Mutagenetix > Incidental Mutation

Incidental Mutation 'R1856:Lrp5'

206187

Institutional Source

Beutler Lab

Gene Symbol

Lrp5

Ensembl Gene

ENSMUSG00000024913

Gene Name

low density lipoprotein receptor-related protein 5

Synonyms

LRP7, LR3

MMRRC Submission

039880-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.924) question?

Stock #

R1856 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

3634828-3736564 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 3647346 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 1299 (A1299T)

Ref Sequence

ENSEMBL: ENSMUSP00000025856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025856] [ENSMUST00000177294] [ENSMUST00000177330]

AlphaFold

Q91VN0

Predicted Effect

probably benign
Transcript: ENSMUST00000025856
AA Change: A1299T

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000025856
Gene: ENSMUSG00000024913
AA Change: A1299T

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
LY	54	96	1.26e0	SMART
LY	99	141	2.11e-13	SMART
LY	142	185	1.32e-14	SMART
LY	186	228	1.6e-13	SMART
LY	229	270	4e-5	SMART
EGF	297	336	1.01e-1	SMART
LY	364	406	5.15e-8	SMART
LY	407	449	4.12e-16	SMART
LY	450	493	7.68e-16	SMART
LY	494	536	6.24e-16	SMART
LY	537	577	3.73e-5	SMART
EGF	603	640	2.48e-1	SMART
LY	666	708	5.92e-8	SMART
LY	709	751	5.65e-14	SMART
LY	752	795	3.81e-11	SMART
LY	796	837	3.54e-6	SMART
LY	838	877	1.33e-1	SMART
EGF	904	941	1.22e0	SMART
LY	968	1009	4.39e-2	SMART
LY	1015	1057	1.81e0	SMART
LY	1058	1102	9.47e-7	SMART
LY	1103	1145	6.91e-9	SMART
LY	1146	1186	1.53e0	SMART
EGF	1215	1253	2.85e-1	SMART
LDLa	1257	1296	1.23e-13	SMART
LDLa	1297	1333	3.26e-9	SMART
LDLa	1334	1371	1.31e-13	SMART
transmembrane domain	1384	1406	N/A	INTRINSIC
low complexity region	1494	1503	N/A	INTRINSIC
low complexity region	1571	1578	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000177294

SMART Domains

Protein: ENSMUSP00000134771
Gene: ENSMUSG00000024913

Domain	Start	End	E-Value	Type
LY	1	26	1.88e1	SMART
LY	27	70	3.81e-11	SMART
LY	71	112	3.54e-6	SMART
LY	113	152	1.33e-1	SMART
EGF	179	216	1.22e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000177330

SMART Domains

Protein: ENSMUSP00000134983
Gene: ENSMUSG00000024913

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
LY	54	96	1.26e0	SMART
LY	99	141	2.11e-13	SMART
LY	142	185	1.32e-14	SMART
LY	186	228	1.6e-13	SMART

