Incidental Mutation 'R1846:Vmn2r115'
ID |
207760 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r115
|
Ensembl Gene |
ENSMUSG00000091076 |
Gene Name |
vomeronasal 2, receptor 115 |
Synonyms |
V2Rp4, EG638102 |
MMRRC Submission |
039871-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.084)
|
Stock # |
R1846 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
23562951-23579102 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 23578357 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Threonine
at position 610
(K610T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131447
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168175]
|
AlphaFold |
E9Q0E7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000168175
AA Change: K610T
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000131447 Gene: ENSMUSG00000091076 AA Change: K610T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
73 |
471 |
1.4e-28 |
PFAM |
Pfam:NCD3G
|
512 |
565 |
2.9e-20 |
PFAM |
Pfam:7tm_3
|
598 |
833 |
5e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.6%
|
Validation Efficiency |
99% (75/76) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2900092C05Rik |
G |
A |
7: 12,246,809 (GRCm39) |
R63Q |
probably benign |
Het |
Adamts20 |
A |
T |
15: 94,243,871 (GRCm39) |
C619S |
probably damaging |
Het |
Alx1 |
T |
C |
10: 102,861,165 (GRCm39) |
D121G |
possibly damaging |
Het |
Anks3 |
A |
C |
16: 4,771,748 (GRCm39) |
M215R |
probably benign |
Het |
Anxa4 |
T |
A |
6: 86,718,893 (GRCm39) |
|
probably null |
Het |
Arhgef25 |
A |
G |
10: 127,021,733 (GRCm39) |
V222A |
probably damaging |
Het |
Bglap2 |
A |
G |
3: 88,285,932 (GRCm39) |
|
probably benign |
Het |
Cars2 |
A |
G |
8: 11,564,674 (GRCm39) |
V22A |
probably benign |
Het |
Ccdc198 |
G |
T |
14: 49,473,420 (GRCm39) |
L102I |
probably damaging |
Het |
Cenpe |
T |
A |
3: 134,945,606 (GRCm39) |
I1040N |
probably damaging |
Het |
Cep170 |
C |
T |
1: 176,583,335 (GRCm39) |
D1015N |
probably damaging |
Het |
Chia1 |
T |
A |
3: 106,038,181 (GRCm39) |
I359N |
probably damaging |
Het |
Crot |
A |
T |
5: 9,038,248 (GRCm39) |
V93E |
probably benign |
Het |
Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
Dnmbp |
T |
C |
19: 43,891,186 (GRCm39) |
I194V |
probably damaging |
Het |
Dock4 |
T |
A |
12: 40,783,267 (GRCm39) |
C734S |
probably benign |
Het |
Eif4e3 |
T |
C |
6: 99,617,662 (GRCm39) |
S70G |
probably benign |
Het |
Entpd3 |
G |
A |
9: 120,387,441 (GRCm39) |
D213N |
probably benign |
Het |
Ern2 |
T |
G |
7: 121,775,759 (GRCm39) |
Y445S |
probably benign |
Het |
Fasn |
A |
G |
11: 120,704,133 (GRCm39) |
S1429P |
probably benign |
Het |
Fat4 |
A |
G |
3: 39,036,532 (GRCm39) |
I3395V |
probably benign |
Het |
Fbln2 |
C |
A |
6: 91,233,399 (GRCm39) |
Q628K |
possibly damaging |
Het |
Fbxo28 |
T |
C |
1: 182,153,845 (GRCm39) |
N164D |
probably benign |
Het |
Fez1 |
T |
C |
9: 36,779,063 (GRCm39) |
S247P |
probably damaging |
Het |
Gars1 |
A |
G |
6: 55,040,153 (GRCm39) |
D360G |
probably benign |
Het |
Gcfc2 |
A |
T |
6: 81,933,873 (GRCm39) |
Q710L |
probably damaging |
Het |
Ggt5 |
A |
G |
10: 75,446,376 (GRCm39) |
|
probably null |
Het |
Glp1r |
A |
G |
17: 31,148,909 (GRCm39) |
|
probably null |
Het |
Hspa14 |
T |
C |
2: 3,492,697 (GRCm39) |
D356G |
possibly damaging |
Het |
Htt |
T |
A |
5: 35,006,288 (GRCm39) |
I1399N |
probably damaging |
Het |
Kmt2e |
G |
A |
5: 23,704,484 (GRCm39) |
|
probably benign |
Het |
Krt36 |
C |
A |
11: 99,996,374 (GRCm39) |
G17C |
probably damaging |
Het |
Lama2 |
T |
C |
10: 27,088,092 (GRCm39) |
E895G |
probably damaging |
Het |
Lamb2 |
G |
A |
9: 108,364,586 (GRCm39) |
R1142H |
probably benign |
Het |
Lhcgr |
C |
T |
17: 89,072,575 (GRCm39) |
|
probably null |
Het |
Lpin2 |
A |
G |
17: 71,532,064 (GRCm39) |
T140A |
probably benign |
Het |
Metap1 |
A |
G |
3: 138,186,443 (GRCm39) |
|
probably benign |
Het |
Mpeg1 |
T |
C |
19: 12,440,486 (GRCm39) |
V648A |
probably benign |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Muc4 |
T |
A |
16: 32,752,369 (GRCm38) |
I749N |
probably benign |
Het |
N4bp2 |
T |
C |
5: 65,965,862 (GRCm39) |
F1304L |
probably damaging |
Het |
Nup85 |
A |
G |
11: 115,459,239 (GRCm39) |
E114G |
probably benign |
Het |
Or2a5 |
A |
G |
6: 42,874,254 (GRCm39) |
S290G |
probably damaging |
Het |
Or4c10 |
A |
G |
2: 89,761,010 (GRCm39) |
T286A |
possibly damaging |
Het |
Or6b2b |
A |
T |
1: 92,418,822 (GRCm39) |
Y218* |
probably null |
Het |
Pafah2 |
GCCCC |
GCCCCC |
4: 134,152,852 (GRCm39) |
|
probably null |
Het |
Parp2 |
T |
A |
14: 51,052,843 (GRCm39) |
C145* |
probably null |
Het |
Plpp6 |
T |
C |
19: 28,941,680 (GRCm39) |
S94P |
probably benign |
Het |
Polr1a |
T |
C |
6: 71,953,172 (GRCm39) |
I1580T |
probably damaging |
Het |
Polrmt |
A |
T |
10: 79,574,043 (GRCm39) |
V860E |
probably damaging |
Het |
Ppp1r17 |
A |
G |
6: 55,999,412 (GRCm39) |
E15G |
possibly damaging |
Het |
Prl7b1 |
A |
T |
13: 27,786,831 (GRCm39) |
W133R |
probably damaging |
Het |
Ptk7 |
A |
G |
17: 46,887,416 (GRCm39) |
|
probably null |
Het |
Rad23b |
C |
T |
4: 55,383,637 (GRCm39) |
Q290* |
probably null |
Het |
Rorb |
C |
T |
19: 18,932,445 (GRCm39) |
E369K |
probably damaging |
Het |
Rusc1 |
T |
C |
3: 88,999,452 (GRCm39) |
D110G |
probably damaging |
Het |
Smg7 |
A |
G |
1: 152,724,601 (GRCm39) |
S527P |
probably damaging |
Het |
Ssbp2 |
C |
T |
13: 91,812,268 (GRCm39) |
P105L |
probably damaging |
Het |
Stt3a |
C |
T |
9: 36,674,681 (GRCm39) |
R34H |
probably damaging |
Het |
Sufu |
T |
A |
19: 46,439,386 (GRCm39) |
I202N |
possibly damaging |
Het |
Thsd7b |
G |
A |
1: 129,540,993 (GRCm39) |
R289Q |
probably damaging |
Het |
Tph1 |
A |
T |
7: 46,309,863 (GRCm39) |
S130T |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,776,030 (GRCm39) |
S1671P |
probably damaging |
Het |
Usp4 |
A |
G |
9: 108,249,935 (GRCm39) |
I441V |
probably benign |
Het |
Vmn1r8 |
A |
G |
6: 57,013,413 (GRCm39) |
N155D |
probably benign |
Het |
Vmn2r62 |
G |
A |
7: 42,438,546 (GRCm39) |
P97S |
probably damaging |
Het |
Zbtb40 |
T |
C |
4: 136,735,150 (GRCm39) |
D297G |
probably benign |
Het |
Zfp174 |
C |
A |
16: 3,672,599 (GRCm39) |
Q383K |
probably benign |
Het |
Zfp318 |
T |
A |
17: 46,724,592 (GRCm39) |
D2198E |
probably benign |
Het |
Zfp628 |
C |
T |
7: 4,923,866 (GRCm39) |
P696L |
possibly damaging |
Het |
Zgrf1 |
T |
A |
3: 127,409,112 (GRCm39) |
N1695K |
probably damaging |
Het |
|
Other mutations in Vmn2r115 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00990:Vmn2r115
|
APN |
17 |
23,575,934 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,345 (GRCm39) |
nonsense |
probably null |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,371 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,135 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,313 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,578,323 (GRCm39) |
missense |
probably benign |
0.22 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,150 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,180 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL00990:Vmn2r115
|
APN |
17 |
23,567,008 (GRCm39) |
nonsense |
probably null |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,798 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,578,753 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
IGL00990:Vmn2r115
|
APN |
17 |
23,565,346 (GRCm39) |
missense |
probably benign |
0.30 |
IGL01073:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
IGL01101:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
IGL01300:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01415:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02309:Vmn2r115
|
APN |
17 |
23,564,113 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02863:Vmn2r115
|
APN |
17 |
23,578,257 (GRCm39) |
missense |
probably damaging |
0.97 |
R0023:Vmn2r115
|
UTSW |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
R0197:Vmn2r115
|
UTSW |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
R0361:Vmn2r115
|
UTSW |
17 |
23,564,196 (GRCm39) |
missense |
probably benign |
0.11 |
R0601:Vmn2r115
|
UTSW |
17 |
23,579,074 (GRCm39) |
missense |
probably null |
0.51 |
R0676:Vmn2r115
|
UTSW |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
R0685:Vmn2r115
|
UTSW |
17 |
23,578,249 (GRCm39) |
missense |
probably benign |
|
R0865:Vmn2r115
|
UTSW |
17 |
23,565,382 (GRCm39) |
missense |
possibly damaging |
0.65 |
R1124:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1145:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1146:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1207:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1266:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1318:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1367:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1420:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
R1604:Vmn2r115
|
UTSW |
17 |
23,564,245 (GRCm39) |
missense |
probably benign |
0.12 |
R1645:Vmn2r115
|
UTSW |
17 |
23,565,192 (GRCm39) |
missense |
possibly damaging |
0.69 |
R1646:Vmn2r115
|
UTSW |
17 |
23,578,513 (GRCm39) |
missense |
probably damaging |
1.00 |
R1650:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1678:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1716:Vmn2r115
|
UTSW |
17 |
23,566,795 (GRCm39) |
missense |
probably benign |
|
R1847:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1885:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R1887:Vmn2r115
|
UTSW |
17 |
23,565,007 (GRCm39) |
missense |
possibly damaging |
0.91 |
R1937:Vmn2r115
|
UTSW |
17 |
23,578,388 (GRCm39) |
missense |
probably damaging |
1.00 |
R2007:Vmn2r115
|
UTSW |
17 |
23,566,927 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2120:Vmn2r115
|
UTSW |
17 |
23,578,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R3161:Vmn2r115
|
UTSW |
17 |
23,575,998 (GRCm39) |
missense |
possibly damaging |
0.82 |
R3780:Vmn2r115
|
UTSW |
17 |
23,564,146 (GRCm39) |
missense |
probably damaging |
1.00 |
R3806:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R3982:Vmn2r115
|
UTSW |
17 |
23,578,948 (GRCm39) |
missense |
probably damaging |
1.00 |
R4019:Vmn2r115
|
UTSW |
17 |
23,579,017 (GRCm39) |
missense |
probably damaging |
1.00 |
R4039:Vmn2r115
|
UTSW |
17 |
23,564,077 (GRCm39) |
missense |
probably benign |
0.26 |
R4087:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
R4089:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
R4379:Vmn2r115
|
UTSW |
17 |
23,564,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4417:Vmn2r115
|
UTSW |
17 |
23,564,854 (GRCm39) |
missense |
probably benign |
0.02 |
R4601:Vmn2r115
|
UTSW |
17 |
23,565,373 (GRCm39) |
missense |
probably benign |
0.01 |
R4874:Vmn2r115
|
UTSW |
17 |
23,578,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R5466:Vmn2r115
|
UTSW |
17 |
23,579,030 (GRCm39) |
missense |
probably damaging |
1.00 |
R5613:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
R5821:Vmn2r115
|
UTSW |
17 |
23,566,937 (GRCm39) |
missense |
probably damaging |
0.99 |
R6120:Vmn2r115
|
UTSW |
17 |
23,565,003 (GRCm39) |
missense |
probably damaging |
1.00 |
R6193:Vmn2r115
|
UTSW |
17 |
23,575,983 (GRCm39) |
missense |
probably benign |
0.01 |
R6213:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R6290:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
R6319:Vmn2r115
|
UTSW |
17 |
23,566,877 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6495:Vmn2r115
|
UTSW |
17 |
23,578,572 (GRCm39) |
missense |
probably benign |
0.02 |
R6599:Vmn2r115
|
UTSW |
17 |
23,565,006 (GRCm39) |
missense |
probably benign |
0.00 |
R6764:Vmn2r115
|
UTSW |
17 |
23,565,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R6970:Vmn2r115
|
UTSW |
17 |
23,564,989 (GRCm39) |
missense |
probably benign |
0.23 |
R7023:Vmn2r115
|
UTSW |
17 |
23,578,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R7236:Vmn2r115
|
UTSW |
17 |
23,578,576 (GRCm39) |
missense |
probably benign |
0.01 |
R7353:Vmn2r115
|
UTSW |
17 |
23,564,887 (GRCm39) |
missense |
possibly damaging |
0.65 |
R7483:Vmn2r115
|
UTSW |
17 |
23,565,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7743:Vmn2r115
|
UTSW |
17 |
23,564,772 (GRCm39) |
nonsense |
probably null |
|
R8005:Vmn2r115
|
UTSW |
17 |
23,563,124 (GRCm39) |
nonsense |
probably null |
|
R8191:Vmn2r115
|
UTSW |
17 |
23,578,530 (GRCm39) |
missense |
probably damaging |
1.00 |
R8544:Vmn2r115
|
UTSW |
17 |
23,564,773 (GRCm39) |
missense |
possibly damaging |
0.88 |
R8890:Vmn2r115
|
UTSW |
17 |
23,578,497 (GRCm39) |
missense |
probably damaging |
0.98 |
R9098:Vmn2r115
|
UTSW |
17 |
23,564,803 (GRCm39) |
missense |
probably benign |
|
R9114:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
R9189:Vmn2r115
|
UTSW |
17 |
23,564,784 (GRCm39) |
missense |
probably damaging |
1.00 |
R9351:Vmn2r115
|
UTSW |
17 |
23,578,482 (GRCm39) |
missense |
probably benign |
0.05 |
R9397:Vmn2r115
|
UTSW |
17 |
23,564,152 (GRCm39) |
nonsense |
probably null |
|
R9410:Vmn2r115
|
UTSW |
17 |
23,578,915 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9593:Vmn2r115
|
UTSW |
17 |
23,578,184 (GRCm39) |
missense |
probably damaging |
0.99 |
V5622:Vmn2r115
|
UTSW |
17 |
23,578,333 (GRCm39) |
missense |
probably benign |
|
V5622:Vmn2r115
|
UTSW |
17 |
23,565,201 (GRCm39) |
missense |
probably damaging |
1.00 |
X0023:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
X0033:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- CCCCATTAGATGTGGATTATTGTGTC -3'
(R):5'- GGCTATGATTTTGAATGCCAGAAC -3'
Sequencing Primer
(F):5'- AGATGTGGATTATTGTGTCCAGTGTC -3'
(R):5'- ATCGTTTTAGCCAAGACAGTGG -3'
|
Posted On |
2014-06-23 |