Mutagenetix > Incidental Mutation

Incidental Mutation 'R5184:Olfr298'

397753

Institutional Source

Beutler Lab

Gene Symbol

Olfr298

Ensembl Gene

ENSMUSG00000062878

Gene Name

olfactory receptor 298

Synonyms

GA_x6K02T2NHDJ-9619796-9620794, MOR219-4

MMRRC Submission

042763-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

R5184 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

86486322-86492484 bp(-) (GRCm38)

Type of Mutation

frame shift

DNA Base Change (assembly)

TG to T at 86489291 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077800] [ENSMUST00000213223] [ENSMUST00000216968] [ENSMUST00000217110]

AlphaFold

Q7TS06

Predicted Effect

probably null
Transcript: ENSMUST00000077800

SMART Domains

Protein: ENSMUSP00000076973
Gene: ENSMUSG00000062878

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	4.2e-37	PFAM
Pfam:7tm_1	39	288	8.4e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213223

Predicted Effect

probably null
Transcript: ENSMUST00000216968

Predicted Effect

probably null
Transcript: ENSMUST00000217110

Meta Mutation Damage Score

0.9756

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.6%

Validation Efficiency

98% (63/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aph1a	T	A	3: 95,895,739		probably null	Het
Arid3a	A	G	10: 79,950,769	E452G	possibly damaging	Het
Barhl2	A	G	5: 106,457,640	S68P	unknown	Het
BC030499	T	C	11: 78,292,747	F194L	probably benign	Het
Carf	T	C	1: 60,108,174	S17P	probably damaging	Het
Ccdc90b	A	G	7: 92,574,811	D145G	probably damaging	Het
Cyp7a1	A	T	4: 6,271,207	N316K	probably benign	Het
Daam2	A	G	17: 49,494,391	I106T	possibly damaging	Het
Dmtf1	A	G	5: 9,126,641	V437A	probably benign	Het
E2f2	A	T	4: 136,184,440	Y254F	possibly damaging	Het
Ehmt1	G	T	2: 24,877,497	P135T	probably damaging	Het
Ern2	T	C	7: 122,179,959	T221A	probably benign	Het
Fam227b	G	A	2: 126,116,123	P241S	probably damaging	Het
Fermt1	A	G	2: 132,941,963	V42A	possibly damaging	Het
Fgf3	A	G	7: 144,842,810	D187G	probably damaging	Het
Flnb	T	A	14: 7,901,945	V936E	probably damaging	Het
Gm5415	A	T	1: 32,545,648	C394S	probably damaging	Het
Herc2	T	C	7: 56,122,351	Y1093H	probably damaging	Het
Invs	A	G	4: 48,283,242		probably benign	Het
Katnb1	T	A	8: 95,097,980	I534N	possibly damaging	Het
Kcnq5	A	T	1: 21,402,487	D826E	probably damaging	Het
Klra9	A	T	6: 130,188,712	N113K	probably benign	Het
Knl1	A	G	2: 119,069,176	K453E	probably damaging	Het
Lgi4	C	T	7: 31,070,757		probably benign	Het
Lpin3	A	G	2: 160,897,138	S289G	probably benign	Het
Mapre1	T	A	2: 153,758,067	V137E	possibly damaging	Het
Mark4	A	G	7: 19,447,243	F144L	possibly damaging	Het
Mogat2	G	T	7: 99,223,635	A114E	possibly damaging	Het
Msh2	C	A	17: 87,723,413	A906E	probably benign	Het
Nell2	A	G	15: 95,527,809	L19P	possibly damaging	Het
Nfia	A	T	4: 97,783,348	K98N	probably damaging	Het
Nutm1	T	A	2: 112,249,000	T857S	possibly damaging	Het
Olfr146	T	A	9: 39,018,702	I280F	probably damaging	Het
Olfr68	T	C	7: 103,777,404	K314E	probably benign	Het
Pde10a	T	C	17: 8,977,155	L706P	probably damaging	Het
Penk	A	G	4: 4,134,296	L117P	probably damaging	Het
Pgap1	A	G	1: 54,481,856	S876P	probably damaging	Het
Pmfbp1	T	C	8: 109,527,767	I478T	possibly damaging	Het
Pole	G	A	5: 110,294,934	E318K	possibly damaging	Het
Prr12	C	A	7: 45,046,377	V1222L	unknown	Het
Prune2	T	C	19: 17,216,357	S3070P	possibly damaging	Het
Rnf19a	A	G	15: 36,244,196	C573R	probably benign	Het
Rp1l1	T	C	14: 64,030,180	S1072P	probably damaging	Het
Sh3pxd2a	T	C	19: 47,273,411	N315S	possibly damaging	Het
Snph	T	C	2: 151,594,544	I86V	probably damaging	Het
Sox6	A	G	7: 115,777,228	Y90H	probably damaging	Het
Tbc1d13	T	A	2: 30,142,311	C145S	probably benign	Het
Tcp11l1	T	C	2: 104,699,944	E65G	probably damaging	Het
Thrb	G	T	14: 18,011,181	E186*	probably null	Het
Tmem101	A	G	11: 102,156,233	Y38H	possibly damaging	Het
Tusc5	T	A	11: 76,680,308	L50Q	probably damaging	Het
Urb1	A	T	16: 90,783,274		probably null	Het
Usp10	G	A	8: 119,956,681	V764I	possibly damaging	Het
Usp25	A	G	16: 77,109,227	E857G	probably benign	Het
Vmn1r17	A	G	6: 57,360,843	V130A	probably benign	Het
Wdr35	T	C	12: 9,018,142	L775P	probably damaging	Het
Xpnpep1	T	C	19: 53,013,414	T134A	probably benign	Het
Zbtb10	T	C	3: 9,264,671	V363A	probably damaging	Het
Zfp108	G	T	7: 24,260,738	K251N	probably benign	Het

Other mutations in Olfr298

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01517:Olfr298	APN	7	86489557	utr 5 prime	probably benign
IGL01603:Olfr298	APN	7	86488931	missense	possibly damaging	0.92
IGL02389:Olfr298	APN	7	86489128	missense	probably damaging	0.98
IGL03146:Olfr298	APN	7	86489194	missense	probably damaging	1.00
R0680:Olfr298	UTSW	7	86489337	missense	probably benign
R0834:Olfr298	UTSW	7	86489490	missense	probably benign	0.11
R1132:Olfr298	UTSW	7	86489217	missense	probably benign	0.03
R1519:Olfr298	UTSW	7	86489125	missense	probably damaging	0.99
R1881:Olfr298	UTSW	7	86489438	missense	probably benign	0.01
R2170:Olfr298	UTSW	7	86488570	missense	probably benign	0.03
R4500:Olfr298	UTSW	7	86488919	missense	probably benign	0.00
R4524:Olfr298	UTSW	7	86488826	missense	probably damaging	1.00
R5521:Olfr298	UTSW	7	86488631	missense	probably benign	0.08
R7448:Olfr298	UTSW	7	86489209	missense	probably damaging	1.00
R7643:Olfr298	UTSW	7	86489568	critical splice acceptor site	probably null
R7688:Olfr298	UTSW	7	86488975	missense	probably benign	0.01
R8104:Olfr298	UTSW	7	86489023	missense	probably damaging	1.00
R8732:Olfr298	UTSW	7	86488853	missense	probably damaging	0.96
R8973:Olfr298	UTSW	7	86489279	missense	probably damaging	1.00
R9235:Olfr298	UTSW	7	86489098	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TGCCAGCTGTGTATAAAGCTC -3'
(R):5'- ACAGACTGTATGTGGGCTGTTC -3'

Sequencing Primer
(F):5'- GCCAGCTGTGTATAAAGCTCCAAAG -3'
(R):5'- CTTTCTGGTAATGTACGTTGCAGTC -3'

Posted On

2016-07-06