Incidental Mutation 'R4686:Vmn1r203'
ID 353694
Institutional Source Beutler Lab
Gene Symbol Vmn1r203
Ensembl Gene ENSMUSG00000069289
Gene Name vomeronasal 1 receptor 203
Synonyms V1rh11
MMRRC Submission 041937-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R4686 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 22708221-22709156 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22708528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 103 (L103P)
Ref Sequence ENSEMBL: ENSMUSP00000154399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091729] [ENSMUST00000227520] [ENSMUST00000228889]
AlphaFold Q8R273
Predicted Effect probably damaging
Transcript: ENSMUST00000091729
AA Change: L103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000089322
Gene: ENSMUSG00000069289
AA Change: L103P

DomainStartEndE-ValueType
transmembrane domain 19 41 N/A INTRINSIC
Pfam:V1R 43 304 5.8e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137651
Predicted Effect probably damaging
Transcript: ENSMUST00000227520
AA Change: L103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228889
AA Change: L103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl2 A G 2: 26,983,837 (GRCm39) N411S probably damaging Het
Adnp A C 2: 168,024,309 (GRCm39) C995W possibly damaging Het
Akap6 CA C 12: 52,934,406 (GRCm39) probably null Het
Ano2 T G 6: 125,767,254 (GRCm39) I228M probably benign Het
Arhgap21 T C 2: 20,868,033 (GRCm39) D830G probably damaging Het
Atp13a2 G A 4: 140,730,587 (GRCm39) probably null Het
Ccdc175 C T 12: 72,159,052 (GRCm39) S629N probably damaging Het
Cdhr4 T C 9: 107,872,883 (GRCm39) W311R probably benign Het
Chaf1b A G 16: 93,681,472 (GRCm39) H30R probably benign Het
Clnk G A 5: 38,899,180 (GRCm39) probably benign Het
Copb1 A G 7: 113,820,971 (GRCm39) S773P possibly damaging Het
Cse1l A G 2: 166,774,080 (GRCm39) D198G probably damaging Het
Ears2 A G 7: 121,647,427 (GRCm39) S286P probably damaging Het
Efcab7 A G 4: 99,735,318 (GRCm39) E114G probably benign Het
Fanca G C 8: 123,995,673 (GRCm39) probably benign Het
Flt3 A G 5: 147,313,858 (GRCm39) L64P probably damaging Het
Gabrb1 A G 5: 71,857,365 (GRCm39) T3A possibly damaging Het
Gm10384 T C 15: 36,871,897 (GRCm39) noncoding transcript Het
Gm5117 G A 8: 32,229,284 (GRCm39) noncoding transcript Het
Gpr141 T A 13: 19,935,951 (GRCm39) I275F probably benign Het
Greb1l A T 18: 10,522,112 (GRCm39) E736V probably damaging Het
Hc T C 2: 34,929,260 (GRCm39) E279G possibly damaging Het
Hivep1 C T 13: 42,309,326 (GRCm39) T522M probably benign Het
Hspa12a T A 19: 58,788,181 (GRCm39) E547V possibly damaging Het
Il10ra A G 9: 45,180,357 (GRCm39) L5S probably damaging Het
Iqcf6 G T 9: 106,504,543 (GRCm39) W69L probably damaging Het
Iqgap2 T C 13: 95,858,117 (GRCm39) N379S probably damaging Het
Itpr2 A G 6: 146,131,273 (GRCm39) I1977T probably damaging Het
Kcnq1 A T 7: 142,661,466 (GRCm39) Y124F probably benign Het
Lamp5 C T 2: 135,900,923 (GRCm39) T41M probably damaging Het
Lgr5 A G 10: 115,294,648 (GRCm39) probably benign Het
Mlec A G 5: 115,288,355 (GRCm39) I167T possibly damaging Het
Myf6 A G 10: 107,329,689 (GRCm39) V198A probably benign Het
Nceh1 C T 3: 27,295,818 (GRCm39) R360C probably damaging Het
Nos2 C A 11: 78,819,456 (GRCm39) T56N possibly damaging Het
Npw T G 17: 24,876,386 (GRCm39) H175P probably benign Het
Nrxn3 A T 12: 89,477,421 (GRCm39) I899F probably damaging Het
Ociad1 A G 5: 73,464,078 (GRCm39) T179A possibly damaging Het
Or1e19 A G 11: 73,316,264 (GRCm39) S182P probably benign Het
Or52b4 A G 7: 102,184,356 (GRCm39) Y134C probably damaging Het
Or8b48 T A 9: 38,493,327 (GRCm39) F251L probably damaging Het
Pacsin2 T C 15: 83,265,976 (GRCm39) N74D probably benign Het
Pcdh7 A G 5: 58,286,511 (GRCm39) I1196V probably benign Het
Pdxk A T 10: 78,282,837 (GRCm39) probably null Het
Phb2 G A 6: 124,690,105 (GRCm39) probably null Het
Pus7l T A 15: 94,438,092 (GRCm39) N251I probably damaging Het
Rgs7bp T A 13: 105,100,597 (GRCm39) N226I probably damaging Het
Runx2 T A 17: 44,950,572 (GRCm39) D327V probably damaging Het
Srp68 A T 11: 116,156,227 (GRCm39) C172S probably damaging Het
Stk25 A G 1: 93,551,142 (GRCm39) probably null Het
Tbrg4 C T 11: 6,568,468 (GRCm39) R437Q probably benign Het
Tedc2 C T 17: 24,436,862 (GRCm39) probably null Het
Teddm1a T A 1: 153,768,196 (GRCm39) I220N probably damaging Het
Thoc1 G T 18: 9,970,312 (GRCm39) E221* probably null Het
Tmem132d G T 5: 127,869,674 (GRCm39) D553E possibly damaging Het
Topors A T 4: 40,261,694 (GRCm39) V530D probably benign Het
Tpx2 T C 2: 152,731,103 (GRCm39) V515A possibly damaging Het
Trim24 A G 6: 37,885,240 (GRCm39) H191R probably damaging Het
Ttn G A 2: 76,567,914 (GRCm39) R27660W probably damaging Het
Vmn1r233 C T 17: 21,214,368 (GRCm39) S194N probably benign Het
Vmn2r108 T C 17: 20,691,636 (GRCm39) K296E probably damaging Het
Vmn2r88 G A 14: 51,650,796 (GRCm39) E170K probably benign Het
Zfp740 C T 15: 102,117,184 (GRCm39) probably benign Het
Zmym5 A G 14: 57,049,618 (GRCm39) probably benign Het
Other mutations in Vmn1r203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01356:Vmn1r203 APN 13 22,708,947 (GRCm39) missense probably damaging 1.00
IGL01527:Vmn1r203 APN 13 22,708,447 (GRCm39) missense possibly damaging 0.89
IGL01808:Vmn1r203 APN 13 22,708,717 (GRCm39) missense probably benign 0.02
IGL01887:Vmn1r203 APN 13 22,709,046 (GRCm39) missense probably benign 0.00
IGL02340:Vmn1r203 APN 13 22,708,997 (GRCm39) nonsense probably null
IGL02543:Vmn1r203 APN 13 22,709,074 (GRCm39) missense probably damaging 1.00
IGL02684:Vmn1r203 APN 13 22,708,539 (GRCm39) missense possibly damaging 0.95
BB005:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
BB015:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
PIT4519001:Vmn1r203 UTSW 13 22,708,765 (GRCm39) missense probably benign 0.01
R0544:Vmn1r203 UTSW 13 22,708,443 (GRCm39) missense possibly damaging 0.94
R1365:Vmn1r203 UTSW 13 22,708,756 (GRCm39) missense probably benign 0.00
R1396:Vmn1r203 UTSW 13 22,708,678 (GRCm39) missense probably benign 0.01
R1794:Vmn1r203 UTSW 13 22,708,521 (GRCm39) missense probably damaging 1.00
R2010:Vmn1r203 UTSW 13 22,708,617 (GRCm39) missense possibly damaging 0.56
R2169:Vmn1r203 UTSW 13 22,708,905 (GRCm39) nonsense probably null
R2333:Vmn1r203 UTSW 13 22,709,113 (GRCm39) missense probably damaging 1.00
R2418:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R2419:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R4322:Vmn1r203 UTSW 13 22,708,408 (GRCm39) missense probably damaging 1.00
R4460:Vmn1r203 UTSW 13 22,708,852 (GRCm39) missense probably damaging 0.98
R5526:Vmn1r203 UTSW 13 22,708,273 (GRCm39) missense probably benign 0.01
R6240:Vmn1r203 UTSW 13 22,708,899 (GRCm39) missense possibly damaging 0.89
R6607:Vmn1r203 UTSW 13 22,708,891 (GRCm39) missense probably benign 0.23
R7575:Vmn1r203 UTSW 13 22,708,588 (GRCm39) missense probably benign 0.12
R7928:Vmn1r203 UTSW 13 22,708,705 (GRCm39) missense probably benign 0.01
R8375:Vmn1r203 UTSW 13 22,709,154 (GRCm39) makesense probably null
R8421:Vmn1r203 UTSW 13 22,709,154 (GRCm39) makesense probably null
R8424:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense probably damaging 1.00
R8845:Vmn1r203 UTSW 13 22,708,720 (GRCm39) missense possibly damaging 0.81
R8933:Vmn1r203 UTSW 13 22,708,691 (GRCm39) missense possibly damaging 0.69
R8956:Vmn1r203 UTSW 13 22,709,004 (GRCm39) missense possibly damaging 0.57
R9493:Vmn1r203 UTSW 13 22,708,423 (GRCm39) missense probably damaging 1.00
Z1177:Vmn1r203 UTSW 13 22,708,579 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GTACTCTGGGGAACATGTCTG -3'
(R):5'- CAGACTTGTGCTTCTAATGGAATGG -3'

Sequencing Primer
(F):5'- ATACATTCAGTTGTTGGGGAAGCC -3'
(R):5'- GGATTAGGTTCGTACTGATTAAAGC -3'
Posted On 2015-10-21