Incidental Mutation 'R8023:Or4c31'
ID 617505
Institutional Source Beutler Lab
Gene Symbol Or4c31
Ensembl Gene ENSMUSG00000049372
Gene Name olfactory receptor family 4 subfamily C member 31
Synonyms MOR230-6, GA_x6K02T2Q125-49948903-49949814, Olfr1183
MMRRC Submission 067462-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8023 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88291686-88292597 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88292022 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 132 (I132V)
Ref Sequence ENSEMBL: ENSMUSP00000154094 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102618] [ENSMUST00000213115] [ENSMUST00000219871]
AlphaFold A0A2I3BQA3
Predicted Effect probably benign
Transcript: ENSMUST00000102618
AA Change: I113V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000099678
Gene: ENSMUSG00000049372
AA Change: I113V

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 32 299 1.8e-5 PFAM
Pfam:7tm_1 38 284 1.5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213115
AA Change: I132V

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000219871
AA Change: I113V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg2 A G 17: 57,152,448 (GRCm39) Y665H probably damaging Het
Acte1 T C 7: 143,445,528 (GRCm39) S192P probably damaging Het
Agbl4 T A 4: 111,474,345 (GRCm39) V378E probably benign Het
Card9 T C 2: 26,247,327 (GRCm39) D274G probably benign Het
Ccnc T C 4: 21,747,578 (GRCm39) probably null Het
Col1a2 T G 6: 4,533,847 (GRCm39) S843A unknown Het
Cux1 T A 5: 136,402,251 (GRCm39) I111F probably damaging Het
Fam24b A C 7: 130,927,869 (GRCm39) S107A probably benign Het
Fndc7 C T 3: 108,774,461 (GRCm39) C599Y probably damaging Het
Gm3604 G A 13: 62,517,683 (GRCm39) A225V probably damaging Het
Grhl3 A G 4: 135,277,640 (GRCm39) V475A probably benign Het
H2ac20 A G 3: 96,128,106 (GRCm39) S19P unknown Het
Heg1 T A 16: 33,550,895 (GRCm39) V958E possibly damaging Het
Hibch T C 1: 52,899,197 (GRCm39) M30T probably benign Het
Hk2 T A 6: 82,705,790 (GRCm39) M838L probably benign Het
Hpd A G 5: 123,314,297 (GRCm39) F206S probably damaging Het
Il34 C T 8: 111,469,284 (GRCm39) C177Y probably damaging Het
Il6ra A G 3: 89,820,260 (GRCm39) probably null Het
Itpr2 A G 6: 146,088,988 (GRCm39) I2240T probably damaging Het
Med24 A G 11: 98,609,321 (GRCm39) probably null Het
Mpz A G 1: 170,987,602 (GRCm39) D246G probably damaging Het
Ncam1 C A 9: 49,421,057 (GRCm39) A753S probably benign Het
Ndufs2 A T 1: 171,064,263 (GRCm39) M375K probably damaging Het
Obox2 A G 7: 15,131,145 (GRCm39) K84E possibly damaging Het
Or51k1 A G 7: 103,661,006 (GRCm39) I301T probably damaging Het
Or7e178 C T 9: 20,225,545 (GRCm39) V224I probably benign Het
Pds5a A T 5: 65,795,241 (GRCm39) L665Q probably damaging Het
Prr29 A G 11: 106,267,099 (GRCm39) E38G probably benign Het
Ptpn3 G C 4: 57,248,688 (GRCm39) D215E probably benign Het
Ptprq G A 10: 107,488,477 (GRCm39) Q987* probably null Het
Ranbp6 T C 19: 29,789,222 (GRCm39) S377G possibly damaging Het
Rps6ka1 A T 4: 133,594,506 (GRCm39) L168Q probably damaging Het
Sall1 A G 8: 89,759,171 (GRCm39) I311T probably damaging Het
Satb2 T C 1: 56,930,390 (GRCm39) Y211C probably damaging Het
Sis T A 3: 72,859,813 (GRCm39) Y314F probably damaging Het
Slc1a7 G A 4: 107,869,473 (GRCm39) V513M probably benign Het
Slc6a20a T C 9: 123,489,657 (GRCm39) N129D probably damaging Het
Slu7 G A 11: 43,336,975 (GRCm39) R572Q probably benign Het
Tbx6 C T 7: 126,382,031 (GRCm39) A123V possibly damaging Het
Tcn2 A T 11: 3,877,579 (GRCm39) I23K possibly damaging Het
Tiparp A G 3: 65,439,224 (GRCm39) D180G probably benign Het
Tln2 A G 9: 67,131,346 (GRCm39) L1400P probably damaging Het
Ttf2 T C 3: 100,863,571 (GRCm39) T588A probably benign Het
Ttn A G 2: 76,769,564 (GRCm39) V2741A unknown Het
Txlna A T 4: 129,533,278 (GRCm39) S83R probably damaging Het
Vmn2r16 C T 5: 109,488,272 (GRCm39) Q382* probably null Het
Vmn2r76 A G 7: 85,879,028 (GRCm39) V424A probably benign Het
Zfc3h1 T A 10: 115,256,553 (GRCm39) L1508I probably damaging Het
Zfp189 G A 4: 49,530,312 (GRCm39) G472R probably damaging Het
Zfp462 G A 4: 55,073,106 (GRCm39) probably null Het
Other mutations in Or4c31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or4c31 APN 2 88,291,696 (GRCm39) missense probably benign
IGL01150:Or4c31 APN 2 88,292,419 (GRCm39) missense possibly damaging 0.93
IGL02894:Or4c31 APN 2 88,292,070 (GRCm39) missense probably damaging 1.00
R0382:Or4c31 UTSW 2 88,292,069 (GRCm39) missense possibly damaging 0.87
R0401:Or4c31 UTSW 2 88,292,269 (GRCm39) missense probably damaging 1.00
R0664:Or4c31 UTSW 2 88,292,515 (GRCm39) missense probably damaging 1.00
R1990:Or4c31 UTSW 2 88,291,686 (GRCm39) start codon destroyed probably null
R3122:Or4c31 UTSW 2 88,291,853 (GRCm39) missense probably damaging 0.99
R4596:Or4c31 UTSW 2 88,292,538 (GRCm39) missense probably benign 0.28
R7361:Or4c31 UTSW 2 88,291,836 (GRCm39) missense probably benign 0.28
R7469:Or4c31 UTSW 2 88,291,691 (GRCm39) missense probably benign
R7858:Or4c31 UTSW 2 88,292,056 (GRCm39) missense probably damaging 1.00
R8147:Or4c31 UTSW 2 88,292,427 (GRCm39) missense possibly damaging 0.93
R9026:Or4c31 UTSW 2 88,292,196 (GRCm39) missense probably damaging 1.00
R9103:Or4c31 UTSW 2 88,291,942 (GRCm39) missense probably benign 0.02
Z1176:Or4c31 UTSW 2 88,292,458 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGAACTTCCTCATCGTGATGAC -3'
(R):5'- TCACATTTGGGCCACAGAATG -3'

Sequencing Primer
(F):5'- TGAGTCAGACACTTGGGAGTCC -3'
(R):5'- CCACAGAATGGTAATCTTAAGGC -3'
Posted On 2020-01-23