Incidental Mutation 'R5982:Vmn2r59'
| ID |
481453 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| MMRRC Submission |
044163-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R5982 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 41695491 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 307
(D307G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000121359
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168489
AA Change: D307G
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: D307G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.5%
- 20x: 92.2%
|
| Validation Efficiency |
98% (81/83) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
T |
A |
11: 109,844,423 (GRCm39) |
E931D |
possibly damaging |
Het |
| Aebp1 |
C |
T |
11: 5,817,911 (GRCm39) |
T62I |
possibly damaging |
Het |
| Babam2 |
A |
T |
5: 31,977,964 (GRCm39) |
E139V |
possibly damaging |
Het |
| Bclaf1 |
C |
T |
10: 20,198,809 (GRCm39) |
R67* |
probably null |
Het |
| Bcr |
C |
A |
10: 75,012,248 (GRCm39) |
T51K |
probably benign |
Het |
| Best3 |
T |
A |
10: 116,840,322 (GRCm39) |
C251S |
probably damaging |
Het |
| Birc6 |
A |
G |
17: 74,955,153 (GRCm39) |
M3457V |
probably benign |
Het |
| C87436 |
C |
A |
6: 86,422,957 (GRCm39) |
T177K |
possibly damaging |
Het |
| Cabin1 |
T |
A |
10: 75,561,394 (GRCm39) |
T1036S |
probably benign |
Het |
| Catsperg2 |
C |
A |
7: 29,412,442 (GRCm39) |
V383L |
possibly damaging |
Het |
| Ccdc182 |
C |
T |
11: 88,185,165 (GRCm39) |
Q82* |
probably null |
Het |
| Ccl9 |
T |
C |
11: 83,466,700 (GRCm39) |
T76A |
probably damaging |
Het |
| Cdc16 |
G |
T |
8: 13,831,399 (GRCm39) |
C544F |
possibly damaging |
Het |
| Cdh18 |
A |
C |
15: 23,474,302 (GRCm39) |
D724A |
possibly damaging |
Het |
| Cdip1 |
G |
A |
16: 4,587,946 (GRCm39) |
P6S |
probably damaging |
Het |
| Col12a1 |
A |
G |
9: 79,537,842 (GRCm39) |
V2542A |
probably damaging |
Het |
| Dnajc13 |
G |
T |
9: 104,061,814 (GRCm39) |
T1380K |
possibly damaging |
Het |
| Dsg4 |
T |
A |
18: 20,598,226 (GRCm39) |
S715T |
possibly damaging |
Het |
| Dync2h1 |
G |
T |
9: 6,955,986 (GRCm39) |
T4132K |
probably benign |
Het |
| Egfem1 |
A |
T |
3: 29,711,419 (GRCm39) |
|
probably null |
Het |
| Etl4 |
G |
T |
2: 20,785,826 (GRCm39) |
V716L |
probably damaging |
Het |
| Exoc3l2 |
A |
G |
7: 19,213,957 (GRCm39) |
E461G |
unknown |
Het |
| Fam135b |
A |
G |
15: 71,320,518 (GRCm39) |
|
probably null |
Het |
| Flrt3 |
G |
T |
2: 140,502,836 (GRCm39) |
P264Q |
possibly damaging |
Het |
| Fmn2 |
G |
C |
1: 174,330,019 (GRCm39) |
E136D |
unknown |
Het |
| Fosl2 |
A |
G |
5: 32,304,217 (GRCm39) |
I51V |
probably benign |
Het |
| Foxm1 |
A |
G |
6: 128,347,998 (GRCm39) |
T307A |
probably damaging |
Het |
| Garem1 |
T |
C |
18: 21,281,408 (GRCm39) |
D316G |
possibly damaging |
Het |
| Gm14403 |
A |
T |
2: 177,200,345 (GRCm39) |
H97L |
probably damaging |
Het |
| Gm5616 |
A |
G |
9: 48,361,890 (GRCm39) |
|
noncoding transcript |
Het |
| Hkdc1 |
T |
C |
10: 62,229,589 (GRCm39) |
D696G |
probably benign |
Het |
| Igkv1-88 |
C |
A |
6: 68,839,432 (GRCm39) |
W60L |
probably damaging |
Het |
| Iqgap3 |
G |
A |
3: 87,998,899 (GRCm39) |
W333* |
probably null |
Het |
| Itgb4 |
C |
T |
11: 115,874,983 (GRCm39) |
R447W |
probably benign |
Het |
| Kcnk3 |
G |
T |
5: 30,780,014 (GRCm39) |
V355L |
probably benign |
Het |
| Kmt5c |
A |
C |
7: 4,749,790 (GRCm39) |
K436T |
probably damaging |
Het |
| Lynx1 |
T |
C |
15: 74,623,264 (GRCm39) |
Y56C |
possibly damaging |
Het |
| Lypd5 |
T |
C |
7: 24,052,462 (GRCm39) |
S149P |
probably damaging |
Het |
| Map3k21 |
A |
T |
8: 126,638,169 (GRCm39) |
N252Y |
probably damaging |
Het |
| Mgat2 |
T |
C |
12: 69,232,454 (GRCm39) |
W343R |
probably damaging |
Het |
| Misp |
T |
G |
10: 79,663,728 (GRCm39) |
Y567* |
probably null |
Het |
| Mrgprb1 |
A |
T |
7: 48,097,568 (GRCm39) |
S115T |
probably benign |
Het |
| Muc16 |
A |
C |
9: 18,558,442 (GRCm39) |
I2617R |
unknown |
Het |
| Myo19 |
T |
A |
11: 84,790,226 (GRCm39) |
V394E |
probably damaging |
Het |
| Myo9b |
T |
A |
8: 71,801,040 (GRCm39) |
L1065Q |
probably benign |
Het |
| Nap1l1 |
A |
G |
10: 111,331,229 (GRCm39) |
D405G |
possibly damaging |
Het |
| Napb |
A |
T |
2: 148,542,411 (GRCm39) |
|
probably null |
Het |
| Nbas |
A |
G |
12: 13,443,431 (GRCm39) |
Y1162C |
probably benign |
Het |
| Nfam1 |
A |
T |
15: 82,917,325 (GRCm39) |
L36Q |
probably damaging |
Het |
| Nrros |
T |
C |
16: 31,963,411 (GRCm39) |
D202G |
probably damaging |
Het |
| Or51k1 |
T |
G |
7: 103,661,117 (GRCm39) |
H264P |
probably damaging |
Het |
| Or7a39 |
T |
G |
10: 78,715,787 (GRCm39) |
Y260* |
probably null |
Het |
| Osgin2 |
T |
C |
4: 15,998,908 (GRCm39) |
E238G |
probably benign |
Het |
| Papss2 |
A |
G |
19: 32,616,636 (GRCm39) |
T221A |
probably benign |
Het |
| Pcdhga12 |
A |
C |
18: 37,901,084 (GRCm39) |
K639Q |
probably damaging |
Het |
| Pkhd1l1 |
T |
A |
15: 44,352,900 (GRCm39) |
|
probably null |
Het |
| Pmepa1 |
A |
G |
2: 173,076,105 (GRCm39) |
S83P |
possibly damaging |
Het |
| Pnp |
G |
A |
14: 51,188,000 (GRCm39) |
V118M |
probably damaging |
Het |
| Ppat |
T |
C |
5: 77,063,112 (GRCm39) |
T500A |
probably benign |
Het |
| Pramel22 |
C |
A |
4: 143,381,034 (GRCm39) |
V330F |
probably damaging |
Het |
| Rab11fip4 |
A |
G |
11: 79,581,601 (GRCm39) |
N532S |
probably benign |
Het |
| Rbm25 |
A |
G |
12: 83,718,725 (GRCm39) |
D499G |
probably damaging |
Het |
| Rnf139 |
A |
G |
15: 58,770,687 (GRCm39) |
I237M |
possibly damaging |
Het |
| Rrp15 |
C |
T |
1: 186,471,952 (GRCm39) |
S85N |
possibly damaging |
Het |
| Sidt1 |
T |
C |
16: 44,082,071 (GRCm39) |
Y568C |
probably damaging |
Het |
| Slirp |
A |
G |
12: 87,490,784 (GRCm39) |
T29A |
probably damaging |
Het |
| Sltm |
G |
C |
9: 70,494,086 (GRCm39) |
E828Q |
probably damaging |
Het |
| Spindoc |
A |
G |
19: 7,351,960 (GRCm39) |
I129T |
probably damaging |
Het |
| Spire1 |
T |
A |
18: 67,630,386 (GRCm39) |
|
probably null |
Het |
| Styx |
A |
G |
14: 45,605,909 (GRCm39) |
T138A |
probably benign |
Het |
| Sv2c |
A |
T |
13: 96,112,571 (GRCm39) |
L642* |
probably null |
Het |
| Taf7 |
T |
C |
18: 37,776,498 (GRCm39) |
E23G |
probably damaging |
Het |
| Tcp10a |
A |
T |
17: 7,612,425 (GRCm39) |
T406S |
possibly damaging |
Het |
| Tnrc6b |
T |
A |
15: 80,765,017 (GRCm39) |
S840T |
probably benign |
Het |
| Tns3 |
A |
G |
11: 8,442,245 (GRCm39) |
I706T |
probably damaging |
Het |
| Tpsab1 |
A |
G |
17: 25,564,346 (GRCm39) |
V36A |
probably benign |
Het |
| Trafd1 |
T |
A |
5: 121,511,342 (GRCm39) |
D492V |
probably damaging |
Het |
| Trp53 |
A |
G |
11: 69,478,244 (GRCm39) |
E51G |
probably benign |
Het |
| Vdr |
C |
T |
15: 97,755,477 (GRCm39) |
A349T |
probably benign |
Het |
| Zfp365 |
C |
A |
10: 67,733,437 (GRCm39) |
V252F |
probably damaging |
Het |
| Zfp830 |
T |
A |
11: 82,655,803 (GRCm39) |
N202K |
probably benign |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTGGGTTGGCAGTTCTCC -3'
(R):5'- TGATCTCTGGCACATGGAATG -3'
Sequencing Primer
(F):5'- GGCAGTTCTCCAAAAGTTGAC -3'
(R):5'- CTCTGGCACATGGAATGCATATTC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation