Incidental Mutation 'R0130:Vmn2r85'
| ID |
208406 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r85
|
| Ensembl Gene |
ENSMUSG00000092048 |
| Gene Name |
vomeronasal 2, receptor 85 |
| Synonyms |
EG623734 |
| MMRRC Submission |
038415-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R0130 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
10 |
| Chromosomal Location |
130253658-130266615 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 130255054 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128792
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171811]
|
| AlphaFold |
G3UW56 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171811
|
| SMART Domains |
Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
9e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.1e-18 |
PFAM |
|
Pfam:7tm_3
|
595 |
831 |
3.7e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 97.7%
- 10x: 93.4%
- 20x: 80.2%
|
| Validation Efficiency |
99% (84/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg8 |
A |
T |
17: 84,994,094 (GRCm39) |
Y37F |
probably damaging |
Het |
| Ablim2 |
G |
A |
5: 35,966,520 (GRCm39) |
|
probably benign |
Het |
| Anxa9 |
A |
G |
3: 95,209,733 (GRCm39) |
S129P |
probably benign |
Het |
| Apol7c |
A |
G |
15: 77,410,562 (GRCm39) |
I128T |
possibly damaging |
Het |
| Arfgef2 |
T |
G |
2: 166,677,639 (GRCm39) |
I88S |
probably damaging |
Het |
| Arfip2 |
A |
G |
7: 105,288,205 (GRCm39) |
|
probably benign |
Het |
| Atp5mf |
A |
T |
5: 145,124,992 (GRCm39) |
|
probably benign |
Het |
| Atp7b |
C |
T |
8: 22,518,188 (GRCm39) |
E205K |
possibly damaging |
Het |
| Atp8b5 |
T |
A |
4: 43,369,715 (GRCm39) |
|
probably null |
Het |
| Cd22 |
A |
G |
7: 30,569,389 (GRCm39) |
Y402H |
possibly damaging |
Het |
| Cd248 |
A |
G |
19: 5,119,990 (GRCm39) |
T613A |
probably benign |
Het |
| Cdcp2 |
C |
T |
4: 106,963,904 (GRCm39) |
|
probably benign |
Het |
| Cenpc1 |
A |
T |
5: 86,194,405 (GRCm39) |
D120E |
probably benign |
Het |
| Chd3 |
T |
A |
11: 69,250,656 (GRCm39) |
H691L |
probably damaging |
Het |
| Colec12 |
C |
T |
18: 9,858,921 (GRCm39) |
P568L |
unknown |
Het |
| Cped1 |
T |
A |
6: 22,121,038 (GRCm39) |
Y373N |
probably benign |
Het |
| Cr2 |
A |
T |
1: 194,848,539 (GRCm39) |
V328D |
probably damaging |
Het |
| Ctnnd2 |
A |
T |
15: 30,922,059 (GRCm39) |
E895V |
probably damaging |
Het |
| D630045J12Rik |
A |
T |
6: 38,126,706 (GRCm39) |
|
probably benign |
Het |
| Dcdc2a |
A |
T |
13: 25,371,655 (GRCm39) |
|
probably benign |
Het |
| Dync1h1 |
C |
A |
12: 110,585,108 (GRCm39) |
T837K |
probably benign |
Het |
| Eif2ak3 |
C |
A |
6: 70,858,716 (GRCm39) |
|
probably benign |
Het |
| Epb41l5 |
A |
C |
1: 119,477,632 (GRCm39) |
V705G |
possibly damaging |
Het |
| Fat2 |
T |
A |
11: 55,142,944 (GRCm39) |
M4302L |
probably benign |
Het |
| Flnb |
T |
C |
14: 7,901,951 (GRCm38) |
V938A |
probably damaging |
Het |
| Frmd4a |
T |
C |
2: 4,608,903 (GRCm39) |
Y928H |
probably damaging |
Het |
| Fyn |
C |
T |
10: 39,387,978 (GRCm39) |
T78M |
probably benign |
Het |
| Gdap2 |
A |
G |
3: 100,109,311 (GRCm39) |
T443A |
probably damaging |
Het |
| Gde1 |
A |
T |
7: 118,294,283 (GRCm39) |
F63L |
probably benign |
Het |
| Gjc3 |
A |
G |
5: 137,956,202 (GRCm39) |
S28P |
probably benign |
Het |
| Gm10250 |
G |
A |
15: 5,150,473 (GRCm39) |
|
probably null |
Het |
| Hp1bp3 |
C |
T |
4: 137,964,520 (GRCm39) |
S348F |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,664,310 (GRCm39) |
V553A |
probably damaging |
Het |
| Lman2l |
G |
T |
1: 36,463,945 (GRCm39) |
S171* |
probably null |
Het |
| Lrp1b |
T |
C |
2: 41,401,520 (GRCm39) |
D378G |
probably damaging |
Het |
| Map3k11 |
T |
C |
19: 5,740,843 (GRCm39) |
L190P |
probably damaging |
Het |
| Mki67 |
T |
A |
7: 135,298,188 (GRCm39) |
Q2282L |
probably damaging |
Het |
| Mthfd2 |
T |
A |
6: 83,285,990 (GRCm39) |
I272F |
probably damaging |
Het |
| Myom1 |
A |
T |
17: 71,352,750 (GRCm39) |
D358V |
probably damaging |
Het |
| Nebl |
T |
C |
2: 17,395,737 (GRCm39) |
|
probably benign |
Het |
| Nebl |
T |
A |
2: 17,397,834 (GRCm39) |
Q487H |
possibly damaging |
Het |
| Nlrp2 |
T |
A |
7: 5,325,417 (GRCm39) |
N14Y |
possibly damaging |
Het |
| Or14a258 |
T |
C |
7: 86,035,514 (GRCm39) |
Y118C |
probably damaging |
Het |
| Or1j11 |
T |
A |
2: 36,312,299 (GRCm39) |
D296E |
probably benign |
Het |
| Or2z8 |
C |
T |
8: 72,812,244 (GRCm39) |
T240M |
probably damaging |
Het |
| Or5ak22 |
T |
A |
2: 85,230,305 (GRCm39) |
S191C |
probably damaging |
Het |
| Or8k40 |
T |
C |
2: 86,584,231 (GRCm39) |
M284V |
probably benign |
Het |
| Pasd1 |
T |
C |
X: 70,983,161 (GRCm39) |
C378R |
possibly damaging |
Het |
| Paxip1 |
C |
T |
5: 27,949,183 (GRCm39) |
|
probably benign |
Het |
| Pclo |
A |
G |
5: 14,729,811 (GRCm39) |
|
probably benign |
Het |
| Pld2 |
T |
G |
11: 70,445,174 (GRCm39) |
N591K |
probably benign |
Het |
| Plekha7 |
A |
G |
7: 115,769,939 (GRCm39) |
M276T |
probably damaging |
Het |
| Prss39 |
T |
A |
1: 34,541,281 (GRCm39) |
|
probably benign |
Het |
| Prtg |
A |
G |
9: 72,716,998 (GRCm39) |
Y113C |
probably damaging |
Het |
| Rab38 |
T |
A |
7: 88,099,749 (GRCm39) |
I88N |
probably damaging |
Het |
| Rbfox2 |
A |
G |
15: 76,976,057 (GRCm39) |
|
probably benign |
Het |
| Samd5 |
A |
G |
10: 9,550,683 (GRCm39) |
W9R |
probably damaging |
Het |
| Sec14l1 |
A |
T |
11: 117,047,233 (GRCm39) |
K637I |
possibly damaging |
Het |
| Sh2b1 |
A |
T |
7: 126,070,620 (GRCm39) |
D360E |
possibly damaging |
Het |
| Sh3bp4 |
A |
G |
1: 89,073,036 (GRCm39) |
N628S |
possibly damaging |
Het |
| Sim1 |
A |
T |
10: 50,784,057 (GRCm39) |
I104F |
probably damaging |
Het |
| Smcp |
T |
A |
3: 92,491,827 (GRCm39) |
T7S |
unknown |
Het |
| Sp4 |
A |
G |
12: 118,264,551 (GRCm39) |
|
probably benign |
Het |
| Tectb |
G |
T |
19: 55,170,393 (GRCm39) |
K81N |
probably damaging |
Het |
| Thbs4 |
G |
T |
13: 92,890,918 (GRCm39) |
H850N |
probably benign |
Het |
| Tiam1 |
T |
C |
16: 89,694,642 (GRCm39) |
M272V |
probably benign |
Het |
| Trav13-3 |
T |
A |
14: 53,967,233 (GRCm39) |
|
noncoding transcript |
Het |
| Ubap2l |
A |
T |
3: 89,928,680 (GRCm39) |
S478T |
possibly damaging |
Het |
|
| Other mutations in Vmn2r85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01160:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01298:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01361:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02185:Vmn2r85
|
APN |
10 |
130,254,561 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02505:Vmn2r85
|
APN |
10 |
130,261,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02607:Vmn2r85
|
APN |
10 |
130,262,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02755:Vmn2r85
|
APN |
10 |
130,261,381 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03188:Vmn2r85
|
APN |
10 |
130,254,612 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03366:Vmn2r85
|
APN |
10 |
130,262,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03397:Vmn2r85
|
APN |
10 |
130,261,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r85
|
UTSW |
10 |
130,261,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0066:Vmn2r85
|
UTSW |
10 |
130,261,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0128:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0503:Vmn2r85
|
UTSW |
10 |
130,258,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Vmn2r85
|
UTSW |
10 |
130,265,387 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1432:Vmn2r85
|
UTSW |
10 |
130,261,155 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1521:Vmn2r85
|
UTSW |
10 |
130,261,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2029:Vmn2r85
|
UTSW |
10 |
130,261,443 (GRCm39) |
nonsense |
probably null |
|
|
R2034:Vmn2r85
|
UTSW |
10 |
130,262,242 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2853:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3084:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3085:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3430:Vmn2r85
|
UTSW |
10 |
130,254,758 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3694:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3932:Vmn2r85
|
UTSW |
10 |
130,254,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Vmn2r85
|
UTSW |
10 |
130,254,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4628:Vmn2r85
|
UTSW |
10 |
130,261,235 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4814:Vmn2r85
|
UTSW |
10 |
130,254,567 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4948:Vmn2r85
|
UTSW |
10 |
130,254,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Vmn2r85
|
UTSW |
10 |
130,261,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4959:Vmn2r85
|
UTSW |
10 |
130,257,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Vmn2r85
|
UTSW |
10 |
130,258,574 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5643:Vmn2r85
|
UTSW |
10 |
130,262,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6061:Vmn2r85
|
UTSW |
10 |
130,261,531 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6115:Vmn2r85
|
UTSW |
10 |
130,258,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r85
|
UTSW |
10 |
130,261,330 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6518:Vmn2r85
|
UTSW |
10 |
130,265,281 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6533:Vmn2r85
|
UTSW |
10 |
130,262,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6610:Vmn2r85
|
UTSW |
10 |
130,261,838 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6809:Vmn2r85
|
UTSW |
10 |
130,261,795 (GRCm39) |
missense |
probably benign |
|
|
R6962:Vmn2r85
|
UTSW |
10 |
130,261,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7075:Vmn2r85
|
UTSW |
10 |
130,258,557 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7104:Vmn2r85
|
UTSW |
10 |
130,262,376 (GRCm39) |
missense |
probably benign |
|
|
R7424:Vmn2r85
|
UTSW |
10 |
130,254,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7516:Vmn2r85
|
UTSW |
10 |
130,254,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7537:Vmn2r85
|
UTSW |
10 |
130,258,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7768:Vmn2r85
|
UTSW |
10 |
130,254,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Vmn2r85
|
UTSW |
10 |
130,265,364 (GRCm39) |
nonsense |
probably null |
|
|
R8115:Vmn2r85
|
UTSW |
10 |
130,261,820 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8262:Vmn2r85
|
UTSW |
10 |
130,254,738 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8395:Vmn2r85
|
UTSW |
10 |
130,261,797 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8409:Vmn2r85
|
UTSW |
10 |
130,261,257 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8547:Vmn2r85
|
UTSW |
10 |
130,261,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8875:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9035:Vmn2r85
|
UTSW |
10 |
130,261,479 (GRCm39) |
missense |
probably benign |
|
|
R9040:Vmn2r85
|
UTSW |
10 |
130,254,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9115:Vmn2r85
|
UTSW |
10 |
130,254,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Vmn2r85
|
UTSW |
10 |
130,265,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,261,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,255,033 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9405:Vmn2r85
|
UTSW |
10 |
130,261,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9502:Vmn2r85
|
UTSW |
10 |
130,261,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9520:Vmn2r85
|
UTSW |
10 |
130,254,993 (GRCm39) |
missense |
probably benign |
|
|
R9653:Vmn2r85
|
UTSW |
10 |
130,261,694 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Vmn2r85
|
UTSW |
10 |
130,261,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r85
|
UTSW |
10 |
130,254,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTAGTGAGCTTGAAAGCCATGACC -3'
(R):5'- TGGTGATCTGTTCCCTCACAATGC -3'
Sequencing Primer
(F):5'- GGCCTTCACAATGGGAGTATC -3'
(R):5'- TGTTCCCTCACAATGCATAGG -3'
|
| Posted On |
2014-06-25 |
Incidental Mutation