Incidental Mutation 'R1640:Dock7'
ID 173442
Institutional Source Beutler Lab
Gene Symbol Dock7
Ensembl Gene ENSMUSG00000028556
Gene Name dedicator of cytokinesis 7
Synonyms m, LOC242555, 3110056M06Rik
MMRRC Submission 039676-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1640 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 98824908-99009152 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 98833483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Asparagine at position 1906 (T1906N)
Ref Sequence ENSEMBL: ENSMUSP00000145604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030286] [ENSMUST00000075836] [ENSMUST00000127417] [ENSMUST00000205650] [ENSMUST00000205652]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000030286
AA Change: T1936N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030286
Gene: ENSMUSG00000028556
AA Change: T1936N

DomainStartEndE-ValueType
Pfam:DUF3398 67 159 6.5e-30 PFAM
coiled coil region 367 394 N/A INTRINSIC
low complexity region 493 504 N/A INTRINSIC
Pfam:DOCK-C2 557 736 1.8e-51 PFAM
low complexity region 789 799 N/A INTRINSIC
low complexity region 862 873 N/A INTRINSIC
low complexity region 888 901 N/A INTRINSIC
low complexity region 1135 1163 N/A INTRINSIC
low complexity region 1350 1364 N/A INTRINSIC
low complexity region 1543 1565 N/A INTRINSIC
Pfam:DHR-2 1571 2095 1.4e-217 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000075836
AA Change: T1908N
SMART Domains Protein: ENSMUSP00000075233
Gene: ENSMUSG00000028556
AA Change: T1908N

DomainStartEndE-ValueType
Pfam:DUF3398 65 159 5.8e-34 PFAM
coiled coil region 367 394 N/A INTRINSIC
low complexity region 493 504 N/A INTRINSIC
Pfam:DOCK-C2 556 737 3.3e-58 PFAM
low complexity region 789 799 N/A INTRINSIC
low complexity region 862 873 N/A INTRINSIC
low complexity region 888 901 N/A INTRINSIC
low complexity region 1105 1133 N/A INTRINSIC
low complexity region 1320 1334 N/A INTRINSIC
low complexity region 1513 1535 N/A INTRINSIC
Pfam:Ded_cyto 1888 2065 6.5e-80 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124040
Predicted Effect probably benign
Transcript: ENSMUST00000124466
Predicted Effect unknown
Transcript: ENSMUST00000127417
AA Change: T1938N
SMART Domains Protein: ENSMUSP00000117797
Gene: ENSMUSG00000028556
AA Change: T1938N

DomainStartEndE-ValueType
low complexity region 140 162 N/A INTRINSIC
Pfam:Ded_cyto 517 694 3e-80 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140225
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205484
Predicted Effect probably damaging
Transcript: ENSMUST00000205650
AA Change: T1906N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206128
Predicted Effect probably benign
Transcript: ENSMUST00000205652
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810004N23Rik C A 8: 125,566,584 (GRCm39) V279L probably damaging Het
Acot6 A T 12: 84,147,900 (GRCm39) Y52F probably damaging Het
Adam22 C T 5: 8,195,689 (GRCm39) V284I probably damaging Het
Agl A T 3: 116,545,739 (GRCm39) H1352Q probably benign Het
Aldh18a1 G A 19: 40,573,943 (GRCm39) P27S probably benign Het
C1ra A G 6: 124,499,233 (GRCm39) N473S probably benign Het
C87436 T C 6: 86,423,233 (GRCm39) L269P probably damaging Het
Calcrl A G 2: 84,164,021 (GRCm39) V390A probably damaging Het
Ccp110 T G 7: 118,314,751 (GRCm39) probably null Het
Cerk A G 15: 86,033,601 (GRCm39) V274A probably damaging Het
Chd1l A T 3: 97,488,307 (GRCm39) S570T probably benign Het
Chst14 T A 2: 118,757,379 (GRCm39) W83R probably damaging Het
Chsy1 A T 7: 65,821,262 (GRCm39) D499V probably benign Het
Ckmt1 C A 2: 121,190,198 (GRCm39) probably null Het
Cnot1 A T 8: 96,496,460 (GRCm39) V282D probably damaging Het
Cntn3 A T 6: 102,218,974 (GRCm39) S549T possibly damaging Het
Cntnap5c A T 17: 58,702,289 (GRCm39) D1203V probably benign Het
Col4a4 A G 1: 82,513,491 (GRCm39) Y169H unknown Het
Cwc22 A G 2: 77,745,874 (GRCm39) F454S possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dhrs7 A T 12: 72,699,089 (GRCm39) W298R possibly damaging Het
Dpy19l3 T C 7: 35,449,203 (GRCm39) T67A probably benign Het
Drc1 A G 5: 30,521,301 (GRCm39) D654G possibly damaging Het
Ech1 A T 7: 28,531,264 (GRCm39) H284L probably damaging Het
Epc1 G A 18: 6,441,175 (GRCm39) Q8* probably null Het
Etv5 A T 16: 22,254,664 (GRCm39) D65E probably damaging Het
F2rl3 A G 8: 73,489,534 (GRCm39) R254G probably benign Het
Fabp5 T G 3: 10,080,170 (GRCm39) F73L probably benign Het
Fbrs T C 7: 127,086,483 (GRCm39) I611T probably damaging Het
Flnc T C 6: 29,433,806 (GRCm39) S117P possibly damaging Het
Frmd4b A C 6: 97,285,634 (GRCm39) S291A possibly damaging Het
Galnt13 A G 2: 54,950,558 (GRCm39) Y413C probably damaging Het
Gfer A G 17: 24,914,337 (GRCm39) Y109H possibly damaging Het
Gli2 T C 1: 118,764,254 (GRCm39) H1299R possibly damaging Het
Gm10110 T C 14: 90,135,679 (GRCm39) noncoding transcript Het
Gprc5a T G 6: 135,055,652 (GRCm39) L33W probably damaging Het
Grin3a T C 4: 49,844,721 (GRCm39) T121A probably benign Het
Grk3 A G 5: 113,163,248 (GRCm39) V33A probably benign Het
Hc A T 2: 34,947,336 (GRCm39) Y59* probably null Het
Hrnr A G 3: 93,239,823 (GRCm39) I3354V unknown Het
Hyou1 C G 9: 44,300,703 (GRCm39) T924S probably benign Het
Ifi209 T G 1: 173,464,931 (GRCm39) H20Q probably damaging Het
Ifi44 A G 3: 151,438,171 (GRCm39) V372A probably benign Het
Igdcc4 T A 9: 65,030,077 (GRCm39) L328H probably damaging Het
Jkampl A G 6: 73,445,869 (GRCm39) Y227H probably benign Het
Kif18a A G 2: 109,120,161 (GRCm39) T155A probably benign Het
Kmt2d A G 15: 98,742,938 (GRCm39) probably benign Het
Kri1 T C 9: 21,191,753 (GRCm39) D281G possibly damaging Het
Larp1b T A 3: 40,988,507 (GRCm39) M1K probably null Het
Loxhd1 A G 18: 77,490,259 (GRCm39) D1225G probably damaging Het
Mzf1 A G 7: 12,777,197 (GRCm39) *736Q probably null Het
Naip2 C T 13: 100,298,489 (GRCm39) A516T possibly damaging Het
Ncf2 T A 1: 152,683,784 (GRCm39) M1K probably null Het
Or5t15 T A 2: 86,681,571 (GRCm39) H157L probably benign Het
Or8h10 A C 2: 86,808,963 (GRCm39) M59R probably damaging Het
Parp12 T C 6: 39,073,574 (GRCm39) D417G probably benign Het
Parp12 T C 6: 39,088,612 (GRCm39) H208R probably damaging Het
Pcif1 T C 2: 164,727,603 (GRCm39) I132T probably benign Het
Pck2 A G 14: 55,786,041 (GRCm39) D610G possibly damaging Het
Plbd1 T C 6: 136,617,123 (GRCm39) K185E probably benign Het
Ppp2r5a T C 1: 191,086,126 (GRCm39) M425V probably damaging Het
Rapgef6 T A 11: 54,548,231 (GRCm39) V805D probably damaging Het
Rprd2 C T 3: 95,671,059 (GRCm39) probably benign Het
