Incidental Mutation 'R5644:Kif1b'
| ID |
501288 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif1b
|
| Ensembl Gene |
ENSMUSG00000063077 |
| Gene Name |
kinesin family member 1B |
| Synonyms |
N-3 kinesin, KIF1Bp130, KIF1Bp204, Kif1b beta, Kif1b alpha, D4Mil1e, A530096N05Rik |
| MMRRC Submission |
043292-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5644 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
149260776-149392150 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 149322939 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 660
(D660G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030806
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030806]
[ENSMUST00000055647]
[ENSMUST00000060537]
|
| AlphaFold |
Q60575 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030806
AA Change: D660G
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000030806
Gene: ENSMUSG00000063077
AA Change: D660G
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
660 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
889 |
902 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055647
|
| SMART Domains |
Protein: ENSMUSP00000061472
Gene: ENSMUSG00000063077
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
685 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
799 |
846 |
9.7e-13 |
PFAM |
|
internal_repeat_1
|
901 |
933 |
7.01e-7 |
PROSPERO |
|
low complexity region
|
1165 |
1179 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1220 |
1368 |
1.1e-46 |
PFAM |
|
low complexity region
|
1444 |
1461 |
N/A |
INTRINSIC |
|
low complexity region
|
1479 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1591 |
N/A |
INTRINSIC |
|
PH
|
1656 |
1755 |
1.02e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060537
|
| SMART Domains |
Protein: ENSMUSP00000056754
Gene: ENSMUSG00000063077
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
362 |
7.61e-175 |
SMART |
|
low complexity region
|
390 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
432 |
450 |
N/A |
INTRINSIC |
|
FHA
|
555 |
612 |
1.61e-4 |
SMART |
|
coiled coil region
|
672 |
731 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
845 |
892 |
7.1e-15 |
PFAM |
|
internal_repeat_1
|
947 |
979 |
4.76e-7 |
PROSPERO |
|
low complexity region
|
1211 |
1225 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1266 |
1413 |
1.1e-40 |
PFAM |
|
low complexity region
|
1490 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1619 |
1637 |
N/A |
INTRINSIC |
|
PH
|
1702 |
1801 |
1.02e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrg6 |
A |
T |
10: 14,308,678 (GRCm39) |
D805E |
probably damaging |
Het |
| Adrb2 |
A |
T |
18: 62,311,753 (GRCm39) |
N357K |
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,988,021 (GRCm39) |
K3102E |
possibly damaging |
Het |
| Alkal2 |
T |
A |
12: 30,934,889 (GRCm39) |
L36Q |
probably damaging |
Het |
| Alkbh8 |
G |
T |
9: 3,385,384 (GRCm39) |
V559F |
probably damaging |
Het |
| Apba2 |
A |
G |
7: 64,365,259 (GRCm39) |
T346A |
probably benign |
Het |
| Arhgap10 |
C |
T |
8: 78,137,684 (GRCm39) |
M302I |
probably benign |
Het |
| Asah1 |
G |
T |
8: 41,813,332 (GRCm39) |
T27K |
possibly damaging |
Het |
| Bag2 |
A |
G |
1: 33,786,034 (GRCm39) |
V96A |
probably damaging |
Het |
| Bicd1 |
C |
T |
6: 149,421,901 (GRCm39) |
A874V |
probably damaging |
Het |
| C4b |
T |
C |
17: 34,961,391 (GRCm39) |
I189M |
probably benign |
Het |
| Cacna1a |
A |
G |
8: 85,189,406 (GRCm39) |
Y119C |
probably damaging |
Het |
| Calcr |
A |
G |
6: 3,708,538 (GRCm39) |
I216T |
probably damaging |
Het |
| Ccar1 |
T |
C |
10: 62,607,757 (GRCm39) |
N302S |
probably benign |
Het |
| Ccdc93 |
A |
G |
1: 121,411,065 (GRCm39) |
H446R |
probably benign |
Het |
| Cct6b |
A |
T |
11: 82,613,281 (GRCm39) |
L420Q |
probably benign |
Het |
| Cemip |
T |
C |
7: 83,638,392 (GRCm39) |
T273A |
probably benign |
Het |
| Cep128 |
A |
T |
12: 91,315,625 (GRCm39) |
I87K |
probably damaging |
Het |
| Cfap221 |
A |
G |
1: 119,860,532 (GRCm39) |
L698P |
probably damaging |
Het |
| Cfap43 |
T |
A |
19: 47,784,114 (GRCm39) |
N473I |
possibly damaging |
Het |
| Clec12b |
T |
A |
6: 129,356,923 (GRCm39) |
I172L |
probably benign |
Het |
| Cntnap5b |
A |
C |
1: 100,311,326 (GRCm39) |
E606D |
probably benign |
Het |
| Cyp2c67 |
A |
C |
19: 39,604,138 (GRCm39) |
V406G |
possibly damaging |
Het |
| Dhx57 |
T |
C |
17: 80,546,302 (GRCm39) |
I1308V |
possibly damaging |
Het |
| Dnah7a |
A |
T |
1: 53,580,138 (GRCm39) |
M1599K |
probably benign |
Het |
| Dnajc21 |
A |
T |
15: 10,462,001 (GRCm39) |
D133E |
probably benign |
Het |
| Dpp8 |
G |
A |
9: 64,953,017 (GRCm39) |
W231* |
probably null |
Het |
| Dvl3 |
T |
A |
16: 20,345,026 (GRCm39) |
I353N |
probably damaging |
Het |
| Fgd6 |
T |
A |
10: 93,969,912 (GRCm39) |
I1187N |
possibly damaging |
Het |
| Fn1 |
A |
T |
1: 71,666,409 (GRCm39) |
Y875N |
probably damaging |
Het |
| Gaa |
T |
A |
11: 119,171,361 (GRCm39) |
M671K |
possibly damaging |
Het |
| Gm11939 |
T |
C |
11: 99,450,138 (GRCm39) |
D52G |
probably damaging |
Het |
| Gm14403 |
A |
T |
2: 177,199,054 (GRCm39) |
H50L |
possibly damaging |
Het |
| Gpam |
A |
T |
19: 55,077,331 (GRCm39) |
D153E |
probably benign |
Het |
| Gzma |
T |
C |
13: 113,234,794 (GRCm39) |
T66A |
probably damaging |
Het |
| Hnmt |
A |
T |
2: 23,904,251 (GRCm39) |
W137R |
probably damaging |
Het |
| Hsd17b7 |
A |
T |
1: 169,783,517 (GRCm39) |
V297D |
probably damaging |
Het |
| Ighv1-85 |
A |
T |
12: 115,963,680 (GRCm39) |
S107T |
possibly damaging |
Het |
| Kif12 |
T |
A |
4: 63,084,130 (GRCm39) |
Q624L |
possibly damaging |
Het |
| Klf13 |
T |
C |
7: 63,541,308 (GRCm39) |
|
probably benign |
Het |
| Klhl41 |
A |
G |
2: 69,500,815 (GRCm39) |
Y92C |
probably damaging |
Het |
| Klrc2 |
A |
T |
6: 129,633,420 (GRCm39) |
C186S |
probably damaging |
Het |
| Lao1 |
T |
A |
4: 118,822,433 (GRCm39) |
|
probably null |
Het |
| Lmo7 |
A |
G |
14: 102,166,772 (GRCm39) |
|
probably benign |
Het |
| Lyst |
A |
T |
13: 13,812,081 (GRCm39) |
Q831L |
possibly damaging |
Het |
| Lzts1 |
A |
G |
8: 69,591,729 (GRCm39) |
S140P |
possibly damaging |
Het |
| Man2b1 |
T |
A |
8: 85,820,839 (GRCm39) |
I679N |
possibly damaging |
Het |
| Mgat5b |
T |
A |
11: 116,864,226 (GRCm39) |
V464E |
probably damaging |
Het |
| Mrgprb5 |
G |
A |
7: 47,817,955 (GRCm39) |
T260I |
probably benign |
Het |
| Mybpc2 |
T |
C |
7: 44,156,477 (GRCm39) |
T825A |
probably benign |
Het |
| Mycbp2 |
T |
A |
14: 103,524,770 (GRCm39) |
K597I |
probably damaging |
Het |
| Naalad2 |
G |
T |
9: 18,246,227 (GRCm39) |
N568K |
possibly damaging |
Het |
| Neurl1a |
A |
G |
19: 47,167,916 (GRCm39) |
N4S |
probably benign |
Het |
| Nfx1 |
T |
C |
4: 40,984,973 (GRCm39) |
W366R |
probably null |
Het |
| Nipbl |
C |
T |
15: 8,388,391 (GRCm39) |
V410I |
probably benign |
Het |
| Nlrp9a |
A |
T |
7: 26,257,993 (GRCm39) |
H537L |
possibly damaging |
Het |
| Nxpe4 |
A |
G |
9: 48,304,050 (GRCm39) |
N46D |
probably benign |
Het |
| Or14j10 |
T |
A |
17: 37,935,323 (GRCm39) |
I68F |
probably benign |
Het |
| Or4c101 |
T |
A |
2: 88,389,849 (GRCm39) |
M1K |
probably null |
Het |
| Or4f60 |
A |
T |
2: 111,902,013 (GRCm39) |
M305K |
probably benign |
Het |
| Or5ae1 |
C |
A |
7: 84,565,327 (GRCm39) |
F113L |
probably benign |
Het |
| Or5b95 |
A |
T |
19: 12,658,336 (GRCm39) |
Y288F |
probably damaging |
Het |
| Or5p58 |
A |
T |
7: 107,694,011 (GRCm39) |
Y255* |
probably null |
Het |
| Or5p60 |
A |
G |
7: 107,723,858 (GRCm39) |
F204S |
probably benign |
Het |
| Or6c2 |
A |
T |
10: 129,362,972 (GRCm39) |
N292I |
probably damaging |
Het |
| Or6c76b |
T |
A |
10: 129,693,296 (GRCm39) |
V303E |
probably benign |
Het |
| Or8u10 |
T |
C |
2: 85,915,503 (GRCm39) |
N206S |
probably damaging |
Het |
| P2ry12 |
A |
T |
3: 59,125,516 (GRCm39) |
M53K |
possibly damaging |
Het |
| Pcca |
G |
A |
14: 123,124,481 (GRCm39) |
C684Y |
probably damaging |
Het |
| Pdzd7 |
A |
G |
19: 45,028,619 (GRCm39) |
S175P |
probably benign |
Het |
| Pgbd1 |
A |
G |
13: 21,607,322 (GRCm39) |
C291R |
probably damaging |
Het |
| Plekhg5 |
T |
C |
4: 152,188,797 (GRCm39) |
V200A |
probably benign |
Het |
| Pola2 |
A |
G |
19: 6,011,198 (GRCm39) |
V42A |
probably benign |
Het |
| Pramel16 |
C |
T |
4: 143,675,374 (GRCm39) |
G484D |
probably benign |
Het |
| Prkcd |
C |
A |
14: 30,329,370 (GRCm39) |
K23N |
probably benign |
Het |
| Ptdss1 |
T |
C |
13: 67,120,604 (GRCm39) |
F267L |
probably damaging |
Het |
| Rad54l |
C |
T |
4: 115,956,144 (GRCm39) |
S561N |
probably benign |
Het |
| Rai14 |
T |
A |
15: 10,593,137 (GRCm39) |
H169L |
probably benign |
Het |
| Rfc3 |
C |
T |
5: 151,573,444 (GRCm39) |
V40I |
probably benign |
Het |
| Rpl31 |
C |
T |
1: 39,409,108 (GRCm39) |
R41C |
probably benign |
Het |
| Rtl1 |
C |
T |
12: 109,558,013 (GRCm39) |
M1275I |
probably benign |
Het |
| Ryr2 |
C |
A |
13: 11,610,468 (GRCm39) |
E4119D |
probably damaging |
Het |
| Senp7 |
T |
C |
16: 56,004,512 (GRCm39) |
|
silent |
Het |
| Sfmbt2 |
A |
T |
2: 10,573,184 (GRCm39) |
I571F |
probably damaging |
Het |
| Sit1 |
T |
A |
4: 43,483,562 (GRCm39) |
T8S |
probably benign |
Het |
| Slc22a30 |
T |
C |
19: 8,381,980 (GRCm39) |
H97R |
possibly damaging |
Het |
| Slco1a5 |
A |
C |
6: 142,183,320 (GRCm39) |
|
probably null |
Het |
| Smc6 |
T |
A |
12: 11,339,995 (GRCm39) |
N434K |
probably benign |
Het |
| Snap91 |
G |
T |
9: 86,672,206 (GRCm39) |
|
probably null |
Het |
| Srsf10 |
T |
C |
4: 135,591,131 (GRCm39) |
S194P |
possibly damaging |
Het |
| St14 |
T |
C |
9: 31,017,806 (GRCm39) |
M205V |
probably benign |
Het |
| Syndig1 |
A |
T |
2: 149,741,428 (GRCm39) |
I5F |
possibly damaging |
Het |
| Tbrg1 |
T |
C |
9: 37,560,709 (GRCm39) |
D389G |
probably benign |
Het |
| Tcaf2 |
G |
A |
6: 42,619,707 (GRCm39) |
R107C |
possibly damaging |
Het |
| Tpmt |
T |
A |
13: 47,182,435 (GRCm39) |
D163V |
probably benign |
Het |
| Trim15 |
T |
C |
17: 37,177,713 (GRCm39) |
E94G |
probably damaging |
Het |
| Trit1 |
T |
C |
4: 122,942,965 (GRCm39) |
I279T |
probably damaging |
Het |
| Trpm8 |
T |
A |
1: 88,287,461 (GRCm39) |
F815I |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,768,867 (GRCm39) |
T2856S |
probably damaging |
Het |
| Ugdh |
A |
T |
5: 65,574,204 (GRCm39) |
D446E |
probably benign |
Het |
| Unc5c |
C |
T |
3: 141,383,886 (GRCm39) |
A88V |
probably damaging |
Het |
| Vmn1r43 |
T |
C |
6: 89,847,354 (GRCm39) |
N44S |
probably damaging |
Het |
| Vmn2r120 |
T |
A |
17: 57,831,977 (GRCm39) |
M271L |
probably benign |
Het |
| Wdr74 |
T |
A |
19: 8,715,240 (GRCm39) |
V133E |
probably damaging |
Het |
| Zfp607b |
T |
C |
7: 27,403,194 (GRCm39) |
L550P |
probably damaging |
Het |
|
| Other mutations in Kif1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Kif1b
|
APN |
4 |
149,305,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01943:Kif1b
|
APN |
4 |
149,299,362 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02240:Kif1b
|
APN |
4 |
149,330,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02414:Kif1b
|
APN |
4 |
149,283,771 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02490:Kif1b
|
APN |
4 |
149,288,665 (GRCm39) |
missense |
probably benign |
|
|
IGL02501:Kif1b
|
APN |
4 |
149,299,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02833:Kif1b
|
APN |
4 |
149,330,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Kif1b
|
APN |
4 |
149,375,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02900:Kif1b
|
APN |
4 |
149,265,266 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03287:Kif1b
|
APN |
4 |
149,299,438 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL03412:Kif1b
|
APN |
4 |
149,359,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4305001:Kif1b
|
UTSW |
4 |
149,305,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0005:Kif1b
|
UTSW |
4 |
149,266,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0129:Kif1b
|
UTSW |
4 |
149,345,658 (GRCm39) |
missense |
probably benign |
|
|
R0180:Kif1b
|
UTSW |
4 |
149,298,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0288:Kif1b
|
UTSW |
4 |
149,283,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Kif1b
|
UTSW |
4 |
149,347,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Kif1b
|
UTSW |
4 |
149,286,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0398:Kif1b
|
UTSW |
4 |
149,288,688 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0403:Kif1b
|
UTSW |
4 |
149,266,424 (GRCm39) |
nonsense |
probably null |
|
|
R0445:Kif1b
|
UTSW |
4 |
149,272,466 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Kif1b
|
UTSW |
4 |
149,279,958 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1728:Kif1b
|
UTSW |
4 |
149,272,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1840:Kif1b
|
UTSW |
4 |
149,272,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1874:Kif1b
|
UTSW |
4 |
149,272,089 (GRCm39) |
missense |
probably benign |
|
|
R1915:Kif1b
|
UTSW |
4 |
149,351,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2124:Kif1b
|
UTSW |
4 |
149,306,753 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2126:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2127:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2128:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2129:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2146:Kif1b
|
UTSW |
4 |
149,268,766 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2255:Kif1b
|
UTSW |
4 |
149,359,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2392:Kif1b
|
UTSW |
4 |
149,305,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2883:Kif1b
|
UTSW |
4 |
149,322,105 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2981:Kif1b
|
UTSW |
4 |
149,304,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3038:Kif1b
|
UTSW |
4 |
149,297,790 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3616:Kif1b
|
UTSW |
4 |
149,346,740 (GRCm39) |
splice site |
probably benign |
|
|
R3935:Kif1b
|
UTSW |
4 |
149,321,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4347:Kif1b
|
UTSW |
4 |
149,331,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4423:Kif1b
|
UTSW |
4 |
149,298,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4637:Kif1b
|
UTSW |
4 |
149,283,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4745:Kif1b
|
UTSW |
4 |
149,322,339 (GRCm39) |
nonsense |
probably null |
|
|
R4807:Kif1b
|
UTSW |
4 |
149,332,378 (GRCm39) |
intron |
probably benign |
|
|
R5618:Kif1b
|
UTSW |
4 |
149,354,346 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5683:Kif1b
|
UTSW |
4 |
149,306,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5696:Kif1b
|
UTSW |
4 |
149,358,306 (GRCm39) |
splice site |
probably null |
|
|
R6022:Kif1b
|
UTSW |
4 |
149,282,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6048:Kif1b
|
UTSW |
4 |
149,348,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6137:Kif1b
|
UTSW |
4 |
149,322,883 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6139:Kif1b
|
UTSW |
4 |
149,321,989 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6171:Kif1b
|
UTSW |
4 |
149,342,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6250:Kif1b
|
UTSW |
4 |
149,298,100 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6423:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6424:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6425:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6443:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6460:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6462:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6463:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6469:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6470:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6471:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6472:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6504:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6536:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6537:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6668:Kif1b
|
UTSW |
4 |
149,297,864 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6698:Kif1b
|
UTSW |
4 |
149,359,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7065:Kif1b
|
UTSW |
4 |
149,286,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7222:Kif1b
|
UTSW |
4 |
149,309,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Kif1b
|
UTSW |
4 |
149,298,547 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7720:Kif1b
|
UTSW |
4 |
149,266,812 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7744:Kif1b
|
UTSW |
4 |
149,321,532 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7797:Kif1b
|
UTSW |
4 |
149,321,844 (GRCm39) |
missense |
probably benign |
|
|
R7829:Kif1b
|
UTSW |
4 |
149,305,447 (GRCm39) |
splice site |
probably null |
|
|
R7869:Kif1b
|
UTSW |
4 |
149,268,833 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7878:Kif1b
|
UTSW |
4 |
149,299,454 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7980:Kif1b
|
UTSW |
4 |
149,354,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8047:Kif1b
|
UTSW |
4 |
149,299,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Kif1b
|
UTSW |
4 |
149,275,642 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8243:Kif1b
|
UTSW |
4 |
149,288,724 (GRCm39) |
missense |
probably benign |
|
|
R8252:Kif1b
|
UTSW |
4 |
149,358,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Kif1b
|
UTSW |
4 |
149,306,805 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8460:Kif1b
|
UTSW |
4 |
149,272,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8462:Kif1b
|
UTSW |
4 |
149,266,797 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8496:Kif1b
|
UTSW |
4 |
149,277,068 (GRCm39) |
nonsense |
probably null |
|
|
R8687:Kif1b
|
UTSW |
4 |
149,345,620 (GRCm39) |
nonsense |
probably null |
|
|
R8694:Kif1b
|
UTSW |
4 |
149,305,024 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8842:Kif1b
|
UTSW |
4 |
149,338,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8883:Kif1b
|
UTSW |
4 |
149,361,342 (GRCm39) |
missense |
probably benign |
|
|
R8971:Kif1b
|
UTSW |
4 |
149,332,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8994:Kif1b
|
UTSW |
4 |
149,279,939 (GRCm39) |
missense |
|
|
|
R9002:Kif1b
|
UTSW |
4 |
149,275,712 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9227:Kif1b
|
UTSW |
4 |
149,322,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Kif1b
|
UTSW |
4 |
149,275,652 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9450:Kif1b
|
UTSW |
4 |
149,322,467 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9478:Kif1b
|
UTSW |
4 |
149,345,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9571:Kif1b
|
UTSW |
4 |
149,305,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Kif1b
|
UTSW |
4 |
149,375,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Kif1b
|
UTSW |
4 |
149,336,195 (GRCm39) |
splice site |
probably null |
|
|
X0009:Kif1b
|
UTSW |
4 |
149,331,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kif1b
|
UTSW |
4 |
149,359,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kif1b
|
UTSW |
4 |
149,350,755 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAATCTTTGCTCAGGCGC -3'
(R):5'- AGCCCTCCAAGAATGTGTTTC -3'
Sequencing Primer
(F):5'- GCCTTCTTTGCGGGATCTGATAC -3'
(R):5'- CCAAGAATGTGTTTCATTTATCCCAG -3'
|
| Posted On |
2017-12-01 |
Incidental Mutation