Incidental Mutation 'R5666:Vmn2r10'
ID |
444419 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r10
|
Ensembl Gene |
ENSMUSG00000067010 |
Gene Name |
vomeronasal 2, receptor 10 |
Synonyms |
VR16, V2r16 |
MMRRC Submission |
043309-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.085)
|
Stock # |
R5666 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 109146910 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 459
(Y459*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
AlphaFold |
K7N621 |
Predicted Effect |
probably null
Transcript: ENSMUST00000079163
AA Change: Y459*
|
SMART Domains |
Protein: ENSMUSP00000078162 Gene: ENSMUSG00000067010 AA Change: Y459*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
SMART Domains |
Protein: ENSMUSP00000135274 Gene: ENSMUSG00000067010
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 60 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930524J08Rik |
T |
C |
5: 100,127,068 (GRCm39) |
|
probably benign |
Het |
Abce1 |
C |
A |
8: 80,416,906 (GRCm39) |
E368D |
probably benign |
Het |
Becn2 |
C |
T |
1: 175,749,179 (GRCm39) |
T415M |
probably damaging |
Het |
Bmper |
T |
A |
9: 23,384,759 (GRCm39) |
M588K |
probably damaging |
Het |
Bop1 |
T |
C |
15: 76,338,433 (GRCm39) |
E503G |
probably benign |
Het |
Btla |
A |
T |
16: 45,070,782 (GRCm39) |
D247V |
probably damaging |
Het |
Cap2 |
T |
A |
13: 46,684,559 (GRCm39) |
|
probably null |
Het |
Chd2 |
A |
T |
7: 73,091,465 (GRCm39) |
I1592K |
probably benign |
Het |
Chd3 |
T |
C |
11: 69,244,177 (GRCm39) |
E1202G |
possibly damaging |
Het |
Cmya5 |
T |
C |
13: 93,182,457 (GRCm39) |
I3568V |
possibly damaging |
Het |
Col4a4 |
A |
G |
1: 82,463,300 (GRCm39) |
|
probably null |
Het |
Cpxm2 |
C |
T |
7: 131,656,625 (GRCm39) |
E546K |
probably benign |
Het |
Cyp2j5 |
C |
T |
4: 96,546,930 (GRCm39) |
V195I |
probably benign |
Het |
Ddb2 |
C |
T |
2: 91,042,926 (GRCm39) |
V353M |
probably damaging |
Het |
Dscam |
G |
A |
16: 96,519,364 (GRCm39) |
T791I |
probably benign |
Het |
Dtd2 |
T |
A |
12: 52,046,643 (GRCm39) |
L65F |
probably damaging |
Het |
E2f1 |
T |
A |
2: 154,411,101 (GRCm39) |
|
probably benign |
Het |
Ephb3 |
A |
G |
16: 21,041,241 (GRCm39) |
N732S |
probably benign |
Het |
Fkbp10 |
G |
T |
11: 100,314,352 (GRCm39) |
W384L |
probably damaging |
Het |
Foxm1 |
C |
T |
6: 128,350,130 (GRCm39) |
S339L |
possibly damaging |
Het |
Fzd6 |
A |
T |
15: 38,894,510 (GRCm39) |
R225S |
probably benign |
Het |
Gfpt1 |
A |
T |
6: 87,030,795 (GRCm39) |
I60F |
possibly damaging |
Het |
Glce |
A |
G |
9: 61,967,793 (GRCm39) |
S453P |
probably damaging |
Het |
Gm4787 |
G |
A |
12: 81,424,805 (GRCm39) |
T451I |
probably benign |
Het |
Hs2st1 |
A |
T |
3: 144,275,554 (GRCm39) |
V22E |
probably damaging |
Het |
Hspa9 |
T |
C |
18: 35,087,300 (GRCm39) |
I2V |
probably null |
Het |
Ikzf2 |
A |
G |
1: 69,617,059 (GRCm39) |
V96A |
probably benign |
Het |
Ilkap |
T |
C |
1: 91,318,863 (GRCm39) |
T38A |
probably benign |
Het |
Lpin3 |
A |
G |
2: 160,739,250 (GRCm39) |
T353A |
probably benign |
Het |
Myh1 |
T |
A |
11: 67,112,178 (GRCm39) |
I1744N |
probably benign |
Het |
Nadsyn1 |
C |
T |
7: 143,361,168 (GRCm39) |
G335S |
probably damaging |
Het |
Ndc1 |
T |
C |
4: 107,246,723 (GRCm39) |
V382A |
possibly damaging |
Het |
Ndufaf4 |
A |
T |
4: 24,898,636 (GRCm39) |
D64V |
probably damaging |
Het |
Nfe2l2 |
T |
C |
2: 75,507,462 (GRCm39) |
T213A |
probably benign |
Het |
Nkain4 |
A |
G |
2: 180,584,995 (GRCm39) |
L73P |
probably damaging |
Het |
Nmt1 |
C |
T |
11: 102,949,041 (GRCm39) |
R299* |
probably null |
Het |
Or1j20 |
T |
A |
2: 36,760,401 (GRCm39) |
D274E |
probably benign |
Het |
Or2y8 |
A |
C |
11: 52,035,525 (GRCm39) |
Y277* |
probably null |
Het |
Or4b12 |
T |
C |
2: 90,096,308 (GRCm39) |
I155M |
probably benign |
Het |
Or5k1 |
G |
A |
16: 58,617,424 (GRCm39) |
P262S |
possibly damaging |
Het |
Padi2 |
G |
T |
4: 140,676,542 (GRCm39) |
R560L |
possibly damaging |
Het |
Palmd |
T |
C |
3: 116,717,750 (GRCm39) |
N249S |
possibly damaging |
Het |
Pde1c |
A |
C |
6: 56,103,842 (GRCm39) |
|
probably null |
Het |
Pdgfra |
T |
C |
5: 75,334,156 (GRCm39) |
S410P |
probably benign |
Het |
Phldb1 |
T |
C |
9: 44,627,078 (GRCm39) |
M456V |
probably damaging |
Het |
Pla2g2d |
T |
A |
4: 138,507,591 (GRCm39) |
C82S |
probably damaging |
Het |
Rgs21 |
A |
G |
1: 144,412,680 (GRCm39) |
V48A |
probably benign |
Het |
Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
Slc4a2 |
G |
T |
5: 24,639,836 (GRCm39) |
V506L |
probably damaging |
Het |
Slc7a4 |
A |
G |
16: 17,393,815 (GRCm39) |
|
probably benign |
Het |
Sptbn5 |
C |
G |
2: 119,916,048 (GRCm39) |
|
probably benign |
Het |
Sstr2 |
T |
A |
11: 113,515,539 (GRCm39) |
W153R |
probably damaging |
Het |
Steap2 |
C |
T |
5: 5,723,681 (GRCm39) |
V400I |
probably benign |
Het |
Syne2 |
G |
A |
12: 75,997,733 (GRCm39) |
G2236D |
probably benign |
Het |
Tas2r130 |
T |
C |
6: 131,607,342 (GRCm39) |
N151S |
possibly damaging |
Het |
Tex52 |
T |
C |
6: 128,352,518 (GRCm39) |
S13P |
probably benign |
Het |
Tmprss13 |
A |
G |
9: 45,256,253 (GRCm39) |
I456V |
probably damaging |
Het |
Trim24 |
T |
C |
6: 37,942,536 (GRCm39) |
F946S |
probably benign |
Het |
Vwa1 |
A |
G |
4: 155,858,922 (GRCm39) |
L13P |
probably damaging |
Het |
Zfp648 |
C |
A |
1: 154,079,963 (GRCm39) |
Q41K |
probably benign |
Het |
|
Other mutations in Vmn2r10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACTTGGAATCCACGGGACTTTG -3'
(R):5'- CTTCTTGCACATTTTACCATGGAAC -3'
Sequencing Primer
(F):5'- GGTCTTTTGCAAGAGTAGCAACC -3'
(R):5'- AAATCATCCATGAGGCATATTGC -3'
|
Posted On |
2016-11-09 |