Incidental Mutation 'R1854:Nalcn'
| ID |
205970 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nalcn
|
| Ensembl Gene |
ENSMUSG00000000197 |
| Gene Name |
sodium leak channel, non-selective |
| Synonyms |
Vgcnl1, A530023G15Rik |
| MMRRC Submission |
039878-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1854 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
123514046-123864556 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 123697824 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glutamine
at position 484
(R484Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000201
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000201]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000000201
AA Change: R484Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000000201
Gene: ENSMUSG00000000197
AA Change: R484Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ion_trans
|
35 |
333 |
2.8e-37 |
PFAM |
|
low complexity region
|
338 |
348 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
383 |
609 |
5.7e-34 |
PFAM |
|
coiled coil region
|
796 |
830 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
885 |
1166 |
2.4e-42 |
PFAM |
|
Pfam:Ion_trans
|
1209 |
1458 |
6.9e-30 |
PFAM |
|
low complexity region
|
1548 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227818
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228860
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061N02Rik |
C |
T |
16: 88,504,668 (GRCm39) |
R43K |
possibly damaging |
Het |
| Acp1 |
A |
G |
12: 30,947,804 (GRCm39) |
I78T |
possibly damaging |
Het |
| Afap1l1 |
G |
T |
18: 61,876,365 (GRCm39) |
D417E |
probably benign |
Het |
| Agap2 |
G |
A |
10: 126,916,385 (GRCm39) |
V299I |
unknown |
Het |
| Ahnak |
C |
T |
19: 8,991,196 (GRCm39) |
A4160V |
possibly damaging |
Het |
| Anapc1 |
T |
C |
2: 128,517,810 (GRCm39) |
E278G |
probably damaging |
Het |
| Atad2 |
G |
A |
15: 57,960,685 (GRCm39) |
P971L |
possibly damaging |
Het |
| Atg2a |
A |
G |
19: 6,302,461 (GRCm39) |
E928G |
probably benign |
Het |
| Atp2b2 |
A |
C |
6: 113,819,244 (GRCm39) |
N16K |
probably damaging |
Het |
| Atp6ap1l |
T |
C |
13: 91,031,707 (GRCm39) |
E325G |
probably damaging |
Het |
| Bfsp2 |
C |
T |
9: 103,327,030 (GRCm39) |
G236S |
probably benign |
Het |
| Ccar1 |
A |
T |
10: 62,600,296 (GRCm39) |
I545N |
probably damaging |
Het |
| Ccser2 |
A |
G |
14: 36,640,548 (GRCm39) |
C11R |
possibly damaging |
Het |
| Cdc42bpg |
A |
T |
19: 6,370,837 (GRCm39) |
H1310L |
possibly damaging |
Het |
| Ces1h |
T |
C |
8: 94,085,450 (GRCm39) |
K339E |
probably benign |
Het |
| Cfap91 |
T |
C |
16: 38,144,659 (GRCm39) |
|
probably null |
Het |
| Cit |
A |
G |
5: 116,011,960 (GRCm39) |
Y189C |
probably damaging |
Het |
| Cnih3 |
C |
A |
1: 181,282,186 (GRCm39) |
S140* |
probably null |
Het |
| Cntrl |
A |
G |
2: 35,012,696 (GRCm39) |
D278G |
probably damaging |
Het |
| Col24a1 |
G |
A |
3: 145,164,895 (GRCm39) |
G1033D |
probably damaging |
Het |
| Col6a1 |
T |
G |
10: 76,557,783 (GRCm39) |
Y151S |
probably damaging |
Het |
| Col6a2 |
T |
A |
10: 76,450,646 (GRCm39) |
Q95L |
probably damaging |
Het |
| Cpd |
G |
T |
11: 76,677,164 (GRCm39) |
P1185Q |
probably damaging |
Het |
| Cycs |
T |
A |
6: 50,542,309 (GRCm39) |
I76F |
possibly damaging |
Het |
| Cyp4f16 |
T |
A |
17: 32,756,073 (GRCm39) |
I34N |
probably damaging |
Het |
| Ddx1 |
A |
C |
12: 13,279,332 (GRCm39) |
S436A |
probably benign |
Het |
| Defa30 |
A |
G |
8: 21,625,500 (GRCm39) |
Y88C |
probably damaging |
Het |
| Dhx30 |
G |
A |
9: 109,917,740 (GRCm39) |
L317F |
probably damaging |
Het |
| Dll3 |
C |
A |
7: 27,995,835 (GRCm39) |
G322V |
probably damaging |
Het |
| Dnah10 |
G |
A |
5: 124,881,753 (GRCm39) |
D2843N |
probably damaging |
Het |
| Dnaja3 |
C |
T |
16: 4,515,133 (GRCm39) |
T266I |
probably damaging |
Het |
| Dpp9 |
T |
C |
17: 56,509,885 (GRCm39) |
I314V |
probably benign |
Het |
| E030025P04Rik |
A |
G |
11: 109,034,744 (GRCm39) |
V48A |
unknown |
Het |
| Enpp2 |
C |
T |
15: 54,709,219 (GRCm39) |
E803K |
probably damaging |
Het |
| Eri3 |
G |
A |
4: 117,506,562 (GRCm39) |
G297D |
probably benign |
Het |
| Esp34 |
A |
G |
17: 38,870,424 (GRCm39) |
E38G |
possibly damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Frzb |
A |
G |
2: 80,276,724 (GRCm39) |
V154A |
possibly damaging |
Het |
| Fsip2 |
G |
T |
2: 82,823,601 (GRCm39) |
A6445S |
possibly damaging |
Het |
| Gm11938 |
G |
A |
11: 99,493,843 (GRCm39) |
T84I |
possibly damaging |
Het |
| Gm4787 |
T |
A |
12: 81,425,108 (GRCm39) |
H350L |
probably damaging |
Het |
| Gpa33 |
A |
G |
1: 165,992,759 (GRCm39) |
I291V |
probably benign |
Het |
| Gpr158 |
A |
G |
2: 21,373,935 (GRCm39) |
Y290C |
probably damaging |
Het |
| Gpsm1 |
G |
T |
2: 26,234,725 (GRCm39) |
G84W |
probably damaging |
Het |
| Hormad1 |
A |
G |
3: 95,487,317 (GRCm39) |
N267S |
probably benign |
Het |
| Htr2a |
A |
T |
14: 74,943,193 (GRCm39) |
I258F |
probably damaging |
Het |
| Htra4 |
T |
C |
8: 25,523,597 (GRCm39) |
T323A |
probably damaging |
Het |
| Ift140 |
T |
A |
17: 25,254,813 (GRCm39) |
F162Y |
probably benign |
Het |
| Islr2 |
T |
C |
9: 58,107,099 (GRCm39) |
T54A |
probably damaging |
Het |
| Kcna4 |
T |
G |
2: 107,126,829 (GRCm39) |
V521G |
probably damaging |
Het |
| Kdr |
C |
T |
5: 76,113,565 (GRCm39) |
G768S |
possibly damaging |
Het |
| Kif6 |
G |
T |
17: 50,208,799 (GRCm39) |
A740S |
probably benign |
Het |
| Lad1 |
T |
A |
1: 135,755,468 (GRCm39) |
V248E |
probably damaging |
Het |
| Lamb1 |
T |
G |
12: 31,368,271 (GRCm39) |
C1134G |
probably damaging |
Het |
| Lamc1 |
A |
G |
1: 153,125,618 (GRCm39) |
Y552H |
probably damaging |
Het |
| Mctp1 |
A |
T |
13: 76,973,860 (GRCm39) |
T706S |
probably damaging |
Het |
| Med12l |
A |
G |
3: 59,168,193 (GRCm39) |
Y1541C |
probably damaging |
Het |
| Mnx1 |
C |
T |
5: 29,682,780 (GRCm39) |
S165N |
unknown |
Het |
| Morn3 |
A |
T |
5: 123,184,692 (GRCm39) |
|
probably null |
Het |
| Nr4a1 |
T |
C |
15: 101,169,645 (GRCm39) |
I305T |
probably benign |
Het |
| Or1j11 |
C |
T |
2: 36,311,886 (GRCm39) |
H159Y |
probably damaging |
Het |
| Or2z2 |
G |
A |
11: 58,346,257 (GRCm39) |
R173W |
probably damaging |
Het |
| Pabir2 |
T |
A |
X: 52,342,933 (GRCm39) |
Q201H |
probably benign |
Het |
| Pcdhb5 |
T |
C |
18: 37,455,393 (GRCm39) |
V591A |
possibly damaging |
Het |
| Pdia3 |
T |
C |
2: 121,262,144 (GRCm39) |
I205T |
probably benign |
Het |
| Pdia4 |
A |
T |
6: 47,790,161 (GRCm39) |
D26E |
unknown |
Het |
| Phactr3 |
C |
A |
2: 177,924,940 (GRCm39) |
L292M |
probably damaging |
Het |
| Phf21b |
T |
A |
15: 84,738,963 (GRCm39) |
I21F |
probably benign |
Het |
| Pign |
A |
G |
1: 105,482,223 (GRCm39) |
V791A |
probably damaging |
Het |
| Pitpna |
A |
G |
11: 75,499,929 (GRCm39) |
|
probably null |
Het |
| Piwil1 |
G |
T |
5: 128,824,903 (GRCm39) |
E534* |
probably null |
Het |
| Plcz1 |
T |
A |
6: 139,938,775 (GRCm39) |
I526F |
probably benign |
Het |
| Pms2 |
A |
T |
5: 143,862,714 (GRCm39) |
K607I |
