Incidental Mutation 'R4665:Arhgef4'
| ID |
351797 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef4
|
| Ensembl Gene |
ENSMUSG00000037509 |
| Gene Name |
Rho guanine nucleotide exchange factor 4 |
| Synonyms |
Asef, 9330140K16Rik, C230030N03Rik |
| MMRRC Submission |
041923-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4665 (G1)
|
| Quality Score |
196 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
34717263-34851819 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 34845113 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Valine
at position 1439
(G1439V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124213
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047664]
[ENSMUST00000159021]
[ENSMUST00000159747]
[ENSMUST00000160855]
[ENSMUST00000162599]
[ENSMUST00000211073]
|
| AlphaFold |
Q7TNR9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047664
AA Change: G68V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000035980
Gene: ENSMUSG00000037509
AA Change: G68V
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
RhoGEF
|
82 |
261 |
3.86e-56 |
SMART |
|
PH
|
294 |
402 |
2.33e-14 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159021
AA Change: G151V
PolyPhen 2
Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000124467
Gene: ENSMUSG00000037509
AA Change: G151V
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
190 |
3.4e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159059
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159747
AA Change: G1439V
PolyPhen 2
Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124213
Gene: ENSMUSG00000037509
AA Change: G1439V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
584 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1254 |
N/A |
INTRINSIC |
|
SH3
|
1361 |
1416 |
3.73e-16 |
SMART |
|
RhoGEF
|
1453 |
1632 |
3.86e-56 |
SMART |
|
PH
|
1665 |
1773 |
2.33e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160855
AA Change: G68V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000124207
Gene: ENSMUSG00000037509
AA Change: G68V
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
187 |
1.2e-21 |
PFAM |
|
low complexity region
|
194 |
211 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000162599
AA Change: G272V
PolyPhen 2
Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000124906
Gene: ENSMUSG00000037509
AA Change: G272V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
87 |
N/A |
INTRINSIC |
|
SH3
|
194 |
249 |
3.73e-16 |
SMART |
|
Pfam:RhoGEF
|
304 |
405 |
1.2e-25 |
PFAM |
|
PH
|
438 |
546 |
2.33e-14 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162760
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211073
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193040
|
| Meta Mutation Damage Score |
0.0769 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
99% (89/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Targeted, other(1) |
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
T |
A |
6: 86,902,059 (GRCm39) |
M76K |
probably null |
Het |
| Abcc4 |
A |
G |
14: 118,766,414 (GRCm39) |
I886T |
probably benign |
Het |
| Adam6a |
T |
C |
12: 113,507,992 (GRCm39) |
Y122H |
possibly damaging |
Het |
| Adgre1 |
A |
G |
17: 57,787,947 (GRCm39) |
T905A |
probably benign |
Het |
| Arap2 |
A |
G |
5: 62,827,312 (GRCm39) |
F969L |
possibly damaging |
Het |
| Atm |
A |
G |
9: 53,375,529 (GRCm39) |
W2097R |
probably benign |
Het |
| Atmin |
A |
G |
8: 117,684,698 (GRCm39) |
D786G |
probably damaging |
Het |
| AU016765 |
T |
A |
17: 64,826,916 (GRCm39) |
|
noncoding transcript |
Het |
| Capn1 |
A |
T |
19: 6,061,045 (GRCm39) |
N253K |
probably benign |
Het |
| Cdc42bpa |
A |
G |
1: 179,972,130 (GRCm39) |
T527A |
probably damaging |
Het |
| Chmp7 |
A |
T |
14: 69,958,404 (GRCm39) |
V255D |
probably damaging |
Het |
| Cldn12 |
A |
G |
5: 5,558,385 (GRCm39) |
F14S |
probably damaging |
Het |
| Cpsf2 |
T |
C |
12: 101,949,466 (GRCm39) |
S61P |
probably damaging |
Het |
| Cpvl |
C |
T |
6: 53,908,918 (GRCm39) |
E282K |
probably benign |
Het |
| Crygn |
T |
A |
5: 24,956,019 (GRCm39) |
|
probably benign |
Het |
| Csde1 |
C |
T |
3: 102,954,388 (GRCm39) |
T386M |
probably damaging |
Het |
| Cux1 |
G |
A |
5: 136,315,653 (GRCm39) |
T1129I |
probably damaging |
Het |
| Dcaf10 |
G |
A |
4: 45,372,769 (GRCm39) |
R394Q |
possibly damaging |
Het |
| Dhx16 |
T |
C |
17: 36,190,835 (GRCm39) |
V11A |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,905,536 (GRCm39) |
M4060T |
possibly damaging |
Het |
| Duox1 |
C |
T |
2: 122,149,956 (GRCm39) |
P116S |
probably benign |
Het |
| Eif5b |
A |
G |
1: 38,084,793 (GRCm39) |
E880G |
probably damaging |
Het |
| Eml6 |
A |
T |
11: 29,769,007 (GRCm39) |
Y67* |
probably null |
Het |
| Faim2 |
C |
A |
15: 99,422,581 (GRCm39) |
|
probably null |
Het |
| Faim2 |
T |
G |
15: 99,422,582 (GRCm39) |
S72R |
probably benign |
Het |
| Fanca |
T |
C |
8: 123,995,711 (GRCm39) |
T1364A |
probably damaging |
Het |
| Fhip1a |
A |
T |
3: 85,637,988 (GRCm39) |
W104R |
probably damaging |
Het |
| Gak |
A |
G |
5: 108,730,826 (GRCm39) |
I860T |
probably benign |
Het |
| Garem2 |
C |
A |
5: 30,319,665 (GRCm39) |
R376S |
probably damaging |
Het |
| Gdf2 |
A |
G |
14: 33,667,408 (GRCm39) |
T377A |
probably damaging |
Het |
| Gm2431 |
A |
T |
7: 141,811,440 (GRCm39) |
C155S |
unknown |
Het |
| Gm5814 |
A |
G |
17: 47,721,288 (GRCm39) |
M1V |
probably null |
Het |
| Gm5901 |
C |
G |
7: 105,026,438 (GRCm39) |
Q69E |
possibly damaging |
Het |
| Gm9945 |
A |
G |
11: 53,371,202 (GRCm39) |
|
probably benign |
Het |
| Gmps |
T |
C |
3: 63,908,956 (GRCm39) |
V486A |
probably benign |
Het |
| Gtf2ird1 |
T |
A |
5: 134,412,756 (GRCm39) |
E55V |
probably damaging |
Het |
| Hoxa11 |
T |
A |
6: 52,220,483 (GRCm39) |
N267Y |
probably damaging |
Het |
| Ifngr2 |
C |
A |
16: 91,356,926 (GRCm39) |
H153Q |
possibly damaging |
Het |
| Ift172 |
G |
T |
5: 31,442,598 (GRCm39) |
Q190K |
possibly damaging |
Het |
| Iqch |
A |
G |
9: 63,352,853 (GRCm39) |
V899A |
probably damaging |
Het |
| Lactb2 |
T |
C |
1: 13,717,624 (GRCm39) |
E133G |
probably damaging |
Het |
| Lig3 |
G |
A |
11: 82,691,076 (GRCm39) |
V110M |
probably damaging |
Het |
| Lin54 |
C |
A |
5: 100,600,943 (GRCm39) |
Q262H |
possibly damaging |
Het |
| Lingo3 |
G |
A |
10: 80,671,372 (GRCm39) |
T186I |
probably damaging |
Het |
| Lrrc7 |
GAAGTTGTTTGGAGATTCTTATCTTA |
GA |
3: 158,024,045 (GRCm39) |
|
probably benign |
Het |
| Ly86 |
T |
A |
13: 37,559,010 (GRCm39) |
F70I |
probably damaging |
Het |
| Mospd2 |
A |
T |
X: 163,730,329 (GRCm39) |
S301T |
probably benign |
Het |
| Mroh2a |
A |
C |
1: 88,169,340 (GRCm39) |
I672L |
probably benign |
Het |
| Myo15a |
A |
T |
11: 60,395,705 (GRCm39) |
|
probably null |
Het |
| Nme8 |
C |
G |
13: 19,858,605 (GRCm39) |
A78P |
probably damaging |
Het |
| Obscn |
C |
T |
11: 59,015,578 (GRCm39) |
V965M |
probably damaging |
Het |
| Or10ag57 |
T |
A |
2: 87,218,220 (GRCm39) |
I57K |
probably damaging |
Het |
| Parn |
T |
C |
16: 13,358,967 (GRCm39) |
K592E |
probably benign |
Het |
| Pax6 |
C |
A |
2: 105,514,343 (GRCm39) |
|
probably benign |
Het |
| Pdcd6 |
A |
T |
13: 74,465,325 (GRCm39) |
M1K |
probably null |
Het |
| Pex11b |
T |
C |
3: 96,551,151 (GRCm39) |
L198P |
possibly damaging |
Het |
| Phldb3 |
C |
T |
7: 24,310,852 (GRCm39) |
A28V |
probably benign |
Het |
| Pkn3 |
C |
A |
2: 29,975,469 (GRCm39) |
|
probably benign |
Het |
| Pknox1 |
T |
C |
17: 31,814,300 (GRCm39) |
|
probably null |
Het |
| Ptprg |
A |
C |
14: 12,215,288 (GRCm38) |
I1092L |
possibly damaging |
Het |
| Pxylp1 |
A |
C |
9: 96,707,338 (GRCm39) |
I281M |
probably damaging |
Het |
| Ramac |
C |
T |
7: 81,418,178 (GRCm39) |
R78W |
probably damaging |
Het |
| Retreg2 |
G |
T |
1: 75,121,310 (GRCm39) |
L195F |
probably damaging |
Het |
| Rgs20 |
G |
C |
1: 5,091,231 (GRCm39) |
F66L |
probably benign |
Het |
| Ripk4 |
C |
T |
16: 97,556,273 (GRCm39) |
V157I |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,765,571 (GRCm39) |
|
probably null |
Het |
| Scaper |
A |
T |
9: 55,819,339 (GRCm39) |
S125R |
probably damaging |
Het |
| Sec16a |
C |
T |
2: 26,302,970 (GRCm39) |
|
probably benign |
Het |
| Slc35f6 |
T |
C |
5: 30,812,957 (GRCm39) |
L37P |
probably damaging |
Het |
| Slc6a12 |
T |
A |
6: 121,335,972 (GRCm39) |
|
probably benign |
Het |
| Slc9a5 |
A |
G |
8: 106,094,760 (GRCm39) |
K784E |
probably damaging |
Het |
| Snd1 |
T |
C |
6: 28,707,053 (GRCm39) |
V455A |
probably damaging |
Het |
| Ssbp2 |
A |
T |
13: 91,687,454 (GRCm39) |
I46L |
possibly damaging |
Het |
| Stil |
A |
G |
4: 114,898,841 (GRCm39) |
D1157G |
probably benign |
Het |
| Tax1bp1 |
T |
A |
6: 52,714,116 (GRCm39) |
C271S |
probably benign |
Het |
| Tdpoz6 |
G |
A |
3: 93,599,776 (GRCm39) |
H198Y |
probably damaging |
Het |
| Tdrd6 |
T |
A |
17: 43,935,007 (GRCm39) |
M2014L |
probably benign |
Het |
| Thsd7a |
T |
A |
6: 12,504,012 (GRCm39) |
I381F |
possibly damaging |
Het |
| Thsd7a |
T |
A |
6: 12,337,313 (GRCm39) |
T1235S |
possibly damaging |
Het |
| Tmprss11d |
T |
C |
5: 86,457,260 (GRCm39) |
D133G |
probably damaging |
Het |
| Tpr |
C |
T |
1: 150,320,150 (GRCm39) |
R2233W |
probably damaging |
Het |
| Ugt1a1 |
CAGAGAGAGAGAGA |
CAGAGAGAGAGA |
1: 88,139,706 (GRCm39) |
|
probably benign |
Het |
| Vgll1 |
A |
G |
X: 56,137,792 (GRCm39) |
R54G |
possibly damaging |
Het |
| Wdr72 |
A |
G |
9: 74,117,306 (GRCm39) |
T673A |
probably benign |
Het |
| Zfp169 |
C |
T |
13: 48,644,339 (GRCm39) |
|
probably benign |
Het |
| Zfp319 |
G |
A |
8: 96,052,201 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Arhgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Arhgef4
|
APN |
1 |
34,850,777 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02376:Arhgef4
|
APN |
1 |
34,845,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Arhgef4
|
APN |
1 |
34,850,804 (GRCm39) |
nonsense |
probably null |
|
|
IGL03240:Arhgef4
|
APN |
1 |
34,845,107 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB004:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Arhgef4
|
UTSW |
1 |
34,771,451 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Arhgef4
|
UTSW |
1 |
34,845,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Arhgef4
|
UTSW |
1 |
34,846,080 (GRCm39) |
splice site |
probably null |
|
|
R0383:Arhgef4
|
UTSW |
1 |
34,849,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Arhgef4
|
UTSW |
1 |
34,784,529 (GRCm39) |
splice site |
probably null |
|
|
R0452:Arhgef4
|
UTSW |
1 |
34,771,403 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0893:Arhgef4
|
UTSW |
1 |
34,846,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1429:Arhgef4
|
UTSW |
1 |
34,849,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Arhgef4
|
UTSW |
1 |
34,763,026 (GRCm39) |
missense |
unknown |
|
|
R1669:Arhgef4
|
UTSW |
1 |
34,771,239 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1780:Arhgef4
|
UTSW |
1 |
34,763,241 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1809:Arhgef4
|
UTSW |
1 |
34,849,636 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1879:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R1908:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1919:Arhgef4
|
UTSW |
1 |
34,850,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2020:Arhgef4
|
UTSW |
1 |
34,762,891 (GRCm39) |
missense |
unknown |
|
|
R2058:Arhgef4
|
UTSW |
1 |
34,761,458 (GRCm39) |
missense |
unknown |
|
|
R2213:Arhgef4
|
UTSW |
1 |
34,846,230 (GRCm39) |
splice site |
probably null |
|
|
R2851:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2852:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2853:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R3697:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R4012:Arhgef4
|
UTSW |
1 |
34,764,187 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4118:Arhgef4
|
UTSW |
1 |
34,771,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Arhgef4
|
UTSW |
1 |
34,845,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4535:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4581:Arhgef4
|
UTSW |
1 |
34,771,205 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4678:Arhgef4
|
UTSW |
1 |
34,761,749 (GRCm39) |
missense |
unknown |
|
|
R4684:Arhgef4
|
UTSW |
1 |
34,850,866 (GRCm39) |
splice site |
probably null |
|
|
R4706:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4745:Arhgef4
|
UTSW |
1 |
34,846,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4747:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R4988:Arhgef4
|
UTSW |
1 |
34,762,535 (GRCm39) |
missense |
unknown |
|
|
R5063:Arhgef4
|
UTSW |
1 |
34,763,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5154:Arhgef4
|
UTSW |
1 |
34,771,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5156:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R5263:Arhgef4
|
UTSW |
1 |
34,764,078 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5450:Arhgef4
|
UTSW |
1 |
34,846,405 (GRCm39) |
intron |
probably benign |
|
|
R5807:Arhgef4
|
UTSW |
1 |
34,846,696 (GRCm39) |
intron |
probably benign |
|
|
R5863:Arhgef4
|
UTSW |
1 |
34,761,926 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6311:Arhgef4
|
UTSW |
1 |
34,763,062 (GRCm39) |
missense |
unknown |
|
|
R6315:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6316:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6318:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6323:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6324:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6325:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6340:Arhgef4
|
UTSW |
1 |
34,771,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Arhgef4
|
UTSW |
1 |
34,845,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Arhgef4
|
UTSW |
1 |
34,761,533 (GRCm39) |
missense |
unknown |
|
|
R7087:Arhgef4
|
UTSW |
1 |
34,850,767 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7297:Arhgef4
|
UTSW |
1 |
34,846,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Arhgef4
|
UTSW |
1 |
34,848,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Arhgef4
|
UTSW |
1 |
34,771,316 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7693:Arhgef4
|
UTSW |
1 |
34,763,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7892:Arhgef4
|
UTSW |
1 |
34,760,885 (GRCm39) |
missense |
unknown |
|
|
R7895:Arhgef4
|
UTSW |
1 |
34,845,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Arhgef4
|
UTSW |
1 |
34,850,762 (GRCm39) |
missense |
probably benign |
|
|
R7973:Arhgef4
|
UTSW |
1 |
34,763,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7979:Arhgef4
|
UTSW |
1 |
34,760,978 (GRCm39) |
missense |
unknown |
|
|
R8160:Arhgef4
|
UTSW |
1 |
34,762,655 (GRCm39) |
missense |
unknown |
|
|
R8175:Arhgef4
|
UTSW |
1 |
34,849,455 (GRCm39) |
missense |
probably benign |
|
|
R8178:Arhgef4
|
UTSW |
1 |
34,761,983 (GRCm39) |
missense |
unknown |
|
|
R9046:Arhgef4
|
UTSW |
1 |
34,850,846 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9077:Arhgef4
|
UTSW |
1 |
34,760,824 (GRCm39) |
missense |
unknown |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,849,576 (GRCm39) |
missense |
probably benign |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,764,241 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9355:Arhgef4
|
UTSW |
1 |
34,849,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9489:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9509:Arhgef4
|
UTSW |
1 |
34,762,772 (GRCm39) |
missense |
unknown |
|
|
R9605:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9665:Arhgef4
|
UTSW |
1 |
34,849,518 (GRCm39) |
missense |
probably benign |
|
|
R9675:Arhgef4
|
UTSW |
1 |
34,845,108 (GRCm39) |
missense |
probably benign |
|
|
R9790:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9791:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF012:Arhgef4
|
UTSW |
1 |
34,763,565 (GRCm39) |
small deletion |
probably benign |
|
|
X0062:Arhgef4
|
UTSW |
1 |
34,763,308 (GRCm39) |
missense |
probably benign |
0.35 |
|
YA93:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,844,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,762,810 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,447 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,002 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TACTGGCCTCAGCTTCAGATG -3'
(R):5'- GTACCCCACTATATGCCACG -3'
Sequencing Primer
(F):5'- CTTCAGATGACCTAGAGCGGAGTTC -3'
(R):5'- AGTGTACCACGCCCTCTGAC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation