|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 119|
|Synonyms||mGR19, T2R19, mt2r19, Tas2r19|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6521 (G1)|
|Chromosomal Location||32177289-32178294 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 32178173 bp|
|Amino Acid Change||Cysteine to Tyrosine at position 295 (C295Y)|
|Ref Sequence||ENSEMBL: ENSMUSP00000050277 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000057633]|
|Predicted Effect||probably damaging
AA Change: C295Y
PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
AA Change: C295Y
|Meta Mutation Damage Score||0.3619|
|Coding Region Coverage||
|Validation Efficiency||100% (48/48)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r119||
(F):5'- GTCAGTGCGATGCTCTCCATTC -3'
(R):5'- GTTGGGCTTTGATCATCAATTTACCC -3'
(F):5'- ATCCTCTATCTCTCCCATGACATG -3'
(R):5'- CCCTTTGAAATGATTAAGCCTCAGG -3'