Incidental Mutation 'R7526:Vmn2r60'
| ID |
582991 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Gprc2a-rs3, Casr-rs3, EG637898 |
| MMRRC Submission |
045598-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.113)
|
| Stock # |
R7526 (G1)
|
| Quality Score |
217.468 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
42116471-42195776 bp(+) (GRCm38) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
AG to A
at 42195734 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000166447
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (74/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700086D15Rik |
A |
T |
11: 65,152,981 (GRCm38) |
F85I |
unknown |
Het |
| Ankrd22 |
A |
T |
19: 34,149,365 (GRCm38) |
W22R |
possibly damaging |
Het |
| Aqr |
A |
T |
2: 114,108,109 (GRCm38) |
H1287Q |
probably damaging |
Het |
| Armh1 |
C |
A |
4: 117,213,741 (GRCm38) |
A396S |
probably benign |
Het |
| Atp8b5 |
A |
G |
4: 43,366,609 (GRCm38) |
E791G |
probably damaging |
Het |
| Bicd1 |
T |
G |
6: 149,513,726 (GRCm38) |
S646A |
possibly damaging |
Het |
| Bmpr1b |
A |
T |
3: 141,856,599 (GRCm38) |
Y276N |
probably damaging |
Het |
| Cadps2 |
T |
C |
6: 23,496,851 (GRCm38) |
H465R |
probably damaging |
Het |
| Card11 |
A |
T |
5: 140,913,429 (GRCm38) |
|
probably null |
Het |
| Ccdc9 |
A |
G |
7: 16,282,400 (GRCm38) |
L139P |
probably damaging |
Het |
| Cdk5rap3 |
A |
T |
11: 96,909,945 (GRCm38) |
M355K |
probably benign |
Het |
| Cnot2 |
A |
T |
10: 116,507,080 (GRCm38) |
V116E |
probably benign |
Het |
| Defb48 |
A |
G |
14: 62,977,831 (GRCm38) |
V32A |
possibly damaging |
Het |
| Dmkn |
A |
G |
7: 30,777,651 (GRCm38) |
D460G |
possibly damaging |
Het |
| Dmxl2 |
A |
G |
9: 54,400,957 (GRCm38) |
V2170A |
possibly damaging |
Het |
| Dnah1 |
A |
T |
14: 31,287,876 (GRCm38) |
F1912I |
possibly damaging |
Het |
| Dok3 |
C |
T |
13: 55,527,493 (GRCm38) |
V71I |
probably benign |
Het |
| Dzip3 |
A |
T |
16: 48,975,474 (GRCm38) |
F178Y |
probably damaging |
Het |
| Enpp1 |
T |
C |
10: 24,674,410 (GRCm38) |
|
probably null |
Het |
| Eogt |
A |
G |
6: 97,113,952 (GRCm38) |
F409L |
probably damaging |
Het |
| Erich6 |
A |
T |
3: 58,630,689 (GRCm38) |
L218H |
probably damaging |
Het |
| Fam186a |
G |
C |
15: 99,941,915 (GRCm38) |
I2149M |
possibly damaging |
Het |
| Fat1 |
G |
A |
8: 45,023,427 (GRCm38) |
V1837I |
probably damaging |
Het |
| Flrt3 |
T |
A |
2: 140,660,206 (GRCm38) |
T501S |
probably damaging |
Het |
| Fmn1 |
A |
C |
2: 113,688,134 (GRCm38) |
E1365D |
probably damaging |
Het |
| Fzd5 |
G |
T |
1: 64,736,092 (GRCm38) |
P170Q |
probably benign |
Het |
| Gm14326 |
G |
A |
2: 177,946,505 (GRCm38) |
H233Y |
probably damaging |
Het |
| Gm19410 |
G |
A |
8: 35,790,612 (GRCm38) |
V735M |
probably damaging |
Het |
| Gm21886 |
ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG |
ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG |
18: 80,089,825 (GRCm38) |
|
probably benign |
Het |
| Gm2832 |
A |
T |
14: 41,280,962 (GRCm38) |
I143L |
|
Het |
| Greb1 |
G |
A |
12: 16,716,765 (GRCm38) |
T344I |
probably benign |
Het |
| Grik2 |
A |
T |
10: 49,523,822 (GRCm38) |
Y271N |
possibly damaging |
Het |
| Grin3b |
A |
G |
10: 79,973,051 (GRCm38) |
N212D |
probably benign |
Het |
| Hgsnat |
A |
G |
8: 25,971,049 (GRCm38) |
L187P |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,656,573 (GRCm38) |
I3152T |
probably damaging |
Het |
| Hsp90aa1 |
A |
T |
12: 110,695,294 (GRCm38) |
I96N |
unknown |
Het |
| Il18r1 |
T |
A |
1: 40,471,772 (GRCm38) |
L6I |
probably damaging |
Het |
| Ing3 |
G |
A |
6: 21,953,799 (GRCm38) |
V80I |
probably damaging |
Het |
| Kif18b |
T |
C |
11: 102,914,667 (GRCm38) |
I255V |
probably damaging |
Het |
| Kif2c |
A |
T |
4: 117,182,432 (GRCm38) |
N20K |
possibly damaging |
Het |
| Mfsd6l |
T |
C |
11: 68,558,038 (GRCm38) |
W572R |
probably damaging |
Het |
| Mybphl |
A |
G |
3: 108,374,180 (GRCm38) |
T71A |
probably benign |
Het |
| Myo7a |
G |
T |
7: 98,085,448 (GRCm38) |
T613K |
possibly damaging |
Het |
| Nfatc3 |
T |
C |
8: 106,079,083 (GRCm38) |
S195P |
probably damaging |
Het |
| Nrg1 |
T |
C |
8: 31,818,323 (GRCm38) |
N603S |
probably benign |
Het |
| Or52ae9 |
T |
C |
7: 103,740,400 (GRCm38) |
Y280C |
probably damaging |
Het |
| Or8k22 |
A |
T |
2: 86,333,353 (GRCm38) |
M1K |
probably null |
Het |
| Or8k37 |
A |
G |
2: 86,639,669 (GRCm38) |
I13T |
possibly damaging |
Het |
| Parp8 |
T |
C |
13: 116,894,805 (GRCm38) |
E457G |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,521,062 (GRCm38) |
F154L |
probably benign |
Het |
| Pear1 |
A |
G |
3: 87,752,568 (GRCm38) |
S704P |
probably damaging |
Het |
| Pkib |
A |
G |
10: 57,736,298 (GRCm38) |
T92A |
probably benign |
Het |
| Pnpla7 |
A |
G |
2: 24,998,666 (GRCm38) |
R376G |
possibly damaging |
Het |
| Pramel28 |
A |
T |
4: 143,965,817 (GRCm38) |
C205S |
probably benign |
Het |
| Ptprd |
T |
A |
4: 76,066,327 (GRCm38) |
E527D |
probably benign |
Het |
| Pum1 |
T |
C |
4: 130,747,026 (GRCm38) |
V469A |
probably damaging |
Het |
| Rnf148 |
G |
A |
6: 23,654,284 (GRCm38) |
Q238* |
probably null |
Het |
| Scn9a |
A |
C |
2: 66,483,646 (GRCm38) |
N1909K |
probably benign |
Het |
| Sema3c |
A |
T |
5: 17,727,596 (GRCm38) |
H699L |
possibly damaging |
Het |
| Sema3f |
A |
T |
9: 107,689,728 (GRCm38) |
C201S |
probably damaging |
Het |
| Serinc2 |
T |
A |
4: 130,258,790 (GRCm38) |
D206V |
probably benign |
Het |
| Serping1 |
A |
T |
2: 84,767,293 (GRCm38) |
S415T |
probably benign |
Het |
| Sirpb1b |
A |
T |
3: 15,548,872 (GRCm38) |
L50Q |
probably damaging |
Het |
| Slc25a22 |
T |
C |
7: 141,431,383 (GRCm38) |
E262G |
probably benign |
Het |
| Slc5a8 |
A |
G |
10: 88,902,491 (GRCm38) |
I205M |
probably damaging |
Het |
| Sod2 |
G |
T |
17: 13,008,031 (GRCm38) |
|
probably benign |
Het |
| Tec |
T |
C |
5: 72,786,019 (GRCm38) |
I118V |
probably benign |
Het |
| Tenm3 |
A |
T |
8: 48,287,812 (GRCm38) |
V1212E |
probably damaging |
Het |
| Tex44 |
G |
A |
1: 86,426,515 (GRCm38) |
V49I |
probably benign |
Het |
| Tmem132d |
A |
T |
5: 127,784,141 (GRCm38) |
L972* |
probably null |
Het |
| Tpte |
G |
A |
8: 22,325,547 (GRCm38) |
|
probably null |
Het |
| Trim6 |
T |
A |
7: 104,232,832 (GRCm38) |
I456N |
probably damaging |
Het |
| Ubr4 |
G |
C |
4: 139,422,417 (GRCm38) |
V520L |
probably benign |
Het |
| Ubxn8 |
A |
T |
8: 33,633,607 (GRCm38) |
N101K |
probably benign |
Het |
| Vmn2r83 |
A |
G |
10: 79,491,558 (GRCm38) |
T667A |
probably damaging |
Het |
| Zpld2 |
T |
C |
4: 134,200,073 (GRCm38) |
|
probably null |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
42,136,486 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
42,136,486 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
42,195,154 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
42,195,466 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
42,195,586 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
42,142,296 (GRCm38) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
42,136,594 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
42,116,547 (GRCm38) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
42,195,140 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
42,135,561 (GRCm38) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
42,142,320 (GRCm38) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
42,135,831 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
42,195,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
42,194,941 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
42,195,771 (GRCm38) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
42,137,052 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
42,136,787 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
42,136,787 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
42,136,713 (GRCm38) |
missense |
probably benign |
0.17 |
|
R1623:Vmn2r60
|
UTSW |
7 |
42,135,855 (GRCm38) |
nonsense |
probably null |
|
|
R1628:Vmn2r60
|
UTSW |
7 |
42,136,406 (GRCm38) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
42,136,670 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
42,136,670 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
42,195,507 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
42,136,827 (GRCm38) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
42,136,433 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
42,140,979 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
42,135,796 (GRCm38) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
42,141,035 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
42,141,035 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
42,116,556 (GRCm38) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
42,135,701 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
42,135,701 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
42,136,454 (GRCm38) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
42,116,528 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
42,116,528 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
42,116,528 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
42,195,243 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
42,135,663 (GRCm38) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
42,135,861 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
42,195,511 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
42,137,024 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
42,135,730 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
42,195,625 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
42,116,508 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
42,194,962 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
42,194,962 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
42,195,423 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
42,136,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
42,135,621 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
42,116,471 (GRCm38) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
42,194,886 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
42,135,663 (GRCm38) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
42,142,292 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
42,142,242 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
42,137,063 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
42,195,112 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
42,136,742 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
42,136,402 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
42,195,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7527:Vmn2r60
|
UTSW |
7 |
42,195,734 (GRCm38) |
frame shift |
probably null |
|
|
R7528:Vmn2r60
|
UTSW |
7 |
42,195,734 (GRCm38) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
42,195,111 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
42,195,087 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
42,141,097 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
42,142,266 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8342:Vmn2r60
|
UTSW |
7 |
42,141,070 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R8362:Vmn2r60
|
UTSW |
7 |
42,195,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
42,195,426 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
42,136,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
42,142,230 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
42,141,094 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
42,136,354 (GRCm38) |
missense |
probably benign |
0.27 |
|
R9190:Vmn2r60
|
UTSW |
7 |
42,195,511 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9229:Vmn2r60
|
UTSW |
7 |
42,142,299 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R9295:Vmn2r60
|
UTSW |
7 |
42,136,531 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9335:Vmn2r60
|
UTSW |
7 |
42,194,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
42,135,748 (GRCm38) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
42,140,939 (GRCm38) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
42,141,114 (GRCm38) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGTCATTCAGCATGCAG -3'
(R):5'- TGTAGGCTAACAAGGGCAC -3'
Sequencing Primer
(F):5'- CAGCATGCAGATATTCTTCTGTG -3'
(R):5'- TAACAAGGGCACAGAGTAAAACTATG -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation