Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02119:Vmn2r59'

280495

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r59

Ensembl Gene

ENSMUSG00000092032

Gene Name

vomeronasal 2, receptor 59

Synonyms

EG628444

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL02119

Quality Score

Status

Chromosome

Chromosomal Location

42011792-42058981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42046169 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 273 (V273A)

Ref Sequence

ENSEMBL: ENSMUSP00000131856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168489]

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121359

Predicted Effect

probably benign
Transcript: ENSMUST00000168489
AA Change: V273A

PolyPhen 2 Score 0.363 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: V273A

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.8e-44	PFAM
Pfam:NCD3G	514	567	4.3e-23	PFAM
Pfam:7tm_3	600	835	5.4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	A	2: 69,328,000		probably null	Het
Acsbg2	T	C	17: 56,868,459		probably benign	Het
Ap3b1	T	C	13: 94,462,403	V495A	probably benign	Het
Astn1	T	C	1: 158,511,154		probably benign	Het
Bora	A	G	14: 99,053,538	D94G	probably damaging	Het
Bpifb9b	G	T	2: 154,313,624	V348L	possibly damaging	Het
Cd160	A	T	3: 96,808,823	I17N	possibly damaging	Het
Cyp2d11	A	C	15: 82,390,064	I372S	probably damaging	Het
Dennd2c	T	A	3: 103,137,243	V380D	probably damaging	Het
Fat4	C	T	3: 38,982,939	A3580V	probably benign	Het
Filip1	A	G	9: 79,818,266	S1024P	probably benign	Het
Flnc	G	A	6: 29,447,512	E1105K	probably damaging	Het
Gbp4	T	A	5: 105,121,042	E415V	probably benign	Het
Gdap1l1	T	A	2: 163,453,668	F224Y	probably damaging	Het
Gm11146	A	T	16: 77,588,610		probably null	Het
Gsn	G	T	2: 35,302,495	R485L	probably damaging	Het
Havcr1	A	G	11: 46,775,493	Y261C	probably damaging	Het
Maneal	A	T	4: 124,859,167	I229N	probably benign	Het
Med24	A	T	11: 98,728,835	M27K	probably benign	Het
Nipsnap2	T	A	5: 129,747,992		probably benign	Het
Noa1	T	A	5: 77,307,579	Q430L	probably benign	Het
Olfr1099	T	C	2: 86,959,183	I92V	probably benign	Het
Olfr365	C	A	2: 37,201,269	S9R	possibly damaging	Het
Olfr74	T	A	2: 87,974,410	N85I	probably benign	Het
Olfr834	T	C	9: 18,988,612	V208A	probably benign	Het
Pde3a	T	A	6: 141,459,803	S460R	probably damaging	Het
Pdzd8	T	C	19: 59,300,490	Q826R	possibly damaging	Het
Pfkfb4	C	T	9: 109,025,110	R351W	probably damaging	Het
Pikfyve	T	A	1: 65,272,571	I1989N	probably damaging	Het
Poldip2	T	A	11: 78,517,908	F200I	probably damaging	Het
Prodh2	T	C	7: 30,506,504	V208A	probably damaging	Het
Ranbp10	T	C	8: 105,827,003	D89G	probably damaging	Het
Rbm33	T	A	5: 28,339,017	S90R	probably damaging	Het
Slc44a4	A	C	17: 34,928,661	D441A	probably damaging	Het
Slc4a10	A	T	2: 62,228,670	I174F	probably damaging	Het
Smim17	T	C	7: 6,427,161		probably benign	Het
Tln1	T	C	4: 43,546,760	E872G	probably damaging	Het
Tmem214	G	A	5: 30,872,746	A296T	probably benign	Het
Top2b	T	C	14: 16,406,733	L625S	probably damaging	Het
Vmn2r9	G	A	5: 108,843,636	L620F	probably damaging	Het
Whrn	T	G	4: 63,435,487	K348Q	probably damaging	Het
Zc3h14	T	C	12: 98,763,895	V399A	probably benign	Het

Other mutations in Vmn2r59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Vmn2r59	APN	7	42012064	missense	possibly damaging	0.91
IGL01432:Vmn2r59	APN	7	42012559	missense	possibly damaging	0.82
IGL02216:Vmn2r59	APN	7	42012393	missense	probably damaging	1.00
IGL02327:Vmn2r59	APN	7	42012231	missense	probably benign
IGL03346:Vmn2r59	APN	7	42043829	missense	probably benign	0.00
IGL03411:Vmn2r59	APN	7	42058916	missense	probably benign	0.43
IGL03412:Vmn2r59	APN	7	42012438	missense	probably benign
PIT4366001:Vmn2r59	UTSW	7	42045781	missense	possibly damaging	0.91
R0068:Vmn2r59	UTSW	7	42046301	missense	probably damaging	0.99
R0094:Vmn2r59	UTSW	7	42012298	missense	probably benign	0.07
R0179:Vmn2r59	UTSW	7	42047008	nonsense	probably null
R0370:Vmn2r59	UTSW	7	42012726	missense	probably benign	0.23
R0412:Vmn2r59	UTSW	7	42046492	splice site	probably benign
R0465:Vmn2r59	UTSW	7	42046908	missense	probably benign
R0487:Vmn2r59	UTSW	7	42047104	nonsense	probably null
R0576:Vmn2r59	UTSW	7	42047105	missense	probably benign	0.01
R0632:Vmn2r59	UTSW	7	42058884	missense	probably damaging	1.00
R1356:Vmn2r59	UTSW	7	42011794	makesense	probably null
R1387:Vmn2r59	UTSW	7	42046097	missense	probably damaging	1.00
R1388:Vmn2r59	UTSW	7	42045709	missense	probably benign	0.01
R1435:Vmn2r59	UTSW	7	42046205	missense	possibly damaging	0.50
R1750:Vmn2r59	UTSW	7	42045827	missense	possibly damaging	0.50
R2020:Vmn2r59	UTSW	7	42043779	missense	probably damaging	1.00
R2249:Vmn2r59	UTSW	7	42058902	missense	probably benign	0.00
R2256:Vmn2r59	UTSW	7	42012245	nonsense	probably null
R2257:Vmn2r59	UTSW	7	42012245	nonsense	probably null
R2441:Vmn2r59	UTSW	7	42046146	missense	probably benign	0.00
R2511:Vmn2r59	UTSW	7	42043766	missense	probably damaging	1.00
R2860:Vmn2r59	UTSW	7	42047003	missense	possibly damaging	0.79
R2861:Vmn2r59	UTSW	7	42047003	missense	possibly damaging	0.79
R3690:Vmn2r59	UTSW	7	42011946	missense	possibly damaging	0.77
R3912:Vmn2r59	UTSW	7	42046320	missense	probably benign	0.00
R4167:Vmn2r59	UTSW	7	42021308	intron	probably benign
R4357:Vmn2r59	UTSW	7	42012220	missense	probably damaging	1.00
R4445:Vmn2r59	UTSW	7	42042450	missense	probably damaging	1.00
R4542:Vmn2r59	UTSW	7	42046073	missense	possibly damaging	0.93
R4587:Vmn2r59	UTSW	7	42046224	missense	probably benign	0.00
R4616:Vmn2r59	UTSW	7	42012438	missense	probably benign
R4653:Vmn2r59	UTSW	7	42043804	missense	probably benign	0.19
R4703:Vmn2r59	UTSW	7	42012262	missense	probably benign	0.01
R4895:Vmn2r59	UTSW	7	42045794	missense	probably damaging	0.98
R4910:Vmn2r59	UTSW	7	42043653	missense	probably benign
R5045:Vmn2r59	UTSW	7	42046072	missense	possibly damaging	0.93
R5105:Vmn2r59	UTSW	7	42047105	missense	probably benign	0.01
R5153:Vmn2r59	UTSW	7	42042410	critical splice donor site	probably null
R5566:Vmn2r59	UTSW	7	42046823	missense	possibly damaging	0.92
R5586:Vmn2r59	UTSW	7	42045681	missense	probably benign	0.12
R5606:Vmn2r59	UTSW	7	42045894	missense	probably benign	0.27
R5616:Vmn2r59	UTSW	7	42058767	splice site	probably null
R5625:Vmn2r59	UTSW	7	42046460	missense	probably benign	0.03
R5696:Vmn2r59	UTSW	7	42046044	missense	probably benign	0.00
R5982:Vmn2r59	UTSW	7	42046067	missense	probably benign	0.00
R6106:Vmn2r59	UTSW	7	42012325	nonsense	probably null
R6196:Vmn2r59	UTSW	7	42012255	missense	probably benign	0.36
R6228:Vmn2r59	UTSW	7	42042411	critical splice donor site	probably null
R6590:Vmn2r59	UTSW	7	42046466	missense	probably damaging	1.00
R6625:Vmn2r59	UTSW	7	42043753	missense	probably benign	0.02
R6690:Vmn2r59	UTSW	7	42046466	missense	probably damaging	1.00
R6768:Vmn2r59	UTSW	7	42011968	missense	probably benign	0.17
R6830:Vmn2r59	UTSW	7	42043747	missense	probably benign	0.10
R6859:Vmn2r59	UTSW	7	42043853	missense	probably damaging	1.00
R7034:Vmn2r59	UTSW	7	42046220	missense	probably benign	0.03
R7036:Vmn2r59	UTSW	7	42046220	missense	probably benign	0.03
R7145:Vmn2r59	UTSW	7	42045764	missense	probably damaging	1.00
R7556:Vmn2r59	UTSW	7	42045809	missense	probably damaging	1.00
R7733:Vmn2r59	UTSW	7	42012019	missense	probably benign	0.17
R7770:Vmn2r59	UTSW	7	42058912	missense	probably damaging	1.00
R7812:Vmn2r59	UTSW	7	42045772	nonsense	probably null
X0025:Vmn2r59	UTSW	7	42045941	missense	probably damaging	1.00
Z1088:Vmn2r59	UTSW	7	42012414	missense	possibly damaging	0.85

Posted On

2015-04-16