Incidental Mutation 'R0726:Vldlr'
| ID |
218892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vldlr
|
| Ensembl Gene |
ENSMUSG00000024924 |
| Gene Name |
very low density lipoprotein receptor |
| Synonyms |
|
| MMRRC Submission |
038908-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.285)
|
| Stock # |
R0726 (G1)
|
| Quality Score |
28 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
27193884-27231631 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 27215786 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 261
(D261V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000025866
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025866]
[ENSMUST00000047645]
[ENSMUST00000164746]
[ENSMUST00000165761]
[ENSMUST00000167487]
[ENSMUST00000172302]
|
| AlphaFold |
P98156 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000025866
AA Change: D261V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000025866
Gene: ENSMUSG00000024924
AA Change: D261V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
Blast:LY
|
461 |
495 |
4e-15 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047645
AA Change: D220V
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000049145
Gene: ENSMUSG00000024924
AA Change: D220V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
1.25e-14 |
SMART |
|
LDLa
|
112 |
149 |
7.15e-15 |
SMART |
|
LDLa
|
151 |
190 |
1.23e-13 |
SMART |
|
LDLa
|
197 |
234 |
1.1e-15 |
SMART |
|
LDLa
|
236 |
273 |
1.13e-12 |
SMART |
|
LDLa
|
276 |
316 |
3.86e-11 |
SMART |
|
EGF_CA
|
315 |
354 |
1e-5 |
SMART |
|
EGF_CA
|
355 |
394 |
6.1e-10 |
SMART |
|
LY
|
420 |
462 |
2.16e-1 |
SMART |
|
LY
|
464 |
506 |
9.54e-12 |
SMART |
|
LY
|
507 |
550 |
2.22e-12 |
SMART |
|
LY
|
551 |
593 |
1.66e-11 |
SMART |
|
LY
|
594 |
637 |
5.97e-4 |
SMART |
|
EGF
|
664 |
709 |
2.16e-1 |
SMART |
|
transmembrane domain
|
728 |
750 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164509
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164746
|
| SMART Domains |
Protein: ENSMUSP00000128193
Gene: ENSMUSG00000024924
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165761
|
| SMART Domains |
Protein: ENSMUSP00000130382
Gene: ENSMUSG00000024924
| Domain | Start | End | E-Value | Type |
|---|
|
LDLa
|
1 |
26 |
1.58e0 |
SMART |
|
EGF
|
28 |
64 |
4e-5 |
SMART |
|
LY
|
88 |
130 |
2.16e-1 |
SMART |
|
LY
|
132 |
174 |
9.54e-12 |
SMART |
|
LY
|
175 |
218 |
2.22e-12 |
SMART |
|
LY
|
219 |
258 |
3.25e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167487
AA Change: D261V
PolyPhen 2
Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000127329
Gene: ENSMUSG00000024924
AA Change: D261V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
LY
|
461 |
503 |
2.16e-1 |
SMART |
|
LY
|
505 |
547 |
9.54e-12 |
SMART |
|
LY
|
548 |
591 |
2.22e-12 |
SMART |
|
LY
|
592 |
634 |
1.66e-11 |
SMART |
|
LY
|
635 |
678 |
5.97e-4 |
SMART |
|
EGF
|
705 |
750 |
2.16e-1 |
SMART |
|
transmembrane domain
|
797 |
819 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172302
AA Change: D261V
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126730
Gene: ENSMUSG00000024924
AA Change: D261V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
LY
|
461 |
503 |
2.16e-1 |
SMART |
|
LY
|
505 |
547 |
9.54e-12 |
SMART |
|
LY
|
548 |
591 |
2.22e-12 |
SMART |
|
LY
|
592 |
634 |
1.66e-11 |
SMART |
|
LY
|
635 |
678 |
5.97e-4 |
SMART |
|
EGF
|
705 |
750 |
2.16e-1 |
SMART |
|
transmembrane domain
|
769 |
791 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.3487 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.1%
- 20x: 89.2%
|
| Validation Efficiency |
98% (90/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acte1 |
A |
G |
7: 143,425,498 (GRCm39) |
D49G |
probably damaging |
Het |
| Alg12 |
T |
C |
15: 88,690,850 (GRCm39) |
Y256C |
probably damaging |
Het |
| Alox15 |
T |
A |
11: 70,241,021 (GRCm39) |
D160V |
probably damaging |
Het |
| Aox1 |
T |
C |
1: 58,373,941 (GRCm39) |
|
probably benign |
Het |
| Bbs9 |
G |
T |
9: 22,705,119 (GRCm39) |
A729S |
probably damaging |
Het |
| Bltp3a |
T |
C |
17: 28,104,463 (GRCm39) |
V503A |
possibly damaging |
Het |
| Bmp2k |
T |
A |
5: 97,235,353 (GRCm39) |
|
probably benign |
Het |
| Braf |
C |
T |
6: 39,639,082 (GRCm39) |
R223Q |
possibly damaging |
Het |
| Cd101 |
A |
T |
3: 100,927,938 (GRCm39) |
S48T |
possibly damaging |
Het |
| Cdh9 |
T |
G |
15: 16,831,130 (GRCm39) |
D322E |
probably benign |
Het |
| Col28a1 |
C |
T |
6: 8,014,495 (GRCm39) |
|
probably null |
Het |
| Cpxm1 |
G |
A |
2: 130,232,859 (GRCm39) |
R712W |
probably damaging |
Het |
| Csnk1g1 |
T |
C |
9: 65,939,637 (GRCm39) |
|
probably benign |
Het |
| Cyp2d37-ps |
A |
C |
15: 82,574,650 (GRCm39) |
|
noncoding transcript |
Het |
| Cyth3 |
T |
C |
5: 143,678,397 (GRCm39) |
V115A |
probably benign |
Het |
| Dnah9 |
C |
T |
11: 65,856,507 (GRCm39) |
V2885M |
probably damaging |
Het |
| Dock9 |
G |
T |
14: 121,889,180 (GRCm39) |
Y326* |
probably null |
Het |
| Espl1 |
T |
C |
15: 102,231,033 (GRCm39) |
I1844T |
probably benign |
Het |
| Fam20a |
T |
A |
11: 109,568,020 (GRCm39) |
N357Y |
probably damaging |
Het |
| Fancc |
C |
A |
13: 63,471,225 (GRCm39) |
R385L |
probably benign |
Het |
| Foxe3 |
A |
T |
4: 114,782,447 (GRCm39) |
L255H |
unknown |
Het |
| Frem2 |
T |
C |
3: 53,427,047 (GRCm39) |
D2967G |
possibly damaging |
Het |
| Gabra6 |
T |
G |
11: 42,205,954 (GRCm39) |
T301P |
probably damaging |
Het |
| Ganab |
T |
A |
19: 8,888,477 (GRCm39) |
Y511N |
probably damaging |
Het |
| Grm4 |
T |
A |
17: 27,657,412 (GRCm39) |
|
probably benign |
Het |
| H1f6 |
G |
T |
13: 23,880,307 (GRCm39) |
K153N |
possibly damaging |
Het |
| Kcnj9 |
G |
A |
1: 172,153,488 (GRCm39) |
S212F |
probably damaging |
Het |
| Kif15 |
C |
A |
9: 122,788,993 (GRCm39) |
H62N |
probably benign |
Het |
| Kptn |
A |
G |
7: 15,854,647 (GRCm39) |
D106G |
probably damaging |
Het |
| Krtap13-1 |
T |
A |
16: 88,526,192 (GRCm39) |
S139T |
probably damaging |
Het |
| Lepr |
C |
A |
4: 101,622,131 (GRCm39) |
N354K |
probably benign |
Het |
| Lypd3 |
G |
T |
7: 24,337,969 (GRCm39) |
E112* |
probably null |
Het |
| Med13l |
A |
T |
5: 118,886,749 (GRCm39) |
N1550I |
probably damaging |
Het |
| Mettl2 |
C |
T |
11: 105,017,670 (GRCm39) |
P60L |
probably benign |
Het |
| Mtcl2 |
G |
T |
2: 156,902,182 (GRCm39) |
R278S |
probably damaging |
Het |
| Muc4 |
A |
G |
16: 32,590,201 (GRCm39) |
E850G |
probably damaging |
Het |
| Mylk |
G |
C |
16: 34,699,845 (GRCm39) |
E403Q |
possibly damaging |
Het |
| Nek1 |
A |
G |
8: 61,542,626 (GRCm39) |
R739G |
probably damaging |
Het |
| Nipbl |
A |
T |
15: 8,381,039 (GRCm39) |
D584E |
probably benign |
Het |
| Nkain3 |
C |
T |
4: 20,158,388 (GRCm39) |
V162M |
possibly damaging |
Het |
| Nmrk1 |
T |
C |
19: 18,618,844 (GRCm39) |
|
probably benign |
Het |
| Nsd2 |
T |
C |
5: 34,018,372 (GRCm39) |
|
probably benign |
Het |
| Or2n1b |
T |
C |
17: 38,459,515 (GRCm39) |
F12S |
probably damaging |
Het |
| Or4b1 |
T |
A |
2: 89,979,627 (GRCm39) |
H241L |
probably damaging |
Het |
| Or4p23 |
A |
T |
2: 88,576,352 (GRCm39) |
N293K |
probably benign |
Het |
| Or5b24 |
T |
A |
19: 12,912,969 (GRCm39) |
V289D |
probably damaging |
Het |
| Or8b44 |
T |
A |
9: 38,410,418 (GRCm39) |
M151K |
possibly damaging |
Het |
| Otulinl |
A |
T |
15: 27,657,033 (GRCm39) |
I338N |
probably damaging |
Het |
| Phex |
T |
A |
X: 156,155,557 (GRCm39) |
|
probably benign |
Het |
| Pip5k1b |
G |
T |
19: 24,356,256 (GRCm39) |
D227E |
probably damaging |
Het |
| Prdm13 |
A |
G |
4: 21,683,914 (GRCm39) |
I119T |
unknown |
Het |
| Rab19 |
G |
T |
6: 39,360,893 (GRCm39) |
V14L |
probably benign |
Het |
| Rasa3 |
A |
G |
8: 13,630,118 (GRCm39) |
|
probably benign |
Het |
| Rgsl1 |
C |
T |
1: 153,678,074 (GRCm39) |
S118N |
probably damaging |
Het |
| Rif1 |
C |
T |
2: 52,000,365 (GRCm39) |
T1273M |
possibly damaging |
Het |
| Scn8a |
A |
G |
15: 100,870,711 (GRCm39) |
N254S |
probably damaging |
Het |
| Sema6a |
T |
C |
18: 47,425,048 (GRCm39) |
T188A |
probably damaging |
Het |
| Sh3pxd2a |
C |
T |
19: 47,257,201 (GRCm39) |
E506K |
probably damaging |
Het |
| Smarca2 |
A |
T |
19: 26,675,803 (GRCm39) |
K1014N |
probably damaging |
Het |
| Smarca4 |
T |
G |
9: 21,611,435 (GRCm39) |
|
probably null |
Het |
| Sntb1 |
T |
C |
15: 55,539,752 (GRCm39) |
R361G |
probably benign |
Het |
| Stx5a |
T |
A |
19: 8,732,275 (GRCm39) |
I208N |
probably damaging |
Het |
| Tas2r102 |
T |
A |
6: 132,739,415 (GRCm39) |
W108R |
probably damaging |
Het |
| Tcl1 |
A |
G |
12: 105,184,929 (GRCm39) |
Y94H |
probably damaging |
Het |
| Tenm3 |
T |
A |
8: 48,689,629 (GRCm39) |
Y1986F |
probably damaging |
Het |
| Tet2 |
G |
A |
3: 133,173,945 (GRCm39) |
P1439L |
probably benign |
Het |
| Tiam2 |
T |
C |
17: 3,563,108 (GRCm39) |
|
probably benign |
Het |
| Ubap2l |
G |
A |
3: 89,928,553 (GRCm39) |
T526M |
probably damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Ushbp1 |
T |
A |
8: 71,841,391 (GRCm39) |
|
probably benign |
Het |
| Usp28 |
C |
T |
9: 48,915,169 (GRCm39) |
R115C |
probably damaging |
Het |
| Vmn2r5 |
C |
T |
3: 64,411,186 (GRCm39) |
D461N |
probably benign |
Het |
| Vmn2r86 |
A |
T |
10: 130,282,265 (GRCm39) |
F784I |
probably damaging |
Het |
| Zfp59 |
A |
T |
7: 27,553,513 (GRCm39) |
I322F |
probably damaging |
Het |
| Zfp607a |
A |
T |
7: 27,578,574 (GRCm39) |
H548L |
probably benign |
Het |
| Zfp626 |
G |
A |
7: 27,518,048 (GRCm39) |
C343Y |
probably damaging |
Het |
|
| Other mutations in Vldlr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01346:Vldlr
|
APN |
19 |
27,217,081 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01575:Vldlr
|
APN |
19 |
27,224,031 (GRCm39) |
missense |
probably benign |
|
|
IGL01626:Vldlr
|
APN |
19 |
27,221,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02213:Vldlr
|
APN |
19 |
27,218,726 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02365:Vldlr
|
APN |
19 |
27,223,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02488:Vldlr
|
APN |
19 |
27,215,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Vldlr
|
APN |
19 |
27,215,485 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02947:Vldlr
|
APN |
19 |
27,217,120 (GRCm39) |
missense |
probably benign |
0.03 |
|
disturbed
|
UTSW |
19 |
27,216,204 (GRCm39) |
nonsense |
probably null |
|
|
r26
|
UTSW |
19 |
27,223,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
spotty
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4142001:Vldlr
|
UTSW |
19 |
27,212,269 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0195:Vldlr
|
UTSW |
19 |
27,215,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0288:Vldlr
|
UTSW |
19 |
27,218,051 (GRCm39) |
splice site |
probably benign |
|
|
R0536:Vldlr
|
UTSW |
19 |
27,217,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0537:Vldlr
|
UTSW |
19 |
27,225,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0542:Vldlr
|
UTSW |
19 |
27,213,655 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0594:Vldlr
|
UTSW |
19 |
27,212,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Vldlr
|
UTSW |
19 |
27,215,663 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1017:Vldlr
|
UTSW |
19 |
27,218,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1148:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1443:Vldlr
|
UTSW |
19 |
27,217,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1493:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1520:Vldlr
|
UTSW |
19 |
27,224,466 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1520:Vldlr
|
UTSW |
19 |
27,217,943 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1657:Vldlr
|
UTSW |
19 |
27,223,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Vldlr
|
UTSW |
19 |
27,218,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2047:Vldlr
|
UTSW |
19 |
27,212,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Vldlr
|
UTSW |
19 |
27,215,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2273:Vldlr
|
UTSW |
19 |
27,225,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vldlr
|
UTSW |
19 |
27,213,688 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R3196:Vldlr
|
UTSW |
19 |
27,220,554 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3752:Vldlr
|
UTSW |
19 |
27,215,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Vldlr
|
UTSW |
19 |
27,195,021 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3835:Vldlr
|
UTSW |
19 |
27,212,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Vldlr
|
UTSW |
19 |
27,215,713 (GRCm39) |
missense |
probably benign |
|
|
R4301:Vldlr
|
UTSW |
19 |
27,215,802 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4470:Vldlr
|
UTSW |
19 |
27,212,219 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4541:Vldlr
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4765:Vldlr
|
UTSW |
19 |
27,217,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Vldlr
|
UTSW |
19 |
27,217,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4795:Vldlr
|
UTSW |
19 |
27,216,252 (GRCm39) |
splice site |
probably null |
|
|
R4839:Vldlr
|
UTSW |
19 |
27,215,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5074:Vldlr
|
UTSW |
19 |
27,215,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5134:Vldlr
|
UTSW |
19 |
27,216,212 (GRCm39) |
nonsense |
probably null |
|
|
R5281:Vldlr
|
UTSW |
19 |
27,221,631 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5466:Vldlr
|
UTSW |
19 |
27,217,243 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5514:Vldlr
|
UTSW |
19 |
27,221,624 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5886:Vldlr
|
UTSW |
19 |
27,221,171 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5889:Vldlr
|
UTSW |
19 |
27,217,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6110:Vldlr
|
UTSW |
19 |
27,215,477 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6343:Vldlr
|
UTSW |
19 |
27,223,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6833:Vldlr
|
UTSW |
19 |
27,217,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6838:Vldlr
|
UTSW |
19 |
27,225,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7169:Vldlr
|
UTSW |
19 |
27,221,728 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vldlr
|
UTSW |
19 |
27,212,241 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7304:Vldlr
|
UTSW |
19 |
27,216,004 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7403:Vldlr
|
UTSW |
19 |
27,213,674 (GRCm39) |
nonsense |
probably null |
|
|
R7658:Vldlr
|
UTSW |
19 |
27,220,536 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7754:Vldlr
|
UTSW |
19 |
27,195,015 (GRCm39) |
start codon destroyed |
probably benign |
0.01 |
|
R8105:Vldlr
|
UTSW |
19 |
27,216,204 (GRCm39) |
nonsense |
probably null |
|
|
R8377:Vldlr
|
UTSW |
19 |
27,212,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8529:Vldlr
|
UTSW |
19 |
27,207,656 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8777:Vldlr
|
UTSW |
19 |
27,217,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vldlr
|
UTSW |
19 |
27,217,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Vldlr
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9400:Vldlr
|
UTSW |
19 |
27,216,175 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9483:Vldlr
|
UTSW |
19 |
27,224,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9502:Vldlr
|
UTSW |
19 |
27,218,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9509:Vldlr
|
UTSW |
19 |
27,221,687 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9630:Vldlr
|
UTSW |
19 |
27,207,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9767:Vldlr
|
UTSW |
19 |
27,212,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9768:Vldlr
|
UTSW |
19 |
27,218,720 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATGATGACGCAGACTGTTCAGAC -3'
(R):5'- ACACAGGAGAAAAGTTCCACTGCTG -3'
Sequencing Primer
(F):5'- TGTTCAGACCAATCAGACGAGTC -3'
(R):5'- ACACAGTCTCGGATGCCATTG -3'
|
| Posted On |
2014-08-22 |
Incidental Mutation