Incidental Mutation 'R4621:Mycbp2'
ID 346183
Institutional Source Beutler Lab
Gene Symbol Mycbp2
Ensembl Gene ENSMUSG00000033004
Gene Name MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms Phr1, Pam, C130061D10Rik
MMRRC Submission 041886-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4621 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 103350847-103584250 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 103457415 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 1627 (T1627K)
Ref Sequence ENSEMBL: ENSMUSP00000124710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000159855
AA Change: T1627K

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: T1627K

DomainStartEndE-ValueType
low complexity region 5 27 N/A INTRINSIC
low complexity region 47 55 N/A INTRINSIC
low complexity region 100 127 N/A INTRINSIC
low complexity region 178 191 N/A INTRINSIC
Pfam:RCC1_2 683 712 1.4e-10 PFAM
low complexity region 737 750 N/A INTRINSIC
low complexity region 793 815 N/A INTRINSIC
Pfam:RCC1_2 942 971 5.5e-10 PFAM
Pfam:RCC1 958 1006 4.8e-15 PFAM
Pfam:PHR 1235 1385 8.2e-44 PFAM
Pfam:PHR 1723 1880 1.4e-43 PFAM
low complexity region 1935 1948 N/A INTRINSIC
low complexity region 2182 2195 N/A INTRINSIC
Pfam:Filamin 2261 2431 7.5e-9 PFAM
Pfam:SH3_3 2472 2539 4.1e-9 PFAM
internal_repeat_3 2612 2679 1.69e-7 PROSPERO
low complexity region 2701 2710 N/A INTRINSIC
low complexity region 2884 2917 N/A INTRINSIC
low complexity region 2970 2984 N/A INTRINSIC
coiled coil region 3263 3290 N/A INTRINSIC
low complexity region 3352 3365 N/A INTRINSIC
low complexity region 3418 3433 N/A INTRINSIC
low complexity region 3678 3695 N/A INTRINSIC
APC10 3810 3968 1.11e-18 SMART
low complexity region 4103 4115 N/A INTRINSIC
low complexity region 4190 4212 N/A INTRINSIC
Blast:BBOX 4327 4370 7e-7 BLAST
RING 4496 4546 5.35e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160758
AA Change: T1594K

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: T1594K

DomainStartEndE-ValueType
low complexity region 14 22 N/A INTRINSIC
low complexity region 67 94 N/A INTRINSIC
low complexity region 145 158 N/A INTRINSIC
Pfam:RCC1_2 650 679 1e-10 PFAM
low complexity region 704 717 N/A INTRINSIC
low complexity region 760 782 N/A INTRINSIC
Pfam:RCC1_2 909 938 1.5e-9 PFAM
Pfam:RCC1 925 973 1.3e-15 PFAM
Pfam:PHR 1202 1353 1.6e-50 PFAM
Pfam:PHR 1690 1848 3.1e-58 PFAM
low complexity region 1902 1915 N/A INTRINSIC
low complexity region 2149 2162 N/A INTRINSIC
Pfam:Filamin 2228 2398 7.6e-9 PFAM
Pfam:SH3_3 2439 2507 2.3e-10 PFAM
internal_repeat_3 2554 2621 2e-7 PROSPERO
low complexity region 2643 2652 N/A INTRINSIC
low complexity region 2774 2807 N/A INTRINSIC
low complexity region 2860 2874 N/A INTRINSIC
coiled coil region 3153 3180 N/A INTRINSIC
low complexity region 3242 3255 N/A INTRINSIC
low complexity region 3308 3323 N/A INTRINSIC
low complexity region 3568 3585 N/A INTRINSIC
APC10 3700 3858 1.11e-18 SMART
low complexity region 3993 4005 N/A INTRINSIC
low complexity region 4080 4102 N/A INTRINSIC
Blast:BBOX 4217 4260 7e-7 BLAST
RING 4386 4436 5.35e-5 SMART
Meta Mutation Damage Score 0.1754 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 100% (90/90)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]
Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd2 T C 7: 78,975,235 (GRCm39) Y142H probably damaging Het
Abra C T 15: 41,732,620 (GRCm39) D149N probably benign Het
Acin1 A T 14: 54,890,900 (GRCm39) probably benign Het
Adap2 T A 11: 80,064,899 (GRCm39) probably null Het
Afdn A G 17: 14,109,082 (GRCm39) E1535G probably damaging Het
Ajm1 G A 2: 25,468,412 (GRCm39) P500S probably damaging Het
Ak9 A G 10: 41,282,887 (GRCm39) N1218D possibly damaging Het
Angptl1 G A 1: 156,672,494 (GRCm39) V107M probably damaging Het
Arhgap26 G A 18: 39,032,894 (GRCm39) probably benign Het
Cage1 A C 13: 38,209,477 (GRCm39) S61A possibly damaging Het
Cdadc1 T C 14: 59,824,004 (GRCm39) T163A probably benign Het
Celsr2 A T 3: 108,302,532 (GRCm39) V2568D possibly damaging Het
Cep44 G A 8: 56,995,951 (GRCm39) T166M probably damaging Het
Cnksr3 T C 10: 7,076,182 (GRCm39) K187E possibly damaging Het
Cyp20a1 A G 1: 60,415,258 (GRCm39) T295A probably benign Het
Dus2 T A 8: 106,757,074 (GRCm39) M88K probably damaging Het
E330034G19Rik A T 14: 24,346,070 (GRCm39) probably benign Het
Ecrg4 G A 1: 43,776,412 (GRCm39) probably null Het
Efna5 T C 17: 62,958,040 (GRCm39) D72G probably benign Het
Epb41l2 T C 10: 25,378,038 (GRCm39) probably null Het
Espn A G 4: 152,215,709 (GRCm39) S408P probably damaging Het
Evi5l T C 8: 4,252,909 (GRCm39) probably benign Het
F830016B08Rik G A 18: 60,433,939 (GRCm39) V341I probably benign Het
Flii A G 11: 60,606,937 (GRCm39) L1013P possibly damaging Het
Fndc10 G A 4: 155,779,264 (GRCm39) V103M probably damaging Het
Frem3 T A 8: 81,395,820 (GRCm39) probably null Het
Gltp C T 5: 114,812,188 (GRCm39) R106Q probably damaging Het
Gtf3c3 A G 1: 54,458,575 (GRCm39) Y449H probably damaging Het
H1f9 G A 11: 94,858,986 (GRCm39) V94M probably damaging Het
Hmga1b T C 11: 120,653,866 (GRCm39) V51A probably damaging Het
Hsph1 A G 5: 149,542,308 (GRCm39) V705A probably benign Het
Igkv13-84 T C 6: 68,916,783 (GRCm39) S27P possibly damaging Het
Il15ra A G 2: 11,723,140 (GRCm39) N55D possibly damaging Het
Kctd19 T G 8: 106,123,103 (GRCm39) N104H probably damaging Het
Kif27 T G 13: 58,478,827 (GRCm39) D572A probably benign Het
Larp1b G A 3: 40,918,424 (GRCm39) G22R possibly damaging Het
Lcn2 A T 2: 32,274,655 (GRCm39) probably benign Het
Lmtk2 T A 5: 144,111,752 (GRCm39) I824N probably benign Het
Ltbp2 A G 12: 84,856,122 (GRCm39) I707T probably damaging Het
Macf1 A G 4: 123,266,141 (GRCm39) probably null Het
Magel2 A T 7: 62,027,486 (GRCm39) H130L unknown Het
Mcoln1 A G 8: 3,555,923 (GRCm39) I73V probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Myh8 A G 11: 67,177,084 (GRCm39) E412G probably damaging Het
Myo9a T A 9: 59,778,355 (GRCm39) D1370E probably benign Het
Ndufaf5 A G 2: 140,025,845 (GRCm39) T135A probably benign Het
Neb G A 2: 52,161,051 (GRCm39) Q2207* probably null Het
Nek3 T C 8: 22,647,055 (GRCm39) Y160C probably damaging Het
Or2y6 G C 11: 52,104,706 (GRCm39) L37V probably benign Het
Or5k8 A T 16: 58,644,469 (GRCm39) I201N possibly damaging Het
Osbpl8 A G 10: 111,105,279 (GRCm39) I245V probably benign Het
Pcdh9 T C 14: 94,125,079 (GRCm39) I241V probably benign Het
Pcdhb12 A G 18: 37,570,213 (GRCm39) Q453R probably benign Het
Pcdhb2 A G 18: 37,428,980 (GRCm39) T318A probably benign Het
Prlr T A 15: 10,319,462 (GRCm39) probably benign Het
Ptprz1 C T 6: 23,001,453 (GRCm39) A1181V possibly damaging Het
Racgap1 C A 15: 99,524,087 (GRCm39) S440I probably benign Het
Rap1gap2 A G 11: 74,326,525 (GRCm39) probably null Het
Rbm5 A G 9: 107,631,345 (GRCm39) V244A probably damaging Het
Rexo5 T G 7: 119,418,722 (GRCm39) I254R probably benign Het
Robo2 A T 16: 73,782,821 (GRCm39) S316T probably benign Het
Satb2 A T 1: 56,884,778 (GRCm39) V382E probably damaging Het