probably benign |
Het |
| Pnn |
T |
A |
12: 59,118,399 (GRCm39) |
N327K |
probably damaging |
Het |
| Pogz |
C |
T |
3: 94,786,160 (GRCm39) |
T863I |
probably benign |
Het |
| Polq |
C |
T |
16: 36,882,471 (GRCm39) |
T1545I |
probably benign |
Het |
| Psd4 |
G |
A |
2: 24,287,468 (GRCm39) |
E467K |
probably benign |
Het |
| Pstpip2 |
T |
A |
18: 77,959,499 (GRCm39) |
L198Q |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,479,188 (GRCm39) |
Y655C |
probably damaging |
Het |
| Qrsl1 |
C |
T |
10: 43,770,541 (GRCm39) |
G117E |
probably damaging |
Het |
| Rad54b |
G |
A |
4: 11,601,669 (GRCm39) |
C408Y |
probably damaging |
Het |
| Ralb |
T |
A |
1: 119,403,797 (GRCm39) |
Q110L |
possibly damaging |
Het |
| Rrm2 |
A |
G |
12: 24,763,151 (GRCm39) |
K218E |
probably damaging |
Het |
| Siglece |
A |
G |
7: 43,309,360 (GRCm39) |
F66S |
probably benign |
Het |
| Slc17a8 |
A |
T |
10: 89,442,627 (GRCm39) |
C69S |
unknown |
Het |
| Slc1a6 |
T |
A |
10: 78,648,758 (GRCm39) |
V493E |
probably damaging |
Het |
| Slc38a11 |
A |
T |
2: 65,193,860 (GRCm39) |
|
probably null |
Het |
| Smarcal1 |
G |
A |
1: 72,625,258 (GRCm39) |
G135D |
possibly damaging |
Het |
| Snrnp70 |
T |
A |
7: 45,026,644 (GRCm39) |
R242* |
probably null |
Het |
| St3gal5 |
T |
C |
6: 72,109,077 (GRCm39) |
L55P |
probably damaging |
Het |
| Sulf1 |
A |
G |
1: 12,908,661 (GRCm39) |
N558S |
probably benign |
Het |
| Supt6 |
T |
C |
11: 78,123,366 (GRCm39) |
I104V |
possibly damaging |
Het |
| Tas2r113 |
T |
A |
6: 132,870,292 (GRCm39) |
Y107N |
probably damaging |
Het |
| Tcf7 |
A |
G |
11: 52,147,891 (GRCm39) |
V187A |
probably benign |
Het |
| Tdrd9 |
G |
A |
12: 112,011,246 (GRCm39) |
G1152R |
probably damaging |
Het |
| Tfpi |
A |
G |
2: 84,288,451 (GRCm39) |
Y9H |
probably benign |
Het |
| Tnk2 |
G |
A |
16: 32,498,960 (GRCm39) |
V758I |
probably damaging |
Het |
| Trim72 |
A |
G |
7: 127,608,254 (GRCm39) |
I251V |
probably benign |
Het |
| Trip12 |
T |
A |
1: 84,705,866 (GRCm39) |
N655Y |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,581,773 (GRCm39) |
V23040A |
probably damaging |
Het |
| Tulp2 |
T |
A |
7: 45,167,367 (GRCm39) |
N188K |
probably damaging |
Het |
| Ube2c |
C |
T |
2: 164,613,282 (GRCm39) |
H67Y |
probably damaging |
Het |
| Unc80 |
C |
A |
1: 66,670,573 (GRCm39) |
P1899T |
possibly damaging |
Het |
| Usp34 |
C |
T |
11: 23,376,153 (GRCm39) |
A1879V |
probably benign |
Het |
| Vmn2r118 |
G |
A |
17: 55,918,556 (GRCm39) |
S112L |
possibly damaging |
Het |
| Wdfy3 |
A |
T |
5: 102,036,052 (GRCm39) |
V2122E |
probably benign |
Het |
| Zcchc4 |
A |
G |
5: 52,973,168 (GRCm39) |
Y344C |
probably damaging |
Het |
| Zdbf2 |
GAAAAA |
GAAAAAA |
1: 63,344,701 (GRCm39) |
|
probably null |
Het |
| Zdhhc25 |
A |
T |
15: 88,484,689 (GRCm39) |
H8L |
probably benign |
Het |
| Zfp455 |
A |
T |
13: 67,355,881 (GRCm39) |
H383L |
probably damaging |
Het |
| Zfp663 |
A |
G |
2: 165,195,211 (GRCm39) |
I336T |
probably benign |
Het |
| Zfp738 |
T |
A |
13: 67,818,476 (GRCm39) |
H505L |
probably damaging |
Het |
| Zfp84 |
T |
G |
7: 29,474,796 (GRCm39) |
F23V |
possibly damaging |
Het |
|
| Other mutations in Nalcn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00952:Nalcn
|
APN |
14 |
123,586,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00964:Nalcn
|
APN |
14 |
123,532,796 (GRCm39) |
splice site |
probably benign |
|
|
IGL01310:Nalcn
|
APN |
14 |
123,554,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01578:Nalcn
|
APN |
14 |
