Incidental Mutation 'R4697:Cntn4'
| ID |
355770 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cntn4
|
| Ensembl Gene |
ENSMUSG00000064293 |
| Gene Name |
contactin 4 |
| Synonyms |
BIG-2A, Axcam |
| MMRRC Submission |
041947-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.397)
|
| Stock # |
R4697 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
105677660-106699310 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 106525485 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 401
(V401A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108889
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079416]
[ENSMUST00000089208]
[ENSMUST00000113258]
[ENSMUST00000113260]
[ENSMUST00000113261]
[ENSMUST00000113264]
|
| AlphaFold |
Q69Z26 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000079416
AA Change: V401A
PolyPhen 2
Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000078385
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089208
AA Change: V401A
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000086616
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113258
AA Change: V401A
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108883
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113260
AA Change: V401A
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108885
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113261
AA Change: V401A
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108886
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113264
AA Change: V401A
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108889
Gene: ENSMUSG00000064293
AA Change: V401A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IGc2
|
41 |
107 |
2.32e-8 |
SMART |
|
IG
|
129 |
215 |
3.4e-6 |
SMART |
|
IGc2
|
238 |
302 |
8.76e-18 |
SMART |
|
IGc2
|
328 |
391 |
2.91e-14 |
SMART |
|
IGc2
|
420 |
484 |
1.58e-10 |
SMART |
|
IG
|
504 |
594 |
9.55e-10 |
SMART |
|
FN3
|
597 |
683 |
1.54e-11 |
SMART |
|
FN3
|
700 |
786 |
8.39e0 |
SMART |
|
FN3
|
801 |
886 |
1.33e-6 |
SMART |
|
FN3
|
901 |
981 |
9.85e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125904
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132395
|
| Meta Mutation Damage Score |
0.7231 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.5%
|
| Validation Efficiency |
96% (75/78) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9030624J02Rik |
T |
A |
7: 118,791,448 |
I455N |
probably damaging |
Het |
| A2m |
T |
C |
6: 121,638,284 |
M1T |
probably null |
Het |
| Aatf |
T |
A |
11: 84,449,138 |
D449V |
probably damaging |
Het |
| Acbd3 |
T |
A |
1: 180,721,944 |
|
probably benign |
Het |
| BC005561 |
A |
G |
5: 104,522,240 |
K1543E |
probably benign |
Het |
| Bicc1 |
T |
A |
10: 70,953,484 |
I366F |
possibly damaging |
Het |
| Ccdc74a |
T |
C |
16: 17,649,749 |
S184P |
possibly damaging |
Het |
| Cux2 |
T |
C |
5: 121,873,753 |
T540A |
probably damaging |
Het |
| Disp2 |
G |
T |
2: 118,791,684 |
E966* |
probably null |
Het |
| Dpp7 |
A |
G |
2: 25,354,919 |
Y209H |
probably benign |
Het |
| Dstyk |
T |
A |
1: 132,449,487 |
F277Y |
probably damaging |
Het |
| Dtx1 |
A |
T |
5: 120,694,408 |
|
probably null |
Het |
| Ear-ps2 |
G |
A |
14: 44,047,060 |
|
noncoding transcript |
Het |
| Ednra |
T |
C |
8: 77,664,995 |
H422R |
probably benign |
Het |
| Erlec1 |
T |
A |
11: 30,952,640 |
I67F |
probably benign |
Het |
| Fam161b |
G |
A |
12: 84,348,558 |
|
probably benign |
Het |
| Gata5 |
A |
T |
2: 180,327,379 |
C345* |
probably null |
Het |
| Glmp |
T |
C |
3: 88,328,274 |
V47A |
probably damaging |
Het |
| Gm9762 |
T |
A |
3: 78,966,550 |
|
noncoding transcript |
Het |
| Gnas |
A |
T |
2: 174,298,080 |
D14V |
probably damaging |
Het |
| Gnl3 |
T |
C |
14: 31,017,329 |
S53G |
probably damaging |
Het |
| Grhl3 |
C |
T |
4: 135,548,466 |
V527M |
probably damaging |
Het |
| Hoxd10 |
T |
A |
2: 74,694,187 |
L281* |
probably null |
Het |
| Kif16b |
T |
G |
2: 142,690,694 |
Y1175S |
probably benign |
Het |
| Kif2b |
A |
G |
11: 91,576,846 |
S204P |
probably benign |
Het |
| Klhl40 |
T |
A |
9: 121,778,734 |
I320N |
probably damaging |
Het |
| Ksr2 |
G |
A |
5: 117,708,147 |
R693Q |
probably damaging |
Het |
| Mis12 |
A |
G |
11: 71,025,326 |
K62E |
possibly damaging |
Het |
| Mlc1 |
A |
G |
15: 88,974,777 |
C102R |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,857,361 |
I1348T |
unknown |
Het |
| Myh7b |
A |
G |
2: 155,629,322 |
E1130G |
probably damaging |
Het |
| Nat8f4 |
T |
C |
6: 85,901,386 |
T52A |
probably benign |
Het |
| Nxpe2 |
C |
A |
9: 48,320,521 |
V379L |
probably benign |
Het |
| Olfr1231 |
C |
A |
2: 89,302,902 |
S230I |
possibly damaging |
Het |
| Olfr1231 |
T |
A |
2: 89,302,903 |
S230C |
probably damaging |
Het |
| Olfr1448 |
C |
T |
19: 12,919,934 |
C125Y |
probably damaging |
Het |
| Olfr1465 |
A |
T |
19: 13,313,717 |
D189E |
probably benign |
Het |
| Olfr288 |
G |
A |
15: 98,186,868 |
R310W |
probably damaging |
Het |
| Pcdhga7 |
A |
T |
18: 37,717,208 |
Y756F |
probably damaging |
Het |
| Pcsk6 |
T |
A |
7: 65,959,241 |
Y284N |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,126,347 |
V1367A |
possibly damaging |
Het |
| Postn |
T |
A |
3: 54,375,071 |
N484K |
probably damaging |
Het |
| Prkd3 |
C |
T |
17: 78,961,171 |
V572I |
probably benign |
Het |
| Qser1 |
T |
C |
2: 104,787,183 |
S1005G |
probably benign |
Het |
| Radil |
G |
T |
5: 142,486,801 |
D951E |
probably benign |
Het |
| Ripk1 |
C |
T |
13: 34,027,942 |
R352* |
probably null |
Het |
| Sacs |
T |
C |
14: 61,212,747 |
F4081L |
probably benign |
Het |
| Sbf1 |
A |
G |
15: 89,315,085 |
V11A |
possibly damaging |
Het |
| Sgip1 |
T |
A |
4: 102,934,587 |
F536I |
probably damaging |
Het |
| Slc45a1 |
A |
G |
4: 150,638,284 |
L381P |
probably damaging |
Het |
| Smarcad1 |
C |
T |
6: 65,052,641 |
P71L |
probably benign |
Het |
| Spns1 |
T |
A |
7: 126,377,037 |
D14V |
probably damaging |
Het |
| Sv2c |
T |
A |
13: 95,986,018 |
I417F |
possibly damaging |
Het |
| Tas2r113 |
T |
A |
6: 132,893,516 |
M169K |
probably benign |
Het |
| Tgm1 |
A |
T |
14: 55,705,681 |
N567K |
probably benign |
Het |
| Tln2 |
C |
T |
9: 67,395,461 |
R76Q |
probably damaging |
Het |
| Trpm6 |
T |
C |
19: 18,853,791 |
V1340A |
probably benign |
Het |
| Tspan18 |
A |
T |
2: 93,312,030 |
|
probably null |
Het |
| Txndc11 |
C |
T |
16: 11,084,314 |
V679I |
probably damaging |
Het |
| Usf1 |
G |
T |
1: 171,416,964 |
G144V |
possibly damaging |
Het |
| Vmn1r59 |
T |
C |
7: 5,454,452 |
Y103C |
probably damaging |
Het |
| Vmn2r23 |
A |
T |
6: 123,741,826 |
I713F |
probably damaging |
Het |
| Vmn2r79 |
A |
T |
7: 87,037,960 |
I850F |
probably damaging |
Het |
| Wdr90 |
C |
T |
17: 25,855,363 |
R676H |
probably benign |
Het |
| Zfp867 |
G |
A |
11: 59,463,661 |
R281W |
probably damaging |
Het |
| Zfp939 |
T |
C |
7: 39,472,942 |
|
noncoding transcript |
Het |
|
| Other mutations in Cntn4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cntn4
|
APN |
6 |
106,506,225 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00725:Cntn4
|
APN |
6 |
106,662,655 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01062:Cntn4
|
APN |
6 |
106,618,278 (GRCm38) |
splice site |
probably benign |
|
|
IGL01432:Cntn4
|
APN |
6 |
106,678,334 (GRCm38) |
splice site |
probably benign |
|
|
IGL01585:Cntn4
|
APN |
6 |
106,618,328 (GRCm38) |
nonsense |
probably null |
|
|
IGL01710:Cntn4
|
APN |
6 |
106,550,431 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
IGL01870:Cntn4
|
APN |
6 |
106,489,715 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL01933:Cntn4
|
APN |
6 |
106,694,384 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01937:Cntn4
|
APN |
6 |
106,437,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01945:Cntn4
|
APN |
6 |
106,437,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02007:Cntn4
|
APN |
6 |
106,655,529 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02506:Cntn4
|
APN |
6 |
106,618,388 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL02561:Cntn4
|
APN |
6 |
106,523,509 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03080:Cntn4
|
APN |
6 |
106,655,539 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03338:Cntn4
|
APN |
6 |
106,655,589 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03097:Cntn4
|
UTSW |
6 |
106,353,712 (GRCm38) |
missense |
probably benign |
0.10 |
|
LCD18:Cntn4
|
UTSW |
6 |
106,553,940 (GRCm38) |
intron |
probably benign |
|
|
R0083:Cntn4
|
UTSW |
6 |
106,525,369 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R0098:Cntn4
|
UTSW |
6 |
106,618,424 (GRCm38) |
splice site |
probably benign |
|
|
R0501:Cntn4
|
UTSW |
6 |
106,618,335 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0626:Cntn4
|
UTSW |
6 |
106,662,578 (GRCm38) |
missense |
probably benign |
0.07 |
|
R0633:Cntn4
|
UTSW |
6 |
106,679,248 (GRCm38) |
splice site |
probably null |
|
|
R0730:Cntn4
|
UTSW |
6 |
106,550,486 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0849:Cntn4
|
UTSW |
6 |
106,667,457 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0883:Cntn4
|
UTSW |
6 |
106,667,540 (GRCm38) |
splice site |
probably benign |
|
|
R0926:Cntn4
|
UTSW |
6 |
106,655,581 (GRCm38) |
missense |
probably benign |
0.21 |
|
R1199:Cntn4
|
UTSW |
6 |
106,353,597 (GRCm38) |
splice site |
probably benign |
|
|
R1293:Cntn4
|
UTSW |
6 |
106,353,724 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1296:Cntn4
|
UTSW |
6 |
106,509,402 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1344:Cntn4
|
UTSW |
6 |
106,344,870 (GRCm38) |
splice site |
probably null |
|
|
R1418:Cntn4
|
UTSW |
6 |
106,344,870 (GRCm38) |
splice site |
probably null |
|
|
R1660:Cntn4
|
UTSW |
6 |
106,679,297 (GRCm38) |
missense |
probably benign |
0.35 |
|
R1751:Cntn4
|
UTSW |
6 |
106,618,410 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1883:Cntn4
|
UTSW |
6 |
106,679,392 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1884:Cntn4
|
UTSW |
6 |
106,679,392 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1899:Cntn4
|
UTSW |
6 |
106,675,813 (GRCm38) |
missense |
probably benign |
0.21 |
|
R1906:Cntn4
|
UTSW |
6 |
106,353,646 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2048:Cntn4
|
UTSW |
6 |
106,437,864 (GRCm38) |
splice site |
probably benign |
|
|
R2113:Cntn4
|
UTSW |
6 |
106,489,697 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3177:Cntn4
|
UTSW |
6 |
106,437,964 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3277:Cntn4
|
UTSW |
6 |
106,437,964 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3944:Cntn4
|
UTSW |
6 |
106,618,414 (GRCm38) |
missense |
probably benign |
0.10 |
|
R4401:Cntn4
|
UTSW |
6 |
106,489,664 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4540:Cntn4
|
UTSW |
6 |
106,675,748 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4688:Cntn4
|
UTSW |
6 |
106,437,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4810:Cntn4
|
UTSW |
6 |
106,655,611 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4816:Cntn4
|
UTSW |
6 |
106,550,497 (GRCm38) |
missense |
probably benign |
|
|
R4873:Cntn4
|
UTSW |
6 |
106,437,913 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R4875:Cntn4
|
UTSW |
6 |
106,437,913 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R4953:Cntn4
|
UTSW |
6 |
106,525,418 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5288:Cntn4
|
UTSW |
6 |
106,181,804 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R5336:Cntn4
|
UTSW |
6 |
106,662,634 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R5386:Cntn4
|
UTSW |
6 |
106,181,804 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R5477:Cntn4
|
UTSW |
6 |
106,673,950 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5514:Cntn4
|
UTSW |
6 |
106,672,883 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5668:Cntn4
|
UTSW |
6 |
106,679,436 (GRCm38) |
splice site |
silent |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,344,786 (GRCm38) |
missense |
probably benign |
|
|
R6334:Cntn4
|
UTSW |
6 |
106,506,192 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6904:Cntn4
|
UTSW |
6 |
106,697,583 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6985:Cntn4
|
UTSW |
6 |
106,679,417 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7246:Cntn4
|
UTSW |
6 |
106,506,219 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7282:Cntn4
|
UTSW |
6 |
106,525,460 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7585:Cntn4
|
UTSW |
6 |
106,489,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7667:Cntn4
|
UTSW |
6 |
106,679,895 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R7781:Cntn4
|
UTSW |
6 |
106,523,614 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7882:Cntn4
|
UTSW |
6 |
106,353,723 (GRCm38) |
missense |
probably benign |
|
|
R8081:Cntn4
|
UTSW |
6 |
106,674,607 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8105:Cntn4
|
UTSW |
6 |
106,353,606 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8221:Cntn4
|
UTSW |
6 |
106,509,510 (GRCm38) |
missense |
probably benign |
0.17 |
|
R8910:Cntn4
|
UTSW |
6 |
106,655,536 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8911:Cntn4
|
UTSW |
6 |
106,353,782 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8916:Cntn4
|
UTSW |
6 |
106,675,954 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9249:Cntn4
|
UTSW |
6 |
106,489,761 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R9376:Cntn4
|
UTSW |
6 |
106,662,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9616:Cntn4
|
UTSW |
6 |
106,697,564 (GRCm38) |
nonsense |
probably null |
|
|
R9767:Cntn4
|
UTSW |
6 |
106,678,434 (GRCm38) |
missense |
probably benign |
0.40 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,523,563 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Cntn4
|
UTSW |
6 |
106,509,464 (GRCm38) |
missense |
probably benign |
0.28 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,662,618 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Cntn4
|
UTSW |
6 |
106,550,425 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTAAGCCCTCTTGACAGAACATG -3'
(R):5'- AAAGTGGCCTCTTCCCATTGC -3'
Sequencing Primer
(F):5'- TTGACAGAACATGTAGCAAAACTGC -3'
(R):5'- CATTGCTTGCAGGCTATATGAC -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation