Incidental Mutation 'R3622:Or5b107'
ID 268692
Institutional Source Beutler Lab
Gene Symbol Or5b107
Ensembl Gene ENSMUSG00000045883
Gene Name olfactory receptor family 5 subfamily B member 107
Synonyms GA_x6K02T2RE5P-3491834-3492772, Olfr1461, MOR202-35
MMRRC Submission 040677-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R3622 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13142380-13143318 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13143020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 214 (M214K)
Ref Sequence ENSEMBL: ENSMUSP00000146358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053772] [ENSMUST00000207113] [ENSMUST00000208489]
AlphaFold Q8VEV7
Predicted Effect probably benign
Transcript: ENSMUST00000053772
AA Change: M214K

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000053269
Gene: ENSMUSG00000045883
AA Change: M214K

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 8e-6 PFAM
Pfam:7tm_1 42 291 2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207113
AA Change: M214K

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000208489
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T A 7: 119,950,036 (GRCm39) Y503* probably null Het
Akap9 C A 5: 4,026,235 (GRCm39) Q1297K possibly damaging Het
Dffb T C 4: 154,049,976 (GRCm39) T296A probably damaging Het
Dpf1 G A 7: 29,015,631 (GRCm39) probably null Het
Elp1 A T 4: 56,759,925 (GRCm39) probably null Het
Grid2ip T C 5: 143,371,774 (GRCm39) S666P probably damaging Het
Gucy2e T A 11: 69,115,877 (GRCm39) E835V probably damaging Het
Hdac5 G A 11: 102,086,644 (GRCm39) P120S probably benign Het
Htr1d T C 4: 136,170,815 (GRCm39) I348T probably damaging Het
Hyal4 A T 6: 24,765,737 (GRCm39) S364C probably damaging Het
Igkv1-133 A T 6: 67,701,944 (GRCm39) Q16L probably benign Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Met A T 6: 17,549,085 (GRCm39) D979V probably damaging Het
Mga A G 2: 119,772,245 (GRCm39) T1702A probably damaging Het
Midn A G 10: 79,986,144 (GRCm39) D78G probably benign Het
Muc5b T C 7: 141,405,595 (GRCm39) probably benign Het
Oma1 T C 4: 103,223,288 (GRCm39) I491T probably benign Het
Or1e30 A G 11: 73,678,567 (GRCm39) T268A probably benign Het
Or5ak24 C T 2: 85,260,837 (GRCm39) C112Y probably benign Het
Or8b48 A G 9: 38,492,792 (GRCm39) Y73C probably damaging Het
Pbld2 T C 10: 62,897,470 (GRCm39) L57P probably damaging Het
Phka2 T A X: 159,327,291 (GRCm39) Y334* probably null Het
Plin4 G T 17: 56,411,112 (GRCm39) T973K possibly damaging Het
R3hdm4 C T 10: 79,748,515 (GRCm39) R143H possibly damaging Het
Rps18 G C 17: 34,171,247 (GRCm39) probably null Het
Samd9l A T 6: 3,374,032 (GRCm39) C1076* probably null Het
Scml4 T C 10: 42,806,607 (GRCm39) probably benign Het
Slc16a10 A G 10: 40,017,890 (GRCm39) V48A probably benign Het
Slc6a5 T C 7: 49,567,371 (GRCm39) V275A probably benign Het
Smad9 C T 3: 54,696,705 (GRCm39) R257W probably damaging Het
Snrpb C A 2: 130,017,299 (GRCm39) R73L probably null Het
Srsf9 C T 5: 115,468,571 (GRCm39) A69V probably damaging Het
Stfa2 A G 16: 36,224,433 (GRCm39) Y90H probably damaging Het
Tgm6 T A 2: 129,993,681 (GRCm39) V640E possibly damaging Het
Tnrc6c C T 11: 117,640,451 (GRCm39) R1414C probably damaging Het
Tyk2 A T 9: 21,038,606 (GRCm39) C8S probably damaging Het
Upp2 G A 2: 58,680,128 (GRCm39) R300Q possibly damaging Het
Utp20 A G 10: 88,593,855 (GRCm39) probably benign Het
Veph1 C T 3: 66,122,858 (GRCm39) V224I probably benign Het
Vmn1r30 A T 6: 58,412,437 (GRCm39) F132I probably benign Het
Vmn2r116 A G 17: 23,605,025 (GRCm39) S113G probably benign Het
Vps53 A C 11: 76,008,609 (GRCm39) V237G probably benign Het
Other mutations in Or5b107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or5b107 APN 19 13,142,735 (GRCm39) missense probably damaging 1.00
IGL01370:Or5b107 APN 19 13,142,663 (GRCm39) missense possibly damaging 0.95
IGL01936:Or5b107 APN 19 13,142,767 (GRCm39) missense probably damaging 1.00
R0098:Or5b107 UTSW 19 13,143,026 (GRCm39) missense probably benign 0.12
R0270:Or5b107 UTSW 19 13,143,251 (GRCm39) missense probably damaging 1.00
R0575:Or5b107 UTSW 19 13,142,751 (GRCm39) nonsense probably null
R0627:Or5b107 UTSW 19 13,142,614 (GRCm39) missense probably benign 0.43
R1779:Or5b107 UTSW 19 13,142,404 (GRCm39) missense probably benign 0.00
R1956:Or5b107 UTSW 19 13,142,560 (GRCm39) missense probably damaging 1.00
R2446:Or5b107 UTSW 19 13,142,811 (GRCm39) missense probably benign 0.00
R4485:Or5b107 UTSW 19 13,142,855 (GRCm39) missense possibly damaging 0.54
R4605:Or5b107 UTSW 19 13,142,612 (GRCm39) missense probably damaging 1.00
R4757:Or5b107 UTSW 19 13,143,277 (GRCm39) missense probably benign 0.01
R4816:Or5b107 UTSW 19 13,142,488 (GRCm39) missense probably benign 0.10
R5038:Or5b107 UTSW 19 13,142,955 (GRCm39) missense probably benign 0.39
R7026:Or5b107 UTSW 19 13,142,779 (GRCm39) missense probably benign 0.08
R8225:Or5b107 UTSW 19 13,142,507 (GRCm39) missense probably damaging 1.00
R8232:Or5b107 UTSW 19 13,142,683 (GRCm39) missense probably benign 0.28
R9095:Or5b107 UTSW 19 13,143,310 (GRCm39) missense probably benign 0.01
R9127:Or5b107 UTSW 19 13,142,396 (GRCm39) missense probably damaging 1.00
R9697:Or5b107 UTSW 19 13,142,888 (GRCm39) missense possibly damaging 0.91
R9784:Or5b107 UTSW 19 13,142,813 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCAGTGTGTAAACCCCTAC -3'
(R):5'- GTGTCCATTGCATGTCTAGAGC -3'

Sequencing Primer
(F):5'- GCAGTGTGTAAACCCCTACATTATAC -3'
(R):5'- GTCTAGAGCTTGGCTGCAAATAC -3'
Posted On 2015-02-19