123,809,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01925:Nalcn
|
APN |
14 |
123,529,260 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02072:Nalcn
|
APN |
14 |
123,560,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02096:Nalcn
|
APN |
14 |
123,831,915 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02212:Nalcn
|
APN |
14 |
123,752,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02306:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02471:Nalcn
|
APN |
14 |
123,560,726 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02478:Nalcn
|
APN |
14 |
123,558,717 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02551:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02630:Nalcn
|
APN |
14 |
123,555,291 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02632:Nalcn
|
APN |
14 |
123,555,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02661:Nalcn
|
APN |
14 |
123,830,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Nalcn
|
APN |
14 |
123,530,881 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02939:Nalcn
|
APN |
14 |
123,536,284 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03035:Nalcn
|
APN |
14 |
123,515,630 (GRCm39) |
nonsense |
probably null |
|
|
IGL03226:Nalcn
|
APN |
14 |
123,518,527 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03242:Nalcn
|
APN |
14 |
123,558,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Narnia
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0019:Nalcn
|
UTSW |
14 |
123,744,901 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0144:Nalcn
|
UTSW |
14 |
123,647,251 (GRCm39) |
splice site |
probably benign |
|
|
R0144:Nalcn
|
UTSW |
14 |
123,608,948 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0359:Nalcn
|
UTSW |
14 |
123,536,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Nalcn
|
UTSW |
14 |
123,744,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0400:Nalcn
|
UTSW |
14 |
123,528,372 (GRCm39) |
splice site |
probably benign |
|
|
R0467:Nalcn
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0506:Nalcn
|
UTSW |
14 |
123,834,026 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0583:Nalcn
|
UTSW |
14 |
123,531,755 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0620:Nalcn
|
UTSW |
14 |
123,536,553 (GRCm39) |
splice site |
probably benign |
|
|
R0624:Nalcn
|
UTSW |
14 |
123,607,444 (GRCm39) |
missense |
probably benign |
|
|
R0883:Nalcn
|
UTSW |
14 |
123,702,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Nalcn
|
UTSW |
14 |
123,551,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Nalcn
|
UTSW |
14 |
123,702,068 (GRCm39) |
splice site |
probably benign |
|
|
R1689:Nalcn
|
UTSW |
14 |
123,522,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1726:Nalcn
|
UTSW |
14 |
123,545,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Nalcn
|
UTSW |
14 |
123,515,678 (GRCm39) |
missense |
probably benign |
|
|
R1869:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1871:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1873:Nalcn
|
UTSW |
14 |
123,521,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1899:Nalcn
|
UTSW |
14 |
123,553,538 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1915:Nalcn
|
UTSW |
14 |
123,540,181 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2016:Nalcn
|
UTSW |
14 |
123,831,993 (GRCm39) |
splice site |
probably null |
|
|
R2034:Nalcn
|
UTSW |
14 |
123,521,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2087:Nalcn
|
UTSW |
14 |
123,518,557 (GRCm39) |
missense |
probably benign |
|
|
R2149:Nalcn
|
UTSW |
14 |
123,607,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2157:Nalcn
|
UTSW |
14 |
123,647,164 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2166:Nalcn
|
UTSW |
14 |
123,607,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2932:Nalcn
|
UTSW |
14 |
123,830,430 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3408:Nalcn
|
UTSW |
14 |
123,834,029 (GRCm39) |
missense |
probably null |
0.98 |
|
R3778:Nalcn
|
UTSW |
14 |
123,702,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3807:Nalcn
|
UTSW |
14 |
123,515,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Nalcn
|
UTSW |
14 |
123,530,834 (GRCm39) |
splice site |
probably benign |
|
|
R3937:Nalcn
|
UTSW |
14 |
123,607,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4001:Nalcn
|
UTSW |
14 |
123,834,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4015:Nalcn
|
UTSW |
14 |
123,723,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nalcn
|
UTSW |
14 |
123,837,401 (GRCm39) |
splice site |
probably benign |
|
|
R4231:Nalcn
|
UTSW |
14 |
123,837,325 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4464:Nalcn
|
UTSW |
14 |
123,560,762 (GRCm39) |
missense |
probably benign |
|
|
R4512:Nalcn
|
UTSW |
14 |
123,532,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Nalcn
|
UTSW |
14 |
123,558,889 (GRCm39) |
synonymous |
silent |
|
|
R4557:Nalcn
|
UTSW |
14 |
123,558,647 (GRCm39) |
intron |
probably benign |
|
|
R4869:Nalcn
|
UTSW |
14 |
123,837,296 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5083:Nalcn
|
UTSW |
14 |
123,560,706 (GRCm39) |
splice site |
probably null |
|
|
R5109:Nalcn
|
UTSW |
14 |
123,515,650 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5131:Nalcn
|
UTSW |
14 |
123,753,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5158:Nalcn
|
UTSW |
14 |
123,753,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5259:Nalcn
|
UTSW |
14 |
123,753,063 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5422:Nalcn
|
UTSW |
14 |
123,752,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Nalcn
|
UTSW |
14 |
123,521,123 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5523:Nalcn
|
UTSW |
14 |
123,647,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5551:Nalcn
|
UTSW |
14 |
123,515,698 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R5667:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5750:Nalcn
|
UTSW |
14 |
123,809,450 (GRCm39) |
missense |
probably benign |
|
|
R5765:Nalcn
|
UTSW |
14 |
123,702,138 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6324:Nalcn
|
UTSW |
14 |
123,647,161 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6523:Nalcn
|
UTSW |
14 |
123,555,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6558:Nalcn
|
UTSW |
14 |
123,723,919 (GRCm39) |
missense |
probably benign |
|
|
R6631:Nalcn
|
UTSW |
14 |
123,697,663 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6667:Nalcn
|
UTSW |
14 |
123,558,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6670:Nalcn
|
UTSW |
14 |
123,702,084 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6724:Nalcn
|
UTSW |
14 |
123,535,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6731:Nalcn
|
UTSW |
14 |
123,837,346 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6957:Nalcn
|
UTSW |
14 |
123,744,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6970:Nalcn
|
UTSW |
14 |
123,551,506 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7010:Nalcn
|
UTSW |
14 |
123,530,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7018:Nalcn
|
UTSW |
14 |
123,647,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Nalcn
|
UTSW |
14 |
123,525,267 (GRCm39) |
missense |
probably benign |
|
|
R7089:Nalcn
|
UTSW |
14 |
123,515,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7128:Nalcn
|
UTSW |
14 |
123,831,914 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7149:Nalcn
|
UTSW |
14 |
123,837,277 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7361:Nalcn
|
UTSW |
14 |
123,529,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Nalcn
|
UTSW |
14 |
123,540,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7408:Nalcn
|
UTSW |
14 |
123,529,272 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7470:Nalcn
|
UTSW |
14 |
123,809,456 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7483:Nalcn
|
UTSW |
14 |
123,551,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7521:Nalcn
|
UTSW |
14 |
123,530,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7558:Nalcn
|
UTSW |
14 |
123,723,797 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7585:Nalcn
|
UTSW |
14 |
123,753,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7591:Nalcn
|
UTSW |
14 |
123,561,297 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7811:Nalcn
|
UTSW |
14 |
123,536,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7983:Nalcn
|
UTSW |
14 |
123,830,409 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8089:Nalcn
|
UTSW |
14 |
123,537,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nalcn
|
UTSW |
14 |
123,702,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8190:Nalcn
|
UTSW |
14 |
123,837,351 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8273:Nalcn
|
UTSW |
14 |
123,554,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8407:Nalcn
|
UTSW |
14 |
123,554,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8497:Nalcn
|
UTSW |
14 |
123,752,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Nalcn
|
UTSW |
14 |
123,608,935 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8549:Nalcn
|
UTSW |
14 |
123,607,448 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8731:Nalcn
|
UTSW |
14 |
123,837,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8862:Nalcn
|
UTSW |
14 |
123,647,199 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8919:Nalcn
|
UTSW |
14 |
123,561,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9073:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9182:Nalcn
|
UTSW |
14 |
123,834,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Nalcn
|
UTSW |
14 |
123,545,792 (GRCm39) |
nonsense |
probably null |
|
|
R9241:Nalcn
|
UTSW |
14 |
123,809,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Nalcn
|
UTSW |
14 |
123,518,567 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9274:Nalcn
|
UTSW |
14 |
123,753,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Nalcn
|
UTSW |
14 |
123,518,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9376:Nalcn
|
UTSW |
14 |
123,515,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
X0060:Nalcn
|
UTSW |
14 |
123,522,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,831,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,531,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGGAAAAGTGGTGAATCTGTCC -3'
(R):5'- GAAACAGTTGCCAATATTTGTCCTC -3'
Sequencing Primer
(F):5'- GAAAAGTGGTGAATCTGTCCAGTTC -3'
(R):5'- TCTCACTAGATAGTAGGCCACGTG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation