Incidental Mutation 'R0326:Adamts16'
| ID |
25897 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts16
|
| Ensembl Gene |
ENSMUSG00000049538 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 16 |
| Synonyms |
|
| MMRRC Submission |
038536-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0326 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
70875921-70989930 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70927730 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 503
(E503G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105316
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080145]
[ENSMUST00000109694]
[ENSMUST00000123552]
|
| AlphaFold |
Q69Z28 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000080145
AA Change: E503G
PolyPhen 2
Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
AA Change: E503G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109694
AA Change: E503G
PolyPhen 2
Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
AA Change: E503G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000123552
AA Change: E503G
PolyPhen 2
Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000122031
Gene: ENSMUSG00000049538
AA Change: E503G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
5.9e-33 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
5.1e-14 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
2.2e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
1.2e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
1.2e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
9.7e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.8%
- 20x: 91.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AA986860 |
C |
T |
1: 130,670,635 (GRCm39) |
P286S |
possibly damaging |
Het |
| Aagab |
T |
A |
9: 63,526,444 (GRCm39) |
S156T |
probably damaging |
Het |
| Abca14 |
T |
G |
7: 119,823,642 (GRCm39) |
Y390D |
probably damaging |
Het |
| Abcc2 |
T |
A |
19: 43,814,386 (GRCm39) |
I1122N |
possibly damaging |
Het |
| Adamts9 |
A |
T |
6: 92,835,038 (GRCm39) |
C697* |
probably null |
Het |
| Adgrv1 |
T |
C |
13: 81,623,112 (GRCm39) |
D3837G |
possibly damaging |
Het |
| Ahcyl |
T |
A |
16: 45,974,246 (GRCm39) |
D377V |
probably benign |
Het |
| Aire |
T |
A |
10: 77,878,433 (GRCm39) |
R128S |
probably damaging |
Het |
| Alkbh2 |
A |
C |
5: 114,262,011 (GRCm39) |
*240E |
probably null |
Het |
| Als2 |
T |
C |
1: 59,219,742 (GRCm39) |
Y1191C |
probably damaging |
Het |
| Anapc5 |
A |
T |
5: 122,952,667 (GRCm39) |
V186E |
probably benign |
Het |
| Apob |
C |
T |
12: 8,040,307 (GRCm39) |
A548V |
probably damaging |
Het |
| B3galt4 |
A |
T |
17: 34,169,722 (GRCm39) |
V172E |
probably damaging |
Het |
| Bbs7 |
A |
C |
3: 36,646,525 (GRCm39) |
C432G |
possibly damaging |
Het |
| Cacna2d3 |
T |
A |
14: 28,767,601 (GRCm39) |
E758V |
probably damaging |
Het |
| Cactin |
T |
G |
10: 81,158,496 (GRCm39) |
L154R |
probably benign |
Het |
| Ccdc88a |
A |
C |
11: 29,411,021 (GRCm39) |
R502S |
probably benign |
Het |
| Ccnf |
A |
T |
17: 24,450,784 (GRCm39) |
I398N |
possibly damaging |
Het |
| Chd1 |
A |
T |
17: 15,988,828 (GRCm39) |
D1527V |
probably damaging |
Het |
| Chd1 |
A |
T |
17: 15,988,830 (GRCm39) |
M1528L |
probably benign |
Het |
| Chrac1 |
G |
A |
15: 72,964,675 (GRCm39) |
|
probably null |
Het |
| Cln3 |
T |
G |
7: 126,182,217 (GRCm39) |
M1L |
probably damaging |
Het |
| Cnot6 |
T |
C |
11: 49,568,263 (GRCm39) |
Y442C |
probably damaging |
Het |
| Col19a1 |
A |
T |
1: 24,324,132 (GRCm39) |
|
probably null |
Het |
| Col1a2 |
T |
C |
6: 4,537,838 (GRCm39) |
F1116L |
unknown |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Cops4 |
T |
G |
5: 100,676,408 (GRCm39) |
V53G |
probably damaging |
Het |
| Crnkl1 |
A |
G |
2: 145,761,875 (GRCm39) |
S561P |
probably benign |
Het |
| Ctnnb1 |
C |
A |
9: 120,780,778 (GRCm39) |
Q99K |
probably benign |
Het |
| Cxcr5 |
T |
C |
9: 44,424,578 (GRCm39) |
S360G |
probably benign |
Het |
| Dab2 |
G |
A |
15: 6,447,797 (GRCm39) |
V60M |
probably damaging |
Het |
| Ddx3y |
A |
T |
Y: 1,263,321 (GRCm39) |
Y648* |
probably null |
Het |
| Dennd2a |
T |
A |
6: 39,474,044 (GRCm39) |
D430V |
probably damaging |
Het |
| Dsp |
G |
T |
13: 38,376,846 (GRCm39) |
E1544* |
probably null |
Het |
| Efcab7 |
A |
T |
4: 99,719,631 (GRCm39) |
M38L |
possibly damaging |
Het |
| Fto |
A |
G |
8: 92,136,155 (GRCm39) |
N141S |
probably damaging |
Het |
| Gabrp |
A |
G |
11: 33,504,362 (GRCm39) |
F318L |
probably damaging |
Het |
| Gmeb1 |
A |
C |
4: 131,969,663 (GRCm39) |
C103W |
probably damaging |
Het |
| Heatr9 |
T |
C |
11: 83,405,365 (GRCm39) |
D365G |
probably damaging |
Het |
| Hif3a |
G |
A |
7: 16,778,325 (GRCm39) |
R436W |
probably benign |
Het |
| Hint2 |
A |
G |
4: 43,654,378 (GRCm39) |
V145A |
probably damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,313,237 (GRCm39) |
L3482* |
probably null |
Het |
| Hsd3b1 |
A |
T |
3: 98,760,590 (GRCm39) |
Y134N |
probably damaging |
Het |
| Impg2 |
T |
A |
16: 56,080,848 (GRCm39) |
V775E |
probably damaging |
Het |
| Ipo5 |
A |
G |
14: 121,159,635 (GRCm39) |
I154M |
probably benign |
Het |
| Itgad |
T |
A |
7: 127,797,550 (GRCm39) |
F893Y |
probably benign |
Het |
| Itprid1 |
A |
T |
6: 55,875,228 (GRCm39) |
M393L |
possibly damaging |
Het |
| Kdm4a |
T |
C |
4: 118,018,903 (GRCm39) |
R438G |
probably benign |
Het |
| Klk1b11 |
T |
A |
7: 43,425,943 (GRCm39) |
M1K |
probably null |
Het |
| Lama5 |
A |
T |
2: 179,824,219 (GRCm39) |
V2602D |
possibly damaging |
Het |
| Lrch3 |
T |
C |
16: 32,799,870 (GRCm39) |
S35P |
probably damaging |
Het |
| Mfn2 |
A |
G |
4: 147,967,745 (GRCm39) |
L441P |
probably damaging |
Het |
| Mgat4c |
A |
T |
10: 102,224,565 (GRCm39) |
I260F |
probably damaging |
Het |
| Mon1b |
T |
A |
8: 114,364,375 (GRCm39) |
S51T |
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,036,744 (GRCm39) |
D993G |
probably benign |
Het |
| Myo1a |
A |
G |
10: 127,552,166 (GRCm39) |
N762D |
probably benign |
Het |
| Nacc2 |
A |
T |
2: 25,950,345 (GRCm39) |
Y464N |
probably damaging |
Het |
| Nckap1 |
A |
G |
2: 80,383,714 (GRCm39) |
I150T |
probably benign |
Het |
| Ndufv2 |
G |
T |
17: 66,387,816 (GRCm39) |
P119T |
probably damaging |
Het |
| Noc4l |
G |
A |
5: 110,800,241 (GRCm39) |
R95* |
probably null |
Het |
| Ntng1 |
A |
T |
3: 110,042,819 (GRCm39) |
Y2* |
probably null |
Het |
| Oog4 |
T |
C |
4: 143,165,773 (GRCm39) |
N53D |
probably benign |
Het |
| Or10ak11 |
A |
T |
4: 118,687,022 (GRCm39) |
V205D |
possibly damaging |
Het |
| Or4d11 |
C |
T |
19: 12,013,525 (GRCm39) |
V194I |
probably benign |
Het |
| Or6c6c |
A |
G |
10: 129,541,638 (GRCm39) |
E297G |
possibly damaging |
Het |
| Or9i1b |
C |
T |
19: 13,896,873 (GRCm39) |
T163I |
probably benign |
Het |
| Phkg2 |
T |
G |
7: 127,173,075 (GRCm39) |
L11R |
probably damaging |
Het |
| Pogz |
A |
G |
3: 94,777,424 (GRCm39) |
D368G |
probably damaging |
Het |
| Prex2 |
T |
A |
1: 11,355,289 (GRCm39) |
L1530Q |
probably damaging |
Het |
| Prmt1 |
C |
T |
7: 44,628,878 (GRCm39) |
E144K |
probably damaging |
Het |
| Prss8 |
T |
A |
7: 127,526,348 (GRCm39) |
I121F |
probably benign |
Het |
| Psmd13 |
T |
C |
7: 140,477,624 (GRCm39) |
L314P |
probably damaging |
Het |
| Ptch2 |
G |
A |
4: 116,966,081 (GRCm39) |
G467D |
probably damaging |
Het |
| Rbm20 |
C |
A |
19: 53,852,596 (GRCm39) |
P1192Q |
probably damaging |
Het |
| Rpl19 |
T |
A |
11: 97,919,200 (GRCm39) |
D45E |
probably benign |
Het |
| Rsph10b |
C |
T |
5: 143,903,946 (GRCm39) |
A219V |
probably damaging |
Het |
| Rtraf |
C |
T |
14: 19,864,600 (GRCm39) |
|
probably null |
Het |
| Scaf1 |
T |
A |
7: 44,658,175 (GRCm39) |
T235S |
probably damaging |
Het |
| Shank1 |
T |
A |
7: 43,968,594 (GRCm39) |
C296S |
unknown |
Het |
| Slc39a7 |
A |
T |
17: 34,247,924 (GRCm39) |
V426D |
probably damaging |
Het |
| Slc41a2 |
A |
T |
10: 83,119,610 (GRCm39) |
V384D |
probably damaging |
Het |
| Slco1c1 |
T |
C |
6: 141,505,499 (GRCm39) |
L475P |
probably benign |
Het |
| Slco6d1 |
A |
C |
1: 98,418,359 (GRCm39) |
K515T |
probably benign |
Het |
| Sos2 |
T |
C |
12: 69,682,459 (GRCm39) |
E253G |
probably damaging |
Het |
| Sp6 |
G |
T |
11: 96,912,361 (GRCm39) |
D25Y |
possibly damaging |
Het |
| Syt11 |
A |
C |
3: 88,669,855 (GRCm39) |
D12E |
possibly damaging |
Het |
| Taf2 |
A |
G |
15: 54,910,856 (GRCm39) |
L606P |
probably damaging |
Het |
| Tbc1d5 |
A |
G |
17: 51,273,764 (GRCm39) |
Y116H |
probably damaging |
Het |
| Tnfrsf8 |
A |
G |
4: 145,015,029 (GRCm39) |
I243T |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,917,153 (GRCm39) |
S2183G |
probably benign |
Het |
| Trim66 |
T |
C |
7: 109,059,379 (GRCm39) |
Y853C |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,567,839 (GRCm39) |
T27685S |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,573,466 (GRCm39) |
E25809G |
probably damaging |
Het |
| Uvssa |
G |
A |
5: 33,566,191 (GRCm39) |
G445S |
probably benign |
Het |
| Zfp326 |
T |
C |
5: 106,058,141 (GRCm39) |
S427P |
probably damaging |
Het |
| Zfp592 |
A |
G |
7: 80,674,637 (GRCm39) |
T534A |
possibly damaging |
Het |
| Zfp672 |
A |
G |
11: 58,207,173 (GRCm39) |
S383P |
possibly damaging |
Het |
| Zfp799 |
A |
G |
17: 33,039,700 (GRCm39) |
S188P |
possibly damaging |
Het |
| Zyg11b |
A |
C |
4: 108,129,450 (GRCm39) |
V54G |
possibly damaging |
Het |
|
| Other mutations in Adamts16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Adamts16
|
APN |
13 |
70,943,603 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01338:Adamts16
|
APN |
13 |
70,984,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01663:Adamts16
|
APN |
13 |
70,941,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01804:Adamts16
|
APN |
13 |
70,949,080 (GRCm39) |
nonsense |
probably null |
|
|
IGL01874:Adamts16
|
APN |
13 |
70,916,823 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01984:Adamts16
|
APN |
13 |
70,935,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02305:Adamts16
|
APN |
13 |
70,921,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02357:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Adamts16
|
APN |
13 |
70,935,289 (GRCm39) |
splice site |
probably benign |
|
|
IGL02450:Adamts16
|
APN |
13 |
70,984,419 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02807:Adamts16
|
APN |
13 |
70,886,897 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03356:Adamts16
|
APN |
13 |
70,901,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
swap
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
switcheroo
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0201:Adamts16
|
UTSW |
13 |
70,927,763 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0336:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R0369:Adamts16
|
UTSW |
13 |
70,927,671 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0422:Adamts16
|
UTSW |
13 |
70,887,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Adamts16
|
UTSW |
13 |
70,916,766 (GRCm39) |
missense |
probably benign |
|
|
R0524:Adamts16
|
UTSW |
13 |
70,949,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0590:Adamts16
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0734:Adamts16
|
UTSW |
13 |
70,886,600 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Adamts16
|
UTSW |
13 |
70,886,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Adamts16
|
UTSW |
13 |
70,916,811 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0920:Adamts16
|
UTSW |
13 |
70,911,680 (GRCm39) |
splice site |
probably benign |
|
|
R1027:Adamts16
|
UTSW |
13 |
70,915,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1535:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Adamts16
|
UTSW |
13 |
70,946,154 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1700:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1734:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1736:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1737:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1738:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1746:Adamts16
|
UTSW |
13 |
70,927,717 (GRCm39) |
splice site |
probably null |
|
|
R1869:Adamts16
|
UTSW |
13 |
70,883,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1944:Adamts16
|
UTSW |
13 |
70,940,005 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1997:Adamts16
|
UTSW |
13 |
70,901,386 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2018:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2135:Adamts16
|
UTSW |
13 |
