Incidental Mutation 'IGL01432:Vmn2r59'
| ID |
84145 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r59
|
| Ensembl Gene |
ENSMUSG00000092032 |
| Gene Name |
vomeronasal 2, receptor 59 |
| Synonyms |
EG628444 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
IGL01432
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 41661983 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 611
(V611I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
| AlphaFold |
E9PUT5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168489
AA Change: V611I
PolyPhen 2
Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: V611I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh9a1 |
T |
C |
1: 167,183,354 (GRCm39) |
S191P |
probably damaging |
Het |
| Aldoart2 |
A |
T |
12: 55,612,566 (GRCm39) |
I164F |
probably damaging |
Het |
| Anapc1 |
C |
A |
2: 128,475,328 (GRCm39) |
A1384S |
probably damaging |
Het |
| Arid5a |
T |
G |
1: 36,358,514 (GRCm39) |
S429A |
possibly damaging |
Het |
| Asxl1 |
A |
G |
2: 153,242,125 (GRCm39) |
K892E |
probably benign |
Het |
| Bltp1 |
T |
A |
3: 37,057,908 (GRCm39) |
V3166E |
possibly damaging |
Het |
| Bpnt1 |
G |
A |
1: 185,086,218 (GRCm39) |
W261* |
probably null |
Het |
| Calu |
A |
G |
6: 29,356,552 (GRCm39) |
D26G |
possibly damaging |
Het |
| Ccdc113 |
C |
T |
8: 96,264,885 (GRCm39) |
|
probably benign |
Het |
| Cd109 |
T |
C |
9: 78,605,405 (GRCm39) |
Y1003H |
probably benign |
Het |
| Cdh9 |
A |
G |
15: 16,831,033 (GRCm39) |
K290R |
probably damaging |
Het |
| Cep131 |
G |
A |
11: 119,967,835 (GRCm39) |
A140V |
possibly damaging |
Het |
| Cfap251 |
A |
G |
5: 123,418,015 (GRCm39) |
I81M |
possibly damaging |
Het |
| Chn1 |
A |
T |
2: 73,462,096 (GRCm39) |
C236S |
probably damaging |
Het |
| Cntn4 |
T |
A |
6: 106,655,295 (GRCm39) |
|
probably benign |
Het |
| Crispld1 |
A |
T |
1: 17,817,025 (GRCm39) |
Q194L |
probably benign |
Het |
| Csmd3 |
A |
G |
15: 47,596,895 (GRCm39) |
V1981A |
probably damaging |
Het |
| Cttn |
A |
G |
7: 144,015,043 (GRCm39) |
I55T |
probably damaging |
Het |
| Ddx46 |
G |
T |
13: 55,785,835 (GRCm39) |
|
probably benign |
Het |
| Diaph1 |
A |
T |
18: 38,030,557 (GRCm39) |
I299N |
unknown |
Het |
| Dll1 |
A |
G |
17: 15,588,768 (GRCm39) |
Y636H |
probably damaging |
Het |
| Eng |
A |
T |
2: 32,559,544 (GRCm39) |
Q111L |
possibly damaging |
Het |
| Exoc6 |
T |
C |
19: 37,578,324 (GRCm39) |
V389A |
possibly damaging |
Het |
| Fbxw26 |
T |
A |
9: 109,547,043 (GRCm39) |
T461S |
probably benign |
Het |
| Gbf1 |
T |
C |
19: 46,268,434 (GRCm39) |
Y1269H |
probably damaging |
Het |
| Gm5852 |
A |
G |
3: 93,635,086 (GRCm39) |
Y90H |
possibly damaging |
Het |
| Gnrhr |
C |
T |
5: 86,330,052 (GRCm39) |
G323R |
probably damaging |
Het |
| Gpr155 |
T |
A |
2: 73,182,229 (GRCm39) |
E661D |
possibly damaging |
Het |
| Grik4 |
A |
T |
9: 42,432,472 (GRCm39) |
C842S |
probably damaging |
Het |
| Iws1 |
A |
G |
18: 32,216,519 (GRCm39) |
|
probably benign |
Het |
| Kif5c |
A |
G |
2: 49,591,089 (GRCm39) |
T314A |
probably damaging |
Het |
| Klhdc1 |
A |
C |
12: 69,298,751 (GRCm39) |
K112T |
probably damaging |
Het |
| Kmt2a |
T |
C |
9: 44,720,393 (GRCm39) |
T3865A |
unknown |
Het |
| Lgr5 |
T |
C |
10: 115,288,997 (GRCm39) |
K477R |
probably damaging |
Het |
| Ly75 |
A |
T |
2: 60,206,351 (GRCm39) |
L106Q |
probably damaging |
Het |
| Mcph1 |
T |
A |
8: 18,675,655 (GRCm39) |
M26K |
probably damaging |
Het |
| Mettl2 |
T |
C |
11: 105,017,348 (GRCm39) |
V9A |
probably benign |
Het |
| Mgat5b |
A |
G |
11: 116,864,202 (GRCm39) |
D456G |
probably benign |
Het |
| Mstn |
A |
G |
1: 53,105,689 (GRCm39) |
T344A |
possibly damaging |
Het |
| Npr1 |
T |
A |
3: 90,370,543 (GRCm39) |
I308F |
possibly damaging |
Het |
| Oasl1 |
G |
A |
5: 115,075,466 (GRCm39) |
V509M |
probably benign |
Het |
| Obscn |
T |
C |
11: 58,924,583 (GRCm39) |
M5727V |
probably benign |
Het |
| Or2d4 |
T |
C |
7: 106,543,748 (GRCm39) |
I153M |
possibly damaging |
Het |
| Or4c114 |
T |
A |
2: 88,904,545 (GRCm39) |
I297F |
probably benign |
Het |
| Or4k15c |
T |
A |
14: 50,321,404 (GRCm39) |
T245S |
probably benign |
Het |
| Or5an1c |
A |
G |
19: 12,218,891 (GRCm39) |
S45P |
probably damaging |
Het |
| Pcgf1 |
T |
C |
6: 83,055,398 (GRCm39) |
I11T |
possibly damaging |
Het |
| Phactr3 |
T |
C |
2: 177,924,893 (GRCm39) |
V276A |
probably benign |
Het |
| Pla2g6 |
A |
T |
15: 79,202,168 (GRCm39) |
M1K |
probably null |
Het |
| Plec |
T |
C |
15: 76,074,728 (GRCm39) |
E413G |
probably damaging |
Het |
| Plxna2 |
G |
T |
1: 194,326,626 (GRCm39) |
A187S |
possibly damaging |
Het |
| Polq |
A |
T |
16: 36,892,184 (GRCm39) |
|
probably benign |
Het |
| Pramel51 |
T |
C |
12: 88,143,202 (GRCm39) |
K139E |
probably benign |
Het |
| Prss39 |
A |
G |
1: 34,541,216 (GRCm39) |
D240G |
probably benign |
Het |
| Ptpn12 |
A |
T |
5: 21,203,553 (GRCm39) |
Y408* |
probably null |
Het |
| Ptprt |
A |
G |
2: 162,109,999 (GRCm39) |
|
probably benign |
Het |
| Rnf6 |
A |
T |
5: 146,152,931 (GRCm39) |
S95T |
possibly damaging |
Het |
| Ryr2 |
T |
C |
13: 11,866,090 (GRCm39) |
S287G |
possibly damaging |
Het |
| Samd4b |
A |
G |
7: 28,113,491 (GRCm39) |
F158S |
possibly damaging |
Het |
| Slco1a5 |
T |
A |
6: 142,182,012 (GRCm39) |
I571L |
possibly damaging |
Het |
| Smchd1 |
T |
C |
17: 71,738,285 (GRCm39) |
T527A |
probably damaging |
Het |
| Smg9 |
T |
C |
7: 24,120,691 (GRCm39) |
|
probably null |
Het |
| Snx25 |
A |
G |
8: 46,558,197 (GRCm39) |
L270P |
probably damaging |
Het |
| Ssh1 |
G |
T |
5: 114,096,883 (GRCm39) |
T165N |
probably benign |
Het |
| Stk24 |
T |
A |
14: 121,540,218 (GRCm39) |
E127V |
probably damaging |
Het |
| Suco |
A |
G |
1: 161,661,689 (GRCm39) |
V914A |
probably damaging |
Het |
| Tbcd |
T |
A |
11: 121,366,506 (GRCm39) |
|
probably benign |
Het |
| Tbcel |
A |
T |
9: 42,355,817 (GRCm39) |
L114Q |
possibly damaging |
Het |
| Trpm1 |
A |
G |
7: 63,884,767 (GRCm39) |
D816G |
probably benign |
Het |
| Uhrf1 |
G |
A |
17: 56,625,250 (GRCm39) |
V566M |
probably damaging |
Het |
| Ulk4 |
T |
A |
9: 121,095,367 (GRCm39) |
E95D |
probably damaging |
Het |
| Vmn1r40 |
T |
C |
6: 89,691,201 (GRCm39) |
M6T |
probably benign |
Het |
| Vwde |
G |
T |
6: 13,193,239 (GRCm39) |
H367N |
probably benign |
Het |
| Xpo6 |
A |
G |
7: 125,723,553 (GRCm39) |
V585A |
probably benign |
Het |
|
| Other mutations in Vmn2r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-11-11 |
Incidental Mutation