Incidental Mutation 'R7665:Olfr391-ps'
ID 591875
Institutional Source Beutler Lab
Gene Symbol Olfr391-ps
Ensembl Gene ENSMUSG00000070382
Gene Name olfactory receptor 391, pseudogene
Synonyms MOR135-24, GA_x6K02T2P1NL-3951666-3950698, MOR135-30_i, Olfr391-ps1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R7665 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73797861-73803052 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73798961 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 265 (N265K)
Ref Sequence ENSEMBL: ENSMUSP00000151029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214485]
AlphaFold A0A0U1RNJ4
Predicted Effect probably benign
Transcript: ENSMUST00000214485
AA Change: N265K

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.2195 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik A G 5: 114,874,323 probably null Het
A830018L16Rik T C 1: 11,972,099 S448P probably damaging Het
Abca4 C T 3: 122,044,490 probably benign Het
Ackr2 A G 9: 121,909,308 M250V probably benign Het
Actn4 A G 7: 28,916,207 I147T probably damaging Het
Adgrv1 C T 13: 81,499,142 S3093N probably damaging Het
Arid5b C T 10: 68,098,587 G495E probably benign Het
Armh1 C A 4: 117,213,741 A396S probably benign Het
Brwd1 G A 16: 96,041,343 T798M probably benign Het
Cdk13 G A 13: 17,772,553 T540I possibly damaging Het
Cdkn1c A G 7: 143,460,634 V25A possibly damaging Het
Col2a1 T C 15: 97,976,700 E1420G unknown Het
Dbf4 G A 5: 8,397,867 P448S probably damaging Het
Dnajb7 T C 15: 81,407,419 N239S probably benign Het
Dnttip1 A G 2: 164,754,141 D102G probably damaging Het
Dpp8 T A 9: 65,078,718 V830D probably damaging Het
Eef1g T C 19: 8,968,289 V29A probably benign Het
Enpp2 T A 15: 54,839,394 Y906F probably damaging Het
Epb41l4a A G 18: 34,006,016 L23P possibly damaging Het
Epp13 G A 7: 6,269,892 probably null Het
Exoc1 T A 5: 76,543,573 M248K probably benign Het
Fam83b T C 9: 76,490,875 Y982C probably damaging Het
Fat4 C T 3: 38,889,178 A740V probably benign Het
Fsip2 T A 2: 82,981,805 S2823T probably benign Het
Gckr T C 5: 31,297,555 Het
Gpr150 A T 13: 76,055,974 V284E probably damaging Het
Grtp1 T G 8: 13,177,103 I344L probably benign Het
Heatr5a T A 12: 51,961,530 N10I probably damaging Het
Herc2 C A 7: 56,153,155 L2109I probably damaging Het
Hs1bp3 T A 12: 8,317,935 D61E probably damaging Het
Ifit1bl1 T A 19: 34,594,883 Y58F probably benign Het
Itfg1 A G 8: 85,764,350 F317L probably benign Het
Itsn1 T C 16: 91,841,603 I764T unknown Het
Med8 A C 4: 118,411,656 probably null Het
Mpeg1 C A 19: 12,463,094 P639T probably damaging Het
Nedd9 A G 13: 41,316,309 L456P probably benign Het
Neo1 A G 9: 58,925,795 S556P probably damaging Het
Nphp3 T A 9: 104,005,393 probably null Het
Nup205 T C 6: 35,177,620 V53A possibly damaging Het
Nvl A T 1: 181,134,944 S154T probably benign Het
Olfr239 G T 17: 33,199,629 G194* probably null Het
Olfr615 A T 7: 103,561,316 I280F probably benign Het
Olfr706 A T 7: 106,886,673 V48D possibly damaging Het
Olfr827 T A 10: 130,211,261 probably null Het
Olfr92 A G 17: 37,111,391 M197T probably benign Het
Parvg T C 15: 84,337,801 I243T probably damaging Het
Paxip1 T A 5: 27,765,738 M538L unknown Het
Pgghg G T 7: 140,945,469 D428Y probably damaging Het
Pik3cd C T 4: 149,654,050 V777M possibly damaging Het
Plcl2 A C 17: 50,607,157 K398T probably benign Het
Plxna1 A T 6: 89,324,538 probably null Het
Rbbp6 T C 7: 122,994,686 Y514H possibly damaging Het
Rbbp6 T A 7: 122,990,032 probably null Het
Scin T A 12: 40,069,415 N538I probably damaging Het
Sdcbp A G 4: 6,385,144 D121G probably benign Het
Sgk1 T C 10: 21,996,662 I311T probably damaging Het
Shq1 A C 6: 100,573,756 L407W probably damaging Het
Sipa1 A T 19: 5,651,671 S979T probably benign Het
Slc25a37 G T 14: 69,249,579 T85K probably benign Het
Soga3 T A 10: 29,196,397 Y562N probably damaging Het
Spag9 A T 11: 94,013,654 Q112L probably damaging Het
Spg11 A T 2: 122,066,267 V1686E probably damaging Het
Stap2 A G 17: 55,997,909 V291A probably benign Het
Tnk2 C T 16: 32,680,526 R886C probably damaging Het
Tnrc6c T A 11: 117,720,951 D138E possibly damaging Het
Unc13c A G 9: 73,680,474 S1426P probably benign Het
Vav1 G A 17: 57,297,086 V163M probably damaging Het
Vmn2r67 T A 7: 85,151,988 K247* probably null Het
Zc2hc1c T C 12: 85,296,562 V491A possibly damaging Het
Zfp51 A G 17: 21,463,581 T153A probably benign Het
Zyx A G 6: 42,356,162 E374G probably damaging Het
Other mutations in Olfr391-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2967:Olfr391-ps UTSW 11 73799107 missense possibly damaging 0.95
R4782:Olfr391-ps UTSW 11 73798839 missense probably benign 0.00
R5011:Olfr391-ps UTSW 11 73799647 missense possibly damaging 0.56
R5984:Olfr391-ps UTSW 11 73799581 missense possibly damaging 0.95
R6276:Olfr391-ps UTSW 11 73799403 missense probably damaging 1.00
R6338:Olfr391-ps UTSW 11 73799319 missense possibly damaging 0.93
R6835:Olfr391-ps UTSW 11 73799235 missense possibly damaging 0.95
R6968:Olfr391-ps UTSW 11 73799379 missense possibly damaging 0.86
R7125:Olfr391-ps UTSW 11 73799164 missense probably benign 0.00
R7258:Olfr391-ps UTSW 11 73799380 missense probably damaging 0.98
R7272:Olfr391-ps UTSW 11 73798869 missense probably damaging 1.00
R8053:Olfr391-ps UTSW 11 73798996 missense probably benign 0.22
R8314:Olfr391-ps UTSW 11 73799742 missense noncoding transcript
R9089:Olfr391-ps UTSW 11 73799226 missense probably damaging 1.00
R9328:Olfr391-ps UTSW 11 73799652 missense probably damaging 1.00
R9788:Olfr391-ps UTSW 11 73798942 missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TAGCATGCTCTTCCTGGTAGATC -3'
(R):5'- CTGGCTTGCTCAGACACTTATG -3'

Sequencing Primer
(F):5'- CTTCCTGGTAGATCCTATGATAAGG -3'
(R):5'- GGCTTGCTCAGACACTTATGTTAATG -3'
Posted On 2019-11-12