Incidental Mutation 'R0134:Or14a260'
ID 21822
Institutional Source Beutler Lab
Gene Symbol Or14a260
Ensembl Gene ENSMUSG00000055610
Gene Name olfactory receptor family 14 subfamily A member 260
Synonyms Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
MMRRC Submission 038419-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R0134 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 7
Chromosomal Location 86332176-86337586 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86335595 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 267 (I267T)
Ref Sequence ENSEMBL: ENSMUSP00000149779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069279] [ENSMUST00000213705] [ENSMUST00000217494]
AlphaFold Q8VFN8
Predicted Effect probably benign
Transcript: ENSMUST00000069279
AA Change: I267T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000063538
Gene: ENSMUSG00000055610
AA Change: I267T

low complexity region 5 16 N/A INTRINSIC
Pfam:7tm_4 29 306 1.6e-42 PFAM
Pfam:7tm_1 39 288 9.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213705
AA Change: I267T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000217494
AA Change: I267T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.4%
  • 20x: 93.3%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059E24Rik T C 19: 21,598,201 (GRCm38) probably benign Het
Abca16 T A 7: 120,540,155 (GRCm38) L1470Q probably damaging Het
Arhgap23 G T 11: 97,444,328 (GRCm38) V70L probably benign Het
Bicd1 T C 6: 149,512,950 (GRCm38) I387T probably benign Het
Btbd9 C T 17: 30,274,942 (GRCm38) D492N possibly damaging Het
Cd59b G A 2: 104,078,941 (GRCm38) probably null Het
Ddx50 A T 10: 62,621,377 (GRCm38) probably benign Het
Dele1 G A 18: 38,261,264 (GRCm38) V505I probably benign Het
Dnlz T C 2: 26,351,368 (GRCm38) N116S probably damaging Het
Efcab14 T C 4: 115,740,531 (GRCm38) F108L probably damaging Het
Esyt2 A G 12: 116,367,710 (GRCm38) N736S probably damaging Het
Exoc4 A G 6: 33,971,946 (GRCm38) D908G possibly damaging Het
Garnl3 T C 2: 33,006,804 (GRCm38) T608A possibly damaging Het
Hdac2 T A 10: 36,989,184 (GRCm38) D131E probably benign Het
Hes1 T C 16: 30,067,250 (GRCm38) V224A probably damaging Het
Hps1 G T 19: 42,766,180 (GRCm38) Q277K probably damaging Het
Ighv15-2 T G 12: 114,565,037 (GRCm38) probably benign Het
Il3 A G 11: 54,265,680 (GRCm38) probably null Het
Itgae A C 11: 73,111,342 (GRCm38) M91L probably benign Het
Kctd21 T A 7: 97,348,091 (GRCm38) I257N probably benign Het
Kif16b A T 2: 142,672,375 (GRCm38) S1215T probably benign Het
Lhx9 A T 1: 138,838,679 (GRCm38) C124S probably damaging Het
Lipo4 A G 19: 33,501,606 (GRCm38) V278A probably benign Het
Lrp1b T C 2: 40,596,983 (GRCm38) E142G probably damaging Het
Macf1 T C 4: 123,432,843 (GRCm38) M2835V possibly damaging Het
Map9 G A 3: 82,359,983 (GRCm38) probably benign Het
Miox C T 15: 89,334,454 (GRCm38) probably benign Het
Mndal A T 1: 173,857,513 (GRCm38) probably benign Het
Nanos3 C T 8: 84,176,134 (GRCm38) R133Q probably damaging Het
Nepn A T 10: 52,400,437 (GRCm38) T29S probably damaging Het
Nlgn1 C T 3: 25,435,925 (GRCm38) C546Y probably damaging Het
Or8k53 T C 2: 86,347,728 (GRCm38) I13V possibly damaging Het
Pdgfra A G 5: 75,166,511 (GRCm38) D123G probably damaging Het
Plekhn1 T C 4: 156,228,243 (GRCm38) R53G probably benign Het
Pnp2 T C 14: 50,963,177 (GRCm38) F100S probably damaging Het
Prickle1 A G 15: 93,510,777 (GRCm38) L47P possibly damaging Het
Ptar1 T A 19: 23,718,095 (GRCm38) C309S probably benign Het
Rimoc1 T C 15: 3,986,294 (GRCm38) K263E probably damaging Het
Rxfp1 A G 3: 79,657,476 (GRCm38) S327P probably damaging Het
Siah2 A G 3: 58,676,115 (GRCm38) V250A probably damaging Het
Siglecg G A 7: 43,411,171 (GRCm38) G325D probably damaging Het
Slc10a7 T A 8: 78,697,158 (GRCm38) probably null Het
Slc9a1 A G 4: 133,420,605 (GRCm38) K645E probably benign Het
Smarca4 T C 9: 21,637,324 (GRCm38) L302P probably damaging Het
Smyd1 G T 6: 71,216,765 (GRCm38) T392N probably damaging Het
Snrnp40 C G 4: 130,378,043 (GRCm38) probably null Het
Tenm3 A T 8: 48,674,472 (GRCm38) L57Q probably damaging Het
Tep1 C T 14: 50,829,693 (GRCm38) V2269I possibly damaging Het
Tpd52l1 A G 10: 31,379,256 (GRCm38) S32P probably damaging Het
Tsfm A G 10: 127,022,929 (GRCm38) probably benign Het
Ttn C A 2: 76,793,130 (GRCm38) V15368L possibly damaging Het
Ttn T A 2: 76,710,124 (GRCm38) R34173W probably damaging Het
Vmn2r13 C A 5: 109,175,049 (GRCm38) V125L probably benign Het
Vps13b T C 15: 35,887,261 (GRCm38) I3272T probably benign Het
Zfp108 A G 7: 24,260,467 (GRCm38) H161R probably benign Het
Zfp518b A G 5: 38,674,659 (GRCm38) M1T probably null Het
Other mutations in Or14a260
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or14a260 APN 7 86,336,061 (GRCm38) missense probably benign 0.00
IGL02419:Or14a260 APN 7 86,335,662 (GRCm38) missense probably damaging 0.98
IGL02519:Or14a260 APN 7 86,335,581 (GRCm38) missense probably benign 0.01
IGL02750:Or14a260 APN 7 86,335,544 (GRCm38) missense probably damaging 1.00
R0123:Or14a260 UTSW 7 86,335,595 (GRCm38) missense probably benign 0.02
R0225:Or14a260 UTSW 7 86,335,595 (GRCm38) missense probably benign 0.02
R1025:Or14a260 UTSW 7 86,335,905 (GRCm38) missense probably benign 0.09
R1511:Or14a260 UTSW 7 86,336,345 (GRCm38) missense possibly damaging 0.49
R1674:Or14a260 UTSW 7 86,335,557 (GRCm38) missense probably damaging 1.00
R2011:Or14a260 UTSW 7 86,335,747 (GRCm38) nonsense probably null
R4588:Or14a260 UTSW 7 86,335,644 (GRCm38) missense probably benign 0.00
R5637:Or14a260 UTSW 7 86,335,604 (GRCm38) missense probably benign 0.00
R6163:Or14a260 UTSW 7 86,336,384 (GRCm38) missense possibly damaging 0.84
R6407:Or14a260 UTSW 7 86,336,069 (GRCm38) missense possibly damaging 0.90
R7342:Or14a260 UTSW 7 86,336,087 (GRCm38) missense probably benign 0.00
R8066:Or14a260 UTSW 7 86,335,806 (GRCm38) missense probably benign 0.00
R8155:Or14a260 UTSW 7 86,336,178 (GRCm38) missense probably damaging 1.00
R8158:Or14a260 UTSW 7 86,335,677 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-04-12