70,949,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2228:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R3410:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3842:Adamts16
|
UTSW |
13 |
70,887,010 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4117:Adamts16
|
UTSW |
13 |
70,916,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4435:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4436:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4526:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4552:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4555:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4556:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4557:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4579:Adamts16
|
UTSW |
13 |
70,927,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4639:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4640:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4641:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4642:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4672:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R5350:Adamts16
|
UTSW |
13 |
70,901,315 (GRCm39) |
nonsense |
probably null |
|
|
R5464:Adamts16
|
UTSW |
13 |
70,909,868 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5613:Adamts16
|
UTSW |
13 |
70,878,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5667:Adamts16
|
UTSW |
13 |
70,984,494 (GRCm39) |
nonsense |
probably null |
|
|
R5735:Adamts16
|
UTSW |
13 |
70,984,337 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5762:Adamts16
|
UTSW |
13 |
70,886,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5907:Adamts16
|
UTSW |
13 |
70,877,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Adamts16
|
UTSW |
13 |
70,918,393 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Adamts16
|
UTSW |
13 |
70,984,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Adamts16
|
UTSW |
13 |
70,927,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Adamts16
|
UTSW |
13 |
70,877,017 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6982:Adamts16
|
UTSW |
13 |
70,916,639 (GRCm39) |
splice site |
probably null |
|
|
R6996:Adamts16
|
UTSW |
13 |
70,946,157 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7313:Adamts16
|
UTSW |
13 |
70,921,074 (GRCm39) |
nonsense |
probably null |
|
|
R7356:Adamts16
|
UTSW |
13 |
70,984,399 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7509:Adamts16
|
UTSW |
13 |
70,935,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Adamts16
|
UTSW |
13 |
70,878,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Adamts16
|
UTSW |
13 |
70,984,265 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7968:Adamts16
|
UTSW |
13 |
70,886,701 (GRCm39) |
missense |
probably benign |
|
|
R8231:Adamts16
|
UTSW |
13 |
70,925,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8232:Adamts16
|
UTSW |
13 |
70,941,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Adamts16
|
UTSW |
13 |
70,984,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8485:Adamts16
|
UTSW |
13 |
70,886,794 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8772:Adamts16
|
UTSW |
13 |
70,984,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Adamts16
|
UTSW |
13 |
70,941,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8921:Adamts16
|
UTSW |
13 |
70,939,910 (GRCm39) |
splice site |
probably benign |
|
|
R8973:Adamts16
|
UTSW |
13 |
70,886,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9132:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9149:Adamts16
|
UTSW |
13 |
70,883,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9159:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9312:Adamts16
|
UTSW |
13 |
70,949,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Adamts16
|
UTSW |
13 |
70,949,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adamts16
|
UTSW |
13 |
70,909,892 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAAAAGTATCTCCCATCATCTGCTCCG -3'
(R):5'- GGAAACCCTCACGTTAGACATCTGC -3'
Sequencing Primer
(F):5'- tggtaggtgcccagtaaatg -3'
(R):5'- ATCCCTTGGTAACTCATCCTGT -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation