Incidental Mutation 'R6544:Olfr1111'
ID 520992
Institutional Source Beutler Lab
Gene Symbol Olfr1111
Ensembl Gene ENSMUSG00000075158
Gene Name olfactory receptor 1111
Synonyms MOR181-2, GA_x6K02T2Q125-48635468-48634530
MMRRC Submission 044670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.215) question?
Stock # R6544 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87149181-87152624 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87149863 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 266 (Y266F)
Ref Sequence ENSEMBL: ENSMUSP00000150760 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099860] [ENSMUST00000214492] [ENSMUST00000216378]
AlphaFold Q7TR55
Predicted Effect probably damaging
Transcript: ENSMUST00000099860
AA Change: Y266F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000097446
Gene: ENSMUSG00000075158
AA Change: Y266F

Pfam:7tm_4 31 307 2.2e-54 PFAM
Pfam:7tm_1 41 290 7e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214492
AA Change: Y266F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216378
AA Change: Y266F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A030005K14Rik T A 1: 83,058,957 (GRCm38) K118* probably null Het
Actr2 A G 11: 20,100,933 (GRCm38) F17L probably damaging Het
Adam26b T C 8: 43,521,781 (GRCm38) I61M probably damaging Het
Ahnak2 A G 12: 112,780,652 (GRCm38) probably benign Het
Angptl3 T C 4: 99,031,438 (GRCm38) L145P probably damaging Het
Ank2 T C 3: 126,933,222 (GRCm38) T808A probably damaging Het
Cadm3 A G 1: 173,367,411 (GRCm38) probably null Het
Cog7 C T 7: 121,935,743 (GRCm38) R573Q probably damaging Het
Dchs1 T A 7: 105,758,178 (GRCm38) I2110F probably damaging Het
Fbxo47 G A 11: 97,856,263 (GRCm38) R326C probably damaging Het
Frmpd1 A T 4: 45,279,024 (GRCm38) D583V probably damaging Het
Gigyf1 T A 5: 137,525,059 (GRCm38) L911Q probably damaging Het
Gm35339 T C 15: 76,358,278 (GRCm38) Y823H probably benign Het
Gm4737 A C 16: 46,154,784 (GRCm38) S77A probably benign Het
Gprin1 G A 13: 54,740,311 (GRCm38) A50V possibly damaging Het
Grik4 A T 9: 42,547,728 (GRCm38) Y571* probably null Het
Gucy2e A G 11: 69,235,657 (GRCm38) V299A probably benign Het
Hectd2 C T 19: 36,612,328 (GRCm38) L618F probably damaging Het
Lactbl1 A T 4: 136,632,989 (GRCm38) I160F possibly damaging Het
Lats1 T A 10: 7,701,670 (GRCm38) V186D possibly damaging Het
Lmtk2 A G 5: 144,173,806 (GRCm38) H448R possibly damaging Het
Map10 T C 8: 125,671,374 (GRCm38) I502T probably benign Het
Mok A G 12: 110,810,755 (GRCm38) F239S probably damaging Het
Mprip G A 11: 59,757,726 (GRCm38) G752D probably benign Het
Naip5 C A 13: 100,223,144 (GRCm38) G528V possibly damaging Het
Neu2 T C 1: 87,596,742 (GRCm38) W150R probably damaging Het
Olfr1156 T A 2: 87,949,991 (GRCm38) M81L probably benign Het
Olfr1434 T C 19: 12,283,155 (GRCm38) Y36H probably damaging Het
Olfr356 T A 2: 36,937,527 (GRCm38) M136K possibly damaging Het
Pip5k1c T A 10: 81,308,996 (GRCm38) Y224N probably damaging Het
Plch1 T C 3: 63,850,978 (GRCm38) E5G probably damaging Het
Pspc1 T C 14: 56,764,203 (GRCm38) *59W probably null Het
Ptprq T C 10: 107,608,241 (GRCm38) T1501A probably damaging Het
Rnf165 T A 18: 77,563,235 (GRCm38) probably benign Het
Rorb G T 19: 18,952,250 (GRCm38) P304T possibly damaging Het
Scn7a A T 2: 66,684,100 (GRCm38) L1110Q probably damaging Het
Serpine2 C T 1: 79,803,130 (GRCm38) probably null Het
Slco1c1 A G 6: 141,531,444 (GRCm38) probably null Het
Smarca2 T A 19: 26,630,931 (GRCm38) V130D probably damaging Het
Sox17 G T 1: 4,492,432 (GRCm38) P117T possibly damaging Het
Sparcl1 A T 5: 104,092,444 (GRCm38) Y371* probably null Het
Tdpoz2 T C 3: 93,651,960 (GRCm38) D235G possibly damaging Het
Tns2 A C 15: 102,113,834 (GRCm38) K1182N possibly damaging Het
Tpte G T 8: 22,315,105 (GRCm38) probably null Het
Ttn A T 2: 76,969,159 (GRCm38) I459K possibly damaging Het
Zc3h15 G A 2: 83,661,148 (GRCm38) R240H probably benign Het
Zfp455 C A 13: 67,207,057 (GRCm38) L130I probably benign Het
Zfp777 A T 6: 48,044,485 (GRCm38) S68T probably damaging Het
Other mutations in Olfr1111
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Olfr1111 APN 2 87,149,825 (GRCm38) missense possibly damaging 0.53
IGL02217:Olfr1111 APN 2 87,149,887 (GRCm38) missense probably benign 0.00
R0789:Olfr1111 UTSW 2 87,149,827 (GRCm38) missense probably damaging 1.00
R1437:Olfr1111 UTSW 2 87,149,771 (GRCm38) missense possibly damaging 0.94
R1696:Olfr1111 UTSW 2 87,150,380 (GRCm38) missense probably benign 0.00
R1700:Olfr1111 UTSW 2 87,149,779 (GRCm38) missense probably damaging 1.00
R1717:Olfr1111 UTSW 2 87,149,806 (GRCm38) nonsense probably null
R4965:Olfr1111 UTSW 2 87,150,659 (GRCm38) start codon destroyed possibly damaging 0.89
R5221:Olfr1111 UTSW 2 87,150,481 (GRCm38) missense probably damaging 1.00
R5297:Olfr1111 UTSW 2 87,150,449 (GRCm38) missense probably benign 0.01
R5837:Olfr1111 UTSW 2 87,150,355 (GRCm38) missense probably benign 0.02
R6911:Olfr1111 UTSW 2 87,149,767 (GRCm38) missense probably damaging 1.00
R8537:Olfr1111 UTSW 2 87,150,038 (GRCm38) missense probably benign 0.02
R8969:Olfr1111 UTSW 2 87,150,584 (GRCm38) missense probably benign
R9747:Olfr1111 UTSW 2 87,150,554 (GRCm38) missense probably benign 0.21
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-06-06