Incidental Mutation 'R9433:Vmn2r59'
ID |
713097 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r59
|
Ensembl Gene |
ENSMUSG00000092032 |
Gene Name |
vomeronasal 2, receptor 59 |
Synonyms |
EG628444 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R9433 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 41695590 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 274
(I274T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
AlphaFold |
E9PUT5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000168489
AA Change: I274T
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000131856 Gene: ENSMUSG00000092032 AA Change: I274T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 79 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam4 |
T |
C |
12: 81,466,723 (GRCm39) |
T633A |
possibly damaging |
Het |
Adgrv1 |
A |
T |
13: 81,714,471 (GRCm39) |
F937L |
probably benign |
Het |
Adipor2 |
A |
T |
6: 119,336,486 (GRCm39) |
F159Y |
probably damaging |
Het |
Ahcyl1 |
A |
G |
3: 107,575,645 (GRCm39) |
V380A |
probably damaging |
Het |
Akp3 |
A |
G |
1: 87,053,517 (GRCm39) |
K157E |
probably benign |
Het |
Arpc1a |
T |
A |
5: 145,045,203 (GRCm39) |
I364N |
possibly damaging |
Het |
Bach1 |
C |
G |
16: 87,516,603 (GRCm39) |
S381R |
probably benign |
Het |
Brms1l |
G |
A |
12: 55,912,863 (GRCm39) |
|
probably null |
Het |
Camk1d |
A |
G |
2: 5,680,777 (GRCm39) |
S6P |
unknown |
Het |
Ccdc112 |
C |
A |
18: 46,424,040 (GRCm39) |
V233L |
probably benign |
Het |
Ccdc113 |
A |
T |
8: 96,272,613 (GRCm39) |
N240I |
possibly damaging |
Het |
Ccdc168 |
A |
T |
1: 44,095,668 (GRCm39) |
V1810E |
possibly damaging |
Het |
Ccdc6 |
T |
C |
10: 70,004,951 (GRCm39) |
V232A |
possibly damaging |
Het |
Cct5 |
A |
G |
15: 31,592,883 (GRCm39) |
I409T |
possibly damaging |
Het |
Cd96 |
A |
G |
16: 45,856,298 (GRCm39) |
Y583H |
probably damaging |
Het |
Cdh22 |
C |
T |
2: 164,954,329 (GRCm39) |
V731M |
probably benign |
Het |
Clcn1 |
C |
T |
6: 42,282,494 (GRCm39) |
P521S |
probably damaging |
Het |
Clec18a |
C |
T |
8: 111,808,322 (GRCm39) |
A27T |
probably benign |
Het |
Cnnm2 |
C |
T |
19: 46,750,807 (GRCm39) |
A199V |
probably benign |
Het |
Copg1 |
G |
A |
6: 87,880,478 (GRCm39) |
A494T |
possibly damaging |
Het |
Cpsf2 |
A |
G |
12: 101,948,252 (GRCm39) |
E16G |
probably damaging |
Het |
Cyp2j5 |
T |
A |
4: 96,552,244 (GRCm39) |
I2F |
probably benign |
Het |
Dgkg |
T |
A |
16: 22,384,065 (GRCm39) |
N463Y |
probably damaging |
Het |
Dnah11 |
T |
C |
12: 117,976,007 (GRCm39) |
D2804G |
probably damaging |
Het |
Efcab12 |
T |
C |
6: 115,792,995 (GRCm39) |
N488D |
probably benign |
Het |
Etv5 |
G |
A |
16: 22,254,668 (GRCm39) |
P64L |
probably damaging |
Het |
Fbrs |
A |
G |
7: 127,084,272 (GRCm39) |
E468G |
probably benign |
Het |
Fcho1 |
A |
T |
8: 72,169,468 (GRCm39) |
M146K |
probably benign |
Het |
Gad1 |
A |
T |
2: 70,423,807 (GRCm39) |
M405L |
|
Het |
Gcc2 |
T |
A |
10: 58,106,592 (GRCm39) |
H609Q |
probably benign |
Het |
Gm11983 |
A |
T |
11: 6,786,902 (GRCm39) |
M75K |
unknown |
Het |
Gm4353 |
T |
A |
7: 115,682,871 (GRCm39) |
I237F |
probably damaging |
Het |
H1f0 |
C |
T |
15: 78,912,947 (GRCm39) |
P9L |
probably damaging |
Het |
Hcn4 |
A |
G |
9: 58,731,222 (GRCm39) |
D143G |
unknown |
Het |
Id1 |
T |
A |
2: 152,578,430 (GRCm39) |
V57D |
probably damaging |
Het |
Ifna13 |
T |
C |
4: 88,562,540 (GRCm39) |
Q28R |
probably benign |
Het |
Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
Lonrf2 |
G |
A |
1: 38,875,538 (GRCm39) |
|
probably benign |
Het |
Magi3 |
C |
T |
3: 103,922,473 (GRCm39) |
A1415T |
probably benign |
Het |
Mia2 |
A |
G |
12: 59,148,371 (GRCm39) |
E77G |
probably damaging |
Het |
Muc16 |
T |
A |
9: 18,483,937 (GRCm39) |
Q6945L |
probably benign |
Het |
Nos2 |
G |
A |
11: 78,850,490 (GRCm39) |
R1116H |
probably damaging |
Het |
Or2w4 |
C |
T |
13: 21,795,224 (GRCm39) |
C305Y |
probably benign |
Het |
Parpbp |
A |
C |
10: 87,975,858 (GRCm39) |
V85G |
probably benign |
Het |
Pcmtd2 |
C |
T |
2: 181,496,837 (GRCm39) |
H273Y |
possibly damaging |
Het |
Pcp4l1 |
C |
T |
1: 171,001,998 (GRCm39) |
G54D |
probably damaging |
Het |
Pkdrej |
T |
C |
15: 85,704,070 (GRCm39) |
H622R |
probably benign |
Het |
Plxnd1 |
G |
T |
6: 115,945,754 (GRCm39) |
D906E |
probably benign |
Het |
Pnpla8 |
T |
C |
12: 44,330,305 (GRCm39) |
S286P |
probably damaging |
Het |
Prss36 |
C |
T |
7: 127,533,339 (GRCm39) |
V631I |
probably benign |
Het |
Ptpn9 |
A |
T |
9: 56,964,010 (GRCm39) |
N381I |
possibly damaging |
Het |
Ranbp9 |
A |
T |
13: 43,576,041 (GRCm39) |
I222N |
probably damaging |
Het |
Rev1 |
T |
C |
1: 38,092,173 (GRCm39) |
T1249A |
probably damaging |
Het |
Ripply2 |
G |
T |
9: 86,901,715 (GRCm39) |
W80C |
probably damaging |
Het |
Rnaseh2b |
C |
A |
14: 62,602,722 (GRCm39) |
P235Q |
probably benign |
Het |
Sacs |
T |
A |
14: 61,443,997 (GRCm39) |
F2014L |
probably damaging |
Het |
Serpinb9f |
A |
G |
13: 33,518,238 (GRCm39) |
N246S |
probably benign |
Het |
Sh3pxd2a |
A |
T |
19: 47,255,539 (GRCm39) |
S1088T |
probably damaging |
Het |
Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
Skint3 |
A |
G |
4: 112,137,432 (GRCm39) |
I367V |
probably benign |
Het |
Slc20a2 |
G |
T |
8: 23,051,211 (GRCm39) |
E415* |
probably null |
Het |
Slc5a1 |
T |
A |
5: 33,310,025 (GRCm39) |
S418T |
probably benign |
Het |
Spats2 |
G |
T |
15: 99,076,446 (GRCm39) |
G175* |
probably null |
Het |
Srebf1 |
A |
T |
11: 60,095,015 (GRCm39) |
F485L |
possibly damaging |
Het |
St8sia4 |
A |
G |
1: 95,555,364 (GRCm39) |
V222A |
|
Het |
Stab1 |
C |
T |
14: 30,865,531 (GRCm39) |
E1786K |
probably benign |
Het |
Stat2 |
A |
G |
10: 128,112,657 (GRCm39) |
M58V |
probably benign |
Het |
Stat5a |
A |
G |
11: 100,765,870 (GRCm39) |
T319A |
probably benign |
Het |
Sufu |
A |
G |
19: 46,385,532 (GRCm39) |
|
probably benign |
Het |
Tle6 |
T |
A |
10: 81,426,880 (GRCm39) |
I579F |
probably damaging |
Het |
Tmem131l |
A |
T |
3: 83,845,459 (GRCm39) |
D390E |
probably benign |
Het |
Trim33 |
T |
A |
3: 103,228,979 (GRCm39) |
|
probably null |
Het |
Usp54 |
A |
G |
14: 20,611,678 (GRCm39) |
V1046A |
probably benign |
Het |
Vit |
G |
A |
17: 78,932,413 (GRCm39) |
G507R |
probably damaging |
Het |
Vmn2r67 |
T |
A |
7: 84,804,917 (GRCm39) |
K65M |
possibly damaging |
Het |
Vmn2r86 |
C |
T |
10: 130,282,567 (GRCm39) |
G683E |
possibly damaging |
Het |
Vwa8 |
T |
C |
14: 79,335,871 (GRCm39) |
|
probably null |
Het |
Zdhhc14 |
A |
G |
17: 5,781,779 (GRCm39) |
D333G |
probably benign |
Het |
Zup1 |
G |
A |
10: 33,795,355 (GRCm39) |
S568L |
probably damaging |
Het |
|
Other mutations in Vmn2r59 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
R7812:Vmn2r59
|
UTSW |
7 |
41,695,196 (GRCm39) |
nonsense |
probably null |
|
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCAACCATCTCTTCACGGTGG -3'
(R):5'- GTCACTTGCCATAGTCTTGTTG -3'
Sequencing Primer
(F):5'- ACCCAGACTTTCCATGTC -3'
(R):5'- GGTCTGATCCTCCCAGATGAC -3'
|
Posted On |
2022-05-16 |