Ryr3 A G 2: 112,731,178 (GRCm39) S711P probably damaging Het
Slc17a3 T A 13: 24,036,340 (GRCm39) L212* probably null Het
Slc4a8 A G 15: 100,681,668 (GRCm39) D41G probably benign Het
Slc9a3 T A 13: 74,306,937 (GRCm39) V354E probably damaging Het
Spen A G 4: 141,196,254 (GRCm39) I3632T probably damaging Het
Tesc A G 5: 118,192,914 (GRCm39) S77G probably benign Het
Tet3 A T 6: 83,346,297 (GRCm39) V1245D probably benign Het
Tox4 T A 14: 52,530,000 (GRCm39) D553E possibly damaging Het
Tpmt A T 13: 47,180,759 (GRCm39) Y193* probably null Het
Trio T C 15: 27,833,130 (GRCm39) Y1169C probably damaging Het
Urb1 G A 16: 90,569,514 (GRCm39) T1404I probably benign Het
Usp47 T C 7: 111,682,334 (GRCm39) S540P probably damaging Het
Vmn1r178 A T 7: 23,593,548 (GRCm39) M126L possibly damaging Het
Vmn1r223 T C 13: 23,434,348 (GRCm39) F314S probably damaging Het
Vmn2r112 A T 17: 22,824,097 (GRCm39) I451L probably benign Het
Zfc3h1 A G 10: 115,242,806 (GRCm39) probably null Het
Zfp503 A T 14: 22,034,969 (GRCm39) L649Q probably damaging Het
Zfp977 A C 7: 42,229,530 (GRCm39) C332G probably damaging Het
Other mutations in Dock7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Dock7 APN 4 98,952,222 (GRCm39) missense probably damaging 1.00
IGL01126:Dock7 APN 4 98,861,789 (GRCm39) splice site probably benign
IGL01490:Dock7 APN 4 98,833,355 (GRCm39) unclassified probably benign
IGL01553:Dock7 APN 4 98,833,803 (GRCm39) nonsense probably null
IGL01728:Dock7 APN 4 98,850,568 (GRCm39) missense probably damaging 1.00
IGL01776:Dock7 APN 4 98,829,178 (GRCm39) missense possibly damaging 0.65
IGL01954:Dock7 APN 4 98,971,388 (GRCm39) missense probably damaging 0.99
IGL01985:Dock7 APN 4 98,911,614 (GRCm39) missense probably benign 0.35
IGL02054:Dock7 APN 4 98,861,646 (GRCm39) missense probably damaging 1.00
IGL02150:Dock7 APN 4 98,968,089 (GRCm39) splice site probably benign
IGL02153:Dock7 APN 4 98,846,304 (GRCm39) missense probably benign 0.15
IGL02183:Dock7 APN 4 98,847,228 (GRCm39) missense possibly damaging 0.89
IGL02494:Dock7 APN 4 98,877,471 (GRCm39) missense probably benign 0.18
IGL02618:Dock7 APN 4 98,971,265 (GRCm39) missense probably benign 0.00
IGL02634:Dock7 APN 4 98,877,533 (GRCm39) missense probably damaging 1.00
IGL02670:Dock7 APN 4 98,854,523 (GRCm39) splice site probably null
IGL02690:Dock7 APN 4 98,857,872 (GRCm39) missense possibly damaging 0.95
IGL02692:Dock7 APN 4 98,875,623 (GRCm39) missense probably damaging 1.00
IGL02833:Dock7 APN 4 98,833,732 (GRCm39) missense probably damaging 1.00
IGL02858:Dock7 APN 4 98,833,442 (GRCm39) nonsense probably null
IGL02875:Dock7 APN 4 98,864,231 (GRCm39) missense probably benign 0.00
IGL03027:Dock7 APN 4 98,958,450 (GRCm39) missense possibly damaging 0.71
IGL03027:Dock7 APN 4 98,866,164 (GRCm39) missense probably benign
IGL03032:Dock7 APN 4 98,854,585 (GRCm39) missense probably benign 0.02
IGL03104:Dock7 APN 4 98,847,260 (GRCm39) missense possibly damaging 0.60
IGL03136:Dock7 APN 4 98,892,028 (GRCm39) missense probably damaging 1.00
IGL03345:Dock7 APN 4 98,873,056 (GRCm39) missense possibly damaging 0.91
Beaming UTSW 4 98,967,992 (GRCm39) nonsense probably null
moonlight UTSW 4 0 () large deletion
Nocturn UTSW 4 98,952,199 (GRCm39) missense probably benign 0.00
sonata UTSW 4 98,889,364 (GRCm39) nonsense probably null
BB005:Dock7 UTSW 4 98,889,335 (GRCm39) missense
BB015:Dock7 UTSW 4 98,889,335 (GRCm39) missense
PIT4810001:Dock7 UTSW 4 98,833,796 (GRCm39) nonsense probably null
R0086:Dock7 UTSW 4 98,833,381 (GRCm39) missense probably damaging 1.00
R0242:Dock7 UTSW 4 98,850,517 (GRCm39) missense probably benign
R0242:Dock7 UTSW 4 98,850,517 (GRCm39) missense probably benign
R0245:Dock7 UTSW 4 98,943,586 (GRCm39) missense possibly damaging 0.64
R0308:Dock7 UTSW 4 98,873,051 (GRCm39) missense probably benign 0.07
R0556:Dock7 UTSW 4 98,833,426 (GRCm39) missense probably damaging 1.00
R0612:Dock7 UTSW 4 98,877,470 (GRCm39) missense probably benign 0.31
R0652:Dock7 UTSW 4 98,943,586 (GRCm39) missense possibly damaging 0.64
R0669:Dock7 UTSW 4 98,875,716 (GRCm39) missense probably benign 0.00
R0681:Dock7 UTSW 4 98,904,941 (GRCm39) missense probably damaging 1.00
R0725:Dock7 UTSW 4 98,833,528 (GRCm39) missense probably damaging 1.00
R0828:Dock7 UTSW 4 98,903,982 (GRCm39) missense probably damaging 1.00
R0837:Dock7 UTSW 4 98,877,495 (GRCm39) missense probably benign 0.01
R0962:Dock7 UTSW 4 98,833,432 (GRCm39) missense possibly damaging 0.85
R1140:Dock7 UTSW 4 98,953,643 (GRCm39) missense possibly damaging 0.82
R1476:Dock7 UTSW 4 98,967,672 (GRCm39) missense possibly damaging 0.52
R1614:Dock7 UTSW 4 98,949,517 (GRCm39) missense probably benign 0.12
R1625:Dock7 UTSW 4 98,850,433 (GRCm39) splice site probably null
R1752:Dock7 UTSW 4 98,854,681 (GRCm39) missense probably damaging 1.00
R1941:Dock7 UTSW 4 98,872,952 (GRCm39) missense probably benign 0.09
R2020:Dock7 UTSW 4 98,847,338 (GRCm39) missense probably damaging 1.00
R2092:Dock7 UTSW 4 98,897,545 (GRCm39) missense possibly damaging 0.95
R2293:Dock7 UTSW 4 98,854,606 (GRCm39) missense probably damaging 1.00
R2424:Dock7 UTSW 4 98,833,544 (GRCm39) nonsense probably null
R3767:Dock7 UTSW 4 98,859,066 (GRCm39) missense probably benign
R3768:Dock7 UTSW 4 98,859,066 (GRCm39) missense probably benign
R3769:Dock7 UTSW 4 98,859,066 (GRCm39) missense probably benign
R3770:Dock7 UTSW 4 98,859,066 (GRCm39) missense probably benign
R3917:Dock7 UTSW 4 98,904,922 (GRCm39) missense probably damaging 1.00
R3943:Dock7 UTSW 4 98,880,668 (GRCm39) missense probably damaging 1.00
R4021:Dock7 UTSW 4 98,892,157 (GRCm39) splice site probably null
R4073:Dock7 UTSW 4 98,896,296 (GRCm39) missense probably benign 0.02
R4170:Dock7 UTSW 4 98,854,638 (GRCm39) missense probably damaging 0.99
R4180:Dock7 UTSW 4 98,904,973 (GRCm39) missense probably benign 0.05
R4261:Dock7 UTSW 4 98,892,123 (GRCm39) missense possibly damaging 0.78
R4321:Dock7 UTSW 4 98,960,691 (GRCm39) missense probably damaging 1.00
R4522:Dock7 UTSW 4 98,850,461 (GRCm39) missense probably damaging 1.00
R4582:Dock7 UTSW 4 98,892,153 (GRCm39) missense possibly damaging 0.90
R4648:Dock7 UTSW 4 98,857,881 (GRCm39) nonsense probably null
R4940:Dock7 UTSW 4 98,908,314 (GRCm39) missense probably damaging 1.00
R5090:Dock7 UTSW 4 98,879,648 (GRCm39) missense probably benign 0.04
R5374:Dock7 UTSW 4 98,877,275 (GRCm39) missense possibly damaging 0.81
R5392:Dock7 UTSW 4 98,896,243 (GRCm39) missense probably damaging 1.00
R5527:Dock7 UTSW 4 98,842,105 (GRCm39) intron probably benign
R5544:Dock7 UTSW 4 98,855,494 (GRCm39) missense probably damaging 1.00
R5556:Dock7 UTSW 4 98,832,972 (GRCm39) missense probably damaging 1.00
R5870:Dock7 UTSW 4 98,952,199 (GRCm39) missense probably benign 0.00
R5899:Dock7 UTSW 4 98,879,660 (GRCm39) missense probably benign
R6360:Dock7 UTSW 4 98,857,899 (GRCm39) missense probably benign 0.02
R6415:Dock7 UTSW 4 98,880,685 (GRCm39) missense probably damaging 1.00
R6468:Dock7 UTSW 4 98,855,464 (GRCm39) missense probably benign 0.15
R6562:Dock7 UTSW 4 98,879,647 (GRCm39) missense probably damaging 0.97
R6613:Dock7 UTSW 4 98,866,197 (GRCm39) missense probably damaging 0.99
R6703:Dock7 UTSW 4 98,834,909 (GRCm39) missense probably damaging 1.00
R6723:Dock7 UTSW 4 98,892,153 (GRCm39) missense possibly damaging 0.90
R6786:Dock7 UTSW 4 98,949,529 (GRCm39) missense probably benign 0.42
R7026:Dock7 UTSW 4 98,967,156 (GRCm39) missense probably benign
R7051:Dock7 UTSW 4 98,834,969 (GRCm39) missense probably damaging 1.00
R7074:Dock7 UTSW 4 98,833,445 (GRCm39) missense unknown
R7106:Dock7 UTSW 4 98,855,563 (GRCm39) missense unknown
R7147:Dock7 UTSW 4 98,849,654 (GRCm39) missense unknown
R7257:Dock7 UTSW 4 98,861,649 (GRCm39) missense unknown
R7334:Dock7 UTSW 4 98,864,180 (GRCm39) missense unknown
R7511:Dock7 UTSW 4 98,967,992 (GRCm39) nonsense probably null
R7511:Dock7 UTSW 4 98,949,519 (GRCm39) missense
R7729:Dock7 UTSW 4 98,943,683 (GRCm39) missense
R7928:Dock7 UTSW 4 98,889,335 (GRCm39) missense
R7984:Dock7 UTSW 4 98,877,303 (GRCm39) missense unknown
R8287:Dock7 UTSW 4 98,866,157 (GRCm39) missense unknown
R8439:Dock7 UTSW 4 98,971,266 (GRCm39) missense
R8466:Dock7 UTSW 4 98,952,336 (GRCm39) missense possibly damaging 0.70
R8758:Dock7 UTSW 4 98,949,555 (GRCm39) missense
R8849:Dock7 UTSW 4 98,904,986 (GRCm39) missense
R8944:Dock7 UTSW 4 98,829,243 (GRCm39) missense probably damaging 1.00
R8964:Dock7 UTSW 4 98,949,476 (GRCm39) missense
R9008:Dock7 UTSW 4 98,833,448 (GRCm39) nonsense probably null
R9040:Dock7 UTSW 4 98,889,364 (GRCm39) nonsense probably null
R9160:Dock7 UTSW 4 98,857,962 (GRCm39) missense unknown
R9168:Dock7 UTSW 4 98,953,643 (GRCm39) missense
R9189:Dock7 UTSW 4 98,877,350 (GRCm39) missense unknown
R9215:Dock7 UTSW 4 98,859,088 (GRCm39) missense unknown
R9243:Dock7 UTSW 4 98,857,871 (GRCm39) missense unknown
R9256:Dock7 UTSW 4 98,971,272 (GRCm39) missense
R9328:Dock7 UTSW 4 98,968,064 (GRCm39) missense
R9332:Dock7 UTSW 4 98,896,280 (GRCm39) missense
R9450:Dock7 UTSW 4 98,861,426 (GRCm39) missense unknown
R9584:Dock7 UTSW 4 98,861,481 (GRCm39) nonsense probably null
R9631:Dock7 UTSW 4 98,854,560 (GRCm39) missense unknown
R9676:Dock7 UTSW 4 98,904,922 (GRCm39) missense probably damaging 1.00
R9701:Dock7 UTSW 4 98,846,384 (GRCm39) missense unknown
R9723:Dock7 UTSW 4 98,960,660 (GRCm39) missense
R9723:Dock7 UTSW 4 98,908,270 (GRCm39) missense
R9727:Dock7 UTSW 4 98,875,568 (GRCm39) missense unknown
R9777:Dock7 UTSW 4 98,877,464 (GRCm39) missense unknown
R9802:Dock7 UTSW 4 98,846,384 (GRCm39) missense unknown
X0027:Dock7 UTSW 4 98,892,090 (GRCm39) missense probably damaging 0.99
Z1176:Dock7 UTSW 4 98,833,462 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGTGTTGCAAATGCCAATTCCTGAG -3'
(R):5'- AGACAGGCACGTTGTTTTGTTTGAC -3'

Sequencing Primer
(F):5'- CACGTAAGTTCACAGTGTGAC -3'
(R):5'- CACATCCTGGGTGACAGATTACTG -3'
Posted On 2014-04-24