Scg2 C T 1: 79,414,381 (GRCm39) R114Q probably benign Het
Scube2 T C 7: 109,399,857 (GRCm39) D893G possibly damaging Het
Snrpn T C 7: 59,637,274 (GRCm39) D14G possibly damaging Het
Spag17 A G 3: 100,010,559 (GRCm39) T2018A probably benign Het
Spata9 T G 13: 76,116,001 (GRCm39) F17V possibly damaging Het
Supt6 A G 11: 78,103,572 (GRCm39) Y1378H possibly damaging Het
Thsd7b T C 1: 129,358,652 (GRCm39) S29P possibly damaging Het
Tmem59 A T 4: 107,047,915 (GRCm39) probably benign Het
Tmem87a A G 2: 120,227,905 (GRCm39) S81P probably benign Het
Togaram1 A T 12: 65,029,224 (GRCm39) E882D possibly damaging Het
Trbj2-4 T A 6: 41,520,308 (GRCm39) probably benign Het
Trim42 T A 9: 97,245,201 (GRCm39) Y533F probably benign Het
Tssk5 C T 15: 76,256,668 (GRCm39) R280Q probably benign Het
Vmn1r82 A G 7: 12,039,263 (GRCm39) T179A possibly damaging Het
Yipf7 T A 5: 69,676,704 (GRCm39) Q145L possibly damaging Het
Other mutations in Mycbp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Mycbp2 APN 14 103,460,486 (GRCm39) missense probably damaging 1.00
IGL00518:Mycbp2 APN 14 103,393,244 (GRCm39) missense probably damaging 1.00
IGL00650:Mycbp2 APN 14 103,380,664 (GRCm39) missense probably damaging 0.97
IGL00653:Mycbp2 APN 14 103,380,664 (GRCm39) missense probably damaging 0.97
IGL00742:Mycbp2 APN 14 103,438,788 (GRCm39) missense probably damaging 1.00
IGL00755:Mycbp2 APN 14 103,432,057 (GRCm39) missense possibly damaging 0.72
IGL00793:Mycbp2 APN 14 103,364,189 (GRCm39) missense possibly damaging 0.77
IGL00916:Mycbp2 APN 14 103,528,719 (GRCm39) splice site probably benign
IGL00960:Mycbp2 APN 14 103,466,820 (GRCm39) missense possibly damaging 0.95
IGL00977:Mycbp2 APN 14 103,410,078 (GRCm39) missense probably damaging 0.98
IGL01349:Mycbp2 APN 14 103,359,983 (GRCm39) missense probably damaging 0.98
IGL01369:Mycbp2 APN 14 103,392,946 (GRCm39) missense possibly damaging 0.61
IGL01410:Mycbp2 APN 14 103,466,928 (GRCm39) splice site probably null
IGL01586:Mycbp2 APN 14 103,378,305 (GRCm39) critical splice donor site probably null
IGL01593:Mycbp2 APN 14 103,528,723 (GRCm39) critical splice donor site probably null
IGL01693:Mycbp2 APN 14 103,365,415 (GRCm39) missense probably damaging 0.99
IGL01730:Mycbp2 APN 14 103,372,640 (GRCm39) nonsense probably null
IGL01820:Mycbp2 APN 14 103,425,937 (GRCm39) missense probably damaging 1.00
IGL01974:Mycbp2 APN 14 103,380,647 (GRCm39) missense possibly damaging 0.88
IGL02071:Mycbp2 APN 14 103,392,343 (GRCm39) nonsense probably null
IGL02178:Mycbp2 APN 14 103,461,802 (GRCm39) missense probably benign 0.01
IGL02324:Mycbp2 APN 14 103,479,643 (GRCm39) missense probably damaging 1.00
IGL02442:Mycbp2 APN 14 103,551,811 (GRCm39) missense probably benign
IGL02607:Mycbp2 APN 14 103,522,709 (GRCm39) missense probably damaging 1.00
IGL02679:Mycbp2 APN 14 103,442,621 (GRCm39) missense probably benign
IGL02702:Mycbp2 APN 14 103,457,560 (GRCm39) missense probably benign 0.01
IGL02709:Mycbp2 APN 14 103,392,697 (GRCm39) missense probably damaging 0.97
IGL02736:Mycbp2 APN 14 103,351,678 (GRCm39) splice site probably benign
IGL02866:Mycbp2 APN 14 103,367,428 (GRCm39) missense probably damaging 0.98
IGL02939:Mycbp2 APN 14 103,414,715 (GRCm39) missense probably benign
IGL03082:Mycbp2 APN 14 103,441,805 (GRCm39) missense probably benign 0.23
IGL03142:Mycbp2 APN 14 103,536,212 (GRCm39) missense probably damaging 0.99
IGL03155:Mycbp2 APN 14 103,392,889 (GRCm39) missense probably benign 0.06
IGL03236:Mycbp2 APN 14 103,536,134 (GRCm39) missense probably damaging 0.99
IGL03256:Mycbp2 APN 14 103,426,025 (GRCm39) missense possibly damaging 0.92
IGL03303:Mycbp2 APN 14 103,485,194 (GRCm39) missense probably damaging 1.00
compost UTSW 14 103,393,889 (GRCm39) missense probably damaging 1.00
decompose UTSW 14 103,457,415 (GRCm39) missense probably benign 0.12
moulder UTSW 14 103,426,028 (GRCm39) missense probably damaging 1.00
N/A - 293:Mycbp2 UTSW 14 103,461,898 (GRCm39) splice site probably benign
R0040:Mycbp2 UTSW 14 103,461,708 (GRCm39) missense probably benign 0.11
R0040:Mycbp2 UTSW 14 103,461,708 (GRCm39) missense probably benign 0.11
R0057:Mycbp2 UTSW 14 103,389,578 (GRCm39) missense probably damaging 0.97
R0063:Mycbp2 UTSW 14 103,394,070 (GRCm39) unclassified probably benign
R0097:Mycbp2 UTSW 14 103,393,198 (GRCm39) missense probably damaging 1.00
R0097:Mycbp2 UTSW 14 103,393,198 (GRCm39) missense probably damaging 1.00
R0268:Mycbp2 UTSW 14 103,551,761 (GRCm39) nonsense probably null
R0388:Mycbp2 UTSW 14 103,394,103 (GRCm39) missense probably benign 0.01
R0410:Mycbp2 UTSW 14 103,372,569 (GRCm39) missense probably damaging 1.00
R0530:Mycbp2 UTSW 14 103,419,895 (GRCm39) missense probably damaging 1.00
R0591:Mycbp2 UTSW 14 103,433,827 (GRCm39) unclassified probably benign
R0671:Mycbp2 UTSW 14 103,432,024 (GRCm39) missense possibly damaging 0.95
R0755:Mycbp2 UTSW 14 103,412,230 (GRCm39) missense probably damaging 1.00
R0817:Mycbp2 UTSW 14 103,466,854 (GRCm39) missense probably damaging 0.99
R0818:Mycbp2 UTSW 14 103,466,854 (GRCm39) missense probably damaging 0.99
R0819:Mycbp2 UTSW 14 103,466,854 (GRCm39) missense probably damaging 0.99
R0881:Mycbp2 UTSW 14 103,457,449 (GRCm39) missense probably benign
R0903:Mycbp2 UTSW 14 103,513,293 (GRCm39) missense probably damaging 0.99
R0940:Mycbp2 UTSW 14 103,500,129 (GRCm39) unclassified probably benign
R0961:Mycbp2 UTSW 14 103,422,271 (GRCm39) missense probably damaging 1.00
R1004:Mycbp2 UTSW 14 103,378,353 (GRCm39) missense probably benign 0.00
R1138:Mycbp2 UTSW 14 103,412,262 (GRCm39) missense possibly damaging 0.84
R1170:Mycbp2 UTSW 14 103,437,588 (GRCm39) nonsense probably null
R1211:Mycbp2 UTSW 14 103,357,999 (GRCm39) missense probably benign 0.31
R1268:Mycbp2 UTSW 14 103,446,218 (GRCm39) missense probably damaging 1.00
R1298:Mycbp2 UTSW 14 103,393,334 (GRCm39) missense probably damaging 1.00
R1341:Mycbp2 UTSW 14 103,536,303 (GRCm39) splice site probably benign
R1469:Mycbp2 UTSW 14 103,425,956 (GRCm39) missense probably damaging 0.99
R1469:Mycbp2 UTSW 14 103,425,956 (GRCm39) missense probably damaging 0.99
R1513:Mycbp2 UTSW 14 103,441,825 (GRCm39) missense probably damaging 1.00
R1528:Mycbp2 UTSW 14 103,470,033 (GRCm39) missense possibly damaging 0.91
R1564:Mycbp2 UTSW 14 103,407,287 (GRCm39) splice site probably null
R1565:Mycbp2 UTSW 14 103,489,945 (GRCm39) missense possibly damaging 0.82
R1656:Mycbp2 UTSW 14 103,485,194 (GRCm39) missense probably damaging 1.00
R1694:Mycbp2 UTSW 14 103,464,947 (GRCm39) missense probably damaging 1.00
R1709:Mycbp2 UTSW 14 103,461,852 (GRCm39) missense probably damaging 1.00
R1728:Mycbp2 UTSW 14 103,392,614 (GRCm39) missense probably damaging 0.98
R1751:Mycbp2 UTSW 14 103,485,841 (GRCm39) missense probably damaging 0.98
R1767:Mycbp2 UTSW 14 103,485,841 (GRCm39) missense probably damaging 0.98
R1772:Mycbp2 UTSW 14 103,419,855 (GRCm39) missense probably damaging 1.00
R1784:Mycbp2 UTSW 14 103,392,614 (GRCm39) missense probably damaging 0.98
R1823:Mycbp2 UTSW 14 103,489,945 (GRCm39) missense possibly damaging 0.82
R1824:Mycbp2 UTSW 14 103,489,945 (GRCm39) missense possibly damaging 0.82
R1844:Mycbp2 UTSW 14 103,393,150 (GRCm39) missense possibly damaging 0.94
R1916:Mycbp2 UTSW 14 103,422,319 (GRCm39) missense probably damaging 1.00
R1944:Mycbp2 UTSW 14 103,466,840 (GRCm39) missense probably damaging 1.00
R1983:Mycbp2 UTSW 14 103,383,407 (GRCm39) missense probably damaging 0.97
R2002:Mycbp2 UTSW 14 103,485,839 (GRCm39) missense probably damaging 0.98
R2031:Mycbp2 UTSW 14 103,426,028 (GRCm39) missense probably damaging 1.00
R2035:Mycbp2 UTSW 14 103,497,675 (GRCm39) missense probably damaging 1.00
R2048:Mycbp2 UTSW 14 103,469,960 (GRCm39) critical splice donor site probably null
R2061:Mycbp2 UTSW 14 103,524,696 (GRCm39) missense probably damaging 0.99
R2113:Mycbp2 UTSW 14 103,457,512 (GRCm39) missense probably damaging 0.99
R2128:Mycbp2 UTSW 14 103,438,666 (GRCm39) missense probably benign 0.01
R2134:Mycbp2 UTSW 14 103,446,329 (GRCm39) missense probably damaging 1.00
R2135:Mycbp2 UTSW 14 103,446,329 (GRCm39) missense probably damaging 1.00
R2135:Mycbp2 UTSW 14 103,383,378 (GRCm39) missense probably benign
R2146:Mycbp2 UTSW 14 103,393,358 (GRCm39) missense probably damaging 0.97
R2147:Mycbp2 UTSW 14 103,393,358 (GRCm39) missense probably damaging 0.97
R2148:Mycbp2 UTSW 14 103,393,358 (GRCm39) missense probably damaging 0.97
R2150:Mycbp2 UTSW 14 103,393,358 (GRCm39) missense probably damaging 0.97
R2163:Mycbp2 UTSW 14 103,407,291 (GRCm39) critical splice donor site probably null
R2248:Mycbp2 UTSW 14 103,407,295 (GRCm39) missense possibly damaging 0.50
R2265:Mycbp2 UTSW 14 103,500,185 (GRCm39) missense probably benign 0.39
R2272:Mycbp2 UTSW 14 103,381,774 (GRCm39) missense probably null 0.66
R2379:Mycbp2 UTSW 14 103,412,386 (GRCm39) missense probably benign
R2495:Mycbp2 UTSW 14 103,437,554 (GRCm39) missense probably damaging 0.99
R2508:Mycbp2 UTSW 14 103,368,681 (GRCm39) missense probably damaging 0.99
R2510:Mycbp2 UTSW 14 103,392,691 (GRCm39) missense probably damaging 0.96
R2851:Mycbp2 UTSW 14 103,381,769 (GRCm39) missense probably damaging 0.99
R2852:Mycbp2 UTSW 14 103,381,769 (GRCm39) missense probably damaging 0.99
R2965:Mycbp2 UTSW 14 103,534,794 (GRCm39) missense probably benign 0.00
R3156:Mycbp2 UTSW 14 103,446,179 (GRCm39) splice site probably benign
R3404:Mycbp2 UTSW 14 103,437,550 (GRCm39) missense probably damaging 0.99
R3410:Mycbp2 UTSW 14 103,372,553 (GRCm39) missense probably damaging 1.00
R3429:Mycbp2 UTSW 14 103,466,866 (GRCm39) missense probably damaging 1.00
R3706:Mycbp2 UTSW 14 103,393,850 (GRCm39) missense probably benign 0.31
R3772:Mycbp2 UTSW 14 103,371,224 (GRCm39) missense possibly damaging 0.82
R3778:Mycbp2 UTSW 14 103,434,721 (GRCm39) missense probably damaging 0.99
R3883:Mycbp2 UTSW 14 103,532,686 (GRCm39) missense probably damaging 0.97
R3884:Mycbp2 UTSW 14 103,532,686 (GRCm39) missense probably damaging 0.97
R3887:Mycbp2 UTSW 14 103,412,233 (GRCm39) missense probably damaging 0.98
R3923:Mycbp2 UTSW 14 103,364,149 (GRCm39) missense probably damaging 1.00
R3926:Mycbp2 UTSW 14 103,441,936 (GRCm39) missense probably damaging 1.00
R3959:Mycbp2 UTSW 14 103,532,688 (GRCm39) missense probably benign 0.00
R3966:Mycbp2 UTSW 14 103,376,161 (GRCm39) splice site probably benign
R4021:Mycbp2 UTSW 14 103,389,593 (GRCm39) missense probably damaging 0.97
R4363:Mycbp2 UTSW 14 103,485,893 (GRCm39) missense probably damaging 1.00
R4405:Mycbp2 UTSW 14 103,360,881 (GRCm39) missense probably damaging 1.00
R4407:Mycbp2 UTSW 14 103,524,664 (GRCm39) missense probably damaging 1.00
R4410:Mycbp2 UTSW 14 103,372,702 (GRCm39) missense probably damaging 1.00
R4434:Mycbp2 UTSW 14 103,371,225 (GRCm39) missense probably damaging 0.99
R4448:Mycbp2 UTSW 14 103,425,938 (GRCm39) missense possibly damaging 0.89
R4452:Mycbp2 UTSW 14 103,393,094 (GRCm39) missense probably damaging 0.99
R4573:Mycbp2 UTSW 14 103,583,733 (GRCm39) missense probably benign 0.05
R4589:Mycbp2 UTSW 14 103,414,749 (GRCm39) missense probably benign 0.04
R4622:Mycbp2 UTSW 14 103,457,415 (GRCm39) missense probably benign 0.12
R4729:Mycbp2 UTSW 14 103,426,027 (GRCm39) missense probably damaging 1.00
R4770:Mycbp2 UTSW 14 103,457,380 (GRCm39) missense probably benign 0.41
R4790:Mycbp2 UTSW 14 103,466,873 (GRCm39) missense probably damaging 1.00
R4884:Mycbp2 UTSW 14 103,448,731 (GRCm39) missense probably damaging 1.00
R4885:Mycbp2 UTSW 14 103,383,382 (GRCm39) missense possibly damaging 0.86
R4956:Mycbp2 UTSW 14 103,524,675 (GRCm39) missense probably damaging 0.99
R4980:Mycbp2 UTSW 14 103,497,821 (GRCm39) splice site probably null
R4994:Mycbp2 UTSW 14 103,407,430 (GRCm39) missense probably benign
R5029:Mycbp2 UTSW 14 103,393,946 (GRCm39) missense probably benign 0.21
R5038:Mycbp2 UTSW 14 103,534,375 (GRCm39) missense probably damaging 1.00
R5044:Mycbp2 UTSW 14 103,376,671 (GRCm39) critical splice donor site probably null
R5231:Mycbp2 UTSW 14 103,583,650 (GRCm39) critical splice donor site probably null
R5305:Mycbp2 UTSW 14 103,583,757 (GRCm39) missense probably benign 0.00
R5322:Mycbp2 UTSW 14 103,423,119 (GRCm39) critical splice acceptor site probably null
R5376:Mycbp2 UTSW 14 103,479,868 (GRCm39) nonsense probably null
R5414:Mycbp2 UTSW 14 103,543,697 (GRCm39) missense probably damaging 1.00
R5453:Mycbp2 UTSW 14 103,438,837 (GRCm39) missense probably damaging 0.99
R5462:Mycbp2 UTSW 14 103,437,562 (GRCm39) missense probably damaging 1.00
R5499:Mycbp2 UTSW 14 103,479,615 (GRCm39) missense probably damaging 1.00
R5502:Mycbp2 UTSW 14 103,411,250 (GRCm39) missense probably damaging 1.00
R5524:Mycbp2 UTSW 14 103,532,673 (GRCm39) missense probably damaging 1.00
R5533:Mycbp2 UTSW 14 103,520,081 (GRCm39) nonsense probably null
R5569:Mycbp2 UTSW 14 103,372,679 (GRCm39) missense probably damaging 1.00
R5574:Mycbp2 UTSW 14 103,380,203 (GRCm39) missense possibly damaging 0.94
R5579:Mycbp2 UTSW 14 103,528,769 (GRCm39) missense probably damaging 0.98
R5590:Mycbp2 UTSW 14 103,360,791 (GRCm39) missense probably damaging 1.00
R5592:Mycbp2 UTSW 14 103,432,113 (GRCm39) missense probably benign 0.02
R5643:Mycbp2 UTSW 14 103,524,770 (GRCm39) missense probably damaging 1.00
R5644:Mycbp2 UTSW 14 103,524,770 (GRCm39) missense probably damaging 1.00
R5645:Mycbp2 UTSW 14 103,426,051 (GRCm39) critical splice acceptor site probably null
R5645:Mycbp2 UTSW 14 103,426,044 (GRCm39) missense probably damaging 1.00
R5646:Mycbp2 UTSW 14 103,407,346 (GRCm39) missense probably benign 0.09
R5648:Mycbp2 UTSW 14 103,528,778 (GRCm39) missense probably damaging 1.00
R5651:Mycbp2 UTSW 14 103,520,101 (GRCm39) missense probably null 0.99
R5668:Mycbp2 UTSW 14 103,357,955 (GRCm39) missense possibly damaging 0.62
R5745:Mycbp2 UTSW 14 103,393,889 (GRCm39) missense possibly damaging 0.94
R5751:Mycbp2 UTSW 14 103,385,986 (GRCm39) missense probably damaging 0.99
R5756:Mycbp2 UTSW 14 103,371,410 (GRCm39) missense probably damaging 0.99
R5837:Mycbp2 UTSW 14 103,361,839 (GRCm39) missense probably damaging 1.00
R5984:Mycbp2 UTSW 14 103,364,120 (GRCm39) missense probably damaging 0.98
R6005:Mycbp2 UTSW 14 103,394,159 (GRCm39) missense probably benign
R6063:Mycbp2 UTSW 14 103,372,582 (GRCm39) missense probably damaging 1.00
R6091:Mycbp2 UTSW 14 103,460,482 (GRCm39) missense probably damaging 1.00
R6120:Mycbp2 UTSW 14 103,513,323 (GRCm39) missense probably benign 0.01
R6129:Mycbp2 UTSW 14 103,522,836 (GRCm39) missense probably benign 0.21
R6147:Mycbp2 UTSW 14 103,392,945 (GRCm39) nonsense probably null
R6161:Mycbp2 UTSW 14 103,536,183 (GRCm39) missense probably damaging 1.00
R6187:Mycbp2 UTSW 14 103,384,453 (GRCm39) missense probably damaging 1.00
R6208:Mycbp2 UTSW 14 103,532,664 (GRCm39) missense probably benign 0.11
R6228:Mycbp2 UTSW 14 103,497,665 (GRCm39) missense probably benign 0.24
R6301:Mycbp2 UTSW 14 103,392,862 (GRCm39) missense probably damaging 1.00
R6311:Mycbp2 UTSW 14 103,500,176 (GRCm39) missense possibly damaging 0.93
R6329:Mycbp2 UTSW 14 103,393,288 (GRCm39) missense probably benign 0.00
R6439:Mycbp2 UTSW 14 103,392,911 (GRCm39) missense probably benign 0.00
R6462:Mycbp2 UTSW 14 103,373,993 (GRCm39) critical splice donor site probably null
R6528:Mycbp2 UTSW 14 103,380,317 (GRCm39) missense probably damaging 0.99
R6736:Mycbp2 UTSW 14 103,429,003 (GRCm39) missense probably null 1.00
R6821:Mycbp2 UTSW 14 103,376,845 (GRCm39) missense probably damaging 1.00
R6851:Mycbp2 UTSW 14 103,497,630 (GRCm39) critical splice donor site probably null
R6948:Mycbp2 UTSW 14 103,522,703 (GRCm39) missense possibly damaging 0.94
R6977:Mycbp2 UTSW 14 103,392,342 (GRCm39) missense probably damaging 0.99
R6985:Mycbp2 UTSW 14 103,444,117 (GRCm39) missense possibly damaging 0.79
R7035:Mycbp2 UTSW 14 103,412,417 (GRCm39) missense probably benign
R7054:Mycbp2 UTSW 14 103,393,534 (GRCm39) missense possibly damaging 0.90
R7108:Mycbp2 UTSW 14 103,360,039 (GRCm39) missense probably damaging 1.00
R7117:Mycbp2 UTSW 14 103,391,513 (GRCm39) missense probably benign 0.21
R7137:Mycbp2 UTSW 14 103,520,115 (GRCm39) missense possibly damaging 0.94
R7169:Mycbp2 UTSW 14 103,497,636 (GRCm39) missense possibly damaging 0.78
R7218:Mycbp2 UTSW 14 103,371,282 (GRCm39) missense probably benign
R7234:Mycbp2 UTSW 14 103,452,773 (GRCm39) missense probably damaging 0.98
R7238:Mycbp2 UTSW 14 103,393,733 (GRCm39) missense probably damaging 1.00
R7244:Mycbp2 UTSW 14 103,446,345 (GRCm39) missense probably damaging 0.98
R7265:Mycbp2 UTSW 14 103,434,679 (GRCm39) critical splice donor site probably null
R7286:Mycbp2 UTSW 14 103,358,027 (GRCm39) missense probably damaging 1.00
R7332:Mycbp2 UTSW 14 103,434,793 (GRCm39) missense probably damaging 0.97
R7332:Mycbp2 UTSW 14 103,393,889 (GRCm39) missense probably damaging 1.00
R7384:Mycbp2 UTSW 14 103,513,829 (GRCm39) missense probably damaging 0.99
R7392:Mycbp2 UTSW 14 103,480,564 (GRCm39) missense probably damaging 0.99
R7392:Mycbp2 UTSW 14 103,389,627 (GRCm39) missense probably damaging 1.00
R7409:Mycbp2 UTSW 14 103,526,180 (GRCm39) missense probably damaging 1.00
R7486:Mycbp2 UTSW 14 103,434,690 (GRCm39) missense probably damaging 0.97
R7643:Mycbp2 UTSW 14 103,583,701 (GRCm39) missense probably benign
R7661:Mycbp2 UTSW 14 103,450,059 (GRCm39) missense probably damaging 1.00
R7663:Mycbp2 UTSW 14 103,429,045 (GRCm39) missense probably damaging 0.99
R7730:Mycbp2 UTSW 14 103,360,791 (GRCm39) missense probably damaging 0.99
R7757:Mycbp2 UTSW 14 103,429,055 (GRCm39) missense probably damaging 1.00
R7773:Mycbp2 UTSW 14 103,485,840 (GRCm39) missense probably damaging 0.97
R7787:Mycbp2 UTSW 14 103,364,533 (GRCm39) missense probably damaging 1.00
R7822:Mycbp2 UTSW 14 103,376,851 (GRCm39) missense probably benign 0.00
R7838:Mycbp2 UTSW 14 103,414,729 (GRCm39) missense probably benign 0.10
R7841:Mycbp2 UTSW 14 103,384,267 (GRCm39) critical splice donor site probably null
R7858:Mycbp2 UTSW 14 103,393,741 (GRCm39) missense probably damaging 1.00
R7873:Mycbp2 UTSW 14 103,393,582 (GRCm39) missense probably damaging 1.00
R7911:Mycbp2 UTSW 14 103,437,621 (GRCm39) missense probably damaging 0.99
R7942:Mycbp2 UTSW 14 103,392,674 (GRCm39) missense probably damaging 0.99
R7951:Mycbp2 UTSW 14 103,452,898 (GRCm39) missense probably damaging 0.99
R7958:Mycbp2 UTSW 14 103,367,400 (GRCm39) missense probably benign 0.00
R8235:Mycbp2 UTSW 14 103,436,110 (GRCm39) missense probably damaging 0.99
R8246:Mycbp2 UTSW 14 103,392,640 (GRCm39) missense probably damaging 0.99
R8338:Mycbp2 UTSW 14 103,372,701 (GRCm39) missense probably damaging 1.00
R8343:Mycbp2 UTSW 14 103,398,111 (GRCm39) splice site probably null
R8361:Mycbp2 UTSW 14 103,376,250 (GRCm39) missense probably damaging 1.00
R8490:Mycbp2 UTSW 14 103,446,267 (GRCm39) missense probably benign 0.00
R8524:Mycbp2 UTSW 14 103,392,895 (GRCm39) missense probably benign 0.23
R8525:Mycbp2 UTSW 14 103,450,155 (GRCm39) missense probably damaging 1.00
R8711:Mycbp2 UTSW 14 103,407,430 (GRCm39) missense probably benign 0.08
R8735:Mycbp2 UTSW 14 103,460,586 (GRCm39) missense probably damaging 0.99
R8825:Mycbp2 UTSW 14 103,466,871 (GRCm39) missense probably damaging 1.00
R8928:Mycbp2 UTSW 14 103,393,781 (GRCm39) missense probably benign
R8974:Mycbp2 UTSW 14 103,361,857 (GRCm39) missense probably damaging 1.00
R8987:Mycbp2 UTSW 14 103,446,232 (GRCm39) missense probably damaging 1.00
R9021:Mycbp2 UTSW 14 103,551,752 (GRCm39) missense probably benign 0.08
R9062:Mycbp2 UTSW 14 103,479,796 (GRCm39) missense probably benign 0.00
R9077:Mycbp2 UTSW 14 103,469,974 (GRCm39) missense probably damaging 1.00
R9208:Mycbp2 UTSW 14 103,532,664 (GRCm39) missense probably benign 0.01
R9285:Mycbp2 UTSW 14 103,434,753 (GRCm39) missense probably damaging 0.97
R9290:Mycbp2 UTSW 14 103,425,960 (GRCm39) missense probably damaging 0.99
R9362:Mycbp2 UTSW 14 103,497,642 (GRCm39) missense probably damaging 0.97
R9520:Mycbp2 UTSW 14 103,497,705 (GRCm39) missense probably benign 0.02
R9557:Mycbp2 UTSW 14 103,372,697 (GRCm39) missense probably benign 0.03
R9639:Mycbp2 UTSW 14 103,433,817 (GRCm39) missense probably damaging 1.00
R9666:Mycbp2 UTSW 14 103,371,474 (GRCm39) missense probably damaging 0.98
R9732:Mycbp2 UTSW 14 103,448,749 (GRCm39) missense probably damaging 1.00
R9736:Mycbp2 UTSW 14 103,434,852 (GRCm39) missense probably damaging 0.96
R9739:Mycbp2 UTSW 14 103,520,229 (GRCm39) missense probably benign 0.11
R9755:Mycbp2 UTSW 14 103,551,806 (GRCm39) missense probably benign
X0024:Mycbp2 UTSW 14 103,384,378 (GRCm39) missense probably damaging 1.00
Z1176:Mycbp2 UTSW 14 103,583,685 (GRCm39) missense probably benign
Z1176:Mycbp2 UTSW 14 103,394,073 (GRCm39) missense probably benign 0.06
Z1177:Mycbp2 UTSW 14 103,407,309 (GRCm39) missense possibly damaging 0.83
Z1177:Mycbp2 UTSW 14 103,372,559 (GRCm39) missense probably damaging 1.00
Z1177:Mycbp2 UTSW 14 103,364,499 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGGAAGATGAGGCACCAACCTAT -3'
(R):5'- AAGCCACTTAGATGACTGGGTGA -3'

Sequencing Primer
(F):5'- CCTCCACTGTAAGAGATTTC -3'
(R):5'- GATATACCCGGGTATATGTG -3'
Posted On 2015-09-25