Incidental Mutation 'R9601:Trank1'
ID 726362
Institutional Source Beutler Lab
Gene Symbol Trank1
Ensembl Gene ENSMUSG00000062296
Gene Name tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms LOC235639, C030048J01Rik, A230061D21Rik, Lba1
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9601 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 111140807-111224843 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111202193 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 1607 (I1607V)
Ref Sequence ENSEMBL: ENSMUSP00000077697 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078626]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000078626
AA Change: I1607V

PolyPhen 2 Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000077697
Gene: ENSMUSG00000062296
AA Change: I1607V

DomainStartEndE-ValueType
low complexity region 4 30 N/A INTRINSIC
low complexity region 34 52 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Blast:TPR 144 177 1e-15 BLAST
Blast:TPR 178 209 8e-13 BLAST
Blast:ANK 332 361 1e-6 BLAST
ANK 369 405 5.29e0 SMART
ANK 538 567 2.11e2 SMART
ANK 572 609 7.29e2 SMART
ANK 621 652 1.21e2 SMART
low complexity region 887 895 N/A INTRINSIC
low complexity region 1152 1172 N/A INTRINSIC
Blast:AAA 1351 1569 1e-6 BLAST
low complexity region 2166 2177 N/A INTRINSIC
low complexity region 2395 2411 N/A INTRINSIC
low complexity region 2636 2649 N/A INTRINSIC
low complexity region 2966 2983 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd6 T C 14: 8,049,808 (GRCm38) L246S possibly damaging Het
Ahcyl A G 16: 45,975,035 (GRCm39) I114T probably benign Het
Arhgap22 C A 14: 33,020,727 (GRCm39) H107N probably damaging Het
Atp6v0a2 G A 5: 124,790,257 (GRCm39) G480D probably damaging Het
Baz2b T C 2: 59,731,847 (GRCm39) T2064A possibly damaging Het
Bop1 T A 15: 76,338,688 (GRCm39) N449I probably benign Het
C8g C T 2: 25,388,916 (GRCm39) probably null Het
Camp T G 9: 109,677,504 (GRCm39) T110P Het
Ccdc141 T C 2: 76,885,073 (GRCm39) T523A possibly damaging Het
Ccdc157 A T 11: 4,094,598 (GRCm39) I578N probably damaging Het
Ccdc187 C T 2: 26,143,445 (GRCm39) A1298T possibly damaging Het
Cdc20 C T 4: 118,290,716 (GRCm39) W428* probably null Het
Chd9 A T 8: 91,732,360 (GRCm39) R1293* probably null Het
Clca3a1 C T 3: 144,453,310 (GRCm39) G505S probably benign Het
Clptm1 C A 7: 19,369,763 (GRCm39) W382C probably damaging Het
Cnot1 A T 8: 96,482,835 (GRCm39) N739K probably benign Het
Cntnap5a T C 1: 116,508,217 (GRCm39) I1243T probably damaging Het
Col12a1 T G 9: 79,525,034 (GRCm39) D2709A probably damaging Het
Cpm T C 10: 117,511,999 (GRCm39) probably null Het
Ctsd C A 7: 141,936,373 (GRCm39) G143C probably damaging Het
Cux2 A G 5: 122,025,461 (GRCm39) V69A possibly damaging Het
Cyp2c66 A T 19: 39,175,054 (GRCm39) I485L probably benign Het
Cyp4a29 T C 4: 115,105,772 (GRCm39) V158A probably damaging Het
Dbx1 A T 7: 49,282,403 (GRCm39) D267E probably damaging Het
Dop1b A G 16: 93,544,531 (GRCm39) Y224C possibly damaging Het
Dsg3 T A 18: 20,666,578 (GRCm39) C596S probably damaging Het
Fcgbpl1 G A 7: 27,853,805 (GRCm39) V1590I possibly damaging Het
Fgd2 G A 17: 29,593,860 (GRCm39) V456I probably benign Het
Gabra1 A T 11: 42,026,401 (GRCm39) I297N probably damaging Het
Grid1 A G 14: 35,167,814 (GRCm39) E446G probably damaging Het
H2bc12 T C 13: 22,220,393 (GRCm39) S113P probably benign Het
Hmmr A T 11: 40,598,210 (GRCm39) Y667* probably null Het
Katnip A G 7: 125,442,092 (GRCm39) Q693R probably benign Het
Klhl25 A G 7: 75,515,757 (GRCm39) D221G probably damaging Het
Krtcap2 T C 3: 89,156,449 (GRCm39) probably null Het
Lipi T A 16: 75,352,706 (GRCm39) N377I possibly damaging Het
Lrp2 C A 2: 69,289,928 (GRCm39) C3637F probably damaging Het
Mrgprh T C 17: 13,096,264 (GRCm39) F168S possibly damaging Het
Naip6 T C 13: 100,436,961 (GRCm39) T521A probably benign Het
Nkpd1 A T 7: 19,257,462 (GRCm39) I414F probably damaging Het
Or4c99 T A 2: 88,330,314 (GRCm39) M295K probably damaging Het
Or52z13 A T 7: 103,246,598 (GRCm39) D25V probably benign Het
Pcdhb21 A T 18: 37,648,385 (GRCm39) I505F probably damaging Het
Plxna1 C T 6: 89,308,253 (GRCm39) R1278Q probably damaging Het
Pofut2 T C 10: 77,095,220 (GRCm39) S22P possibly damaging Het
Prrc2b C A 2: 32,090,953 (GRCm39) R442S probably damaging Het
Sema3e T A 5: 14,302,397 (GRCm39) F641I possibly damaging Het
Sfswap G A 5: 129,618,463 (GRCm39) V466I possibly damaging Het
Slc22a21 A T 11: 53,850,051 (GRCm39) V268E possibly damaging Het
Slc6a17 T C 3: 107,380,930 (GRCm39) D525G possibly damaging Het
Spata21 C T 4: 140,822,467 (GRCm39) T91I possibly damaging Het
Spryd7 T G 14: 61,783,228 (GRCm39) H98P probably benign Het
Sptb G T 12: 76,667,763 (GRCm39) T778K probably damaging Het
Syne1 C T 10: 5,209,270 (GRCm39) R3411Q probably benign Het
Ttll1 T C 15: 83,380,516 (GRCm39) D283G probably benign Het
Ufl1 G A 4: 25,275,807 (GRCm39) R199W probably benign Het
Vmn1r159 A G 7: 22,542,616 (GRCm39) S139P probably damaging Het
Vmn2r97 A G 17: 19,134,770 (GRCm39) I63V probably benign Het
Vps13a T C 19: 16,623,337 (GRCm39) S2775G possibly damaging Het
Zfp992 C T 4: 146,551,976 (GRCm39) H566Y probably damaging Het
Other mutations in Trank1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00234:Trank1 APN 9 111,221,677 (GRCm39) missense probably damaging 1.00
IGL00467:Trank1 APN 9 111,193,734 (GRCm39) splice site probably benign
IGL00569:Trank1 APN 9 111,174,579 (GRCm39) missense possibly damaging 0.69
IGL00585:Trank1 APN 9 111,178,358 (GRCm39) missense possibly damaging 0.82
IGL01070:Trank1 APN 9 111,195,861 (GRCm39) missense probably damaging 1.00
IGL01134:Trank1 APN 9 111,220,849 (GRCm39) missense probably benign
IGL01154:Trank1 APN 9 111,215,468 (GRCm39) missense probably benign 0.00
IGL01355:Trank1 APN 9 111,194,588 (GRCm39) missense possibly damaging 0.94
IGL01407:Trank1 APN 9 111,193,790 (GRCm39) missense probably damaging 0.99
IGL01410:Trank1 APN 9 111,194,117 (GRCm39) missense probably benign 0.00
IGL01410:Trank1 APN 9 111,194,327 (GRCm39) missense probably benign 0.00
IGL01504:Trank1 APN 9 111,202,612 (GRCm39) missense probably damaging 1.00
IGL01744:Trank1 APN 9 111,178,431 (GRCm39) missense probably damaging 1.00
IGL02043:Trank1 APN 9 111,193,028 (GRCm39) missense probably damaging 0.98
IGL02104:Trank1 APN 9 111,219,780 (GRCm39) missense possibly damaging 0.85
IGL02193:Trank1 APN 9 111,196,344 (GRCm39) missense probably benign 0.43
IGL02581:Trank1 APN 9 111,212,193 (GRCm39) missense probably benign 0.00
IGL02630:Trank1 APN 9 111,202,143 (GRCm39) missense possibly damaging 0.70
IGL02839:Trank1 APN 9 111,193,824 (GRCm39) missense probably damaging 1.00
IGL02897:Trank1 APN 9 111,196,585 (GRCm39) missense probably damaging 0.99
IGL03065:Trank1 APN 9 111,219,361 (GRCm39) missense possibly damaging 0.64
IGL03123:Trank1 APN 9 111,196,475 (GRCm39) missense probably damaging 1.00
IGL03143:Trank1 APN 9 111,195,155 (GRCm39) missense probably damaging 1.00
IGL03323:Trank1 APN 9 111,181,184 (GRCm39) missense probably damaging 1.00
1mM(1):Trank1 UTSW 9 111,222,049 (GRCm39) missense probably damaging 1.00
PIT4486001:Trank1 UTSW 9 111,219,175 (GRCm39) missense probably damaging 1.00
PIT4812001:Trank1 UTSW 9 111,176,980 (GRCm39) missense probably damaging 1.00
R0035:Trank1 UTSW 9 111,195,844 (GRCm39) missense probably benign 0.00
R0064:Trank1 UTSW 9 111,172,263 (GRCm39) missense probably damaging 1.00
R0064:Trank1 UTSW 9 111,172,263 (GRCm39) missense probably damaging 1.00
R0089:Trank1 UTSW 9 111,221,978 (GRCm39) missense probably benign 0.00
R0207:Trank1 UTSW 9 111,195,321 (GRCm39) missense probably damaging 1.00
R0255:Trank1 UTSW 9 111,195,092 (GRCm39) missense possibly damaging 0.92
R0334:Trank1 UTSW 9 111,222,008 (GRCm39) missense probably damaging 1.00
R0334:Trank1 UTSW 9 111,194,421 (GRCm39) missense probably benign 0.00
R0383:Trank1 UTSW 9 111,220,545 (GRCm39) missense probably benign 0.08
R0421:Trank1 UTSW 9 111,220,907 (GRCm39) missense probably damaging 1.00
R0494:Trank1 UTSW 9 111,220,361 (GRCm39) missense probably benign 0.19
R0518:Trank1 UTSW 9 111,162,876 (GRCm39) missense probably damaging 1.00
R0560:Trank1 UTSW 9 111,220,154 (GRCm39) missense possibly damaging 0.88
R0637:Trank1 UTSW 9 111,219,509 (GRCm39) missense probably damaging 1.00
R0731:Trank1 UTSW 9 111,194,556 (GRCm39) missense probably damaging 1.00
R0761:Trank1 UTSW 9 111,195,681 (GRCm39) missense probably damaging 1.00
R0766:Trank1 UTSW 9 111,176,537 (GRCm39) missense probably benign 0.45
R0827:Trank1 UTSW 9 111,178,485 (GRCm39) unclassified probably benign
R1005:Trank1 UTSW 9 111,162,789 (GRCm39) missense probably benign 0.13
R1108:Trank1 UTSW 9 111,194,375 (GRCm39) missense probably benign 0.00
R1155:Trank1 UTSW 9 111,196,038 (GRCm39) missense possibly damaging 0.95
R1470:Trank1 UTSW 9 111,172,300 (GRCm39) missense possibly damaging 0.91
R1470:Trank1 UTSW 9 111,172,300 (GRCm39) missense possibly damaging 0.91
R1596:Trank1 UTSW 9 111,195,358 (GRCm39) missense possibly damaging 0.93
R1601:Trank1 UTSW 9 111,202,545 (GRCm39) missense probably damaging 1.00
R1751:Trank1 UTSW 9 111,220,547 (GRCm39) missense probably benign
R1754:Trank1 UTSW 9 111,221,939 (GRCm39) missense probably benign 0.00
R1767:Trank1 UTSW 9 111,220,547 (GRCm39) missense probably benign
R1768:Trank1 UTSW 9 111,221,995 (GRCm39) missense probably damaging 0.96
R1809:Trank1 UTSW 9 111,221,893 (GRCm39) missense probably benign 0.34
R1912:Trank1 UTSW 9 111,219,777 (GRCm39) missense probably benign 0.00
R1920:Trank1 UTSW 9 111,176,996 (GRCm39) critical splice donor site probably null
R1960:Trank1 UTSW 9 111,220,696 (GRCm39) missense probably damaging 1.00
R1993:Trank1 UTSW 9 111,207,900 (GRCm39) missense probably benign 0.20
R2012:Trank1 UTSW 9 111,194,096 (GRCm39) missense probably benign
R2025:Trank1 UTSW 9 111,221,107 (GRCm39) missense probably benign 0.01
R2050:Trank1 UTSW 9 111,193,856 (GRCm39) missense probably damaging 1.00
R2857:Trank1 UTSW 9 111,196,001 (GRCm39) missense probably benign 0.00
R2912:Trank1 UTSW 9 111,221,551 (GRCm39) missense probably damaging 0.98
R2962:Trank1 UTSW 9 111,181,148 (GRCm39) missense probably damaging 1.00
R3030:Trank1 UTSW 9 111,220,598 (GRCm39) missense possibly damaging 0.63
R3821:Trank1 UTSW 9 111,207,887 (GRCm39) missense probably damaging 1.00
R3822:Trank1 UTSW 9 111,207,887 (GRCm39) missense probably damaging 1.00
R3892:Trank1 UTSW 9 111,193,827 (GRCm39) missense probably benign 0.03
R4105:Trank1 UTSW 9 111,181,265 (GRCm39) missense probably damaging 1.00
R4166:Trank1 UTSW 9 111,202,592 (GRCm39) nonsense probably null
R4237:Trank1 UTSW 9 111,196,103 (GRCm39) missense probably benign 0.04
R4239:Trank1 UTSW 9 111,196,103 (GRCm39) missense probably benign 0.04
R4394:Trank1 UTSW 9 111,194,265 (GRCm39) missense possibly damaging 0.86
R4417:Trank1 UTSW 9 111,195,036 (GRCm39) missense probably benign 0.17
R4611:Trank1 UTSW 9 111,191,329 (GRCm39) missense probably damaging 1.00
R4694:Trank1 UTSW 9 111,221,129 (GRCm39) missense probably benign 0.40
R4731:Trank1 UTSW 9 111,219,478 (GRCm39) missense probably damaging 1.00
R4843:Trank1 UTSW 9 111,195,146 (GRCm39) missense probably benign 0.00
R4852:Trank1 UTSW 9 111,220,963 (GRCm39) missense possibly damaging 0.68
R4859:Trank1 UTSW 9 111,194,078 (GRCm39) missense probably benign 0.17
R4868:Trank1 UTSW 9 111,194,709 (GRCm39) missense probably damaging 1.00
R5080:Trank1 UTSW 9 111,218,289 (GRCm39) missense probably damaging 0.99
R5156:Trank1 UTSW 9 111,219,762 (GRCm39) missense probably damaging 1.00
R5174:Trank1 UTSW 9 111,194,627 (GRCm39) missense probably benign 0.00
R5234:Trank1 UTSW 9 111,215,535 (GRCm39) missense probably damaging 1.00
R5386:Trank1 UTSW 9 111,191,470 (GRCm39) missense probably benign 0.12
R5419:Trank1 UTSW 9 111,220,369 (GRCm39) missense probably damaging 1.00
R5435:Trank1 UTSW 9 111,220,958 (GRCm39) missense probably benign 0.00
R5444:Trank1 UTSW 9 111,222,026 (GRCm39) missense probably benign 0.04
R5543:Trank1 UTSW 9 111,195,180 (GRCm39) missense probably damaging 0.97
R5560:Trank1 UTSW 9 111,219,635 (GRCm39) missense probably damaging 1.00
R5772:Trank1 UTSW 9 111,195,744 (GRCm39) missense possibly damaging 0.86
R5774:Trank1 UTSW 9 111,220,294 (GRCm39) missense probably damaging 1.00
R5843:Trank1 UTSW 9 111,194,928 (GRCm39) missense possibly damaging 0.59
R5858:Trank1 UTSW 9 111,221,604 (GRCm39) missense probably benign
R5878:Trank1 UTSW 9 111,195,753 (GRCm39) missense possibly damaging 0.93
R5900:Trank1 UTSW 9 111,220,784 (GRCm39) missense probably damaging 1.00
R5917:Trank1 UTSW 9 111,191,485 (GRCm39) missense probably benign 0.38
R5954:Trank1 UTSW 9 111,194,201 (GRCm39) missense probably benign 0.13
R6041:Trank1 UTSW 9 111,206,864 (GRCm39) missense possibly damaging 0.94
R6112:Trank1 UTSW 9 111,220,805 (GRCm39) missense probably damaging 1.00
R6165:Trank1 UTSW 9 111,220,940 (GRCm39) missense probably benign 0.00
R6255:Trank1 UTSW 9 111,181,314 (GRCm39) critical splice donor site probably null
R6395:Trank1 UTSW 9 111,196,268 (GRCm39) missense probably damaging 1.00
R6567:Trank1 UTSW 9 111,176,589 (GRCm39) missense probably benign 0.02
R6644:Trank1 UTSW 9 111,193,902 (GRCm39) missense possibly damaging 0.85
R6724:Trank1 UTSW 9 111,194,984 (GRCm39) missense probably damaging 1.00
R6788:Trank1 UTSW 9 111,219,747 (GRCm39) missense probably damaging 1.00
R6831:Trank1 UTSW 9 111,206,967 (GRCm39) missense probably benign 0.00
R6934:Trank1 UTSW 9 111,202,158 (GRCm39) missense probably damaging 0.99
R7127:Trank1 UTSW 9 111,194,864 (GRCm39) missense possibly damaging 0.85
R7206:Trank1 UTSW 9 111,174,583 (GRCm39) critical splice donor site probably null
R7236:Trank1 UTSW 9 111,202,142 (GRCm39) missense possibly damaging 0.93
R7247:Trank1 UTSW 9 111,196,580 (GRCm39) missense probably damaging 1.00
R7292:Trank1 UTSW 9 111,206,938 (GRCm39) missense probably benign 0.02
R7310:Trank1 UTSW 9 111,196,194 (GRCm39) missense probably damaging 1.00
R7431:Trank1 UTSW 9 111,191,470 (GRCm39) missense probably benign 0.12
R7448:Trank1 UTSW 9 111,195,417 (GRCm39) missense probably benign 0.01
R7477:Trank1 UTSW 9 111,194,025 (GRCm39) missense probably benign 0.00
R7514:Trank1 UTSW 9 111,193,824 (GRCm39) missense probably damaging 1.00
R7595:Trank1 UTSW 9 111,195,059 (GRCm39) missense probably damaging 1.00
R7637:Trank1 UTSW 9 111,194,364 (GRCm39) missense possibly damaging 0.71
R7648:Trank1 UTSW 9 111,220,753 (GRCm39) missense probably benign
R7737:Trank1 UTSW 9 111,195,080 (GRCm39) nonsense probably null
R7784:Trank1 UTSW 9 111,193,171 (GRCm39) missense probably damaging 1.00
R7884:Trank1 UTSW 9 111,221,584 (GRCm39) missense probably benign
R7912:Trank1 UTSW 9 111,220,596 (GRCm39) missense probably benign 0.04
R7938:Trank1 UTSW 9 111,194,096 (GRCm39) missense probably benign
R7979:Trank1 UTSW 9 111,206,967 (GRCm39) missense probably benign 0.00
R8064:Trank1 UTSW 9 111,181,144 (GRCm39) nonsense probably null
R8100:Trank1 UTSW 9 111,221,861 (GRCm39) missense probably damaging 1.00
R8124:Trank1 UTSW 9 111,207,995 (GRCm39) missense probably benign 0.31
R8198:Trank1 UTSW 9 111,219,880 (GRCm39) missense probably benign 0.09
R8219:Trank1 UTSW 9 111,193,977 (GRCm39) missense probably damaging 1.00
R8223:Trank1 UTSW 9 111,194,957 (GRCm39) missense probably damaging 1.00
R8316:Trank1 UTSW 9 111,178,370 (GRCm39) missense probably benign 0.38
R8347:Trank1 UTSW 9 111,196,317 (GRCm39) missense probably damaging 1.00
R8436:Trank1 UTSW 9 111,220,450 (GRCm39) missense possibly damaging 0.86
R8489:Trank1 UTSW 9 111,219,343 (GRCm39) missense probably benign 0.01
R8682:Trank1 UTSW 9 111,194,412 (GRCm39) missense probably benign 0.01
R8768:Trank1 UTSW 9 111,218,344 (GRCm39) missense probably benign 0.00
R8770:Trank1 UTSW 9 111,219,892 (GRCm39) missense probably benign 0.00
R8829:Trank1 UTSW 9 111,176,591 (GRCm39) missense probably benign
R8838:Trank1 UTSW 9 111,193,973 (GRCm39) missense probably benign 0.03
R8855:Trank1 UTSW 9 111,141,289 (GRCm39) missense unknown
R8929:Trank1 UTSW 9 111,208,003 (GRCm39) missense possibly damaging 0.93
R9047:Trank1 UTSW 9 111,191,500 (GRCm39) missense probably damaging 0.99
R9090:Trank1 UTSW 9 111,174,547 (GRCm39) missense probably damaging 1.00
R9114:Trank1 UTSW 9 111,162,843 (GRCm39) missense probably damaging 1.00
R9133:Trank1 UTSW 9 111,220,770 (GRCm39) missense possibly damaging 0.93
R9177:Trank1 UTSW 9 111,221,579 (GRCm39) missense probably benign 0.00
R9178:Trank1 UTSW 9 111,196,268 (GRCm39) missense probably damaging 1.00
R9271:Trank1 UTSW 9 111,174,547 (GRCm39) missense probably damaging 1.00
R9314:Trank1 UTSW 9 111,195,049 (GRCm39) missense probably damaging 1.00
R9373:Trank1 UTSW 9 111,194,259 (GRCm39) missense probably benign 0.25
R9380:Trank1 UTSW 9 111,221,738 (GRCm39) missense probably benign 0.07
R9435:Trank1 UTSW 9 111,193,890 (GRCm39) missense probably benign 0.04
R9501:Trank1 UTSW 9 111,176,943 (GRCm39) missense probably benign 0.00
R9593:Trank1 UTSW 9 111,191,365 (GRCm39) missense probably benign 0.30
R9729:Trank1 UTSW 9 111,220,537 (GRCm39) missense probably damaging 1.00
X0064:Trank1 UTSW 9 111,172,304 (GRCm39) missense possibly damaging 0.57
Z1088:Trank1 UTSW 9 111,193,778 (GRCm39) missense probably damaging 0.99
Z1177:Trank1 UTSW 9 111,221,938 (GRCm39) missense possibly damaging 0.47
Z1177:Trank1 UTSW 9 111,196,445 (GRCm39) missense possibly damaging 0.83
Z1177:Trank1 UTSW 9 111,140,970 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGCTGTGCAGTATCTGACAG -3'
(R):5'- CCAGGATTGACTTGGTCATCTC -3'

Sequencing Primer
(F):5'- AGGAATCCTCAATCTTGCATCTGGAG -3'
(R):5'- CATCTCGGACTGGGGAGATAGTC -3'
Posted On 2022-10-06