Mutagenetix > Incidental Mutation

Incidental Mutation 'R4979:Or7a42'

384685

Institutional Source

Beutler Lab

Gene Symbol

Or7a42

Ensembl Gene

ENSMUSG00000094080

Gene Name

olfactory receptor family 7 subfamily A member 42

Synonyms

GA_x6K02T2QGN0-2857086-2856154, MOR139-5P, Olfr8

MMRRC Submission

042574-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.143) question?

Stock #

R4979 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

78791041-78791973 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 78791766 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 242 (C242*)

Ref Sequence

ENSEMBL: ENSMUSP00000148856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081571] [ENSMUST00000203851] [ENSMUST00000214952]

AlphaFold

Q60892

Predicted Effect

probably null
Transcript: ENSMUST00000081571
AA Change: C242*

SMART Domains

Protein: ENSMUSP00000080282
Gene: ENSMUSG00000094080
AA Change: C242*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	1.3e-47	PFAM
Pfam:7tm_1	42	291	3e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000203851
AA Change: C242*

SMART Domains

Protein: ENSMUSP00000144916
Gene: ENSMUSG00000094080
AA Change: C242*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	1.3e-47	PFAM
Pfam:7tm_1	42	291	3e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214952
AA Change: C242*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216819

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.7%
20x: 93.4%

Validation Efficiency

99% (79/80)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	G	A	17: 9,220,643 (GRCm39)	E381K	probably damaging	Het
Abca1	T	C	4: 53,085,092 (GRCm39)		probably null	Het
Abca7	C	T	10: 79,840,617 (GRCm39)	Q870*	probably null	Het
Ambp	C	T	4: 63,070,888 (GRCm39)	V64M	probably benign	Het
Ank1	T	C	8: 23,622,212 (GRCm39)	V1542A	probably damaging	Het
Anln	T	C	9: 22,287,797 (GRCm39)	Y168C	probably benign	Het
Apoa4	T	A	9: 46,152,803 (GRCm39)	N29K	probably benign	Het
Arfgef1	T	C	1: 10,283,334 (GRCm39)	T192A	probably damaging	Het
Atad2b	G	T	12: 5,084,513 (GRCm39)	D1420Y	probably damaging	Het
Baiap3	A	G	17: 25,465,336 (GRCm39)	W648R	possibly damaging	Het
Bank1	A	G	3: 135,960,662 (GRCm39)	L198P	probably damaging	Het
Bicd2	A	G	13: 49,532,940 (GRCm39)	K509E	possibly damaging	Het
Cacna1e	T	C	1: 154,289,739 (GRCm39)	D1821G	probably damaging	Het
Ccdc80	G	A	16: 44,936,650 (GRCm39)	V692M	possibly damaging	Het
Ccdc88a	C	T	11: 29,432,133 (GRCm39)	Q308*	probably null	Het
Ccl8	T	C	11: 82,006,973 (GRCm39)	V62A	probably damaging	Het
Clspn	C	A	4: 126,472,179 (GRCm39)	P951Q	probably damaging	Het
Cngb1	T	A	8: 95,985,785 (GRCm39)	I858F	probably damaging	Het
Cspp1	T	A	1: 10,196,688 (GRCm39)	N900K	probably damaging	Het
Ctc1	C	T	11: 68,924,328 (GRCm39)	A960V	probably damaging	Het
Ctnnd2	A	G	15: 31,009,221 (GRCm39)	E1106G	probably damaging	Het
Dido1	C	T	2: 180,302,606 (GRCm39)	R1766H	probably damaging	Het
Dipk1a	A	T	5: 108,057,400 (GRCm39)	L386*	probably null	Het
Dnajc13	G	T	9: 104,063,922 (GRCm39)	N1341K	probably damaging	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Homo
E2f8	G	A	7: 48,524,918 (GRCm39)		probably benign	Het
Entpd8	A	G	2: 24,972,967 (GRCm39)	D91G	possibly damaging	Het
Fars2	A	G	13: 36,388,564 (GRCm39)	R18G	possibly damaging	Het
Fcgbp	A	G	7: 27,816,995 (GRCm39)	S2486G	probably benign	Het
Fibin	C	T	2: 110,192,963 (GRCm39)	D60N	possibly damaging	Het
Fpgs	A	G	2: 32,577,379 (GRCm39)		probably benign	Het
Galnt15	A	G	14: 31,765,247 (GRCm39)	D303G	probably damaging	Het
Gli3	C	A	13: 15,899,049 (GRCm39)	T812K	possibly damaging	Het
Gpbar1	G	C	1: 74,318,404 (GRCm39)	A216P	probably benign	Het
Grin2d	A	G	7: 45,507,357 (GRCm39)	I448T	probably benign	Het
Il21	C	A	3: 37,286,653 (GRCm39)	S21I	probably damaging	Het
Iqce	G	T	5: 140,677,376 (GRCm39)	D148E	probably damaging	Het
Iqcg	T	A	16: 32,839,884 (GRCm39)	E354V	probably damaging	Het
Iws1	T	C	18: 32,226,320 (GRCm39)		probably benign	Het
Ly75	C	T	2: 60,206,238 (GRCm39)	G144S	probably damaging	Het
Marco	C	A	1: 120,421,954 (GRCm39)	M83I	probably benign	Het
Mettl6	A	T	14: 31,201,752 (GRCm39)	L185H	probably damaging	Het
Mppe1	C	T	18: 67,362,773 (GRCm39)	G154D	probably damaging	Het
Mrpl42	T	C	10: 95,326,237 (GRCm39)	E85G	probably benign	Het
Neb	A	G	2: 52,079,921 (GRCm39)	V5518A	probably damaging	Het
Or12d13	A	T	17: 37,647,759 (GRCm39)	F121L	probably benign	Het
Or52p1	T	A	7: 104,267,812 (GRCm39)	F317I	probably null	Het
Or5b105	A	T	19: 13,080,053 (GRCm39)	I199N	probably damaging	Het
Or7d10	G	T	9: 19,831,655 (GRCm39)	S50I	probably benign	Het
Perm1	A	G	4: 156,302,034 (GRCm39)	T193A	probably benign	Het
Prkd2	T	A	7: 16,582,652 (GRCm39)	C172S	probably damaging	Het
Prr23a3	T	A	9: 98,747,431 (GRCm39)	D128E	possibly damaging	Het
Prss28	A	G	17: 25,528,711 (GRCm39)	Y51C	probably damaging	Het
Psmb1	A	T	17: 15,696,451 (GRCm39)	M85K	probably benign	Het
Rae1	T	A	2: 172,854,401 (GRCm39)		probably benign	Het
Rasal1	A	G	5: 120,816,741 (GRCm39)	D759G	probably benign	Het
Rcvrn	G	A	11: 67,586,246 (GRCm39)	G2R	probably damaging	Het
Robo3	C	T	9: 37,334,640 (GRCm39)	A597T	probably damaging	Het
Rsf1	GCG	GCGACGGCGCCG	7: 97,229,114 (GRCm39)		probably benign	Homo
Sdcbp	T	A	4: 6,378,980 (GRCm39)	Y22*	probably null	Het
Sin3a	T	C	9: 57,025,360 (GRCm39)	F1069L	probably damaging	Het
Slitrk3	C	T	3: 72,957,129 (GRCm39)	V548I	possibly damaging	Het
Tbc1d22a	A	G	15: 86,275,287 (GRCm39)	H403R	probably damaging	Het
Tbr1	G	T	2: 61,635,593 (GRCm39)		probably null	Het
Tiam2	T	A	17: 3,555,985 (GRCm39)	D65E	probably damaging	Het
Tpcn2	A	G	7: 144,813,833 (GRCm39)	S488P	probably benign	Het
Trav9-2	T	C	14: 53,828,695 (GRCm39)	S22P	probably damaging	Het
Trim34a	T	A	7: 103,897,069 (GRCm39)	N44K	probably benign	Het
Unc79	C	G	12: 103,078,691 (GRCm39)	P1619A	probably benign	Het
Usp22	A	T	11: 61,048,042 (GRCm39)	V426E	probably damaging	Het
Vhl	A	T	6: 113,601,159 (GRCm39)	M20L	unknown	Het
Vmn1r215	G	A	13: 23,260,064 (GRCm39)	A35T	probably benign	Het
Vmn1r222	G	A	13: 23,416,602 (GRCm39)	L204F	possibly damaging	Het
Zfp871	A	T	17: 32,994,829 (GRCm39)	H115Q	probably damaging	Het
Zpr1	T	A	9: 46,189,640 (GRCm39)	F340L	probably benign	Het

Other mutations in Or7a42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01022:Or7a42	APN	10	78,791,188 (GRCm39)	missense	possibly damaging	0.48
IGL01480:Or7a42	APN	10	78,791,978 (GRCm39)	utr 3 prime	probably benign
IGL02505:Or7a42	APN	10	78,791,767 (GRCm39)	missense	probably benign	0.02
IGL02543:Or7a42	APN	10	78,791,773 (GRCm39)	missense	probably damaging	1.00
IGL03323:Or7a42	APN	10	78,791,434 (GRCm39)	missense	probably benign
PIT4466001:Or7a42	UTSW	10	78,791,676 (GRCm39)	missense	probably benign	0.00
R1496:Or7a42	UTSW	10	78,791,682 (GRCm39)	missense	probably benign	0.41
R1754:Or7a42	UTSW	10	78,791,531 (GRCm39)	missense	probably damaging	0.99
R1878:Or7a42	UTSW	10	78,791,639 (GRCm39)	missense	possibly damaging	0.62
R2760:Or7a42	UTSW	10	78,791,876 (GRCm39)	missense	probably damaging	0.99
R4202:Or7a42	UTSW	10	78,791,129 (GRCm39)	missense	probably benign
R4206:Or7a42	UTSW	10	78,791,117 (GRCm39)	missense	probably benign	0.00
R4517:Or7a42	UTSW	10	78,791,877 (GRCm39)	nonsense	probably null
R4613:Or7a42	UTSW	10	78,791,899 (GRCm39)	missense	probably damaging	1.00
R4799:Or7a42	UTSW	10	78,791,931 (GRCm39)	missense	probably null	0.92
R5008:Or7a42	UTSW	10	78,791,905 (GRCm39)	missense	probably damaging	1.00
R5700:Or7a42	UTSW	10	78,791,318 (GRCm39)	missense	probably damaging	1.00
R5876:Or7a42	UTSW	10	78,791,191 (GRCm39)	missense	probably benign	0.15
R6439:Or7a42	UTSW	10	78,791,818 (GRCm39)	missense	probably damaging	1.00
R6930:Or7a42	UTSW	10	78,791,615 (GRCm39)	missense	possibly damaging	0.84
R7110:Or7a42	UTSW	10	78,791,284 (GRCm39)	missense	possibly damaging	0.83
R7405:Or7a42	UTSW	10	78,791,531 (GRCm39)	missense	probably benign	0.14
R7524:Or7a42	UTSW	10	78,791,325 (GRCm39)	nonsense	probably null
R8198:Or7a42	UTSW	10	78,791,558 (GRCm39)	missense	probably damaging	0.97
R9227:Or7a42	UTSW	10	78,791,929 (GRCm39)	missense	possibly damaging	0.92
R9230:Or7a42	UTSW	10	78,791,929 (GRCm39)	missense	possibly damaging	0.92
Z1176:Or7a42	UTSW	10	78,791,053 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCAGCTGTCTCAACTCACATG -3'
(R):5'- GCCAGTCCAATGATACACTTTACAG -3'

Sequencing Primer
(F):5'- GTCTCAACTCACATGTTTAGACAGC -3'
(R):5'- AATAGCCTCTCCAGAGCTTTC -3'

Posted On

2016-05-10