Mutagenetix > Incidental Mutation

Incidental Mutation 'R5437:Prkdc'

428448

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DOXNPH, DNA-PKcs, XRCC7, dxnph, DNA-PK, DNAPDcs

MMRRC Submission

043002-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.955) question?

Stock #

R5437 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

15637866-15842235 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 15769875 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 2541 (L2541F)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000023352
AA Change: L2541F

PolyPhen 2 Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: L2541F

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Meta Mutation Damage Score

0.1575

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.7%

Validation Efficiency

97% (63/65)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	G	A	11: 110,319,796 (GRCm38)	Q186*	probably null	Het
Acaca	G	A	11: 84,346,820 (GRCm38)		probably null	Het
Acsm3	C	A	7: 119,778,497 (GRCm38)		probably benign	Het
Aoc1	C	A	6: 48,907,750 (GRCm38)	Q576K	probably benign	Het
Atp6v0a4	T	A	6: 38,076,733 (GRCm38)	N378I	probably damaging	Het
BC003331	T	G	1: 150,363,518 (GRCm38)	I385L	probably benign	Het
Cacna1i	A	T	15: 80,371,529 (GRCm38)	H871L	probably damaging	Het
Clic4	C	G	4: 135,217,246 (GRCm38)	R206P	probably damaging	Het
Commd9	G	A	2: 101,901,028 (GRCm38)	G186D	probably damaging	Het
Cpne9	C	T	6: 113,304,630 (GRCm38)		probably benign	Het
Crhr2	C	T	6: 55,100,733 (GRCm38)	V196I	probably damaging	Het
Dctn5	T	A	7: 122,133,329 (GRCm38)		probably benign	Het
Dhtkd1	C	T	2: 5,924,119 (GRCm38)	R247Q	probably benign	Het
Dmrta1	G	A	4: 89,691,756 (GRCm38)	G318R	possibly damaging	Het
Dpp6	T	A	5: 27,663,501 (GRCm38)	Y487*	probably null	Het
Eef1akmt3	A	T	10: 127,033,247 (GRCm38)	N119K	probably damaging	Het
Eloa	A	T	4: 136,012,885 (GRCm38)	L75Q	probably damaging	Het
Fat3	G	A	9: 16,085,308 (GRCm38)	T1202M	probably damaging	Het
Fcho2	A	G	13: 98,777,474 (GRCm38)	I205T	possibly damaging	Het
Fkbp10	A	C	11: 100,421,023 (GRCm38)	D174A	probably damaging	Het
Gcnt2	T	A	13: 40,861,176 (GRCm38)	F274L	probably damaging	Het
Gtf3c1	A	T	7: 125,667,368 (GRCm38)	C969S	probably damaging	Het
Hook3	T	C	8: 26,061,422 (GRCm38)	E130G	probably benign	Het
Itgb4	C	T	11: 115,984,157 (GRCm38)	R447W	probably benign	Het
Itsn1	T	A	16: 91,818,591 (GRCm38)		probably benign	Het
Kif13b	C	T	14: 64,806,114 (GRCm38)	R1788C	probably damaging	Het
Kif3a	C	T	11: 53,598,726 (GRCm38)	S135F	probably damaging	Het
Klf5	C	T	14: 99,301,459 (GRCm38)	R23*	probably null	Het
Lcn5	A	G	2: 25,658,011 (GRCm38)	I11V	probably benign	Het
Mpp7	A	T	18: 7,458,930 (GRCm38)		probably null	Het
Mroh5	T	C	15: 73,787,969 (GRCm38)	I338V	probably benign	Het
Mthfd2l	A	G	5: 90,948,898 (GRCm38)	N126S	possibly damaging	Het
Myo18b	G	T	5: 112,757,573 (GRCm38)	A2053E	possibly damaging	Het
Naip6	A	T	13: 100,303,304 (GRCm38)	C318*	probably null	Het
Ndufs7	C	T	10: 80,254,924 (GRCm38)	R116C	possibly damaging	Het
Olfr1378	T	C	11: 50,969,108 (GRCm38)	M30T	probably benign	Het
Pnkd	T	C	1: 74,349,737 (GRCm38)	V214A	possibly damaging	Het
Popdc2	T	G	16: 38,362,901 (GRCm38)	V82G	probably benign	Het
Ptpn9	A	T	9: 57,020,037 (GRCm38)	H66L	possibly damaging	Het
Pygm	T	A	19: 6,390,382 (GRCm38)	N397K	probably damaging	Het
Rabgap1l	T	A	1: 160,722,147 (GRCm38)	E324D	probably damaging	Het
Rnf6	G	A	5: 146,210,280 (GRCm38)	R643C	probably damaging	Het
Ryr2	C	T	13: 11,655,713 (GRCm38)	V3466M	probably damaging	Het
Scn7a	A	G	2: 66,676,346 (GRCm38)	Y1400H	probably damaging	Het
Sept10	T	A	10: 59,176,959 (GRCm38)	N279I	probably damaging	Het
Sh3rf2	A	T	18: 42,141,014 (GRCm38)	Y415F	probably benign	Het
Sorcs1	T	C	19: 50,252,602 (GRCm38)	T449A	probably benign	Het
Tcam1	C	T	11: 106,285,423 (GRCm38)	T325M	probably damaging	Het
Tctn1	A	G	5: 122,258,879 (GRCm38)	I147T	probably benign	Het
Tet1	G	T	10: 62,814,451 (GRCm38)	H30Q	probably benign	Het
Tmem109	A	G	19: 10,872,014 (GRCm38)	I159T	probably damaging	Het
Tmem40	C	T	6: 115,759,031 (GRCm38)		probably benign	Het
Tnfrsf21	C	T	17: 43,037,862 (GRCm38)	P122S	possibly damaging	Het
Uaca	A	G	9: 60,871,451 (GRCm38)	D1038G	probably benign	Het
Ubr2	C	G	17: 46,963,697 (GRCm38)	E852D	probably benign	Het
Ubr3	A	T	2: 69,944,390 (GRCm38)	N518I	probably damaging	Het
Unc80	T	G	1: 66,654,578 (GRCm38)	L2596R	possibly damaging	Het
Zcchc3	G	A	2: 152,414,732 (GRCm38)	P16S	probably benign	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,697,226 (GRCm38)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,809,644 (GRCm38)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,790,466 (GRCm38)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,775,847 (GRCm38)	splice site	probably null
IGL00489:Prkdc	APN	16	15,799,926 (GRCm38)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,664,239 (GRCm38)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,652,358 (GRCm38)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,736,835 (GRCm38)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,787,158 (GRCm38)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,779,426 (GRCm38)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,816,639 (GRCm38)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,759,754 (GRCm38)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,739,564 (GRCm38)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,702,115 (GRCm38)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,669,321 (GRCm38)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,726,704 (GRCm38)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,829,692 (GRCm38)	missense	probably benign
IGL01335:Prkdc	APN	16	15,816,896 (GRCm38)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,835,166 (GRCm38)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,713,587 (GRCm38)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,652,302 (GRCm38)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,667,745 (GRCm38)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,734,994 (GRCm38)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,698,887 (GRCm38)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,708,779 (GRCm38)	missense	probably benign
IGL02121:Prkdc	APN	16	15,717,184 (GRCm38)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,669,285 (GRCm38)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,809,759 (GRCm38)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,785,979 (GRCm38)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,785,978 (GRCm38)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,816,758 (GRCm38)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,670,535 (GRCm38)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,714,282 (GRCm38)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,726,542 (GRCm38)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,670,601 (GRCm38)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,769,825 (GRCm38)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,836,043 (GRCm38)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,752,726 (GRCm38)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,833,666 (GRCm38)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,831,327 (GRCm38)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,651,519 (GRCm38)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,800,016 (GRCm38)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,799,984 (GRCm38)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,705,310 (GRCm38)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,713,635 (GRCm38)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,700,744 (GRCm38)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,769,801 (GRCm38)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,670,626 (GRCm38)	nonsense	probably null
anhimid	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
anhinga	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
Bushtit	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
clover	UTSW	16	15,702,156 (GRCm38)	splice site	probably benign
crackle	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
Daffy	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
darter	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,808,058 (GRCm38)	missense	probably benign	0.01
envenomation	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
hobgoblin	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
Incubus	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
liming	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
newt	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
primitive	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
roadrunner	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
Schreier	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
screamer	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
Screamer10	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
screamer2	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
screamer3	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
screamer4	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
screamer5	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
screamer6	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
screamer7	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
Screamer8	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
Screamer9	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
Tweetie	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
updock	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,708,701 (GRCm38)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,726,504 (GRCm38)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,699,007 (GRCm38)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,736,799 (GRCm38)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,791,927 (GRCm38)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,833,740 (GRCm38)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,833,788 (GRCm38)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,808,088 (GRCm38)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,772,057 (GRCm38)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,690,407 (GRCm38)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,810,801 (GRCm38)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,785,971 (GRCm38)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,829,716 (GRCm38)	missense	probably benign
R1027:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,654,749 (GRCm38)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,767,951 (GRCm38)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,752,782 (GRCm38)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,759,746 (GRCm38)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,690,282 (GRCm38)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,759,723 (GRCm38)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,664,227 (GRCm38)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,667,700 (GRCm38)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,731,566 (GRCm38)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
R1531:Prkdc	UTSW	16	15,772,106 (GRCm38)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,675,328 (GRCm38)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,734,058 (GRCm38)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,676,989 (GRCm38)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
R1762:Prkdc	UTSW	16	15,637,961 (GRCm38)	missense	probably benign
R1789:Prkdc	UTSW	16	15,739,524 (GRCm38)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,808,058 (GRCm38)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,829,635 (GRCm38)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,725,436 (GRCm38)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,714,215 (GRCm38)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,714,266 (GRCm38)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R1939:Prkdc	UTSW	16	15,835,913 (GRCm38)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,677,009 (GRCm38)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,687,352 (GRCm38)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,715,963 (GRCm38)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,687,390 (GRCm38)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,705,207 (GRCm38)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,698,824 (GRCm38)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2271:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2272:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2356:Prkdc	UTSW	16	15,684,204 (GRCm38)	missense	probably benign
R2852:Prkdc	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,799,967 (GRCm38)	missense	probably benign
R3834:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,829,611 (GRCm38)	splice site	probably null
R4151:Prkdc	UTSW	16	15,816,773 (GRCm38)	missense	probably benign
R4233:Prkdc	UTSW	16	15,835,919 (GRCm38)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,806,099 (GRCm38)	splice site	probably null
R4296:Prkdc	UTSW	16	15,737,905 (GRCm38)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,768,022 (GRCm38)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,773,739 (GRCm38)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,700,653 (GRCm38)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,736,870 (GRCm38)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,767,966 (GRCm38)	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15,810,824 (GRCm38)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,663,074 (GRCm38)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,816,774 (GRCm38)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,734,052 (GRCm38)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,772,030 (GRCm38)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,702,112 (GRCm38)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,810,837 (GRCm38)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,667,715 (GRCm38)	missense	probably benign
R4785:Prkdc	UTSW	16	15,648,976 (GRCm38)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,702,075 (GRCm38)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,678,309 (GRCm38)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,838,018 (GRCm38)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,772,048 (GRCm38)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,790,580 (GRCm38)	missense	probably benign
R5151:Prkdc	UTSW	16	15,716,035 (GRCm38)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,772,121 (GRCm38)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,734,955 (GRCm38)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,714,974 (GRCm38)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,831,312 (GRCm38)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,805,950 (GRCm38)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,795,097 (GRCm38)	missense	probably benign	0.20
R5452:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,678,308 (GRCm38)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,651,469 (GRCm38)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,706,791 (GRCm38)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,809,612 (GRCm38)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,829,769 (GRCm38)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,810,770 (GRCm38)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,664,233 (GRCm38)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,779,388 (GRCm38)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,816,752 (GRCm38)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,737,834 (GRCm38)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,734,098 (GRCm38)	missense	probably benign
R5883:Prkdc	UTSW	16	15,715,914 (GRCm38)	missense	probably benign
R5895:Prkdc	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,783,157 (GRCm38)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,739,471 (GRCm38)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,772,073 (GRCm38)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,790,592 (GRCm38)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,787,155 (GRCm38)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,714,919 (GRCm38)	missense	probably benign
R6376:Prkdc	UTSW	16	15,769,885 (GRCm38)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,698,815 (GRCm38)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,795,075 (GRCm38)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,651,538 (GRCm38)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,777,072 (GRCm38)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,808,156 (GRCm38)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,783,263 (GRCm38)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,799,989 (GRCm38)	missense	probably benign
R6950:Prkdc	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,769,966 (GRCm38)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,790,453 (GRCm38)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,689,343 (GRCm38)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,698,803 (GRCm38)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,714,263 (GRCm38)	missense	probably benign
R7283:Prkdc	UTSW	16	15,717,764 (GRCm38)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,648,738 (GRCm38)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,737,943 (GRCm38)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,831,319 (GRCm38)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,806,096 (GRCm38)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,689,277 (GRCm38)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,715,006 (GRCm38)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,708,903 (GRCm38)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,779,451 (GRCm38)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,816,885 (GRCm38)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,664,244 (GRCm38)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,705,253 (GRCm38)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,714,141 (GRCm38)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,790,676 (GRCm38)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,651,536 (GRCm38)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,648,924 (GRCm38)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,664,368 (GRCm38)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,663,035 (GRCm38)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,808,204 (GRCm38)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,783,165 (GRCm38)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,727,659 (GRCm38)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,673,760 (GRCm38)	intron	probably benign
R8971:Prkdc	UTSW	16	15,675,365 (GRCm38)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,799,862 (GRCm38)	splice site	probably null
R9052:Prkdc	UTSW	16	15,690,296 (GRCm38)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,705,289 (GRCm38)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,708,928 (GRCm38)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,667,601 (GRCm38)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,839,215 (GRCm38)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,730,471 (GRCm38)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,730,470 (GRCm38)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,730,477 (GRCm38)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,799,954 (GRCm38)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,715,955 (GRCm38)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,839,180 (GRCm38)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,740,278 (GRCm38)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,687,422 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AAAGCTATGAAGTCTGCACATG -3'
(R):5'- CACATGTCCATATCTTAAGCAAGG -3'

Sequencing Primer
(F):5'- AGTCTGCACATGACATTATGGG -3'
(R):5'- GTCCATATCTTAAGCAAGGTGTATG -3'

Posted On

2016-09-01