Incidental Mutation 'R4517:Cyp4f37'
ID |
332968 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cyp4f37
|
Ensembl Gene |
ENSMUSG00000062464 |
Gene Name |
cytochrome P450, family 4, subfamily f, polypeptide 37 |
Synonyms |
Gm9705 |
MMRRC Submission |
041761-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.222)
|
Stock # |
R4517 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
32840283-32855158 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 32850566 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Valine
at position 340
(I340V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000076827
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077639]
|
AlphaFold |
Q3V1F1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000077639
AA Change: I340V
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000076827 Gene: ENSMUSG00000062464 AA Change: I340V
Domain | Start | End | E-Value | Type |
Pfam:p450
|
52 |
515 |
1.1e-136 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.6%
|
Validation Efficiency |
95% (39/41) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ank |
A |
G |
15: 27,562,835 (GRCm39) |
H181R |
possibly damaging |
Het |
B4galnt4 |
A |
G |
7: 140,647,635 (GRCm39) |
K408E |
probably damaging |
Het |
Cd209a |
T |
A |
8: 3,795,525 (GRCm39) |
D123V |
probably damaging |
Het |
Echs1 |
A |
G |
7: 139,692,409 (GRCm39) |
S113P |
possibly damaging |
Het |
Fap |
T |
C |
2: 62,361,059 (GRCm39) |
I391V |
probably benign |
Het |
Glb1l |
C |
T |
1: 75,185,347 (GRCm39) |
C121Y |
probably damaging |
Het |
Glod4 |
T |
A |
11: 76,134,397 (GRCm39) |
D25V |
probably damaging |
Het |
Gpc5 |
T |
A |
14: 115,789,651 (GRCm39) |
N508K |
possibly damaging |
Het |
H2-M10.3 |
C |
T |
17: 36,678,722 (GRCm39) |
|
probably null |
Het |
Ibsp |
C |
A |
5: 104,453,863 (GRCm39) |
S67* |
probably null |
Het |
Ifit1bl2 |
C |
T |
19: 34,607,164 (GRCm39) |
|
probably benign |
Het |
Iqgap2 |
A |
G |
13: 95,800,569 (GRCm39) |
|
probably null |
Het |
Kcnma1 |
A |
G |
14: 23,387,097 (GRCm39) |
S982P |
probably damaging |
Het |
Kif5b |
T |
C |
18: 6,213,272 (GRCm39) |
S707G |
probably benign |
Het |
Lrrk2 |
A |
G |
15: 91,589,323 (GRCm39) |
I437V |
probably benign |
Het |
Mapkbp1 |
T |
C |
2: 119,855,545 (GRCm39) |
|
probably benign |
Het |
Mcu |
T |
C |
10: 59,303,456 (GRCm39) |
Y127C |
probably damaging |
Het |
Mlst8 |
T |
C |
17: 24,695,031 (GRCm39) |
Y284C |
probably damaging |
Het |
Nr2f2 |
T |
G |
7: 70,007,870 (GRCm39) |
N204T |
probably benign |
Het |
Or13a26 |
A |
G |
7: 140,285,004 (GRCm39) |
Y280C |
probably damaging |
Het |
Or7a42 |
T |
A |
10: 78,791,877 (GRCm39) |
Y279* |
probably null |
Het |
Pabir3 |
G |
A |
X: 52,382,376 (GRCm39) |
R94H |
possibly damaging |
Het |
Pcf11 |
T |
C |
7: 92,295,696 (GRCm39) |
Y1451C |
probably damaging |
Het |
Plekhn1 |
T |
C |
4: 156,309,988 (GRCm39) |
S109G |
probably damaging |
Het |
Rttn |
T |
C |
18: 89,047,097 (GRCm39) |
S920P |
probably damaging |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Tas2r135 |
A |
T |
6: 42,383,013 (GRCm39) |
H184L |
probably benign |
Het |
Tmem38a |
C |
T |
8: 73,326,005 (GRCm39) |
P20S |
possibly damaging |
Het |
Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
Vmn2r102 |
A |
G |
17: 19,901,475 (GRCm39) |
Y534C |
probably damaging |
Het |
Wdr62 |
A |
G |
7: 29,969,683 (GRCm39) |
V259A |
probably damaging |
Het |
Whrn |
A |
G |
4: 63,379,517 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Cyp4f37 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01140:Cyp4f37
|
APN |
17 |
32,848,027 (GRCm39) |
missense |
probably benign |
0.20 |
IGL01994:Cyp4f37
|
APN |
17 |
32,844,150 (GRCm39) |
nonsense |
probably null |
|
IGL02073:Cyp4f37
|
APN |
17 |
32,846,825 (GRCm39) |
missense |
possibly damaging |
0.59 |
IGL02145:Cyp4f37
|
APN |
17 |
32,849,009 (GRCm39) |
missense |
probably benign |
0.43 |
IGL02814:Cyp4f37
|
APN |
17 |
32,853,645 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02873:Cyp4f37
|
APN |
17 |
32,844,142 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02937:Cyp4f37
|
APN |
17 |
32,844,163 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03170:Cyp4f37
|
APN |
17 |
32,844,093 (GRCm39) |
splice site |
probably benign |
|
R0625:Cyp4f37
|
UTSW |
17 |
32,853,652 (GRCm39) |
missense |
probably damaging |
1.00 |
R1774:Cyp4f37
|
UTSW |
17 |
32,848,864 (GRCm39) |
missense |
possibly damaging |
0.59 |
R1871:Cyp4f37
|
UTSW |
17 |
32,853,639 (GRCm39) |
missense |
probably damaging |
1.00 |
R2232:Cyp4f37
|
UTSW |
17 |
32,853,244 (GRCm39) |
missense |
probably benign |
0.23 |
R2847:Cyp4f37
|
UTSW |
17 |
32,848,099 (GRCm39) |
missense |
probably damaging |
1.00 |
R2848:Cyp4f37
|
UTSW |
17 |
32,848,099 (GRCm39) |
missense |
probably damaging |
1.00 |
R4027:Cyp4f37
|
UTSW |
17 |
32,850,646 (GRCm39) |
missense |
probably benign |
0.00 |
R4463:Cyp4f37
|
UTSW |
17 |
32,846,710 (GRCm39) |
critical splice acceptor site |
probably null |
|
R4573:Cyp4f37
|
UTSW |
17 |
32,848,061 (GRCm39) |
missense |
probably benign |
0.23 |
R4670:Cyp4f37
|
UTSW |
17 |
32,844,126 (GRCm39) |
missense |
probably benign |
|
R5752:Cyp4f37
|
UTSW |
17 |
32,850,306 (GRCm39) |
missense |
probably damaging |
1.00 |
R5930:Cyp4f37
|
UTSW |
17 |
32,848,957 (GRCm39) |
missense |
possibly damaging |
0.79 |
R6248:Cyp4f37
|
UTSW |
17 |
32,848,864 (GRCm39) |
missense |
possibly damaging |
0.59 |
R7412:Cyp4f37
|
UTSW |
17 |
32,848,818 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7969:Cyp4f37
|
UTSW |
17 |
32,844,181 (GRCm39) |
missense |
probably benign |
0.00 |
R8066:Cyp4f37
|
UTSW |
17 |
32,854,047 (GRCm39) |
missense |
probably benign |
0.21 |
R8187:Cyp4f37
|
UTSW |
17 |
32,854,171 (GRCm39) |
missense |
probably benign |
|
R8303:Cyp4f37
|
UTSW |
17 |
32,853,152 (GRCm39) |
critical splice acceptor site |
probably null |
|
R8309:Cyp4f37
|
UTSW |
17 |
32,853,952 (GRCm39) |
missense |
probably damaging |
1.00 |
R8407:Cyp4f37
|
UTSW |
17 |
32,853,158 (GRCm39) |
missense |
probably damaging |
1.00 |
R8869:Cyp4f37
|
UTSW |
17 |
32,844,096 (GRCm39) |
missense |
probably benign |
0.01 |
R9054:Cyp4f37
|
UTSW |
17 |
32,853,253 (GRCm39) |
missense |
probably benign |
0.25 |
R9565:Cyp4f37
|
UTSW |
17 |
32,844,205 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9674:Cyp4f37
|
UTSW |
17 |
32,846,841 (GRCm39) |
critical splice donor site |
probably null |
|
X0057:Cyp4f37
|
UTSW |
17 |
32,844,198 (GRCm39) |
missense |
probably benign |
0.01 |
|
Predicted Primers |
PCR Primer
(F):5'- GTAGAGGTGTGCCAGTCTCAAG -3'
(R):5'- AATCCCTAAAAGCACGGGG -3'
Sequencing Primer
(F):5'- GCCAGTCTCAAGTAACTATTTTGGG -3'
(R):5'- GGGGTTAAGACTCTGTAATCCAACC -3'
|
Posted On |
2015-08-18 |