Incidental Mutation 'R7223:Pcdha8'
| ID |
561986 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcdha8
|
| Ensembl Gene |
ENSMUSG00000103800 |
| Gene Name |
protocadherin alpha 8 |
| Synonyms |
|
| MMRRC Submission |
045295-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R7223 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
36992371-37187657 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 36993148 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Valine
at position 228
(L228V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142159
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070797]
[ENSMUST00000115659]
[ENSMUST00000115661]
[ENSMUST00000115662]
[ENSMUST00000192168]
[ENSMUST00000192295]
[ENSMUST00000192503]
[ENSMUST00000192512]
[ENSMUST00000192631]
[ENSMUST00000193389]
[ENSMUST00000193777]
[ENSMUST00000194038]
[ENSMUST00000193839]
[ENSMUST00000194544]
[ENSMUST00000194751]
[ENSMUST00000195590]
|
| AlphaFold |
Q91Y12 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070797
|
| SMART Domains |
Protein: ENSMUSP00000068828
Gene: ENSMUSG00000103442
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
22 |
132 |
3.09e-2 |
SMART |
|
CA
|
156 |
241 |
6.14e-20 |
SMART |
|
CA
|
265 |
349 |
3.92e-27 |
SMART |
|
CA
|
373 |
454 |
4.94e-24 |
SMART |
|
CA
|
478 |
564 |
1e-24 |
SMART |
|
CA
|
592 |
672 |
4.55e-14 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
797 |
931 |
5.3e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115659
|
| SMART Domains |
Protein: ENSMUSP00000111323
Gene: ENSMUSG00000103770
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
51 |
N/A |
INTRINSIC |
|
CA
|
75 |
161 |
2.46e-2 |
SMART |
|
CA
|
185 |
270 |
8.1e-20 |
SMART |
|
CA
|
294 |
378 |
1.69e-22 |
SMART |
|
CA
|
402 |
483 |
1.52e-24 |
SMART |
|
CA
|
507 |
593 |
5.68e-24 |
SMART |
|
CA
|
624 |
705 |
6.69e-12 |
SMART |
|
transmembrane domain
|
727 |
749 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
828 |
962 |
5.6e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115661
|
| SMART Domains |
Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
796 |
930 |
3.9e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115662
|
| SMART Domains |
Protein: ENSMUSP00000111326
Gene: ENSMUSG00000104148
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
6.34e-2 |
SMART |
|
CA
|
155 |
240 |
2.98e-18 |
SMART |
|
CA
|
264 |
348 |
2.17e-29 |
SMART |
|
CA
|
372 |
453 |
2.84e-24 |
SMART |
|
CA
|
477 |
563 |
5.02e-25 |
SMART |
|
CA
|
594 |
675 |
8.16e-16 |
SMART |
|
transmembrane domain
|
695 |
717 |
N/A |
INTRINSIC |
|
low complexity region
|
916 |
940 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192168
|
| SMART Domains |
Protein: ENSMUSP00000142293
Gene: ENSMUSG00000103092
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
2.2e-2 |
SMART |
|
CA
|
155 |
240 |
2.05e-21 |
SMART |
|
CA
|
264 |
348 |
8.81e-21 |
SMART |
|
CA
|
372 |
453 |
2.01e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
591 |
673 |
1.63e-15 |
SMART |
|
transmembrane domain
|
693 |
715 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
926 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192295
|
| SMART Domains |
Protein: ENSMUSP00000142103
Gene: ENSMUSG00000104252
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
568 |
5.38e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192503
|
| SMART Domains |
Protein: ENSMUSP00000141989
Gene: ENSMUSG00000102312
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
11 |
17 |
N/A |
INTRINSIC |
|
CA
|
42 |
128 |
3.78e-2 |
SMART |
|
CA
|
152 |
237 |
8.94e-22 |
SMART |
|
CA
|
261 |
345 |
3.74e-24 |
SMART |
|
CA
|
369 |
450 |
1.09e-25 |
SMART |
|
CA
|
474 |
560 |
1.42e-24 |
SMART |
|
CA
|
588 |
670 |
2.96e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
910 |
934 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192512
|
| SMART Domains |
Protein: ENSMUSP00000141408
Gene: ENSMUSG00000104252
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192631
|
| SMART Domains |
Protein: ENSMUSP00000142156
Gene: ENSMUSG00000104318
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
2.58e-2 |
SMART |
|
CA
|
155 |
240 |
4.27e-19 |
SMART |
|
CA
|
264 |
348 |
1.42e-24 |
SMART |
|
CA
|
372 |
453 |
9.36e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
671 |
4.03e-6 |
SMART |
|
transmembrane domain
|
696 |
718 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
929 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193389
|
| SMART Domains |
Protein: ENSMUSP00000141459
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
5.67e-2 |
SMART |
|
CA
|
155 |
240 |
4.72e-21 |
SMART |
|
CA
|
264 |
348 |
1.9e-25 |
SMART |
|
CA
|
372 |
453 |
3.31e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
676 |
5.91e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193777
|
| SMART Domains |
Protein: ENSMUSP00000141587
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
21 |
131 |
5.67e-2 |
SMART |
|
CA
|
155 |
240 |
4.72e-21 |
SMART |
|
CA
|
264 |
348 |
1.9e-25 |
SMART |
|
CA
|
372 |
453 |
3.31e-25 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
676 |
5.91e-13 |
SMART |
|
low complexity region
|
914 |
938 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194038
AA Change: L228V
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000142159
Gene: ENSMUSG00000103800
AA Change: L228V
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
6.34e-2 |
SMART |
|
CA
|
155 |
240 |
4.27e-19 |
SMART |
|
CA
|
264 |
348 |
2.04e-25 |
SMART |
|
CA
|
372 |
453 |
2.84e-24 |
SMART |
|
CA
|
477 |
563 |
9.88e-24 |
SMART |
|
CA
|
594 |
676 |
8.62e-15 |
SMART |
|
transmembrane domain
|
699 |
721 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
938 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193839
|
| SMART Domains |
Protein: ENSMUSP00000142308
Gene: ENSMUSG00000103442
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
22 |
132 |
3.09e-2 |
SMART |
|
CA
|
156 |
241 |
6.14e-20 |
SMART |
|
CA
|
265 |
349 |
3.92e-27 |
SMART |
|
CA
|
373 |
454 |
4.94e-24 |
SMART |
|
CA
|
478 |
564 |
1e-24 |
SMART |
|
CA
|
592 |
672 |
4.55e-14 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193984
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194544
|
| SMART Domains |
Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CA
|
18 |
66 |
5e-20 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194751
|
| SMART Domains |
Protein: ENSMUSP00000142285
Gene: ENSMUSG00000103707
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
21 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_2
|
29 |
112 |
4.5e-32 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195590
|
| SMART Domains |
Protein: ENSMUSP00000141355
Gene: ENSMUSG00000104148
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
6.34e-2 |
SMART |
|
CA
|
155 |
240 |
2.98e-18 |
SMART |
|
CA
|
264 |
348 |
2.17e-29 |
SMART |
|
CA
|
372 |
453 |
2.84e-24 |
SMART |
|
CA
|
477 |
563 |
5.02e-25 |
SMART |
|
CA
|
594 |
675 |
8.16e-16 |
SMART |
|
transmembrane domain
|
695 |
717 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
A |
T |
2: 69,274,143 (GRCm38) |
V733E |
probably benign |
Het |
| Adam34 |
A |
T |
8: 43,652,004 (GRCm38) |
N201K |
probably benign |
Het |
| Aldh3b2 |
A |
C |
19: 3,979,592 (GRCm38) |
S322R |
probably damaging |
Het |
| Anpep |
A |
T |
7: 79,825,310 (GRCm38) |
L914Q |
probably damaging |
Het |
| Arhgap30 |
T |
C |
1: 171,407,571 (GRCm38) |
F535S |
probably damaging |
Het |
| Baiap3 |
G |
A |
17: 25,243,840 (GRCm38) |
R1075C |
probably benign |
Het |
| Baz2a |
G |
T |
10: 128,112,606 (GRCm38) |
G252V |
probably damaging |
Het |
| Brinp3 |
T |
A |
1: 146,901,074 (GRCm38) |
S420T |
possibly damaging |
Het |
| Carmil3 |
T |
C |
14: 55,496,238 (GRCm38) |
F359S |
possibly damaging |
Het |
| Ccdc124 |
A |
T |
8: 70,868,526 (GRCm38) |
L190Q |
probably damaging |
Het |
| Ccr6 |
T |
C |
17: 8,256,140 (GRCm38) |
V59A |
probably damaging |
Het |
| Ccr8 |
T |
A |
9: 120,094,617 (GRCm38) |
I266N |
probably damaging |
Het |
| Cdh23 |
T |
A |
10: 60,331,817 (GRCm38) |
E1798V |
probably damaging |
Het |
| Cdk5rap2 |
T |
C |
4: 70,235,447 (GRCm38) |
N1713S |
probably benign |
Het |
| Cep19 |
T |
A |
16: 32,104,015 (GRCm38) |
I33N |
probably damaging |
Het |
| Cers3 |
A |
T |
7: 66,783,415 (GRCm38) |
Y196F |
probably damaging |
Het |
| Cidea |
T |
C |
18: 67,366,421 (GRCm38) |
I126T |
probably damaging |
Het |
| Copg2 |
A |
T |
6: 30,812,754 (GRCm38) |
Y546* |
probably null |
Het |
| Cul3 |
A |
T |
1: 80,287,000 (GRCm38) |
V261E |
probably benign |
Het |
| Cyp2g1 |
A |
T |
7: 26,814,632 (GRCm38) |
D221V |
probably damaging |
Het |
| Cyp8b1 |
G |
A |
9: 121,915,097 (GRCm38) |
H390Y |
probably damaging |
Het |
| Daam1 |
T |
C |
12: 71,988,943 (GRCm38) |
F971L |
probably damaging |
Het |
| Dnajc24 |
G |
A |
2: 106,001,966 (GRCm38) |
S24L |
possibly damaging |
Het |
| Dpysl3 |
T |
C |
18: 43,438,042 (GRCm38) |
S56G |
probably benign |
Het |
| Esp1 |
A |
G |
17: 40,731,081 (GRCm38) |
D88G |
probably benign |
Het |
| Fam171b |
A |
G |
2: 83,878,230 (GRCm38) |
T359A |
probably damaging |
Het |
| Fam186b |
T |
C |
15: 99,279,837 (GRCm38) |
E536G |
possibly damaging |
Het |
| Fbxo3 |
T |
C |
2: 104,043,012 (GRCm38) |
V156A |
possibly damaging |
Het |
| Gls2 |
C |
A |
10: 128,199,194 (GRCm38) |
H65Q |
probably benign |
Het |
| Gp2 |
A |
G |
7: 119,451,498 (GRCm38) |
|
probably null |
Het |
| Gpcpd1 |
T |
A |
2: 132,534,056 (GRCm38) |
K435I |
probably benign |
Het |
| Gpx6 |
T |
A |
13: 21,317,670 (GRCm38) |
|
probably null |
Het |
| Hps3 |
A |
T |
3: 20,030,419 (GRCm38) |
S202T |
probably benign |
Het |
| Htr1d |
T |
A |
4: 136,443,501 (GRCm38) |
L347H |
probably damaging |
Het |
| Igfals |
T |
C |
17: 24,881,234 (GRCm38) |
L433P |
probably damaging |
Het |
| Ilvbl |
C |
T |
10: 78,583,696 (GRCm38) |
H537Y |
probably benign |
Het |
| Iqgap2 |
A |
T |
13: 95,628,972 (GRCm38) |
M1530K |
probably damaging |
Het |
| Jarid2 |
A |
G |
13: 44,896,322 (GRCm38) |
T247A |
possibly damaging |
Het |
| L3hypdh |
C |
T |
12: 72,074,009 (GRCm38) |
V323I |
possibly damaging |
Het |
| Lama3 |
C |
T |
18: 12,582,608 (GRCm38) |
T1707I |
possibly damaging |
Het |
| Map6 |
G |
T |
7: 99,268,025 (GRCm38) |
A2S |
probably damaging |
Het |
| Mfap3 |
T |
A |
11: 57,530,240 (GRCm38) |
I349K |
probably benign |
Het |
| Mybl2 |
A |
G |
2: 163,072,705 (GRCm38) |
T248A |
probably benign |
Het |
| N6amt1 |
A |
G |
16: 87,362,660 (GRCm38) |
*151W |
probably null |
Het |
| Nhlrc1 |
A |
G |
13: 47,014,208 (GRCm38) |
V191A |
probably benign |
Het |
| Nkx2-5 |
T |
C |
17: 26,839,620 (GRCm38) |
E120G |
possibly damaging |
Het |
| Olfr1066 |
T |
A |
2: 86,455,867 (GRCm38) |
I135F |
possibly damaging |
Het |
| Olfr1380 |
T |
A |
11: 49,564,098 (GRCm38) |
M59K |
probably damaging |
Het |
| Olfr582 |
C |
A |
7: 103,041,632 (GRCm38) |
T46N |
possibly damaging |
Het |
| Olfr890 |
T |
C |
9: 38,143,753 (GRCm38) |
V201A |
probably benign |
Het |
| Pcsk2 |
A |
G |
2: 143,690,333 (GRCm38) |
T134A |
possibly damaging |
Het |
| Phldb3 |
G |
A |
7: 24,624,653 (GRCm38) |
R484Q |
probably benign |
Het |
| Pipox |
A |
G |
11: 77,881,186 (GRCm38) |
S371P |
probably damaging |
Het |
| Plekhg1 |
T |
C |
10: 3,873,343 (GRCm38) |
S159P |
|
Het |
| Psme4 |
C |
T |
11: 30,874,226 (GRCm38) |
P1737S |
probably benign |
Het |
| Pygm |
G |
A |
19: 6,388,863 (GRCm38) |
D328N |
probably benign |
Het |
| Rabgef1 |
A |
T |
5: 130,190,960 (GRCm38) |
E88V |
probably benign |
Het |
| Rims2 |
G |
T |
15: 39,437,032 (GRCm38) |
R245L |
probably benign |
Het |
| Slc38a4 |
T |
C |
15: 97,010,345 (GRCm38) |
I172V |
probably damaging |
Het |
| Slc4a10 |
T |
A |
2: 62,268,665 (GRCm38) |
Y586N |
probably damaging |
Het |
| Snap91 |
C |
T |
9: 86,879,557 (GRCm38) |
|
probably benign |
Het |
| Sorcs1 |
C |
T |
19: 50,190,042 (GRCm38) |
V881I |
probably benign |
Het |
| Spef2 |
A |
T |
15: 9,601,640 (GRCm38) |
V1512E |
unknown |
Het |
| Sufu |
T |
C |
19: 46,453,277 (GRCm38) |
I292T |
possibly damaging |
Het |
| Tet1 |
T |
C |
10: 62,813,671 (GRCm38) |
N87D |
possibly damaging |
Het |
| Tmem108 |
T |
C |
9: 103,499,534 (GRCm38) |
T239A |
not run |
Het |
| Tmem121 |
A |
T |
12: 113,188,494 (GRCm38) |
K111* |
probably null |
Het |
| Tpp2 |
T |
A |
1: 43,968,888 (GRCm38) |
D417E |
probably damaging |
Het |
| Tpr |
G |
A |
1: 150,439,256 (GRCm38) |
E2025K |
possibly damaging |
Het |
| Trappc3 |
C |
T |
4: 126,275,152 (GRCm38) |
A145V |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,890,981 (GRCm38) |
D6754G |
probably null |
Het |
| Unc13c |
T |
A |
9: 73,629,191 (GRCm38) |
M1627L |
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,810,217 (GRCm38) |
I3327V |
probably benign |
Het |
| Vmn1r74 |
C |
T |
7: 11,846,967 (GRCm38) |
Q65* |
probably null |
Het |
| Wdr18 |
G |
A |
10: 79,960,368 (GRCm38) |
R69H |
probably damaging |
Het |
| Zbed5 |
G |
T |
5: 129,900,438 (GRCm38) |
D132Y |
probably damaging |
Het |
| Zfp644 |
A |
T |
5: 106,637,582 (GRCm38) |
Y366* |
probably null |
Het |
| Zfyve26 |
T |
C |
12: 79,246,171 (GRCm38) |
N2068S |
probably damaging |
Het |
| Zic2 |
T |
C |
14: 122,476,091 (GRCm38) |
F139S |
probably damaging |
Het |
| Zmynd11 |
T |
C |
13: 9,710,162 (GRCm38) |
Q141R |
probably benign |
Het |
| Zrsr1 |
A |
G |
11: 22,973,388 (GRCm38) |
E54G |
probably benign |
Het |
| Zscan10 |
G |
A |
17: 23,609,482 (GRCm38) |
D333N |
probably benign |
Het |
|
| Other mutations in Pcdha8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0751:Pcdha8
|
UTSW |
18 |
36,994,070 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3416:Pcdha8
|
UTSW |
18 |
36,992,630 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3755:Pcdha8
|
UTSW |
18 |
36,993,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3756:Pcdha8
|
UTSW |
18 |
36,993,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3882:Pcdha8
|
UTSW |
18 |
36,993,571 (GRCm38) |
missense |
probably benign |
0.08 |
|
R3882:Pcdha8
|
UTSW |
18 |
36,993,046 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4036:Pcdha8
|
UTSW |
18 |
36,992,861 (GRCm38) |
missense |
probably benign |
|
|
R4038:Pcdha8
|
UTSW |
18 |
36,992,861 (GRCm38) |
missense |
probably benign |
|
|
R4204:Pcdha8
|
UTSW |
18 |
36,994,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4246:Pcdha8
|
UTSW |
18 |
36,992,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4596:Pcdha8
|
UTSW |
18 |
36,993,558 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4773:Pcdha8
|
UTSW |
18 |
36,994,573 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5124:Pcdha8
|
UTSW |
18 |
36,993,715 (GRCm38) |
missense |
probably benign |
0.09 |
|
R5396:Pcdha8
|
UTSW |
18 |
36,993,734 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5435:Pcdha8
|
UTSW |
18 |
36,993,599 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5562:Pcdha8
|
UTSW |
18 |
36,992,971 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5896:Pcdha8
|
UTSW |
18 |
36,993,519 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6277:Pcdha8
|
UTSW |
18 |
36,994,358 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6415:Pcdha8
|
UTSW |
18 |
36,994,561 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6620:Pcdha8
|
UTSW |
18 |
36,992,528 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6641:Pcdha8
|
UTSW |
18 |
36,993,797 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6766:Pcdha8
|
UTSW |
18 |
36,994,700 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6807:Pcdha8
|
UTSW |
18 |
36,994,348 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7120:Pcdha8
|
UTSW |
18 |
36,993,787 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7358:Pcdha8
|
UTSW |
18 |
36,992,777 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7701:Pcdha8
|
UTSW |
18 |
36,993,811 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7712:Pcdha8
|
UTSW |
18 |
36,992,684 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R7883:Pcdha8
|
UTSW |
18 |
36,993,143 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8150:Pcdha8
|
UTSW |
18 |
36,993,211 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8685:Pcdha8
|
UTSW |
18 |
36,993,950 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8705:Pcdha8
|
UTSW |
18 |
36,993,853 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8743:Pcdha8
|
UTSW |
18 |
36,994,319 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8956:Pcdha8
|
UTSW |
18 |
36,993,188 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9068:Pcdha8
|
UTSW |
18 |
36,994,270 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9076:Pcdha8
|
UTSW |
18 |
36,993,232 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R9241:Pcdha8
|
UTSW |
18 |
36,993,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9406:Pcdha8
|
UTSW |
18 |
36,993,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9467:Pcdha8
|
UTSW |
18 |
36,993,790 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R9512:Pcdha8
|
UTSW |
18 |
36,993,571 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9550:Pcdha8
|
UTSW |
18 |
36,994,346 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9607:Pcdha8
|
UTSW |
18 |
36,993,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9708:Pcdha8
|
UTSW |
18 |
36,992,495 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTCCAATGCTCTGCTGAC -3'
(R):5'- CCACTCACAGTGTCCATGTG -3'
Sequencing Primer
(F):5'- TGACTTACAGACTGAGCACCAATG -3'
(R):5'- TCCATGTGGAACTTGGATTTTATATC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation