Incidental Mutation 'R0755:Pkdrej'
| ID |
70472 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pkdrej
|
| Ensembl Gene |
ENSMUSG00000052496 |
| Gene Name |
polycystin (PKD) family receptor for egg jelly |
| Synonyms |
|
| MMRRC Submission |
038935-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.098)
|
| Stock # |
R0755 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
85698877-85705934 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85700336 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 1867
(I1867L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086352
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064370]
[ENSMUST00000071876]
[ENSMUST00000134631]
[ENSMUST00000144067]
[ENSMUST00000150995]
[ENSMUST00000154814]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064370
AA Change: I1867L
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000086352
Gene: ENSMUSG00000052496
AA Change: I1867L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:REJ
|
130 |
598 |
6.2e-116 |
PFAM |
|
coiled coil region
|
657 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
942 |
947 |
N/A |
INTRINSIC |
|
GPS
|
984 |
1050 |
1.37e-2 |
SMART |
|
transmembrane domain
|
1067 |
1089 |
N/A |
INTRINSIC |
|
LH2
|
1114 |
1230 |
3.35e-6 |
SMART |
|
transmembrane domain
|
1274 |
1292 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1312 |
1334 |
N/A |
INTRINSIC |
|
low complexity region
|
1407 |
1415 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1451 |
1473 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1483 |
1505 |
N/A |
INTRINSIC |
|
low complexity region
|
1571 |
1579 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1581 |
1603 |
N/A |
INTRINSIC |
|
Pfam:PKD_channel
|
1621 |
2051 |
5.2e-154 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071876
|
| SMART Domains |
Protein: ENSMUSP00000071772
Gene: ENSMUSG00000064284
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:C6_DPF
|
13 |
106 |
3.2e-41 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134631
|
| SMART Domains |
Protein: ENSMUSP00000121889
Gene: ENSMUSG00000064284
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:C6_DPF
|
13 |
109 |
1.6e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144067
|
| SMART Domains |
Protein: ENSMUSP00000119728
Gene: ENSMUSG00000064284
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:C6_DPF
|
13 |
109 |
1.6e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150995
|
| SMART Domains |
Protein: ENSMUSP00000123174
Gene: ENSMUSG00000064284
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:C6_DPF
|
13 |
109 |
1.6e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154814
|
| SMART Domains |
Protein: ENSMUSP00000116823
Gene: ENSMUSG00000064284
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:C6_DPF
|
13 |
78 |
1e-35 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null males are fertile in unrestricted mating trials but show lower reproductive success in sequential mating and artificial insemination trials. Although mutant sperm are able to capacitate in vitro, they acquire exocytotic competence at a slower rate than wild-type sperm. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730061H03Rik |
A |
T |
14: 55,797,638 (GRCm39) |
|
probably benign |
Het |
| Acin1 |
A |
G |
14: 54,889,292 (GRCm39) |
M1T |
probably null |
Het |
| Akp3 |
G |
A |
1: 87,055,593 (GRCm39) |
G547R |
unknown |
Het |
| Aldh1a1 |
A |
G |
19: 20,595,358 (GRCm39) |
M96V |
probably benign |
Het |
| Ankfn1 |
T |
A |
11: 89,282,913 (GRCm39) |
M245L |
probably benign |
Het |
| Arhgap19 |
T |
C |
19: 41,769,614 (GRCm39) |
K54E |
probably damaging |
Het |
| Atp1a2 |
T |
C |
1: 172,116,948 (GRCm39) |
Q223R |
probably benign |
Het |
| Atp8a2 |
C |
T |
14: 60,247,330 (GRCm39) |
V557I |
possibly damaging |
Het |
| AU041133 |
A |
T |
10: 81,986,724 (GRCm39) |
K126* |
probably null |
Het |
| Axin1 |
T |
A |
17: 26,401,480 (GRCm39) |
Y351N |
possibly damaging |
Het |
| Baiap2l1 |
T |
C |
5: 144,221,367 (GRCm39) |
K176E |
probably damaging |
Het |
| Baz2a |
C |
T |
10: 127,955,560 (GRCm39) |
T848I |
possibly damaging |
Het |
| Bbs2 |
A |
C |
8: 94,808,708 (GRCm39) |
V333G |
probably benign |
Het |
| BC051019 |
G |
A |
7: 109,315,302 (GRCm39) |
Q318* |
probably null |
Het |
| Bltp1 |
T |
C |
3: 37,000,513 (GRCm39) |
S1231P |
probably damaging |
Het |
| Cdc37 |
C |
T |
9: 21,051,160 (GRCm39) |
D362N |
probably damaging |
Het |
| Cep170 |
A |
T |
1: 176,583,319 (GRCm39) |
V1020E |
probably damaging |
Het |
| Chrm4 |
T |
C |
2: 91,758,747 (GRCm39) |
V385A |
probably benign |
Het |
| Cntrl |
G |
A |
2: 35,035,151 (GRCm39) |
S373N |
probably damaging |
Het |
| Col23a1 |
G |
A |
11: 51,467,706 (GRCm39) |
G19D |
probably damaging |
Het |
| Cyb5r4 |
G |
T |
9: 86,911,625 (GRCm39) |
A100S |
probably damaging |
Het |
| Dctn1 |
C |
T |
6: 83,166,059 (GRCm39) |
P115S |
probably damaging |
Het |
| Dhrs2 |
C |
T |
14: 55,472,247 (GRCm39) |
T46M |
probably damaging |
Het |
| Disp2 |
T |
C |
2: 118,620,243 (GRCm39) |
F325S |
probably benign |
Het |
| Dnah11 |
T |
G |
12: 117,918,564 (GRCm39) |
T3456P |
possibly damaging |
Het |
| Dnah11 |
C |
A |
12: 118,162,360 (GRCm39) |
V70F |
probably benign |
Het |
| Duoxa1 |
T |
A |
2: 122,135,161 (GRCm39) |
T195S |
probably benign |
Het |
| Dync2i1 |
T |
C |
12: 116,175,412 (GRCm39) |
I922V |
probably benign |
Het |
| Eif2ak1 |
T |
A |
5: 143,821,742 (GRCm39) |
F353I |
possibly damaging |
Het |
| Esam |
A |
G |
9: 37,447,998 (GRCm39) |
T211A |
probably damaging |
Het |
| Faf1 |
A |
G |
4: 109,819,036 (GRCm39) |
N636S |
probably benign |
Het |
| Fbxo25 |
A |
G |
8: 13,985,219 (GRCm39) |
Y305C |
probably benign |
Het |
| Fchsd1 |
C |
T |
18: 38,101,803 (GRCm39) |
|
probably null |
Het |
| Fdxacb1 |
T |
A |
9: 50,683,025 (GRCm39) |
D329E |
possibly damaging |
Het |
| Gvin2 |
A |
T |
7: 105,545,892 (GRCm39) |
F2387I |
possibly damaging |
Het |
| Hbq1b |
A |
T |
11: 32,237,104 (GRCm39) |
|
probably null |
Het |
| Hmcn2 |
T |
A |
2: 31,343,172 (GRCm39) |
V4566E |
probably damaging |
Het |
| Igkv6-29 |
G |
A |
6: 70,116,053 (GRCm39) |
T5I |
probably benign |
Het |
| Itfg1 |
A |
T |
8: 86,452,834 (GRCm39) |
D511E |
possibly damaging |
Het |
| Jmjd1c |
C |
T |
10: 66,932,378 (GRCm39) |
|
probably benign |
Het |
| Kat6b |
T |
A |
14: 21,687,661 (GRCm39) |
M570K |
probably damaging |
Het |
| Kdm4d |
T |
A |
9: 14,375,591 (GRCm39) |
K89M |
probably damaging |
Het |
| Krt19 |
A |
T |
11: 100,032,965 (GRCm39) |
D194E |
possibly damaging |
Het |
| Lamc1 |
A |
T |
1: 153,123,196 (GRCm39) |
Y665N |
possibly damaging |
Het |
| Lct |
A |
T |
1: 128,221,872 (GRCm39) |
S1556T |
possibly damaging |
Het |
| Macf1 |
A |
G |
4: 123,263,719 (GRCm39) |
L4924P |
probably damaging |
Het |
| Mef2c |
G |
A |
13: 83,804,472 (GRCm39) |
|
probably null |
Het |
| Mff |
G |
A |
1: 82,728,326 (GRCm39) |
|
probably null |
Het |
| Mycbp2 |
A |
T |
14: 103,412,230 (GRCm39) |
L2581Q |
probably damaging |
Het |
| Mylk |
G |
C |
16: 34,699,845 (GRCm39) |
E403Q |
possibly damaging |
Het |
| Nos3 |
T |
A |
5: 24,572,295 (GRCm39) |
L123M |
probably damaging |
Het |
| Ntn5 |
C |
T |
7: 45,335,952 (GRCm39) |
P128S |
probably benign |
Het |
| Nudt9 |
T |
C |
5: 104,212,920 (GRCm39) |
V331A |
probably damaging |
Het |
| Or2y3 |
A |
T |
17: 38,393,085 (GRCm39) |
Y261* |
probably null |
Het |
| Or7g34 |
T |
C |
9: 19,478,415 (GRCm39) |
I88M |
possibly damaging |
Het |
| Pcdh7 |
A |
T |
5: 57,877,664 (GRCm39) |
K406N |
possibly damaging |
Het |
| Plppr4 |
C |
T |
3: 117,116,319 (GRCm39) |
G455R |
possibly damaging |
Het |
| Pramel11 |
A |
G |
4: 143,624,299 (GRCm39) |
V66A |
probably damaging |
Het |
| Prkag2 |
G |
C |
5: 25,152,629 (GRCm39) |
S158R |
probably benign |
Het |
| Ptprq |
T |
G |
10: 107,418,400 (GRCm39) |
T1659P |
probably benign |
Het |
| Rasl12 |
A |
G |
9: 65,318,241 (GRCm39) |
K202E |
probably benign |
Het |
| Rb1 |
A |
C |
14: 73,434,653 (GRCm39) |
*922G |
probably null |
Het |
| Rsf1 |
C |
T |
7: 97,229,174 (GRCm39) |
P22S |
probably damaging |
Het |
| Scn1a |
T |
G |
2: 66,151,379 (GRCm39) |
T797P |
probably damaging |
Het |
| Sgsm2 |
A |
G |
11: 74,756,323 (GRCm39) |
V342A |
probably damaging |
Het |
| Slc22a7 |
T |
G |
17: 46,749,113 (GRCm39) |
H68P |
possibly damaging |
Het |
| Slc4a2 |
G |
A |
5: 24,640,575 (GRCm39) |
A652T |
probably benign |
Het |
| Slc5a1 |
T |
A |
5: 33,290,733 (GRCm39) |
L106M |
probably benign |
Het |
| Slco1c1 |
C |
T |
6: 141,477,258 (GRCm39) |
P19S |
probably damaging |
Het |
| Snx1 |
A |
G |
9: 66,005,738 (GRCm39) |
F127S |
probably damaging |
Het |
| Snx31 |
A |
T |
15: 36,534,576 (GRCm39) |
I199N |
probably damaging |
Het |
| Snx33 |
T |
C |
9: 56,832,741 (GRCm39) |
I443V |
possibly damaging |
Het |
| Sptbn1 |
A |
G |
11: 30,089,016 (GRCm39) |
F749L |
probably damaging |
Het |
| Stoml3 |
T |
A |
3: 53,405,559 (GRCm39) |
Y53* |
probably null |
Het |
| Stxbp2 |
A |
G |
8: 3,692,019 (GRCm39) |
T554A |
probably benign |
Het |
| Tal1 |
T |
C |
4: 114,925,573 (GRCm39) |
I214T |
probably damaging |
Het |
| Tas2r140 |
T |
A |
6: 40,468,344 (GRCm39) |
I58N |
probably damaging |
Het |
| Thap1 |
A |
G |
8: 26,648,501 (GRCm39) |
Y8C |
probably damaging |
Het |
| Thsd7a |
A |
T |
6: 12,555,368 (GRCm39) |
L172Q |
probably damaging |
Het |
| Ube3c |
T |
A |
5: 29,842,740 (GRCm39) |
D735E |
probably damaging |
Het |
| Unc80 |
G |
A |
1: 66,544,082 (GRCm39) |
D402N |
probably damaging |
Het |
| Upf1 |
G |
T |
8: 70,786,779 (GRCm39) |
R902S |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,570,982 (GRCm39) |
Y1276H |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,576,026 (GRCm39) |
F843L |
probably benign |
Het |
| Vmn1r198 |
C |
T |
13: 22,539,402 (GRCm39) |
T296I |
probably benign |
Het |
| Vmn1r33 |
A |
T |
6: 66,588,892 (GRCm39) |
S221T |
probably damaging |
Het |
| Vmn2r103 |
A |
G |
17: 19,993,830 (GRCm39) |
D69G |
probably benign |
Het |
| Vmn2r14 |
T |
G |
5: 109,364,226 (GRCm39) |
L563F |
possibly damaging |
Het |
| Vmn2r60 |
G |
A |
7: 41,844,869 (GRCm39) |
G744D |
probably damaging |
Het |
| Vstm4 |
T |
C |
14: 32,614,601 (GRCm39) |
V181A |
probably damaging |
Het |
| Wdr72 |
G |
A |
9: 74,052,376 (GRCm39) |
V136I |
probably benign |
Het |
| Zfp236 |
T |
A |
18: 82,638,457 (GRCm39) |
N1388Y |
probably damaging |
Het |
| Zfp53 |
T |
A |
17: 21,728,839 (GRCm39) |
F291I |
probably damaging |
Het |
| Zfp944 |
A |
T |
17: 22,558,889 (GRCm39) |
H119Q |
possibly damaging |
Het |
|
| Other mutations in Pkdrej |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00921:Pkdrej
|
APN |
15 |
85,701,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00981:Pkdrej
|
APN |
15 |
85,703,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01066:Pkdrej
|
APN |
15 |
85,700,360 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01461:Pkdrej
|
APN |
15 |
85,704,575 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL01514:Pkdrej
|
APN |
15 |
85,702,264 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01606:Pkdrej
|
APN |
15 |
85,701,901 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01836:Pkdrej
|
APN |
15 |
85,705,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02089:Pkdrej
|
APN |
15 |
85,700,489 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02197:Pkdrej
|
APN |
15 |
85,699,994 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02331:Pkdrej
|
APN |
15 |
85,705,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02559:Pkdrej
|
APN |
15 |
85,702,049 (GRCm39) |
missense |
probably benign |
|
|
IGL02708:Pkdrej
|
APN |
15 |
85,704,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02739:Pkdrej
|
APN |
15 |
85,703,895 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02741:Pkdrej
|
APN |
15 |
85,701,631 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02882:Pkdrej
|
APN |
15 |
85,701,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02968:Pkdrej
|
APN |
15 |
85,700,382 (GRCm39) |
nonsense |
probably null |
|
|
IGL03250:Pkdrej
|
APN |
15 |
85,705,556 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
FR4548:Pkdrej
|
UTSW |
15 |
85,703,881 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Pkdrej
|
UTSW |
15 |
85,703,881 (GRCm39) |
small insertion |
probably benign |
|
|
PIT1430001:Pkdrej
|
UTSW |
15 |
85,705,493 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4280001:Pkdrej
|
UTSW |
15 |
85,704,136 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0004:Pkdrej
|
UTSW |
15 |
85,702,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0116:Pkdrej
|
UTSW |
15 |
85,701,746 (GRCm39) |
nonsense |
probably null |
|
|
R0117:Pkdrej
|
UTSW |
15 |
85,700,300 (GRCm39) |
splice site |
probably null |
|
|
R0137:Pkdrej
|
UTSW |
15 |
85,705,768 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0141:Pkdrej
|
UTSW |
15 |
85,699,831 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0325:Pkdrej
|
UTSW |
15 |
85,703,752 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0714:Pkdrej
|
UTSW |
15 |
85,699,712 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0749:Pkdrej
|
UTSW |
15 |
85,702,275 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0750:Pkdrej
|
UTSW |
15 |
85,702,275 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0938:Pkdrej
|
UTSW |
15 |
85,702,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1126:Pkdrej
|
UTSW |
15 |
85,700,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1204:Pkdrej
|
UTSW |
15 |
85,702,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1353:Pkdrej
|
UTSW |
15 |
85,703,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Pkdrej
|
UTSW |
15 |
85,701,334 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1510:Pkdrej
|
UTSW |
15 |
85,700,963 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1573:Pkdrej
|
UTSW |
15 |
85,702,275 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1588:Pkdrej
|
UTSW |
15 |
85,701,442 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1739:Pkdrej
|
UTSW |
15 |
85,704,628 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1779:Pkdrej
|
UTSW |
15 |
85,705,372 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1781:Pkdrej
|
UTSW |
15 |
85,705,372 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1828:Pkdrej
|
UTSW |
15 |
85,703,483 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1865:Pkdrej
|
UTSW |
15 |
85,704,525 (GRCm39) |
nonsense |
probably null |
|
|
R1870:Pkdrej
|
UTSW |
15 |
85,700,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1937:Pkdrej
|
UTSW |
15 |
85,703,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2069:Pkdrej
|
UTSW |
15 |
85,705,432 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2113:Pkdrej
|
UTSW |
15 |
85,703,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2135:Pkdrej
|
UTSW |
15 |
85,700,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2428:Pkdrej
|
UTSW |
15 |
85,701,773 (GRCm39) |
nonsense |
probably null |
|
|
R2991:Pkdrej
|
UTSW |
15 |
85,704,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Pkdrej
|
UTSW |
15 |
85,701,205 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3162:Pkdrej
|
UTSW |
15 |
85,700,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Pkdrej
|
UTSW |
15 |
85,700,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3747:Pkdrej
|
UTSW |
15 |
85,705,278 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3748:Pkdrej
|
UTSW |
15 |
85,705,278 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3749:Pkdrej
|
UTSW |
15 |
85,705,278 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4028:Pkdrej
|
UTSW |
15 |
85,701,693 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4169:Pkdrej
|
UTSW |
15 |
85,700,515 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4241:Pkdrej
|
UTSW |
15 |
85,702,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4242:Pkdrej
|
UTSW |
15 |
85,702,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4705:Pkdrej
|
UTSW |
15 |
85,705,368 (GRCm39) |
nonsense |
probably null |
|
|
R4939:Pkdrej
|
UTSW |
15 |
85,704,484 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4954:Pkdrej
|
UTSW |
15 |
85,700,602 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4974:Pkdrej
|
UTSW |
15 |
85,704,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4982:Pkdrej
|
UTSW |
15 |
85,703,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5105:Pkdrej
|
UTSW |
15 |
85,700,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Pkdrej
|
UTSW |
15 |
85,702,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Pkdrej
|
UTSW |
15 |
85,701,319 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5631:Pkdrej
|
UTSW |
15 |
85,704,638 (GRCm39) |
missense |
probably benign |
|
|
R5909:Pkdrej
|
UTSW |
15 |
85,702,497 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5998:Pkdrej
|
UTSW |
15 |
85,699,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6037:Pkdrej
|
UTSW |
15 |
85,703,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6037:Pkdrej
|
UTSW |
15 |
85,703,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6125:Pkdrej
|
UTSW |
15 |
85,700,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6270:Pkdrej
|
UTSW |
15 |
85,705,306 (GRCm39) |
nonsense |
probably null |
|
|
R6500:Pkdrej
|
UTSW |
15 |
85,703,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6776:Pkdrej
|
UTSW |
15 |
85,701,510 (GRCm39) |
nonsense |
probably null |
|
|
R6786:Pkdrej
|
UTSW |
15 |
85,702,850 (GRCm39) |
missense |
probably benign |
|
|
R6866:Pkdrej
|
UTSW |
15 |
85,705,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6954:Pkdrej
|
UTSW |
15 |
85,702,054 (GRCm39) |
nonsense |
probably null |
|
|
R7086:Pkdrej
|
UTSW |
15 |
85,704,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7231:Pkdrej
|
UTSW |
15 |
85,700,389 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7233:Pkdrej
|
UTSW |
15 |
85,705,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7289:Pkdrej
|
UTSW |
15 |
85,705,301 (GRCm39) |
missense |
probably benign |
|
|
R7549:Pkdrej
|
UTSW |
15 |
85,703,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7582:Pkdrej
|
UTSW |
15 |
85,703,122 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7677:Pkdrej
|
UTSW |
15 |
85,699,788 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7791:Pkdrej
|
UTSW |
15 |
85,700,132 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7873:Pkdrej
|
UTSW |
15 |
85,700,724 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8121:Pkdrej
|
UTSW |
15 |
85,699,655 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8140:Pkdrej
|
UTSW |
15 |
85,702,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Pkdrej
|
UTSW |
15 |
85,705,493 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8222:Pkdrej
|
UTSW |
15 |
85,701,640 (GRCm39) |
missense |
probably benign |
|
|
R8432:Pkdrej
|
UTSW |
15 |
85,701,494 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8755:Pkdrej
|
UTSW |
15 |
85,703,807 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8786:Pkdrej
|
UTSW |
15 |
85,704,044 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8817:Pkdrej
|
UTSW |
15 |
85,702,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8827:Pkdrej
|
UTSW |
15 |
85,699,732 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8966:Pkdrej
|
UTSW |
15 |
85,702,012 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8988:Pkdrej
|
UTSW |
15 |
85,700,538 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9028:Pkdrej
|
UTSW |
15 |
85,701,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9257:Pkdrej
|
UTSW |
15 |
85,700,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Pkdrej
|
UTSW |
15 |
85,700,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9404:Pkdrej
|
UTSW |
15 |
85,703,270 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9433:Pkdrej
|
UTSW |
15 |
85,704,070 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9454:Pkdrej
|
UTSW |
15 |
85,702,420 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9479:Pkdrej
|
UTSW |
15 |
85,699,571 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9720:Pkdrej
|
UTSW |
15 |
85,702,497 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9748:Pkdrej
|
UTSW |
15 |
85,704,871 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9760:Pkdrej
|
UTSW |
15 |
85,705,268 (GRCm39) |
missense |
probably benign |
0.30 |
|
Z1177:Pkdrej
|
UTSW |
15 |
85,700,738 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGCCAGGCGCACATTATAGAAG -3'
(R):5'- GTGGAACTGACCACTCTGAATCCAG -3'
Sequencing Primer
(F):5'- GAACCTGGAATATCTGAGTGTCTTC -3'
(R):5'- ACACCAGTCTGATGTGTAGC -3'
|
| Posted On |
2013-09-30 |
Incidental Mutation