Incidental Mutation 'R3822:Vmn2r60'
ID 275223
Institutional Source Beutler Lab
Gene Symbol Vmn2r60
Ensembl Gene ENSMUSG00000090619
Gene Name vomeronasal 2, receptor 60
Synonyms Casr-rs3, EG637898, Gprc2a-rs3
MMRRC Submission 040884-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R3822 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 41765895-41845200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41785125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 112 (E112D)
Ref Sequence ENSEMBL: ENSMUSP00000128493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166447]
AlphaFold A0A3B2WBC8
Predicted Effect probably damaging
Transcript: ENSMUST00000166447
AA Change: E112D

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: E112D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 78 471 1.2e-44 PFAM
Pfam:NCD3G 514 567 5.1e-23 PFAM
Pfam:7tm_3 600 835 1.4e-51 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 T A 11: 101,301,971 (GRCm39) I332F probably damaging Het
Acp3 G T 9: 104,201,916 (GRCm39) Q76K probably damaging Het
Anp32e A T 3: 95,842,181 (GRCm39) I100L probably benign Het
Ccdc13 C A 9: 121,660,085 (GRCm39) L76F probably damaging Het
Cd44 T C 2: 102,731,738 (GRCm39) probably null Het
Chka A G 19: 3,932,038 (GRCm39) probably benign Het
Cnot6 A T 11: 49,579,999 (GRCm39) S98T probably benign Het
Cth A G 3: 157,624,136 (GRCm39) F127S probably benign Het
Dnah9 C A 11: 65,741,829 (GRCm39) probably null Het
Dysf T C 6: 84,184,070 (GRCm39) probably benign Het
Flad1 T A 3: 89,318,494 (GRCm39) I20F probably damaging Het
Gm20730 C T 6: 43,058,656 (GRCm39) S52N probably benign Het
Gpr89 A G 3: 96,800,260 (GRCm39) S113P probably benign Het
Herpud2 G A 9: 25,036,220 (GRCm39) Q147* probably null Het
Hivep1 A T 13: 42,337,787 (GRCm39) H2622L possibly damaging Het
Hlcs T C 16: 94,068,840 (GRCm39) N274D probably benign Het
Ido2 T C 8: 25,023,771 (GRCm39) I356V probably benign Het
Insyn2b T C 11: 34,353,007 (GRCm39) S350P probably benign Het
Itgam A G 7: 127,711,458 (GRCm39) probably null Het
Lama1 C A 17: 68,086,041 (GRCm39) probably null Het
Lrrc4b T A 7: 44,111,982 (GRCm39) V618E probably damaging Het
Man1a2 A G 3: 100,539,913 (GRCm39) I176T possibly damaging Het
Mns1 A G 9: 72,346,730 (GRCm39) E71G probably damaging Het
Ncoa6 T A 2: 155,248,858 (GRCm39) N1482I probably damaging Het
Neto2 C A 8: 86,389,924 (GRCm39) E180* probably null Het
Psmb7 A T 2: 38,503,440 (GRCm39) probably benign Het
Rin2 C T 2: 145,664,550 (GRCm39) T60M probably benign Het
Slc28a3 A G 13: 58,706,092 (GRCm39) V639A probably benign Het
Tenm2 A T 11: 35,915,147 (GRCm39) I2129N probably damaging Het
Topaz1 A G 9: 122,626,848 (GRCm39) D1492G possibly damaging Het
Trank1 G A 9: 111,207,887 (GRCm39) G1711R probably damaging Het
Trpm1 A G 7: 63,867,451 (GRCm39) probably benign Het
Ugt1a6a T A 1: 88,066,251 (GRCm39) V19E probably benign Het
Wdr4 T G 17: 31,731,195 (GRCm39) Q55P probably damaging Het
Xpnpep1 G A 19: 52,992,250 (GRCm39) probably benign Het
Zfyve16 A T 13: 92,657,769 (GRCm39) L714Q probably damaging Het
Other mutations in Vmn2r60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Vmn2r60 APN 7 41,785,910 (GRCm39) missense probably benign 0.09
IGL01623:Vmn2r60 APN 7 41,785,910 (GRCm39) missense probably benign 0.09
IGL02363:Vmn2r60 APN 7 41,844,578 (GRCm39) missense probably benign 0.02
IGL02485:Vmn2r60 APN 7 41,844,890 (GRCm39) missense possibly damaging 0.54
IGL02651:Vmn2r60 APN 7 41,845,010 (GRCm39) missense probably damaging 0.99
IGL02660:Vmn2r60 APN 7 41,791,720 (GRCm39) nonsense probably null
IGL03135:Vmn2r60 APN 7 41,786,018 (GRCm39) missense probably benign 0.13
IGL03307:Vmn2r60 APN 7 41,765,971 (GRCm39) missense probably benign 0.14
R0310:Vmn2r60 UTSW 7 41,844,564 (GRCm39) missense possibly damaging 0.54
R0314:Vmn2r60 UTSW 7 41,784,985 (GRCm39) splice site probably benign
R0328:Vmn2r60 UTSW 7 41,791,744 (GRCm39) splice site probably benign
R0464:Vmn2r60 UTSW 7 41,785,255 (GRCm39) missense probably damaging 0.99
R0755:Vmn2r60 UTSW 7 41,844,869 (GRCm39) missense probably damaging 1.00
R1119:Vmn2r60 UTSW 7 41,844,365 (GRCm39) missense possibly damaging 0.68
R1162:Vmn2r60 UTSW 7 41,845,195 (GRCm39) missense probably benign 0.29
R1241:Vmn2r60 UTSW 7 41,786,476 (GRCm39) missense probably benign 0.01
R1404:Vmn2r60 UTSW 7 41,786,211 (GRCm39) missense probably damaging 0.99
R1404:Vmn2r60 UTSW 7 41,786,211 (GRCm39) missense probably damaging 0.99
R1488:Vmn2r60 UTSW 7 41,786,137 (GRCm39) missense probably benign 0.17
R1623:Vmn2r60 UTSW 7 41,785,279 (GRCm39) nonsense probably null
R1628:Vmn2r60 UTSW 7 41,785,830 (GRCm39) nonsense probably null
R1883:Vmn2r60 UTSW 7 41,786,094 (GRCm39) missense probably damaging 0.99
R1884:Vmn2r60 UTSW 7 41,786,094 (GRCm39) missense probably damaging 0.99
R2182:Vmn2r60 UTSW 7 41,844,931 (GRCm39) missense probably benign 0.06
R2275:Vmn2r60 UTSW 7 41,786,251 (GRCm39) nonsense probably null
R2847:Vmn2r60 UTSW 7 41,785,857 (GRCm39) missense probably benign 0.07
R2885:Vmn2r60 UTSW 7 41,790,403 (GRCm39) missense possibly damaging 0.91
R2894:Vmn2r60 UTSW 7 41,785,220 (GRCm39) missense probably benign
R2921:Vmn2r60 UTSW 7 41,790,459 (GRCm39) missense probably damaging 0.98
R2922:Vmn2r60 UTSW 7 41,790,459 (GRCm39) missense probably damaging 0.98
R3772:Vmn2r60 UTSW 7 41,765,980 (GRCm39) missense probably benign 0.35
R3820:Vmn2r60 UTSW 7 41,785,125 (GRCm39) missense probably damaging 0.98
R3872:Vmn2r60 UTSW 7 41,785,878 (GRCm39) missense probably benign 0.19
R4222:Vmn2r60 UTSW 7 41,765,952 (GRCm39) missense probably benign 0.08
R4223:Vmn2r60 UTSW 7 41,765,952 (GRCm39) missense probably benign 0.08
R4224:Vmn2r60 UTSW 7 41,765,952 (GRCm39) missense probably benign 0.08
R4526:Vmn2r60 UTSW 7 41,844,667 (GRCm39) missense probably damaging 0.96
R4547:Vmn2r60 UTSW 7 41,785,087 (GRCm39) missense probably null 0.54
R4840:Vmn2r60 UTSW 7 41,785,285 (GRCm39) missense probably damaging 1.00
R5173:Vmn2r60 UTSW 7 41,844,935 (GRCm39) missense probably damaging 0.97
R5231:Vmn2r60 UTSW 7 41,786,448 (GRCm39) missense possibly damaging 0.93
R5480:Vmn2r60 UTSW 7 41,785,154 (GRCm39) missense probably damaging 0.98
R5521:Vmn2r60 UTSW 7 41,845,049 (GRCm39) missense probably damaging 0.99
R5834:Vmn2r60 UTSW 7 41,765,932 (GRCm39) missense probably benign 0.17
R6038:Vmn2r60 UTSW 7 41,844,386 (GRCm39) missense probably benign 0.04
R6038:Vmn2r60 UTSW 7 41,844,386 (GRCm39) missense probably benign 0.04
R6112:Vmn2r60 UTSW 7 41,844,847 (GRCm39) missense probably damaging 1.00
R6149:Vmn2r60 UTSW 7 41,786,400 (GRCm39) missense probably damaging 1.00
R6170:Vmn2r60 UTSW 7 41,785,045 (GRCm39) missense possibly damaging 0.94
R6383:Vmn2r60 UTSW 7 41,765,895 (GRCm39) start codon destroyed probably null 0.04
R6811:Vmn2r60 UTSW 7 41,844,310 (GRCm39) missense probably damaging 1.00
R6876:Vmn2r60 UTSW 7 41,785,087 (GRCm39) missense probably null 0.54
R6997:Vmn2r60 UTSW 7 41,791,716 (GRCm39) missense probably benign 0.00
R7040:Vmn2r60 UTSW 7 41,791,666 (GRCm39) missense probably benign 0.00
R7116:Vmn2r60 UTSW 7 41,786,487 (GRCm39) missense probably benign 0.00
R7128:Vmn2r60 UTSW 7 41,844,536 (GRCm39) missense probably damaging 0.96
R7232:Vmn2r60 UTSW 7 41,786,166 (GRCm39) missense possibly damaging 0.83
R7296:Vmn2r60 UTSW 7 41,785,826 (GRCm39) missense probably benign 0.01
R7376:Vmn2r60 UTSW 7 41,844,631 (GRCm39) missense probably damaging 1.00
R7526:Vmn2r60 UTSW 7 41,845,158 (GRCm39) frame shift probably null
R7527:Vmn2r60 UTSW 7 41,845,158 (GRCm39) frame shift probably null
R7528:Vmn2r60 UTSW 7 41,845,158 (GRCm39) frame shift probably null
R7764:Vmn2r60 UTSW 7 41,844,535 (GRCm39) missense probably damaging 0.99
R7843:Vmn2r60 UTSW 7 41,844,511 (GRCm39) missense probably benign 0.00
R8080:Vmn2r60 UTSW 7 41,790,521 (GRCm39) missense probably benign 0.30
R8290:Vmn2r60 UTSW 7 41,791,690 (GRCm39) missense probably damaging 1.00
R8342:Vmn2r60 UTSW 7 41,790,494 (GRCm39) missense possibly damaging 0.63
R8362:Vmn2r60 UTSW 7 41,844,954 (GRCm39) missense probably damaging 1.00
R8418:Vmn2r60 UTSW 7 41,844,850 (GRCm39) missense probably damaging 0.97
R8848:Vmn2r60 UTSW 7 41,786,169 (GRCm39) missense probably damaging 1.00
R8860:Vmn2r60 UTSW 7 41,791,654 (GRCm39) missense probably damaging 0.99
R8882:Vmn2r60 UTSW 7 41,790,518 (GRCm39) missense probably benign 0.00
R8913:Vmn2r60 UTSW 7 41,785,778 (GRCm39) missense probably benign 0.27
R9190:Vmn2r60 UTSW 7 41,844,935 (GRCm39) missense probably damaging 0.99
R9229:Vmn2r60 UTSW 7 41,791,723 (GRCm39) missense possibly damaging 0.95
R9295:Vmn2r60 UTSW 7 41,785,955 (GRCm39) missense probably benign 0.01
R9335:Vmn2r60 UTSW 7 41,844,332 (GRCm39) missense probably damaging 1.00
R9796:Vmn2r60 UTSW 7 41,785,172 (GRCm39) missense probably benign
RF024:Vmn2r60 UTSW 7 41,790,363 (GRCm39) missense probably benign 0.01
X0023:Vmn2r60 UTSW 7 41,790,538 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACCACTGCGCTAAATAGAAAAGTTG -3'
(R):5'- AAAGGGTACTTGTTTCCTAGGTCC -3'

Sequencing Primer
(F):5'- AGAAAAGTTGTATGGTCTATGGCTTC -3'
(R):5'- GGTACTTGTTTCCTAGGTCCTACATC -3'
Posted On 2015-04-02