Incidental Mutation 'R7556:Vmn2r69'
| ID |
584770 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r69
|
| Ensembl Gene |
ENSMUSG00000091006 |
| Gene Name |
vomeronasal 2, receptor 69 |
| Synonyms |
|
| MMRRC Submission |
045624-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R7556 (G1)
|
| Quality Score |
154.468 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85055584-85064884 bp(-) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
GAAAA to GAAAAA
at 85060768 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171213]
|
| AlphaFold |
G3XA45 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000171213
|
| SMART Domains |
Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.3e-28 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
1.8e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
3.2e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
C |
T |
9: 46,221,611 (GRCm39) |
W11* |
probably null |
Het |
| A2ml1 |
A |
G |
6: 128,546,927 (GRCm39) |
S401P |
probably damaging |
Het |
| Adamtsl1 |
T |
A |
4: 86,195,358 (GRCm39) |
Y592N |
probably benign |
Het |
| Adh6b |
C |
T |
3: 138,058,546 (GRCm39) |
T76I |
probably damaging |
Het |
| Aebp2 |
C |
A |
6: 140,623,137 (GRCm39) |
P503Q |
probably benign |
Het |
| Ankrd2 |
A |
G |
19: 42,028,839 (GRCm39) |
D134G |
|
Het |
| Atf7ip |
T |
C |
6: 136,538,239 (GRCm39) |
S491P |
probably damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,680,991 (GRCm39) |
D832G |
probably benign |
Het |
| Atrnl1 |
G |
A |
19: 57,643,278 (GRCm39) |
V389I |
probably benign |
Het |
| Bahcc1 |
T |
C |
11: 120,178,589 (GRCm39) |
S2383P |
probably damaging |
Het |
| Brd9 |
A |
G |
13: 74,092,886 (GRCm39) |
D292G |
possibly damaging |
Het |
| Cacna1e |
G |
T |
1: 154,348,419 (GRCm39) |
Q781K |
probably benign |
Het |
| Ccdc9 |
T |
C |
7: 16,018,491 (GRCm39) |
|
probably benign |
Het |
| Cdc42ep4 |
C |
G |
11: 113,619,366 (GRCm39) |
E342Q |
probably damaging |
Het |
| Celf3 |
C |
T |
3: 94,387,590 (GRCm39) |
T54M |
probably damaging |
Het |
| Cenpn |
T |
C |
8: 117,664,008 (GRCm39) |
Y267H |
probably damaging |
Het |
| Chrnb4 |
T |
C |
9: 54,942,339 (GRCm39) |
T312A |
probably benign |
Het |
| Clcn3 |
T |
A |
8: 61,382,521 (GRCm39) |
T383S |
probably damaging |
Het |
| Cln3 |
T |
C |
7: 126,174,242 (GRCm39) |
Q327R |
probably damaging |
Het |
| Cnep1r1 |
T |
C |
8: 88,851,761 (GRCm39) |
L50P |
probably damaging |
Het |
| Cnot6 |
T |
C |
11: 49,566,144 (GRCm39) |
N512S |
probably benign |
Het |
| Col7a1 |
T |
A |
9: 108,811,533 (GRCm39) |
|
probably null |
Het |
| Cryba4 |
C |
T |
5: 112,398,969 (GRCm39) |
R25Q |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,290,389 (GRCm39) |
I1260V |
probably null |
Het |
| Dock2 |
G |
T |
11: 34,611,778 (GRCm39) |
T195K |
probably benign |
Het |
| Dpp9 |
A |
T |
17: 56,497,012 (GRCm39) |
I740N |
possibly damaging |
Het |
| Fbxl21 |
A |
T |
13: 56,674,741 (GRCm39) |
N31Y |
probably benign |
Het |
| Frat1 |
G |
A |
19: 41,818,959 (GRCm39) |
R118Q |
possibly damaging |
Het |
| Gna11 |
A |
G |
10: 81,367,208 (GRCm39) |
F228S |
|
Het |
| Golgb1 |
A |
T |
16: 36,736,155 (GRCm39) |
M1842L |
probably benign |
Het |
| Got1 |
A |
T |
19: 43,491,469 (GRCm39) |
M327K |
probably damaging |
Het |
| H4c9 |
A |
G |
13: 22,225,414 (GRCm39) |
I27T |
probably damaging |
Het |
| Hexa |
T |
A |
9: 59,470,582 (GRCm39) |
L468Q |
probably damaging |
Het |
| Ift57 |
G |
A |
16: 49,526,491 (GRCm39) |
V178I |
probably benign |
Het |
| Kbtbd13 |
T |
C |
9: 65,298,757 (GRCm39) |
T60A |
probably benign |
Het |
| Klk1b5 |
A |
G |
7: 43,496,649 (GRCm39) |
T194A |
probably damaging |
Het |
| Krtap16-3 |
C |
A |
16: 88,759,666 (GRCm39) |
G16C |
unknown |
Het |
| Lamb3 |
T |
C |
1: 193,014,757 (GRCm39) |
S639P |
probably benign |
Het |
| Mapt |
C |
A |
11: 104,189,528 (GRCm39) |
P182Q |
probably benign |
Het |
| Mcf2l |
A |
G |
8: 13,023,071 (GRCm39) |
T86A |
probably damaging |
Het |
| Mecom |
G |
T |
3: 30,041,220 (GRCm39) |
H125N |
probably benign |
Het |
| Med18 |
T |
C |
4: 132,187,247 (GRCm39) |
H84R |
probably benign |
Het |
| Muc2 |
A |
G |
7: 141,307,439 (GRCm39) |
Y798C |
|
Het |
| Mycbp |
T |
C |
4: 123,799,060 (GRCm39) |
Y17H |
probably damaging |
Het |
| Nacad |
C |
T |
11: 6,551,272 (GRCm39) |
V640M |
possibly damaging |
Het |
| Ncoa1 |
C |
T |
12: 4,320,794 (GRCm39) |
V1092I |
probably damaging |
Het |
| Nomo1 |
A |
G |
7: 45,715,642 (GRCm39) |
E696G |
probably damaging |
Het |
| Notch4 |
G |
A |
17: 34,794,444 (GRCm39) |
C741Y |
probably damaging |
Het |
| Or10g7 |
A |
G |
9: 39,905,978 (GRCm39) |
N291D |
probably damaging |
Het |
| Or6d12 |
C |
T |
6: 116,493,697 (GRCm39) |
Q320* |
probably null |
Het |
| Osbpl10 |
C |
A |
9: 115,036,692 (GRCm39) |
H229Q |
probably damaging |
Het |
| Pif1 |
A |
T |
9: 65,496,993 (GRCm39) |
|
probably null |
Het |
| Plk2 |
T |
G |
13: 110,533,122 (GRCm39) |
|
probably null |
Het |
| Ppp1r42 |
T |
C |
1: 10,065,408 (GRCm39) |
H172R |
probably benign |
Het |
| Ring1 |
A |
G |
17: 34,240,688 (GRCm39) |
I363T |
possibly damaging |
Het |
| Rnf168 |
T |
G |
16: 32,117,863 (GRCm39) |
Y475D |
probably damaging |
Het |
| Sbf2 |
T |
A |
7: 109,913,260 (GRCm39) |
K1671N |
probably benign |
Het |
| Sema6d |
A |
G |
2: 124,496,109 (GRCm39) |
N51S |
probably damaging |
Het |
| Setx |
C |
A |
2: 29,036,505 (GRCm39) |
Q997K |
possibly damaging |
Het |
| Skint5 |
T |
G |
4: 113,425,162 (GRCm39) |
Q1088P |
unknown |
Het |
| Slc22a27 |
T |
C |
19: 7,843,119 (GRCm39) |
D528G |
probably damaging |
Het |
| Slc6a7 |
T |
A |
18: 61,140,514 (GRCm39) |
K173* |
probably null |
Het |
| Smc2 |
T |
C |
4: 52,457,379 (GRCm39) |
F380L |
probably benign |
Het |
| Spata31d1a |
T |
C |
13: 59,849,798 (GRCm39) |
M777V |
probably benign |
Het |
| Stkld1 |
A |
T |
2: 26,837,307 (GRCm39) |
N319I |
possibly damaging |
Het |
| Tanc2 |
T |
C |
11: 105,799,857 (GRCm39) |
V93A |
|
Het |
| Tbx20 |
T |
C |
9: 24,661,573 (GRCm39) |
|
probably null |
Het |
| Trbv20 |
G |
A |
6: 41,165,715 (GRCm39) |
V47I |
probably benign |
Het |
| Trip4 |
A |
T |
9: 65,782,155 (GRCm39) |
C192* |
probably null |
Het |
| Tsbp1 |
A |
T |
17: 34,656,691 (GRCm39) |
I103F |
unknown |
Het |
| Tulp2 |
A |
G |
7: 45,168,005 (GRCm39) |
|
probably null |
Het |
| Ush2a |
C |
A |
1: 188,689,690 (GRCm39) |
P5084Q |
probably benign |
Het |
| Virma |
T |
C |
4: 11,518,927 (GRCm39) |
Y675H |
probably damaging |
Het |
| Vmn2r102 |
T |
A |
17: 19,898,093 (GRCm39) |
N369K |
probably benign |
Het |
| Vmn2r59 |
A |
T |
7: 41,695,233 (GRCm39) |
M393K |
probably damaging |
Het |
| Xpot |
A |
G |
10: 121,449,411 (GRCm39) |
S30P |
probably benign |
Het |
| Zfp947 |
T |
C |
17: 22,364,597 (GRCm39) |
Y359C |
probably benign |
Het |
|
| Other mutations in Vmn2r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r69
|
APN |
7 |
85,055,739 (GRCm39) |
missense |
probably benign |
|
|
IGL01457:Vmn2r69
|
APN |
7 |
85,055,836 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01760:Vmn2r69
|
APN |
7 |
85,056,072 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01834:Vmn2r69
|
APN |
7 |
85,061,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02001:Vmn2r69
|
APN |
7 |
85,056,434 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02057:Vmn2r69
|
APN |
7 |
85,060,990 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02289:Vmn2r69
|
APN |
7 |
85,056,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Vmn2r69
|
APN |
7 |
85,058,960 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02478:Vmn2r69
|
APN |
7 |
85,055,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02554:Vmn2r69
|
APN |
7 |
85,059,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02723:Vmn2r69
|
APN |
7 |
85,059,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Vmn2r69
|
UTSW |
7 |
85,060,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0560:Vmn2r69
|
UTSW |
7 |
85,058,922 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0909:Vmn2r69
|
UTSW |
7 |
85,055,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0976:Vmn2r69
|
UTSW |
7 |
85,056,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Vmn2r69
|
UTSW |
7 |
85,059,058 (GRCm39) |
splice site |
probably benign |
|
|
R1459:Vmn2r69
|
UTSW |
7 |
85,055,908 (GRCm39) |
nonsense |
probably null |
|
|
R1482:Vmn2r69
|
UTSW |
7 |
85,056,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Vmn2r69
|
UTSW |
7 |
85,060,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2016:Vmn2r69
|
UTSW |
7 |
85,056,493 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2108:Vmn2r69
|
UTSW |
7 |
85,059,404 (GRCm39) |
missense |
probably benign |
|
|
R2571:Vmn2r69
|
UTSW |
7 |
85,064,764 (GRCm39) |
missense |
probably benign |
|
|
R2910:Vmn2r69
|
UTSW |
7 |
85,055,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2920:Vmn2r69
|
UTSW |
7 |
85,060,973 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3708:Vmn2r69
|
UTSW |
7 |
85,061,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3710:Vmn2r69
|
UTSW |
7 |
85,055,601 (GRCm39) |
missense |
probably benign |
|
|
R4757:Vmn2r69
|
UTSW |
7 |
85,061,575 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4823:Vmn2r69
|
UTSW |
7 |
85,060,508 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4870:Vmn2r69
|
UTSW |
7 |
85,060,793 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4918:Vmn2r69
|
UTSW |
7 |
85,055,967 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5022:Vmn2r69
|
UTSW |
7 |
85,060,367 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5174:Vmn2r69
|
UTSW |
7 |
85,064,739 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5200:Vmn2r69
|
UTSW |
7 |
85,055,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Vmn2r69
|
UTSW |
7 |
85,060,991 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5643:Vmn2r69
|
UTSW |
7 |
85,056,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Vmn2r69
|
UTSW |
7 |
85,061,117 (GRCm39) |
splice site |
probably null |
|
|
R6083:Vmn2r69
|
UTSW |
7 |
85,055,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6140:Vmn2r69
|
UTSW |
7 |
85,060,657 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6306:Vmn2r69
|
UTSW |
7 |
85,064,799 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6330:Vmn2r69
|
UTSW |
7 |
85,060,835 (GRCm39) |
missense |
probably benign |
|
|
R6380:Vmn2r69
|
UTSW |
7 |
85,061,067 (GRCm39) |
missense |
probably benign |
|
|
R6466:Vmn2r69
|
UTSW |
7 |
85,056,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6542:Vmn2r69
|
UTSW |
7 |
85,060,413 (GRCm39) |
nonsense |
probably null |
|
|
R6583:Vmn2r69
|
UTSW |
7 |
85,059,017 (GRCm39) |
missense |
probably benign |
|
|
R6623:Vmn2r69
|
UTSW |
7 |
85,056,309 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6709:Vmn2r69
|
UTSW |
7 |
85,061,069 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6732:Vmn2r69
|
UTSW |
7 |
85,060,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6741:Vmn2r69
|
UTSW |
7 |
85,061,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7070:Vmn2r69
|
UTSW |
7 |
85,060,688 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7234:Vmn2r69
|
UTSW |
7 |
85,056,315 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7323:Vmn2r69
|
UTSW |
7 |
85,060,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7427:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7428:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7453:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7532:Vmn2r69
|
UTSW |
7 |
85,059,622 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7562:Vmn2r69
|
UTSW |
7 |
85,056,420 (GRCm39) |
missense |
probably benign |
|
|
R7592:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7708:Vmn2r69
|
UTSW |
7 |
85,061,755 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7803:Vmn2r69
|
UTSW |
7 |
85,056,324 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7960:Vmn2r69
|
UTSW |
7 |
85,055,973 (GRCm39) |
missense |
probably benign |
|
|
R7966:Vmn2r69
|
UTSW |
7 |
85,060,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8071:Vmn2r69
|
UTSW |
7 |
85,055,713 (GRCm39) |
nonsense |
probably null |
|
|
R8237:Vmn2r69
|
UTSW |
7 |
85,060,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8347:Vmn2r69
|
UTSW |
7 |
85,064,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8737:Vmn2r69
|
UTSW |
7 |
85,055,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Vmn2r69
|
UTSW |
7 |
85,064,883 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R8831:Vmn2r69
|
UTSW |
7 |
85,059,018 (GRCm39) |
nonsense |
probably null |
|
|
R8856:Vmn2r69
|
UTSW |
7 |
85,061,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8998:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8999:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9161:Vmn2r69
|
UTSW |
7 |
85,056,177 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9228:Vmn2r69
|
UTSW |
7 |
85,064,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,056,084 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9541:Vmn2r69
|
UTSW |
7 |
85,056,209 (GRCm39) |
missense |
probably benign |
|
|
R9620:Vmn2r69
|
UTSW |
7 |
85,061,504 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1176:Vmn2r69
|
UTSW |
7 |
85,055,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGATGGTGGCAATGAACATC -3'
(R):5'- GTGATTGTTACAAGTGATGACCAAGG -3'
Sequencing Primer
(F):5'- TGGCAAAGGAAAATTCACTACTG -3'
(R):5'- TGTTACAAGTGATGACCAAGGAATAC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation