Incidental Mutation 'R7700:Tpp2'
| ID |
593902 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
045761-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R7700 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 44009626 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 487
(I487V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087933
AA Change: I487V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: I487V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186441
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
AA Change: I487V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
AA Change: I487V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188313
AA Change: I487V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: I487V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: I487V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: I487V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (85/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810009A15Rik |
T |
C |
19: 8,867,417 (GRCm39) |
L72P |
probably benign |
Het |
| 4930407I10Rik |
C |
A |
15: 81,948,306 (GRCm39) |
H734Q |
probably benign |
Het |
| Acadl |
A |
G |
1: 66,877,522 (GRCm39) |
V343A |
possibly damaging |
Het |
| Acot4 |
A |
T |
12: 84,090,011 (GRCm39) |
D236V |
probably damaging |
Het |
| App |
T |
A |
16: 84,837,197 (GRCm39) |
|
probably null |
Het |
| Arfgef1 |
G |
A |
1: 10,264,636 (GRCm39) |
T470I |
possibly damaging |
Het |
| Arhgef5 |
T |
C |
6: 43,251,691 (GRCm39) |
I814T |
probably benign |
Het |
| Atr |
A |
T |
9: 95,757,743 (GRCm39) |
R968* |
probably null |
Het |
| Bltp1 |
T |
A |
3: 37,028,321 (GRCm39) |
N2329K |
possibly damaging |
Het |
| Bltp1 |
C |
T |
3: 37,080,303 (GRCm39) |
S267L |
probably benign |
Het |
| Capn7 |
C |
T |
14: 31,074,401 (GRCm39) |
T268I |
probably benign |
Het |
| Ccdc192 |
A |
G |
18: 57,696,388 (GRCm39) |
|
probably null |
Het |
| Ccn1 |
C |
T |
3: 145,354,447 (GRCm39) |
G155R |
probably damaging |
Het |
| Csmd2 |
G |
T |
4: 128,439,549 (GRCm39) |
|
probably null |
Het |
| Cubn |
A |
T |
2: 13,352,989 (GRCm39) |
F1916L |
probably benign |
Het |
| Cubn |
A |
G |
2: 13,494,728 (GRCm39) |
V107A |
possibly damaging |
Het |
| Cyp11b1 |
T |
A |
15: 74,707,691 (GRCm39) |
T473S |
probably damaging |
Het |
| Dip2c |
T |
G |
13: 9,709,347 (GRCm39) |
S1396A |
probably benign |
Het |
| Dop1b |
T |
G |
16: 93,595,649 (GRCm39) |
|
probably null |
Het |
| Dyrk1b |
T |
C |
7: 27,883,737 (GRCm39) |
Y198H |
probably damaging |
Het |
| Echdc2 |
G |
T |
4: 108,031,274 (GRCm39) |
R206L |
probably benign |
Het |
| Ep400 |
C |
T |
5: 110,843,898 (GRCm39) |
R1594Q |
unknown |
Het |
| Esyt1 |
T |
A |
10: 128,351,723 (GRCm39) |
|
probably benign |
Het |
| Fmnl2 |
G |
A |
2: 52,926,520 (GRCm39) |
R69Q |
|
Het |
| Fry |
T |
A |
5: 150,328,792 (GRCm39) |
H1308Q |
probably damaging |
Het |
| Fyb2 |
T |
A |
4: 104,867,651 (GRCm39) |
D667E |
probably benign |
Het |
| Gimap7 |
T |
A |
6: 48,700,791 (GRCm39) |
Y126N |
possibly damaging |
Het |
| Gm1979 |
A |
T |
5: 26,205,178 (GRCm39) |
W266R |
probably damaging |
Het |
| Gm28042 |
T |
A |
2: 119,870,197 (GRCm39) |
M712K |
possibly damaging |
Het |
| Gm3238 |
A |
G |
10: 77,606,469 (GRCm39) |
*231R |
probably null |
Het |
| Gm5592 |
C |
A |
7: 40,935,831 (GRCm39) |
A111E |
probably damaging |
Het |
| Gm7694 |
A |
G |
1: 170,128,717 (GRCm39) |
*271Q |
probably null |
Het |
| Gm9195 |
A |
C |
14: 72,693,342 (GRCm39) |
|
probably null |
Het |
| Ift81 |
T |
C |
5: 122,732,623 (GRCm39) |
M304V |
possibly damaging |
Het |
| Igfals |
T |
C |
17: 25,099,548 (GRCm39) |
L213P |
probably damaging |
Het |
| Ints3 |
G |
A |
3: 90,329,111 (GRCm39) |
P83S |
probably benign |
Het |
| Kcna10 |
T |
G |
3: 107,102,856 (GRCm39) |
S496A |
probably damaging |
Het |
| Kmt2d |
G |
A |
15: 98,741,600 (GRCm39) |
A4520V |
unknown |
Het |
| Lemd3 |
A |
T |
10: 120,813,995 (GRCm39) |
Y413N |
probably damaging |
Het |
| Lgr6 |
T |
C |
1: 134,923,770 (GRCm39) |
N453S |
probably damaging |
Het |
| Lmtk3 |
A |
C |
7: 45,441,998 (GRCm39) |
D352A |
probably damaging |
Het |
| Lrrc4c |
T |
C |
2: 97,461,024 (GRCm39) |
M550T |
possibly damaging |
Het |
| Maml2 |
A |
T |
9: 13,532,385 (GRCm39) |
Q533L |
|
Het |
| Mdn1 |
T |
A |
4: 32,741,344 (GRCm39) |
D3815E |
probably damaging |
Het |
| Megf8 |
C |
T |
7: 25,029,353 (GRCm39) |
A299V |
possibly damaging |
Het |
| Meis3 |
G |
T |
7: 15,911,481 (GRCm39) |
E59D |
probably benign |
Het |
| Mppe1 |
A |
G |
18: 67,358,775 (GRCm39) |
*398R |
probably null |
Het |
| Mtmr7 |
G |
A |
8: 41,059,927 (GRCm39) |
A62V |
possibly damaging |
Het |
| Mtus1 |
T |
A |
8: 41,537,006 (GRCm39) |
T237S |
possibly damaging |
Het |
| Ndfip2 |
T |
A |
14: 105,525,193 (GRCm39) |
V158E |
possibly damaging |
Het |
| Nrbp2 |
T |
G |
15: 75,962,746 (GRCm39) |
T53P |
probably damaging |
Het |
| Nrde2 |
G |
A |
12: 100,097,094 (GRCm39) |
P902L |
probably benign |
Het |
| Or10ab5 |
T |
A |
7: 108,244,879 (GRCm39) |
K301N |
probably damaging |
Het |
| Or11g24 |
T |
A |
14: 50,662,792 (GRCm39) |
M272K |
probably benign |
Het |
| Or2y13 |
A |
G |
11: 49,415,381 (GRCm39) |
Y277C |
probably damaging |
Het |
| Or6c202 |
T |
C |
10: 128,995,924 (GRCm39) |
M310V |
probably benign |
Het |
| Pcdha1 |
A |
G |
18: 37,064,115 (GRCm39) |
T260A |
probably damaging |
Het |
| Pdlim1 |
T |
G |
19: 40,238,102 (GRCm39) |
K98N |
probably damaging |
Het |
| Pdxk |
A |
T |
10: 78,279,764 (GRCm39) |
|
probably null |
Het |
| Phrf1 |
G |
A |
7: 140,834,842 (GRCm39) |
G207R |
unknown |
Het |
| Pik3r6 |
A |
G |
11: 68,419,389 (GRCm39) |
K124R |
probably damaging |
Het |
| Polr2b |
T |
A |
5: 77,488,268 (GRCm39) |
F823I |
probably benign |
Het |
| Prss58 |
T |
C |
6: 40,872,322 (GRCm39) |
I234V |
probably damaging |
Het |
| Ptpn14 |
A |
T |
1: 189,597,608 (GRCm39) |
N766I |
probably benign |
Het |
| Qrfprl |
T |
A |
6: 65,429,940 (GRCm39) |
I212N |
probably benign |
Het |
| Repin1 |
T |
A |
6: 48,574,756 (GRCm39) |
S562T |
probably damaging |
Het |
| Rgr |
C |
T |
14: 36,766,552 (GRCm39) |
D165N |
probably damaging |
Het |
| Rho |
T |
C |
6: 115,912,200 (GRCm39) |
F221L |
probably damaging |
Het |
| Rictor |
C |
T |
15: 6,801,635 (GRCm39) |
S441L |
probably benign |
Het |
| Rnase2a |
A |
G |
14: 51,493,248 (GRCm39) |
I39T |
probably damaging |
Het |
| Rpl13a |
T |
G |
7: 44,776,660 (GRCm39) |
I43L |
probably benign |
Het |
| Rpp30 |
T |
C |
19: 36,066,558 (GRCm39) |
V97A |
probably benign |
Het |
| Scube3 |
T |
C |
17: 28,386,023 (GRCm39) |
Y755H |
probably damaging |
Het |
| Sec24a |
A |
T |
11: 51,603,084 (GRCm39) |
V788E |
probably damaging |
Het |
| Spns2 |
A |
T |
11: 72,380,443 (GRCm39) |
L60* |
probably null |
Het |
| Strc |
T |
C |
2: 121,202,229 (GRCm39) |
N1213S |
possibly damaging |
Het |
| Tec |
A |
T |
5: 72,943,367 (GRCm39) |
I116N |
possibly damaging |
Het |
| Tll1 |
A |
T |
8: 64,546,988 (GRCm39) |
D319E |
probably benign |
Het |
| Tmem121b |
T |
C |
6: 120,470,388 (GRCm39) |
T110A |
unknown |
Het |
| Tmem232 |
T |
A |
17: 65,572,213 (GRCm39) |
I593F |
probably damaging |
Het |
| Ubr4 |
C |
A |
4: 139,136,178 (GRCm39) |
C934* |
probably null |
Het |
| Vmn1r68 |
A |
G |
7: 10,261,559 (GRCm39) |
Y180H |
probably benign |
Het |
| Vmn2r25 |
T |
C |
6: 123,816,882 (GRCm39) |
D233G |
possibly damaging |
Het |
| Wdr6 |
A |
G |
9: 108,453,560 (GRCm39) |
W108R |
possibly damaging |
Het |
| Zng1 |
A |
G |
19: 24,920,045 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTACTTGTGTGATGCAAGCAG -3'
(R):5'- CACTCGGTAACTTACGTCTGAC -3'
Sequencing Primer
(F):5'- GTGTGATGCAAGCAGTTTAAATC -3'
(R):5'- AAAGAGCCTTTGTGCCCTTTTTG -3'
|
| Posted On |
2019-11-12 |
Incidental Mutation