
AA Change: I1778N

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000193455
AA Change: I1778N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000141971
Gene: ENSMUSG00000036334
AA Change: I1778N

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000194546
AA Change: I1778N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000141391
Gene: ENSMUSG00000036334
AA Change: I1778N

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1d A G 2: 131,388,412 (GRCm39) I381T probably damaging Het
Armt1 T A 10: 4,404,064 (GRCm39) F383Y possibly damaging Het
Cdca2 A G 14: 67,932,445 (GRCm39) V486A probably benign Het
Cep78 A G 19: 15,933,733 (GRCm39) L615S probably damaging Het
Clec2h C A 6: 128,650,979 (GRCm39) C86* probably null Het
Cntnap5a C T 1: 116,508,262 (GRCm39) T1258I probably benign Het
Dhrs7c T A 11: 67,706,628 (GRCm39) M262K possibly damaging Het
Dmpk C A 7: 18,822,117 (GRCm39) F332L probably damaging Het
Dnaaf4 G A 9: 72,876,348 (GRCm39) V308I probably benign Het
Fap A G 2: 62,385,142 (GRCm39) F73L probably benign Het
Il6ra T C 3: 89,797,655 (GRCm39) T71A probably benign Het
Itpr2 C A 6: 146,224,725 (GRCm39) A1389S probably damaging Het
Mob3b T C 4: 35,083,983 (GRCm39) N69D probably damaging Het
Nr1h3 A G 2: 91,023,070 (GRCm39) W21R probably damaging Het
Or4f56 A T 2: 111,703,593 (GRCm39) N202K probably damaging Het
Ovca2 A G 11: 75,069,596 (GRCm39) V9A possibly damaging Het
Ovch2 T A 7: 107,394,041 (GRCm39) K137N probably damaging Het
Pabpc1l A G 2: 163,869,536 (GRCm39) N112S probably damaging Het
Plekho1 T A 3: 95,899,496 (GRCm39) N99I probably damaging Het
Recql5 A C 11: 115,785,499 (GRCm39) S666A probably benign Het
Scn3a G T 2: 65,338,833 (GRCm39) H615Q probably benign Het
Sel1l3 A G 5: 53,297,141 (GRCm39) probably benign Het
Slc38a2 A T 15: 96,590,258 (GRCm39) S328T probably damaging Het
Taok1 T C 11: 77,466,503 (GRCm39) probably benign Het
Tsnax T A 8: 125,759,451 (GRCm39) Y237* probably null Het
Ttn T A 2: 76,544,974 (GRCm39) K24382N probably damaging Het
Ugt1a9 T A 1: 87,999,165 (GRCm39) V205E possibly damaging Het
Unc80 C A 1: 66,569,145 (GRCm39) D933E possibly damaging Het
Vnn1 A T 10: 23,779,323 (GRCm39) T411S probably benign Het
Wdr27 C A 17: 15,128,860 (GRCm39) G531V possibly damaging Het
Zfp760 G T 17: 21,941,193 (GRCm39) V123L probably benign Het
Other mutations in Igsf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Igsf10 APN 3 59,238,960 (GRCm39) missense probably benign 0.03
IGL00790:Igsf10 APN 3 59,226,938 (GRCm39) missense probably damaging 1.00
IGL00916:Igsf10 APN 3 59,238,548 (GRCm39) missense probably damaging 0.97
IGL00928:Igsf10 APN 3 59,238,018 (GRCm39) missense probably benign 0.00
IGL01066:Igsf10 APN 3 59,235,203 (GRCm39) critical splice donor site probably null
IGL01107:Igsf10 APN 3 59,238,945 (GRCm39) missense probably damaging 1.00
IGL01420:Igsf10 APN 3 59,227,071 (GRCm39) missense probably benign 0.02
IGL01533:Igsf10 APN 3 59,226,651 (GRCm39) missense probably damaging 0.98
IGL01537:Igsf10 APN 3 59,237,452 (GRCm39) missense probably benign 0.00
IGL01676:Igsf10 APN 3 59,236,756 (GRCm39) missense probably benign 0.17
IGL01676:Igsf10 APN 3 59,233,432 (GRCm39) missense probably benign 0.06
IGL01960:Igsf10 APN 3 59,226,158 (GRCm39) missense probably benign 0.00
IGL02123:Igsf10 APN 3 59,226,081 (GRCm39) missense probably damaging 0.97
IGL02268:Igsf10 APN 3 59,238,573 (GRCm39) nonsense probably null
IGL02313:Igsf10 APN 3 59,238,111 (GRCm39) missense probably benign 0.01
IGL02368:Igsf10 APN 3 59,235,652 (GRCm39) missense probably benign
IGL02494:Igsf10 APN 3 59,235,427 (GRCm39) missense probably damaging 0.98
IGL02549:Igsf10 APN 3 59,236,662 (GRCm39) missense probably benign 0.03
IGL02616:Igsf10 APN 3 59,226,027 (GRCm39) missense probably benign 0.06
IGL02957:Igsf10 APN 3 59,238,285 (GRCm39) missense probably damaging 1.00
IGL03067:Igsf10 APN 3 59,226,339 (GRCm39) missense probably benign 0.25
IGL03104:Igsf10 APN 3 59,226,905 (GRCm39) missense probably damaging 1.00
IGL03124:Igsf10 APN 3 59,227,086 (GRCm39) missense probably benign 0.01
IGL03212:Igsf10 APN 3 59,235,586 (GRCm39) missense probably benign 0.09
IGL03347:Igsf10 APN 3 59,239,321 (GRCm39) missense possibly damaging 0.94
IGL03357:Igsf10 APN 3 59,243,632 (GRCm39) missense probably benign 0.35
F6893:Igsf10 UTSW 3 59,238,481 (GRCm39) missense probably damaging 1.00
FR4449:Igsf10 UTSW 3 59,226,531 (GRCm39) missense probably damaging 1.00
PIT1430001:Igsf10 UTSW 3 59,235,579 (GRCm39) missense probably benign 0.06
PIT4402001:Igsf10 UTSW 3 59,233,000 (GRCm39) missense probably benign 0.00
PIT4810001:Igsf10 UTSW 3 59,225,903 (GRCm39) missense probably damaging 1.00
R0068:Igsf10 UTSW 3 59,238,045 (GRCm39) missense probably damaging 0.98
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0112:Igsf10 UTSW 3 59,233,429 (GRCm39) missense probably benign 0.00
R0141:Igsf10 UTSW 3 59,238,253 (GRCm39) missense probably damaging 1.00
R0538:Igsf10 UTSW 3 59,227,527 (GRCm39) missense probably damaging 0.99
R0551:Igsf10 UTSW 3 59,236,089 (GRCm39) missense probably benign 0.01
R0556:Igsf10 UTSW 3 59,236,296 (GRCm39) missense probably benign 0.02
R0582:Igsf10 UTSW 3 59,227,188 (GRCm39) missense probably benign 0.00
R0630:Igsf10 UTSW 3 59,233,483 (GRCm39) missense probably damaging 1.00
R0675:Igsf10 UTSW 3 59,236,015 (GRCm39) missense probably benign 0.14
R0948:Igsf10 UTSW 3 59,238,525 (GRCm39) missense probably damaging 1.00
R1252:Igsf10 UTSW 3 59,239,269 (GRCm39) missense probably benign 0.03
R1412:Igsf10 UTSW 3 59,235,196 (GRCm39) splice site probably benign
R1473:Igsf10 UTSW 3 59,226,188 (GRCm39) missense probably damaging 1.00
R1585:Igsf10 UTSW 3 59,237,838 (GRCm39) missense probably damaging 1.00
R1650:Igsf10 UTSW 3 59,233,583 (GRCm39) missense probably damaging 1.00
R1660:Igsf10 UTSW 3 59,238,706 (GRCm39) missense probably damaging 1.00
R1671:Igsf10 UTSW 3 59,235,921 (GRCm39) nonsense probably null
R1748:Igsf10 UTSW 3 59,226,514 (GRCm39) missense probably damaging 1.00
R1758:Igsf10 UTSW 3 59,236,617 (GRCm39) missense probably benign 0.09
R1856:Igsf10 UTSW 3 59,238,693 (GRCm39) missense possibly damaging 0.63
R1912:Igsf10 UTSW 3 59,236,993 (GRCm39) missense probably benign 0.40
R2148:Igsf10 UTSW 3 59,243,998 (GRCm39) missense possibly damaging 0.77
R2155:Igsf10 UTSW 3 59,239,101 (GRCm39) missense probably damaging 1.00
R2509:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2511:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2680:Igsf10 UTSW 3 59,232,875 (GRCm39) missense probably benign 0.14
R2913:Igsf10 UTSW 3 59,239,157 (GRCm39) missense possibly damaging 0.70
R2927:Igsf10 UTSW 3 59,236,848 (GRCm39) missense probably benign
R3547:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3547:Igsf10 UTSW 3 59,237,962 (GRCm39) missense probably benign 0.02
R3548:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3620:Igsf10 UTSW 3 59,243,752 (GRCm39) missense probably damaging 1.00
R3732:Igsf10 UTSW 3 59,233,135 (GRCm39) missense probably benign 0.29
R3743:Igsf10 UTSW 3 59,233,546 (GRCm39) missense possibly damaging 0.69
R3973:Igsf10 UTSW 3 59,239,345 (GRCm39) missense probably damaging 1.00
R4005:Igsf10 UTSW 3 59,235,981 (GRCm39) missense probably benign 0.00
R4184:Igsf10 UTSW 3 59,227,152 (GRCm39) missense probably damaging 1.00
R4302:Igsf10 UTSW 3 59,226,171 (GRCm39) missense probably damaging 1.00
R4404:Igsf10 UTSW 3 59,236,972 (GRCm39) missense probably benign 0.04
R4575:Igsf10 UTSW 3 59,237,521 (GRCm39) missense probably benign
R4676:Igsf10 UTSW 3 59,233,370 (GRCm39) missense probably benign 0.23
R4700:Igsf10 UTSW 3 59,227,751 (GRCm39) missense probably damaging 0.99
R4765:Igsf10 UTSW 3 59,237,126 (GRCm39) missense probably benign 0.01
R4986:Igsf10 UTSW 3 59,236,027 (GRCm39) missense probably benign 0.24
R5012:Igsf10 UTSW 3 59,226,143 (GRCm39) missense probably damaging 1.00
R5070:Igsf10 UTSW 3 59,235,714 (GRCm39) missense probably benign 0.02
R5083:Igsf10 UTSW 3 59,233,694 (GRCm39) missense probably damaging 1.00
R5336:Igsf10 UTSW 3 59,227,553 (GRCm39) missense probably damaging 1.00
R5462:Igsf10 UTSW 3 59,233,175 (GRCm39) missense probably damaging 1.00
R5648:Igsf10 UTSW 3 59,235,574 (GRCm39) missense probably benign 0.01
R5810:Igsf10 UTSW 3 59,226,492 (GRCm39) missense probably damaging 1.00
R5871:Igsf10 UTSW 3 59,237,832 (GRCm39) missense possibly damaging 0.83
R5880:Igsf10 UTSW 3 59,238,252 (GRCm39) missense probably damaging 1.00
R5935:Igsf10 UTSW 3 59,235,578 (GRCm39) missense probably benign 0.12
R5979:Igsf10 UTSW 3 59,243,894 (GRCm39) missense probably damaging 1.00
R6145:Igsf10 UTSW 3 59,239,077 (GRCm39) missense possibly damaging 0.83
R6222:Igsf10 UTSW 3 59,226,336 (GRCm39) missense possibly damaging 0.90
R6224:Igsf10 UTSW 3 59,232,931 (GRCm39) missense probably damaging 1.00
R6264:Igsf10 UTSW 3 59,235,928 (GRCm39) missense possibly damaging 0.88
R6283:Igsf10 UTSW 3 59,226,870 (GRCm39) missense probably damaging 1.00
R6336:Igsf10 UTSW 3 59,237,760 (GRCm39) missense probably benign 0.00
R6490:Igsf10 UTSW 3 59,236,992 (GRCm39) missense probably benign 0.06
R6785:Igsf10 UTSW 3 59,226,665 (GRCm39) missense probably damaging 1.00
R6873:Igsf10 UTSW 3 59,235,865 (GRCm39) missense probably benign
R6889:Igsf10 UTSW 3 59,239,354 (GRCm39) missense probably benign
R7024:Igsf10 UTSW 3 59,239,122 (GRCm39) missense probably benign 0.00
R7056:Igsf10 UTSW 3 59,238,501 (GRCm39) missense probably damaging 1.00
R7128:Igsf10 UTSW 3 59,236,326 (GRCm39) missense probably benign
R7251:Igsf10 UTSW 3 59,226,875 (GRCm39) missense probably damaging 1.00
R7313:Igsf10 UTSW 3 59,236,837 (GRCm39) missense probably benign 0.05
R7340:Igsf10 UTSW 3 59,233,189 (GRCm39) missense probably damaging 1.00
R7447:Igsf10 UTSW 3 59,239,222 (GRCm39) missense probably benign 0.39
R7506:Igsf10 UTSW 3 59,226,775 (GRCm39) missense probably damaging 1.00
R7678:Igsf10 UTSW 3 59,226,761 (GRCm39) missense possibly damaging 0.81
R7695:Igsf10 UTSW 3 59,233,612 (GRCm39) missense probably damaging 1.00
R7709:Igsf10 UTSW 3 59,238,964 (GRCm39) missense probably damaging 0.96
R7749:Igsf10 UTSW 3 59,236,549 (GRCm39) missense possibly damaging 0.88
R7808:Igsf10 UTSW 3 59,235,489 (GRCm39) missense probably benign 0.00
R7850:Igsf10 UTSW 3 59,227,053 (GRCm39) missense probably benign 0.33
R7879:Igsf10 UTSW 3 59,238,145 (GRCm39) missense probably damaging 1.00
R7886:Igsf10 UTSW 3 59,235,748 (GRCm39) missense probably benign 0.01
R7891:Igsf10 UTSW 3 59,235,832 (GRCm39) nonsense probably null
R7946:Igsf10 UTSW 3 59,227,125 (GRCm39) missense possibly damaging 0.69
R7948:Igsf10 UTSW 3 59,239,279 (GRCm39) missense probably benign 0.02
R8004:Igsf10 UTSW 3 59,237,130 (GRCm39) missense probably benign 0.01
R8096:Igsf10 UTSW 3 59,236,380 (GRCm39) missense probably damaging 0.98
R8141:Igsf10 UTSW 3 59,237,949 (GRCm39) missense probably damaging 0.96
R8183:Igsf10 UTSW 3 59,238,036 (GRCm39) missense probably benign 0.04
R8203:Igsf10 UTSW 3 59,236,254 (GRCm39) missense probably benign 0.11
R8325:Igsf10 UTSW 3 59,225,954 (GRCm39) missense probably damaging 0.96
R8350:Igsf10 UTSW 3 59,238,949 (GRCm39) missense probably damaging 1.00
R8387:Igsf10 UTSW 3 59,236,564 (GRCm39) missense probably damaging 1.00
R8488:Igsf10 UTSW 3 59,227,431 (GRCm39) missense probably damaging 1.00
R8697:Igsf10 UTSW 3 59,226,308 (GRCm39) missense probably benign 0.02
R8786:Igsf10 UTSW 3 59,238,063 (GRCm39) missense probably benign 0.25
R8804:Igsf10 UTSW 3 59,243,876 (GRCm39) missense probably damaging 1.00
R8886:Igsf10 UTSW 3 59,237,410 (GRCm39) missense probably benign 0.00
R8902:Igsf10 UTSW 3 59,243,633 (GRCm39) missense probably benign 0.00
R8906:Igsf10 UTSW 3 59,233,739 (GRCm39) missense probably benign 0.01
R8917:Igsf10 UTSW 3 59,226,888 (GRCm39) missense possibly damaging 0.69
R9051:Igsf10 UTSW 3 59,236,668 (GRCm39) missense probably benign 0.00
R9178:Igsf10 UTSW 3 59,233,480 (GRCm39) missense possibly damaging 0.69
R9228:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9230:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9231:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9232:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9417:Igsf10 UTSW 3 59,236,526 (GRCm39) missense possibly damaging 0.94
R9609:Igsf10 UTSW 3 59,226,869 (GRCm39) missense probably damaging 1.00
R9631:Igsf10 UTSW 3 59,237,904 (GRCm39) missense probably damaging 1.00
R9689:Igsf10 UTSW 3 59,233,624 (GRCm39) missense probably damaging 1.00
R9762:Igsf10 UTSW 3 59,237,106 (GRCm39) missense probably damaging 1.00
R9770:Igsf10 UTSW 3 59,227,199 (GRCm39) missense probably benign 0.07
R9798:Igsf10 UTSW 3 59,239,126 (GRCm39) missense probably damaging 1.00
Z1088:Igsf10 UTSW 3 59,237,359 (GRCm39) missense possibly damaging 0.59
Z1177:Igsf10 UTSW 3 59,237,026 (GRCm39) nonsense probably null
Posted On 2015-04-16