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 91.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm5	T	A	4: 144,504,453 (GRCm39)	M233L	probably benign	Het
Abca14	T	G	7: 119,877,404 (GRCm39)	F1017L	probably damaging	Het
Abcb11	A	C	2: 69,076,267 (GRCm39)	V1147G	probably damaging	Het
Abcc10	T	A	17: 46,617,529 (GRCm39)	S1128C	probably damaging	Het
Adam6a	G	A	12: 113,508,923 (GRCm39)	C432Y	probably damaging	Het
Adamdec1	C	T	14: 68,808,397 (GRCm39)	V318M	probably damaging	Het
Ahnak	C	A	19: 8,979,412 (GRCm39)	S232Y	possibly damaging	Het
Amt	A	C	9: 108,174,361 (GRCm39)	H42P	probably damaging	Het
Anapc1	A	T	2: 128,501,708 (GRCm39)	L778Q	probably damaging	Het
Ankhd1	G	A	18: 36,777,580 (GRCm39)	A1588T	probably benign	Het
Anln	A	T	9: 22,264,627 (GRCm39)	L881Q	probably damaging	Het
Appl1	A	G	14: 26,649,706 (GRCm39)	S607P	probably damaging	Het
Arg2	G	T	12: 79,194,436 (GRCm39)	V87L	probably benign	Het
Atp13a2	C	T	4: 140,731,323 (GRCm39)	P869L	probably benign	Het
Atxn7l1	T	A	12: 33,408,769 (GRCm39)	D310E	probably damaging	Het
Cd6	A	T	19: 10,775,966 (GRCm39)	D164E	probably damaging	Het
Cdan1	C	A	2: 120,555,417 (GRCm39)	V775L	probably benign	Het
Cep164	A	T	9: 45,687,056 (GRCm39)		probably null	Het
Cep41	A	G	6: 30,661,005 (GRCm39)	S61P	probably damaging	Het
Clcn7	C	A	17: 25,379,445 (GRCm39)	D764E	probably damaging	Het
Cog2	G	A	8: 125,278,142 (GRCm39)	G703S	possibly damaging	Het
Cramp1	T	C	17: 25,187,952 (GRCm39)	D1214G	probably damaging	Het
Cst7	G	T	2: 150,419,628 (GRCm39)	C98F	probably damaging	Het
Ctc1	T	A	11: 68,925,484 (GRCm39)	L1007Q	probably damaging	Het
Cyb5r4	G	A	9: 86,904,262 (GRCm39)	A11T	possibly damaging	Het
Dcaf8	A	G	1: 172,003,120 (GRCm39)	D306G	probably damaging	Het
Defb38	T	A	8: 19,073,592 (GRCm39)	K27I	probably benign	Het
Disp3	T	C	4: 148,356,089 (GRCm39)	E257G	probably damaging	Het
Dnajc6	T	C	4: 101,456,185 (GRCm39)	S58P	probably damaging	Het
Dock10	A	T	1: 80,584,285 (GRCm39)	D140E	possibly damaging	Het
Dop1a	T	C	9: 86,374,057 (GRCm39)	V172A	probably damaging	Het
Dync1h1	G	A	12: 110,602,943 (GRCm39)	E2195K	probably benign	Het
Eci3	C	T	13: 35,137,011 (GRCm39)	A171T	possibly damaging	Het
Eml2	A	G	7: 18,927,986 (GRCm39)	D284G	probably damaging	Het
Eml5	T	C	12: 98,776,843 (GRCm39)	D1377G	probably damaging	Het
Fam186a	T	C	15: 99,838,183 (GRCm39)	E2687G	possibly damaging	Het
Fut9	A	C	4: 25,620,352 (GRCm39)	L154R	probably damaging	Het
Gabrb2	A	G	11: 42,517,540 (GRCm39)	N454S	probably benign	Het
Gpr183	T	A	14: 122,192,153 (GRCm39)	I123L	probably benign	Het
Gucy1b1	A	T	3: 81,965,659 (GRCm39)	N62K	probably benign	Het
Hcrtr2	T	C	9: 76,167,067 (GRCm39)	N90S	probably damaging	Het
Hectd1	A	T	12: 51,791,577 (GRCm39)	L2556Q	probably damaging	Het
Hfm1	T	A	5: 106,995,542 (GRCm39)	M1290L	probably benign	Het
Hgsnat	A	G	8: 26,447,284 (GRCm39)	W337R	probably benign	Het
Hmbox1	T	C	14: 65,066,097 (GRCm39)	Y291C	probably damaging	Het
Hmcn1	T	C	1: 150,597,415 (GRCm39)	N1749S	probably benign	Het
Igsf10	T	C	3: 59,238,693 (GRCm39)	D496G	possibly damaging	Het
Iqch	C	T	9: 63,441,619 (GRCm39)		probably null	Het
Irf6	A	G	1: 192,849,843 (GRCm39)	D255G	probably benign	Het
Kif9	G	A	9: 110,346,787 (GRCm39)	G642R	probably null	Het
Klhl20	A	G	1: 160,934,312 (GRCm39)	Y236H	probably benign	Het
Krt39	T	A	11: 99,409,914 (GRCm39)	K208*	probably null	Het
Lama3	T	A	18: 12,670,838 (GRCm39)	L808*	probably null	Het
Lysmd4	A	G	7: 66,875,979 (GRCm39)	Q214R	probably benign	Het
Macf1	T	A	4: 123,263,641 (GRCm39)	E6960V	probably damaging	Het
Mcpt2	A	G	14: 56,281,156 (GRCm39)	E120G	probably benign	Het
Mpeg1	A	G	19: 12,439,720 (GRCm39)	T393A	probably benign	Het
Myh4	G	A	11: 67,146,508 (GRCm39)	E1494K	probably damaging	Het
Nbas	T	G	12: 13,524,230 (GRCm39)	S1695R	possibly damaging	Het
Nlgn1	G	T	3: 25,494,201 (GRCm39)	Y249*	probably null	Het
Ntn4	C	T	10: 93,543,215 (GRCm39)	R314W	probably damaging	Het
Nup107	A	G	10: 117,586,811 (GRCm39)	L910P	probably damaging	Het
Obscn	T	A	11: 58,931,122 (GRCm39)	D5838V	probably damaging	Het
Or10g7	T	C	9: 39,905,655 (GRCm39)	I183T	probably benign	Het
Or1j18	T	C	2: 36,624,357 (GRCm39)	I8T	probably benign	Het
Or4c113	G	A	2: 88,885,203 (GRCm39)	T189M	possibly damaging	Het
Or8d2b	T	C	9: 38,788,892 (GRCm39)	I140T	possibly damaging	Het
Otogl	G	T	10: 107,690,125 (GRCm39)	S915Y	possibly damaging	Het
P2rx7	T	A	5: 122,819,095 (GRCm39)	C506S	probably damaging	Het
P4hb	T	C	11: 120,454,044 (GRCm39)	E350G	probably benign	Het
Papolg	A	T	11: 23,817,379 (GRCm39)	V606E	probably benign	Het
Pappa	A	T	4: 65,258,980 (GRCm39)	D1576V	probably damaging	Het
Pclo	G	T	5: 14,828,566 (GRCm39)	V1402F	probably damaging	Het
Pdcd11	A	G	19: 47,086,626 (GRCm39)	T211A	probably benign	Het
Pdzd2	T	C	15: 12,373,941 (GRCm39)	R2065G	possibly damaging	Het
Plcl2	T	C	17: 50,914,878 (GRCm39)	V629A	probably benign	Het
Prkcsh	G	A	9: 21,915,871 (GRCm39)	V92I	possibly damaging	Het
Prpf19	G	T	19: 10,879,780 (GRCm39)	V320F	probably damaging	Het
Ptpn3	T	A	4: 57,239,682 (GRCm39)	I283F	probably damaging	Het
Rcc2	T	A	4: 140,447,915 (GRCm39)	D480E	probably benign	Het
Rnf182	G	A	13: 43,821,518 (GRCm39)	C23Y	probably damaging	Het
Rnf186	C	T	4: 138,694,673 (GRCm39)	T71I	probably benign	Het
Scyl3	A	G	1: 163,761,265 (GRCm39)		probably null	Het
Slc12a6	G	T	2: 112,166,272 (GRCm39)		probably null	Het
Slc1a2	C	A	2: 102,607,912 (GRCm39)	S520Y	probably damaging	Het
Slc35e2	T	A	4: 155,696,186 (GRCm39)	L191Q	probably damaging	Het
Snrnp40	C	G	4: 130,271,836 (GRCm39)		probably null	Het
Snx33	T	C	9: 56,833,295 (GRCm39)	H258R	possibly damaging	Het
Tecpr2	A	T	12: 110,899,498 (GRCm39)	H622L	probably benign	Het
Thbs3	A	T	3: 89,133,713 (GRCm39)	E888D	probably damaging	Het
Tlk2	T	C	11: 105,112,124 (GRCm39)	L159P	probably benign	Het
Tmem70	A	T	1: 16,747,497 (GRCm39)	T205S	probably damaging	Het
Trappc10	T	A	10: 78,032,285 (GRCm39)	H1001L	probably benign	Het
Trim12a	T	C	7: 103,950,064 (GRCm39)	T292A	probably benign	Het
Trip11	G	A	12: 101,849,592 (GRCm39)	R92*	probably null	Het
Trpa1	G	A	1: 14,969,612 (GRCm39)	Q386*	probably null	Het
Trpc4	T	A	3: 54,187,410 (GRCm39)	V454D	probably damaging	Het
Ttc36	A	T	9: 44,714,051 (GRCm39)	D22E	probably benign	Het
Ttk	A	T	9: 83,751,316 (GRCm39)	I798F	probably damaging	Het
Ttn	T	C	2: 76,573,977 (GRCm39)	I17312V	probably damaging	Het
Txndc15	A	T	13: 55,865,875 (GRCm39)	E113V	possibly damaging	Het
Ube2d4	T	A	15: 58,718,448 (GRCm39)		noncoding transcript	Het
Urb1	T	A	16: 90,558,583 (GRCm39)	T1723S	probably benign	Het
Vmn1r65	A	T	7: 6,011,265 (GRCm39)	V323D	possibly damaging	Het
Vmn2r54	A	G	7: 12,366,238 (GRCm39)	M232T	probably benign	Het
Wdr59	A	G	8: 112,202,813 (GRCm39)	S577P	probably damaging	Het
Wfikkn2	C	T	11: 94,128,949 (GRCm39)	W397*	probably null	Het
Ypel1	T	A	16: 16,899,511 (GRCm39)		probably null	Het
Ythdf1	T	A	2: 180,552,763 (GRCm39)	D484V	probably damaging	Het
Zdhhc17	A	G	10: 110,783,154 (GRCm39)		probably null	Het
Zfp472	A	T	17: 33,184,887 (GRCm39)	H2L	possibly damaging	Het
Zfp953	A	T	13: 67,493,422 (GRCm39)	M74K	probably benign	Het
Zmat4	C	T	8: 24,419,151 (GRCm39)	T61M	probably benign	Het

Other mutations in Lrp5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00834:Lrp5	APN	19	3,699,404 (GRCm39)	missense	probably benign
IGL00902:Lrp5	APN	19	3,650,774 (GRCm39)	missense	probably damaging	1.00
IGL02032:Lrp5	APN	19	3,665,886 (GRCm39)	splice site	probably benign
IGL02331:Lrp5	APN	19	3,641,816 (GRCm39)	missense	possibly damaging	0.64
IGL02401:Lrp5	APN	19	3,643,585 (GRCm39)	missense	probably damaging	1.00
IGL02471:Lrp5	APN	19	3,652,408 (GRCm39)	missense	probably benign	0.31
IGL02572:Lrp5	APN	19	3,664,283 (GRCm39)	missense	probably benign	0.17
IGL02637:Lrp5	APN	19	3,680,269 (GRCm39)	missense	probably benign	0.03
IGL02696:Lrp5	APN	19	3,652,253 (GRCm39)	missense	probably benign
IGL02742:Lrp5	APN	19	3,654,022 (GRCm39)	missense	probably damaging	0.99
IGL02804:Lrp5	APN	19	3,650,777 (GRCm39)	missense	possibly damaging	0.63
IGL03089:Lrp5	APN	19	3,670,314 (GRCm39)	splice site	probably null
IGL03243:Lrp5	APN	19	3,680,159 (GRCm39)	missense	probably benign	0.12
Contrarian	UTSW	19	3,709,355 (GRCm39)	missense	probably damaging	1.00
Contrarian2	UTSW	19	3,702,296 (GRCm39)	missense	probably damaging	1.00
lucent	UTSW	19	3,736,353 (GRCm39)	critical splice donor site	probably null
Microtome	UTSW	19	3,672,638 (GRCm39)	missense	probably damaging	1.00
r18	UTSW	19	0 ()	small insertion
Spicule	UTSW	19	3,662,197 (GRCm39)	critical splice donor site	probably null
Stirrup	UTSW	19	3,650,753 (GRCm39)	missense	probably damaging	1.00
PIT4494001:Lrp5	UTSW	19	3,660,091 (GRCm39)	missense	probably damaging	1.00
R0219:Lrp5	UTSW	19	3,647,349 (GRCm39)	missense	probably damaging	1.00
R0526:Lrp5	UTSW	19	3,678,295 (GRCm39)	missense	probably damaging	1.00
R0597:Lrp5	UTSW	19	3,650,777 (GRCm39)	missense	possibly damaging	0.63
R0883:Lrp5	UTSW	19	3,655,308 (GRCm39)	missense	probably damaging	1.00
R1086:Lrp5	UTSW	19	3,699,476 (GRCm39)	missense	probably benign	0.28
R1417:Lrp5	UTSW	19	3,636,425 (GRCm39)	missense	probably benign	0.04
R1468:Lrp5	UTSW	19	3,670,191 (GRCm39)	missense	possibly damaging	0.76
R1468:Lrp5	UTSW	19	3,670,191 (GRCm39)	missense	possibly damaging	0.76
R1533:Lrp5	UTSW	19	3,664,234 (GRCm39)	missense	probably benign	0.17
R1538:Lrp5	UTSW	19	3,697,585 (GRCm39)	missense	possibly damaging	0.70
R1930:Lrp5	UTSW	19	3,660,131 (GRCm39)	missense	probably benign	0.02
R1931:Lrp5	UTSW	19	3,660,131 (GRCm39)	missense	probably benign	0.02
R1932:Lrp5	UTSW	19	3,660,131 (GRCm39)	missense	probably benign	0.02
R1951:Lrp5	UTSW	19	3,670,298 (GRCm39)	missense	possibly damaging	0.89
R2016:Lrp5	UTSW	19	3,660,056 (GRCm39)	missense	probably benign	0.04
R2131:Lrp5	UTSW	19	3,672,708 (GRCm39)	missense	possibly damaging	0.87
R2153:Lrp5	UTSW	19	3,664,339 (GRCm39)	missense	probably benign	0.22
R2403:Lrp5	UTSW	19	3,647,430 (GRCm39)	missense	probably damaging	1.00
R3158:Lrp5	UTSW	19	3,665,849 (GRCm39)	missense	probably damaging	0.97
R3771:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3772:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3773:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3825:Lrp5	UTSW	19	3,655,290 (GRCm39)	nonsense	probably null
R3887:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3888:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3893:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R3917:Lrp5	UTSW	19	3,662,330 (GRCm39)	missense	probably damaging	1.00
R4279:Lrp5	UTSW	19	3,641,778 (GRCm39)	missense	possibly damaging	0.94
R4714:Lrp5	UTSW	19	3,709,454 (GRCm39)	missense	probably damaging	1.00
R4825:Lrp5	UTSW	19	3,664,292 (GRCm39)	missense	probably damaging	1.00
R5102:Lrp5	UTSW	19	3,709,304 (GRCm39)	missense	probably damaging	0.96
R5138:Lrp5	UTSW	19	3,678,319 (GRCm39)	missense	probably benign	0.03
R5497:Lrp5	UTSW	19	3,652,319 (GRCm39)	missense	probably damaging	1.00
R5632:Lrp5	UTSW	19	3,672,512 (GRCm39)	missense	probably benign
R5887:Lrp5	UTSW	19	3,654,094 (GRCm39)	missense	probably benign	0.01
R5950:Lrp5	UTSW	19	3,652,333 (GRCm39)	missense	probably benign	0.17
R5987:Lrp5	UTSW	19	3,678,299 (GRCm39)	missense	probably damaging	1.00
R6080:Lrp5	UTSW	19	3,678,316 (GRCm39)	missense	probably benign	0.32
R6181:Lrp5	UTSW	19	3,678,427 (GRCm39)	missense	probably damaging	1.00
R6236:Lrp5	UTSW	19	3,680,483 (GRCm39)	splice site	probably null
R6332:Lrp5	UTSW	19	3,709,355 (GRCm39)	missense	probably damaging	1.00
R6511:Lrp5	UTSW	19	3,702,296 (GRCm39)	missense	probably damaging	1.00
R6641:Lrp5	UTSW	19	3,702,287 (GRCm39)	missense	probably damaging	1.00
R6791:Lrp5	UTSW	19	3,650,753 (GRCm39)	missense	probably damaging	1.00
R6865:Lrp5	UTSW	19	3,670,013 (GRCm39)	critical splice donor site	probably null
R6906:Lrp5	UTSW	19	3,672,638 (GRCm39)	missense	probably damaging	1.00
R6922:Lrp5	UTSW	19	3,655,301 (GRCm39)	missense	probably damaging	1.00
R7091:Lrp5	UTSW	19	3,680,184 (GRCm39)	missense	probably damaging	1.00
R7303:Lrp5	UTSW	19	3,641,774 (GRCm39)	missense	probably damaging	0.99
R7368:Lrp5	UTSW	19	3,670,085 (GRCm39)	missense	possibly damaging	0.95
R7381:Lrp5	UTSW	19	3,643,588 (GRCm39)	missense	probably benign	0.20
R7385:Lrp5	UTSW	19	3,662,197 (GRCm39)	critical splice donor site	probably null
R7392:Lrp5	UTSW	19	3,660,199 (GRCm39)	missense	probably damaging	1.00
R7448:Lrp5	UTSW	19	3,699,439 (GRCm39)	missense	probably benign	0.01
R7585:Lrp5	UTSW	19	3,654,094 (GRCm39)	missense	possibly damaging	0.88
R7662:Lrp5	UTSW	19	3,736,353 (GRCm39)	critical splice donor site	probably null
R7984:Lrp5	UTSW	19	3,662,342 (GRCm39)	missense	probably damaging	1.00
R8056:Lrp5	UTSW	19	3,647,337 (GRCm39)	missense	probably damaging	0.98
R8391:Lrp5	UTSW	19	3,654,185 (GRCm39)	missense	probably damaging	1.00
R8881:Lrp5	UTSW	19	3,641,015 (GRCm39)	missense	probably damaging	0.98
R8885:Lrp5	UTSW	19	3,702,170 (GRCm39)	missense	probably damaging	1.00
R9051:Lrp5	UTSW	19	3,680,156 (GRCm39)	missense	possibly damaging	0.89
R9263:Lrp5	UTSW	19	3,654,190 (GRCm39)	missense	probably damaging	1.00
R9376:Lrp5	UTSW	19	3,670,286 (GRCm39)	missense	probably benign	0.00
R9400:Lrp5	UTSW	19	3,635,272 (GRCm39)	missense	probably benign	0.00
R9536:Lrp5	UTSW	19	3,672,672 (GRCm39)	missense	probably damaging	1.00
R9600:Lrp5	UTSW	19	3,641,712 (GRCm39)	missense	probably benign	0.00
Z1177:Lrp5	UTSW	19	3,678,345 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CCCCGTGTTTGATGTATAGGAAG -3'
(R):5'- CACAAAGTCAGTGGAAGCGC -3'

Sequencing Primer
(F):5'- CCGTGTTTGATGTATAGGAAGGAAGG -3'
(R):5'- CAGCGATGCCTTTGCGTG -3'

Posted On

2014-06-23