Incidental Mutation 'R7646:Wdr90'
ID 590566
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission 045724-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7646 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 26063745-26080475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 26079104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 246 (V246A)
Ref Sequence ENSEMBL: ENSMUSP00000135420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026828] [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably benign
Transcript: ENSMUST00000026828
SMART Domains Protein: ENSMUSP00000026828
Gene: ENSMUSG00000025732

DomainStartEndE-ValueType
Pfam:FAM195 59 158 8.3e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079461
AA Change: V264A

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: V264A

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176575
Predicted Effect probably benign
Transcript: ENSMUST00000176678
Predicted Effect probably benign
Transcript: ENSMUST00000176923
AA Change: V246A

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: V246A

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176963
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177170
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,113,937 (GRCm39) H936R probably benign Het
Afg3l1 C A 8: 124,219,766 (GRCm39) D431E possibly damaging Het
Agrn T C 4: 156,279,811 (GRCm39) N120S probably damaging Het
Apob A G 12: 8,059,189 (GRCm39) D2557G probably damaging Het
Atl2 A G 17: 80,162,036 (GRCm39) Y359H probably damaging Het
Banp T C 8: 122,750,775 (GRCm39) S489P possibly damaging Het
Cage1 A G 13: 38,206,823 (GRCm39) C341R probably damaging Het
Cdh23 T C 10: 60,140,931 (GRCm39) N3139S possibly damaging Het
Chd2 G T 7: 73,085,521 (GRCm39) S1704R possibly damaging Het
Col4a2 T A 8: 11,495,086 (GRCm39) F1515I probably benign Het
Crocc T A 4: 140,748,966 (GRCm39) Q1613L probably null Het
Cttnbp2 A T 6: 18,375,939 (GRCm39) S1533R probably damaging Het
Dlgap5 C T 14: 47,636,976 (GRCm39) probably null Het
Dnah8 G A 17: 30,868,651 (GRCm39) D362N probably benign Het
Elf5 G T 2: 103,269,588 (GRCm39) K56N probably benign Het
Emsy G A 7: 98,268,560 (GRCm39) P508S probably damaging Het
Fam135a T C 1: 24,067,704 (GRCm39) H1055R probably benign Het
Fh1 C T 1: 175,442,479 (GRCm39) V124I probably benign Het
Gbf1 T A 19: 46,272,111 (GRCm39) D1610E probably damaging Het
Glp1r A G 17: 31,155,257 (GRCm39) K415E probably benign Het
Glyr1 T C 16: 4,836,361 (GRCm39) D496G probably damaging Het
Herc2 A G 7: 55,784,361 (GRCm39) I1342V probably benign Het
Hoxa7 A G 6: 52,192,699 (GRCm39) *230Q probably null Het
Ice1 A G 13: 70,737,916 (GRCm39) V2177A possibly damaging Het
Ildr1 T A 16: 36,542,281 (GRCm39) M271K possibly damaging Het
Klk1b22 T G 7: 43,765,542 (GRCm39) probably null Het
Lig3 T A 11: 82,674,304 (GRCm39) N43K probably benign Het
Mcmdc2 A G 1: 9,982,360 (GRCm39) T83A possibly damaging Het
Megf10 GGCAGCAACAGCACCAGCAGCAACAGCACCAGCAGCA GGCAGCAACAGCACCAGCAGCA 18: 57,427,071 (GRCm39) probably benign Het
Mki67 A T 7: 135,298,498 (GRCm39) S2179T possibly damaging Het
Mrpl38 G A 11: 116,023,593 (GRCm39) S282L probably damaging Het
Ndst2 A G 14: 20,774,527 (GRCm39) probably null Het
Nlrp4a C G 7: 26,148,987 (GRCm39) A198G probably damaging Het
Nup98 A C 7: 101,803,242 (GRCm39) S653A probably benign Het
Or12e8 A G 2: 87,188,102 (GRCm39) I105V probably benign Het
Or13a27 A G 7: 139,925,864 (GRCm39) F13L probably damaging Het
Or14j10 G T 17: 37,935,295 (GRCm39) T77K probably damaging Het
Or51ai2 G A 7: 103,587,504 (GRCm39) A306T probably damaging Het
Or8k37 C A 2: 86,469,513 (GRCm39) D180Y probably damaging Het
Pclo A T 5: 14,570,909 (GRCm39) D98V probably damaging Het
Peg3 A T 7: 6,712,221 (GRCm39) D1000E probably benign Het
Polr3h A G 15: 81,801,571 (GRCm39) Y131H probably damaging Het
Rapgef6 A G 11: 54,516,780 (GRCm39) I346V probably benign Het
Rufy1 T A 11: 50,301,436 (GRCm39) K332M probably damaging Het
Scn1a T C 2: 66,118,102 (GRCm39) M404V possibly damaging Het
Septin8 T A 11: 53,428,744 (GRCm39) probably null Het
Sesn3 A G 9: 14,219,911 (GRCm39) D100G probably damaging Het
Setx A G 2: 29,067,561 (GRCm39) I2388V possibly damaging Het
Skint5 T A 4: 113,620,739 (GRCm39) probably null Het
Slc25a23 C T 17: 57,366,759 (GRCm39) probably benign Het
Slc4a7 G A 14: 14,773,348 (GRCm38) E773K probably benign Het
Slco3a1 G A 7: 74,154,344 (GRCm39) A76V probably damaging Het
Stradb A T 1: 59,033,567 (GRCm39) D410V probably benign Het
Syne1 T C 10: 5,122,949 (GRCm39) D329G probably damaging Het
Syt4 A C 18: 31,574,658 (GRCm39) S320A possibly damaging Het
Tnfsf4 A G 1: 161,244,733 (GRCm39) T141A possibly damaging Het
Trim34b G A 7: 103,984,559 (GRCm39) A279T probably damaging Het
Trpm6 A T 19: 18,845,325 (GRCm39) D1675V probably benign Het
Vmn2r24 T A 6: 123,793,169 (GRCm39) M832K probably benign Het
Xkr6 G T 14: 63,844,423 (GRCm39) D149Y probably damaging Het
Zfp108 A G 7: 23,960,840 (GRCm39) Y477C probably damaging Het
Zfp37 T G 4: 62,109,532 (GRCm39) I552L probably damaging Het
Zfp426 A T 9: 20,381,320 (GRCm39) S556T probably damaging Het
Zfp954 G A 7: 7,118,720 (GRCm39) L275F possibly damaging Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 26,068,338 (GRCm39) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 26,073,661 (GRCm39) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 26,067,383 (GRCm39) missense probably benign
IGL02116:Wdr90 APN 17 26,078,466 (GRCm39) missense probably benign 0.12
IGL02172:Wdr90 APN 17 26,069,408 (GRCm39) missense probably benign 0.22
IGL02716:Wdr90 APN 17 26,076,194 (GRCm39) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 26,067,649 (GRCm39) nonsense probably null
IGL03229:Wdr90 APN 17 26,064,437 (GRCm39) splice site probably benign
IGL03367:Wdr90 APN 17 26,066,765 (GRCm39) splice site probably benign
IGL03098:Wdr90 UTSW 17 26,078,961 (GRCm39) intron probably benign
R0111:Wdr90 UTSW 17 26,067,418 (GRCm39) splice site probably benign
R0454:Wdr90 UTSW 17 26,079,023 (GRCm39) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 26,079,459 (GRCm39) missense probably benign 0.00
R0488:Wdr90 UTSW 17 26,067,591 (GRCm39) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 26,074,632 (GRCm39) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 26,065,367 (GRCm39) missense probably benign 0.04
R0799:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R1177:Wdr90 UTSW 17 26,065,028 (GRCm39) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 26,079,422 (GRCm39) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 26,068,284 (GRCm39) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 26,074,173 (GRCm39) missense probably benign 0.05
R2087:Wdr90 UTSW 17 26,065,577 (GRCm39) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 26,070,715 (GRCm39) missense probably benign
R2208:Wdr90 UTSW 17 26,079,362 (GRCm39) missense probably damaging 1.00
R2345:Wdr90 UTSW 17 26,078,136 (GRCm39) missense probably benign 0.05
R2391:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 26,074,326 (GRCm39) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 26,069,472 (GRCm39) missense probably benign 0.01
R3979:Wdr90 UTSW 17 26,078,252 (GRCm39) missense probably benign 0.00
R4111:Wdr90 UTSW 17 26,068,342 (GRCm39) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 26,072,705 (GRCm39) missense probably benign 0.25
R4459:Wdr90 UTSW 17 26,079,976 (GRCm39) missense possibly damaging 0.95
R4697:Wdr90 UTSW 17 26,074,337 (GRCm39) missense probably benign 0.03
R4735:Wdr90 UTSW 17 26,078,424 (GRCm39) missense probably benign
R4907:Wdr90 UTSW 17 26,079,624 (GRCm39) intron probably benign
R5070:Wdr90 UTSW 17 26,065,307 (GRCm39) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 26,074,277 (GRCm39) missense probably benign 0.01
R5268:Wdr90 UTSW 17 26,069,819 (GRCm39) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 26,080,441 (GRCm39) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 26,064,572 (GRCm39) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 26,063,995 (GRCm39) unclassified probably benign
R5545:Wdr90 UTSW 17 26,064,830 (GRCm39) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 26,076,166 (GRCm39) missense probably benign 0.00
R5973:Wdr90 UTSW 17 26,065,381 (GRCm39) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 26,064,107 (GRCm39) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 26,067,504 (GRCm39) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 26,064,885 (GRCm39) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 26,068,623 (GRCm39) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 26,064,367 (GRCm39) missense probably benign 0.00
R7288:Wdr90 UTSW 17 26,065,286 (GRCm39) missense probably benign 0.03
R7304:Wdr90 UTSW 17 26,070,480 (GRCm39) missense probably benign 0.10
R7309:Wdr90 UTSW 17 26,079,676 (GRCm39) missense probably benign 0.02
R7391:Wdr90 UTSW 17 26,065,502 (GRCm39) missense probably benign 0.08
R7622:Wdr90 UTSW 17 26,073,083 (GRCm39) missense probably benign 0.00
R7772:Wdr90 UTSW 17 26,080,465 (GRCm39) start gained probably benign
R7779:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 26,071,532 (GRCm39) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 26,079,513 (GRCm39) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 26,069,723 (GRCm39) missense probably benign 0.00
R8126:Wdr90 UTSW 17 26,067,951 (GRCm39) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 26,064,141 (GRCm39) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 26,064,399 (GRCm39) missense probably benign 0.21
R8919:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8938:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8940:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R9038:Wdr90 UTSW 17 26,076,200 (GRCm39) missense
R9079:Wdr90 UTSW 17 26,076,403 (GRCm39) missense
R9401:Wdr90 UTSW 17 26,064,750 (GRCm39) small insertion probably benign
R9471:Wdr90 UTSW 17 26,080,015 (GRCm39) missense possibly damaging 0.72
R9642:Wdr90 UTSW 17 26,072,694 (GRCm39) critical splice donor site probably null
X0064:Wdr90 UTSW 17 26,067,537 (GRCm39) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 26,079,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CACTTGGAAACCTTGTGGGG -3'
(R):5'- AGCTGGCAGATAAGAACCAC -3'

Sequencing Primer
(F):5'- TAGAAGCAAAATCAATATCTGGGGAC -3'
(R):5'- CTTACCAATTTCAGAGGAGAGCCATG -3'
Posted On 2019-10-24