Incidental Mutation 'R6004:Vmn2r10'
| ID |
478502 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| MMRRC Submission |
044182-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
R6004 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 109146944 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Threonine
at position 448
(N448T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079163
AA Change: N448T
PolyPhen 2
Score 0.303 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: N448T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.4%
- 10x: 96.8%
- 20x: 89.1%
|
| Validation Efficiency |
98% (55/56) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp6 |
C |
T |
3: 97,082,997 (GRCm39) |
A336V |
probably benign |
Het |
| Adam5 |
T |
A |
8: 25,271,685 (GRCm39) |
Y574F |
probably benign |
Het |
| Arl6 |
A |
T |
16: 59,444,257 (GRCm39) |
W80R |
probably damaging |
Het |
| Bmal1 |
A |
T |
7: 112,879,934 (GRCm39) |
D22V |
probably damaging |
Het |
| Cars2 |
A |
G |
8: 11,597,743 (GRCm39) |
I111T |
probably damaging |
Het |
| Chrd |
T |
C |
16: 20,553,987 (GRCm39) |
L317S |
possibly damaging |
Het |
| Cyp4a12b |
A |
G |
4: 115,290,664 (GRCm39) |
D262G |
probably benign |
Het |
| Dcaf6 |
A |
G |
1: 165,216,254 (GRCm39) |
S450P |
probably benign |
Het |
| Dnah3 |
T |
C |
7: 119,685,520 (GRCm39) |
D164G |
probably benign |
Het |
| Gpx6 |
A |
C |
13: 21,503,239 (GRCm39) |
T218P |
probably benign |
Het |
| Htr1f |
T |
C |
16: 64,746,239 (GRCm39) |
N351S |
probably damaging |
Het |
| Idua |
A |
G |
5: 108,828,510 (GRCm39) |
E241G |
probably benign |
Het |
| Ighv14-2 |
T |
A |
12: 113,958,255 (GRCm39) |
Q62L |
probably damaging |
Het |
| Ighv1-65 |
C |
T |
12: 115,496,056 (GRCm39) |
|
noncoding transcript |
Het |
| Inpp4a |
T |
C |
1: 37,411,451 (GRCm39) |
S372P |
probably damaging |
Het |
| Itgax |
A |
T |
7: 127,730,624 (GRCm39) |
H114L |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 27,111,781 (GRCm39) |
F746L |
probably benign |
Het |
| Lrrc37a |
C |
T |
11: 103,393,362 (GRCm39) |
V688M |
possibly damaging |
Het |
| Ltbp2 |
A |
G |
12: 84,922,923 (GRCm39) |
V28A |
probably benign |
Het |
| Mill2 |
A |
T |
7: 18,590,463 (GRCm39) |
D166V |
probably benign |
Het |
| Mroh2a |
G |
A |
1: 88,176,377 (GRCm39) |
C982Y |
probably damaging |
Het |
| Msh3 |
T |
A |
13: 92,478,922 (GRCm39) |
|
probably null |
Het |
| Myh15 |
A |
T |
16: 48,980,062 (GRCm39) |
M1395L |
probably benign |
Het |
| Npepps |
T |
C |
11: 97,113,950 (GRCm39) |
E642G |
probably benign |
Het |
| Nrg4 |
T |
C |
9: 55,166,667 (GRCm39) |
T68A |
possibly damaging |
Het |
| Or10ag60 |
T |
A |
2: 87,438,253 (GRCm39) |
F174I |
probably damaging |
Het |
| Or4b1d |
T |
C |
2: 89,969,343 (GRCm39) |
N47D |
probably benign |
Het |
| Or4f60 |
G |
T |
2: 111,902,371 (GRCm39) |
L186I |
probably damaging |
Het |
| Or6c66b |
T |
A |
10: 129,376,759 (GRCm39) |
Y118N |
probably benign |
Het |
| Or8b41 |
A |
G |
9: 38,055,256 (GRCm39) |
K270R |
probably damaging |
Het |
| Or9g20 |
A |
T |
2: 85,629,726 (GRCm39) |
V296E |
probably damaging |
Het |
| Otogl |
T |
A |
10: 107,715,390 (GRCm39) |
I429F |
probably damaging |
Het |
| Pank4 |
G |
T |
4: 155,061,678 (GRCm39) |
G532C |
probably damaging |
Het |
| Plce1 |
A |
G |
19: 38,710,315 (GRCm39) |
T1150A |
probably damaging |
Het |
| Ppp2r2b |
T |
C |
18: 43,192,224 (GRCm39) |
|
probably null |
Het |
| Prkrip1 |
A |
G |
5: 136,226,636 (GRCm39) |
M68T |
probably damaging |
Het |
| Psme4 |
T |
A |
11: 30,806,896 (GRCm39) |
|
probably benign |
Het |
| Raet1d |
T |
A |
10: 22,247,293 (GRCm39) |
I123N |
probably damaging |
Het |
| Rp1 |
T |
G |
1: 4,267,808 (GRCm39) |
T825P |
unknown |
Het |
| Rttn |
T |
C |
18: 89,039,816 (GRCm39) |
I839T |
probably damaging |
Het |
| Sgo2b |
G |
A |
8: 64,379,707 (GRCm39) |
Q1042* |
probably null |
Het |
| Skint11 |
A |
G |
4: 114,088,925 (GRCm39) |
T240A |
probably benign |
Het |
| Speg |
A |
T |
1: 75,392,247 (GRCm39) |
K1382* |
probably null |
Het |
| Srsf7 |
A |
T |
17: 80,513,282 (GRCm39) |
D68E |
probably damaging |
Het |
| Stag3 |
A |
T |
5: 138,287,468 (GRCm39) |
D131V |
probably damaging |
Het |
| Strip2 |
T |
A |
6: 29,926,570 (GRCm39) |
C152S |
probably damaging |
Het |
| Timm44 |
G |
T |
8: 4,317,747 (GRCm39) |
D191E |
probably benign |
Het |
| Tlnrd1 |
A |
G |
7: 83,531,987 (GRCm39) |
V148A |
probably damaging |
Het |
| Trp63 |
T |
C |
16: 25,582,146 (GRCm39) |
|
probably null |
Het |
| Tusc3 |
G |
C |
8: 39,538,560 (GRCm39) |
G200R |
probably damaging |
Het |
| Vmn2r50 |
G |
A |
7: 9,783,986 (GRCm39) |
R163C |
probably benign |
Het |
| Vmn2r53 |
T |
C |
7: 12,316,328 (GRCm39) |
H497R |
probably benign |
Het |
| Vps39 |
A |
G |
2: 120,176,131 (GRCm39) |
V83A |
possibly damaging |
Het |
| Ylpm1 |
A |
T |
12: 85,075,858 (GRCm39) |
N861I |
possibly damaging |
Het |
| Zfp712 |
A |
G |
13: 67,189,769 (GRCm39) |
C253R |
probably damaging |
Het |
| Zfp930 |
A |
G |
8: 69,680,556 (GRCm39) |
T84A |
probably benign |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATACCCACTGATGATCCTCCTG -3'
(R):5'- CTTCTTGCACATTTTACCATGGAAC -3'
Sequencing Primer
(F):5'- GTGGCCCACTCCAAATCTTCAG -3'
(R):5'- AAATCATCCATGAGGCATATTGC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation