Incidental Mutation 'R9803:Or2t45'
ID 735326
Institutional Source Beutler Lab
Gene Symbol Or2t45
Ensembl Gene ENSMUSG00000056959
Gene Name olfactory receptor family 2 subfamily T member 45
Synonyms GA_x6K02T2NKPP-630272-629343, MOR278-1, Olfr315
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R9803 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58668915-58669912 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58669595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 214 (V214A)
Ref Sequence ENSEMBL: ENSMUSP00000144944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081533] [ENSMUST00000203256] [ENSMUST00000205189]
AlphaFold Q8VFG7
Predicted Effect probably benign
Transcript: ENSMUST00000081533
AA Change: V214A

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000080248
Gene: ENSMUSG00000056959
AA Change: V214A

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 3.5e-51 PFAM
Pfam:7TM_GPCR_Srsx 34 252 1.3e-7 PFAM
Pfam:7tm_1 41 290 6.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203256
AA Change: V214A

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000144944
Gene: ENSMUSG00000056959
AA Change: V214A

DomainStartEndE-ValueType
Pfam:7tm_4 29 126 1.2e-13 PFAM
Pfam:7TM_GPCR_Srsx 35 126 1.8e-5 PFAM
Pfam:7tm_1 41 126 4.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205189
SMART Domains Protein: ENSMUSP00000145387
Gene: ENSMUSG00000059504

DomainStartEndE-ValueType
Pfam:7tm_4 26 259 8.9e-42 PFAM
Pfam:7TM_GPCR_Srsx 33 246 9.4e-6 PFAM
Pfam:7tm_1 39 259 1.1e-25 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700069L16Rik A G 5: 113,841,964 (GRCm39) S52P unknown Het
Ank2 A G 3: 126,752,726 (GRCm39) M330T possibly damaging Het
Ankar C T 1: 72,698,340 (GRCm39) V905I possibly damaging Het
Anln G T 9: 22,283,518 (GRCm39) D438E probably damaging Het
C1ql3 T C 2: 13,009,200 (GRCm39) N215S probably damaging Het
Ccdc110 A G 8: 46,395,626 (GRCm39) S506G probably benign Het
Ccdc87 A G 19: 4,891,175 (GRCm39) T556A probably benign Het
Cma1 A T 14: 56,179,186 (GRCm39) N236K probably benign Het
Csmd2 T C 4: 128,262,986 (GRCm39) F724S Het
Cts8 T C 13: 61,401,136 (GRCm39) K130R possibly damaging Het
Daam1 A T 12: 71,990,922 (GRCm39) T179S unknown Het
Fancd2os T C 6: 113,574,938 (GRCm39) T23A possibly damaging Het
Gbgt1 T A 2: 28,394,866 (GRCm39) I168N probably damaging Het
Gckr G A 5: 31,457,368 (GRCm39) G127D probably damaging Het
Gm11444 G A 11: 85,737,699 (GRCm39) Q164* probably null Het
Gm28042 T A 2: 119,868,984 (GRCm39) V526E possibly damaging Het
Gm8947 T C 1: 151,068,722 (GRCm39) V185A possibly damaging Het
Hoxd13 C A 2: 74,499,247 (GRCm39) H198Q possibly damaging Het
Hps6 T A 19: 45,993,947 (GRCm39) L628* probably null Het
Igha G A 12: 113,222,759 (GRCm39) H221Y Het
Ighm A G 12: 113,382,635 (GRCm39) S453P Het
Inpp5f A C 7: 128,278,515 (GRCm39) D435A possibly damaging Het
Lfng A G 5: 140,593,528 (GRCm39) T120A probably damaging Het
Lrrc4 C T 6: 28,662,199 (GRCm39) A172T probably benign Het
Lrrc56 A G 7: 140,787,520 (GRCm39) T386A probably benign Het
Mapkbp1 A T 2: 119,841,256 (GRCm39) H81L probably benign Het
Mfsd14b C A 13: 65,221,414 (GRCm39) V293L probably benign Het
Mrto4 T A 4: 139,076,381 (GRCm39) N70I probably damaging Het
Mxra8 C T 4: 155,924,282 (GRCm39) probably benign Het
Myo1h A G 5: 114,483,997 (GRCm39) E548G Het
Ncan C T 8: 70,560,751 (GRCm39) D739N probably benign Het
Oxgr1 T C 14: 120,259,563 (GRCm39) T215A possibly damaging Het
Pcdhgb7 T A 18: 37,885,088 (GRCm39) V86E probably damaging Het
Pclo G A 5: 14,762,629 (GRCm39) V416M Het
Phf3 G T 1: 30,869,872 (GRCm39) T392K probably benign Het
Pkhd1 A T 1: 20,637,073 (GRCm39) V379E probably damaging Het
Ppfia3 T C 7: 44,990,539 (GRCm39) Y1080C probably benign Het
Ptprs C A 17: 56,729,217 (GRCm39) G1254C probably damaging Het
Qsox1 A T 1: 155,658,416 (GRCm39) D384E probably benign Het
Rergl A G 6: 139,477,761 (GRCm39) F23L probably damaging Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Sidt2 A G 9: 45,854,912 (GRCm39) Y588H probably damaging Het
Tas2r139 T A 6: 42,118,066 (GRCm39) I66K probably damaging Het
Tbc1d30 T A 10: 121,107,980 (GRCm39) D474V probably damaging Het
Tenm4 G A 7: 96,202,685 (GRCm39) G100D probably damaging Het
Tmem258 G A 19: 10,184,637 (GRCm39) V75I probably benign Het
Tmem91 G T 7: 25,369,988 (GRCm39) H95N probably damaging Het
Trps1 T C 15: 50,710,090 (GRCm39) K87E possibly damaging Het
Tspan11 T A 6: 127,920,680 (GRCm39) M209K probably benign Het
Tspan17 C A 13: 54,941,092 (GRCm39) Q124K probably benign Het
Uts2b G A 16: 27,179,692 (GRCm39) R105* probably null Het
Vmn2r110 T A 17: 20,803,730 (GRCm39) T282S probably benign Het
Xdh T A 17: 74,229,455 (GRCm39) M333L probably benign Het
Zbtb3 A G 19: 8,781,833 (GRCm39) E482G probably damaging Het
Other mutations in Or2t45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01526:Or2t45 APN 11 58,669,123 (GRCm39) missense probably benign 0.21
IGL03265:Or2t45 APN 11 58,669,697 (GRCm39) missense probably damaging 1.00
R0395:Or2t45 UTSW 11 58,669,195 (GRCm39) missense probably benign 0.05
R1760:Or2t45 UTSW 11 58,669,195 (GRCm39) missense possibly damaging 0.79
R1782:Or2t45 UTSW 11 58,669,631 (GRCm39) missense probably damaging 1.00
R2330:Or2t45 UTSW 11 58,669,825 (GRCm39) missense probably damaging 1.00
R3831:Or2t45 UTSW 11 58,669,571 (GRCm39) splice site probably null
R4898:Or2t45 UTSW 11 58,669,132 (GRCm39) missense possibly damaging 0.60
R5227:Or2t45 UTSW 11 58,669,705 (GRCm39) missense possibly damaging 0.70
R6257:Or2t45 UTSW 11 58,669,829 (GRCm39) missense probably damaging 0.96
R7253:Or2t45 UTSW 11 58,669,822 (GRCm39) missense probably damaging 1.00
R8751:Or2t45 UTSW 11 58,669,213 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTGTGCATACCTGACAGTGG -3'
(R):5'- AGGCAGACACCACTTTGTC -3'

Sequencing Primer
(F):5'- ATACCTGACAGTGGGGTCCTG -3'
(R):5'- GTCACTCTTGCCTGGCTGG -3'
Posted On 2022-11-14